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( Yuying Wang ),( Xue Yan ),( Weiwei Zhang ),( Yuanyuan Liu ),( Deping Han ),( Kedao Teng ),( Yunfei Ma ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.6
Farm animals such as piglets are often affected by environmental stress, which can disturb the gut ecosystem. Antibiotics were commonly used to prevent diarrhea in weaned piglets, but this was banned by the European Union due to the development of antibiotic resistance. However, the use of probiotics instead of antibiotics may reduce the risk posed by pathogenic microorganisms and reduce the incidence of gastrointestinal diseases. Therefore, this study was conducted to investigate the effects of Lactobacillus casei Zhang on the mechanical barrier and immune function of early-weaned piglets infected using Escherichia coli K88 based on histomorphology and immunology. Fourteen-day-old weaned piglets were divided into a control group and experimental groups that were fed L. casei Zhang and infected with E. coli K88 with or without prefeeding and/or postfeeding of L. casei Zhang. The L. casei Zhang dose used was 107 CFU/g diet. Jejunum segments were obtained before histological, immunohistochemical, and western blot analyses were performed. In addition, the relative mRNA expression of toll receptors and cytokines was measured. Piglets fed L. casei Zhang showed significantly increased jejunum villus height, villus height-crypt depth ratio, muscle thickness, and expression of proliferating cell nuclear antigen and tight junction proteins ZO-1 and occludin. The use of L. casei Zhang effectively reduced intestinal inflammation after infection. We found that L. casei Zhang feeding prevented the jejunum damage induced by E. coli K88, suggesting that it may be a potential alternative to antibiotics for preventing diarrhea in early-weaned piglets.
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Yue Lin,Yuanyuan Zhang,Qiongtao Song,Tao Song,Xue Han,Ying Zhang,Xuan Zhang,Xi Chu,Fenghua Zhang,Li Chu,Jianping Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10
To explore the cardiovascular protective effectsof Magnesium isoglycyrrhizinate (MI), especially theunderlying cellular mechanisms related to L-type calciumchannels and myocardial contractility, and to examine theeffects of MI on hERG K? current expressed in HEK293cells. We used the whole-cell patch clamp technique,video-based edge detection and dual excitation fluorescencephotomultiplier systems to explore the effect of MIon L-type Ca2? currents (ICa-L) and cell contraction in ratcardiomyocytes. We also examined the rapidly activatingdelayed rectifier potassium current (IKr) expressed inHEK293 cells using a perforated patch clamp. MI inhibitedICa-L in a dose-dependent manner, with a half-maximalinhibitory concentration (IC50) of 0.22 mg/ml, and themaximal inhibitory effect was 61.10 ± 0.59%. MI at aconcentration of 0.3 mg/ml reduced cell shortening by24.12 ± 3.97% and the peak value of the Ca2? transient by36.54 ± 4.96%. MI had no significant influence on hERGK? channels expressed in HEK293 cells at all testpotentials. MI exerts protective effects on the heart via theinhibition of ICa-L and cell shortening in rat cardiomyocytes. However, MI had no significant influence on IKr;thus, MI may exert cardioprotective effects without causingdrug-induced long QT syndrome.
Crowded Cluster Cores: An Algorithm for Deblending in Dark Energy Survey Images
