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함수 언어에 기반을 둔 구조적 분석의 정형적 명세와 실행
신윤식,김태남,임은기,이기수 金烏工科大學校 1993 論文集 Vol.14 No.-
An executable specification language for Structured Analysis specification and its execution model are presented. The model is based on Applicative State Transition system and the interpretation of data flow diagram in a viewpoint of data availability. AST system receives at most one input and does not accept until an output is issued. Our model is extended with availability list so that concurrency inherent in DFD can be treated.
Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis
Kim, Sang-Heon,Kim, Sang-Hoon,Bahn, Joon-Woo,Kim, Yoon-Keun,Chang, Yoon-Seok,Shin, Eun-Soon,Kim, Youn-Seup,Park, Jae-Seuk,Kim, Bo-Hyung,Jang, In-Jin,Song, Junghan,Kim, Seung-Hyun,Park, Hae-Sim,Min, Ky Future Medicine 2009 Pharmacogenomics Vol.10 No.11
<P>AIMS: Although some genetic risk factors have been reported for the development of hepatitis due to anti-TB drugs, an extensive candidate gene approach evaluating drug-metabolizing enzymes has not been attempted. This study aimed to investigate the association of genetic polymorphisms in drug-metabolizing enzymes with anti-TB drug-induced hepatitis. MATERIALS & METHODS: We compared genotype distributions of tagging SNPs in promoter, exons and haplotypes in seven drug-metabolizing enzyme genes (CYP2C9, CYP2C19, CYP2D6, CYP2E1, NAT2, UGT1A1 and UGT1A3) between 67 cases and 159 controls. RESULTS: Among four tagging SNPs of N-acetyltransferase 2 (NAT2), -9796T>A in promoter and R197Q were significantly associated (p = 0.0016 and p = 0.0007, respectively). NAT2 haplotype 2 [A-A-A-G] carrying A allele of -9796T>A and A allele of R197Q showed significant association (p = 0.0004). However, there was no significant association between genotypes of other enzyme-metabolizing genes and anti-TB drug-induced hepatitis. The constructs containing -9796A of NAT2 showed significantly lower luciferase activity (p < 0.01), suggesting decreased expression of NAT2. The variant alleles and haplotype 2 showed significantly higher peak serum levels of isoniazid, lower acetyl isoniazid:isoniazid ratio and lower isoniazid clearance compared with wild-types. CONCLUSION: These findings suggest that genetic variants in the promoter and exons of NAT2 increase the risk of anti-TB drug-induced hepatitis by modifying acetylation phenotypes and/or gene expression of NAT2, and there is no essential role for genetic mutation of the other metabolizing enzymes in the development of this adverse reaction.</P>
Kim, Eun Ky,Oh, Tae Jung,Kim, Lee-Kyung,Cho, Young Min The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.2
<P>Dietary fiber improves hyperglycemia in patients with type 2 diabetes through its physicochemical properties and possible modulation of gut hormone secretion, such as glucagon-like peptide 1 (GLP-1). We assessed the effect of dietary fiber-enriched cereal flakes (DC) on postprandial hyperglycemia and gut hormone secretion in patients with type 2 diabetes. Thirteen participants ate isocaloric meals based on either DC or conventional cereal flakes (CC) in a crossover design. DC or CC was provided for dinner, night snack on day 1 and breakfast on day 2, followed by a high-fat lunch. On day 2, the levels of plasma glucose, GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and insulin were measured. Compared to CC, DC intake exhibited a lower post-breakfast 2-hours glucose level (198.5±12.8 vs. 245.9±15.2 mg/dL, <I>P</I><0.05) and a lower incremental peak of glucose from baseline (101.8±9.1 vs. 140.3±14.3 mg/dL, <I>P</I><0.001). The incremental area under the curve (iAUC) of glucose after breakfast was lower with DC than with CC (<I>P</I><0.001). However, there were no differences in the plasma insulin, glucagon, GLP-1, and GIP levels. In conclusion, acute administration of DC attenuates postprandial hyperglycemia without any significant change in the representative glucose-regulating hormones in patients with type 2 diabetes (ClinicalTrials.gov. NCT 01997281).</P>
Kim, Eun Ky,Lee, Ji Seon,Cheong, Hae Il,Chung, Sung Soo,Kwak, Soo Heon,Park, Kyong Soo Korea Genome Organization 2014 Genomics & informatics Vol.12 No.4
Mutation in HNF1B, the hepatocyte nuclear factor-$1{\beta}$ (HNF-$1{\beta}$) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion. However, the functional role of HNF-$1{\beta}$ in insulin secretion and glucose metabolism is not fully understood. We identified a family with early-onset diabetes that fulfilled the criteria of MODY. Sanger sequencing revealed that a heterozygous P159L (CCT to CTT in codon 159 in the DNA-binding domain) mutation in HNF1B was segregated according to the affected status. To investigate the functional consequences of this HNF1B mutation, we generated a P159L HNF1B construct. The wild-type and mutant HNF1B constructs were transfected into COS-7 cells in the presence of the promoter sequence of human glucose transporter type 2 (GLUT2). The luciferase reporter assay revealed that P159L HNF1B had decreased transcriptional activity compared to wild-type (p < 0.05). Electrophoretic mobility shift assay showed reduced DNA binding activity of P159L HNF1B. In the MIN6 pancreatic ${\beta}$-cell line, overexpression of the P159L mutant was significantly associated with decreased mRNA levels of GLUT2 compared to wild-type (p < 0.05). However, INS expression was not different between the wild-type and mutant HNF1B constructs. These findings suggests that the impaired insulin secretion in this family with the P159L HNF1B mutation may be related to altered GLUT2 expression in ${\beta}$-cells rather than decreased insulin gene expression. In conclusion, we have identified a Korean family with an HNF1B mutation and characterized its effect on the pathogenesis of diabetes.
Pyrolysis characteristics and kinetics of microalgal <i>Aurantiochytrium</i> sp. KRS101
Vo, The Ky,Ly, Hoang Vu,Lee, Ok Kyung,Lee, Eun Yeol,Kim, Chul Ho,Seo, Jeong-Woo,Kim, Jinsoo,Kim, Seung-Soo Pergamon Press 2017 Energy Vol.118 No.-
<P><B>Abstract</B></P> <P>Microalgae have recently attracted tremendous attention as a possible feedstock for biofuel production. In this study, the pyrolysis characteristics and kinetics of <I>Aurantiochytrium</I> sp. KRS101, a kind of heterotrophic oleaginous microalgae, were investigated by means of thermogravimetric analysis and pyrolysis in a micro-tubing reactor. Most biochemical components of the microalgae (carbohydrates, proteins, and lipids) were decomposed between 150 and 600 °C at heating rates of 5–20 °C/min. Derivative thermogravimetry (DTG) curves were deconvoluted to more fully understand the separate decompositions of carbohydrates, proteins, and lipids. Experimental results of pyrolysis in the micro-tubing reactor were consistent with the predictions of the proposed lumped kinetic model, and the kinetic rate constants indicated that the predominant reaction pathway under the investigated pyrolysis conditions was from biomass to bio-oil rather than from biomass to gas.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Systematic study and first attempt at pyrolysis of <I>Aurantiochytrium</I> sp. KRS101. </LI> <LI> Investigation of pyrolysis characteristics and kinetics by means of non-isothermal TGA and isothermal pyrolysis experiments. </LI> <LI> Study of the influence of pyrolysis conditions upon product yield distribution and composition. </LI> <LI> Application of a quantitative kinetic model and mechanism study for pyrolysis of microalgae. </LI> </UL> </P>
p38 MAPK을 이용한 항염증 효능 규명 프로토타입 개발
김철(Chul Kim),예상준(Sang-jun Yae),남기엽(Ky-youb Nam),김상균(Sang-kyun Kim),장현철(Hyun-chul Jang),김진현(Jin-hyun Kim),김영은(Young-eun Kim),송미영(Mi-young Song) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.3
Objectives : The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway. Methods : We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathwaystudio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds' interaction. Results & Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell's cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.
( Ji Hyun Lee ),( Eun Ky Kim ),( Eun Roh ),( Jae Hyun Bae ),( Jung Hee Kim ),( Ji Won Yoon ),( Seong Yeon Kim ),( Sang Wan Kim ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: We aimed to assess the roles of pre-contrast Hounsfi eld units (HU) and the size of tumor on computed tomography (CT) to distinguish between benign and malignant lesions in cancer patients Methods: From 2000 to 2012, total 1029 patients with adrenal incidentalomas were reviewed retrospectively. We investigated baseline clinical characteristics and radiological features of adrenal incidentalomas in 181 (17.6%) patients with cancer. Receiver operating characteristic (ROC) curve analysis was used to suggest the reference of size and mean Hounsfi eld units for excluding adrenal metastasis in cancer patients with adrenal mass. Results: Mean age was 59.7 ± 12.8 years, and 62% of patients were male. Initial size was 23.1 ± 19.6 mm, and 60% of tumors were in the left side. Bilateral adrenal tumors were found in 6.0%. Biochemically functioning tumors were in 9.4% of patients. Thirty-two patients underwent adrenalectomies, which revealed metastasis in 12 patients (52.4%). We compared the cases of adrenal metastasis (M) to the cases of benign adrenal lesions (B). The tumor size was 33.6 ± 14.9 mm (M) versus 17.1 ± 7.7 mm (B) (p<0.001). The attenuation value was 37.8 ± 10.1 HU (M) versus 16.7 ± 28.5 U (B) (p=0.007). The Area under the curve of size and Hounsfi eld units were 0.968 and 0.845, respectively. The tumor size change per year(mm/yr) was 12.9 ± 31.7 (M) versus 0.7 ± 1.2 (B) (p<0.001) The primary cancers were lung cancer (n=4), renal cell carcinoma (n=2), lymphoma (n=2), hepatocellular carcinoma (n=2), breast cancer (n=1), and others. Conclusions: Benign lesions may be suggested with cut-off values of tumor size <28.5 mm and <26HU on CT in cancer patients with adrenal mass.
장문석,오명숙,이병희,양웅모,김원남,김도림,김향미,박은화,박완수,김윤경,박성규,Chang, Mun-Seog,Oh, Myung-Sook,Lee, Byong-Hee,Yang, Woong-Mo,Kim, Won-Nam,Kim, Do-Rim,Kim, Hyang-Mi,Park, Eun-Hwa,Park, Wan-Su,Kim, Yun-Kyung,Park, Seong-Ky 대한한의학방제학회 2006 大韓韓醫學方劑學會誌 Vol.14 No.1
The purpose of this study was to investigate the effect of water extract of Dioscoreae Rhizome on the reproduction activity of Wistar male rat. The group treated with 1.0 g/kg/day oral administrations of water extract of Dioscoreae Rhizoma (SK0l6) during 8 weeks was compared with the normal group. Sperm count, sperm motility, body weight, and testis weight were investigated in two groups. Sperm count. body weight, and testis weight of two groups did not show the significant difference. But sperm motility of the treated group was reduced significantly (the normal group: 56.43 %, SK0l6 group: 53.47 %, p < 0.05). According to the results, SK0l6 have no effects on sperm count, body weight. and testis weight but reduced sperm motility significantly.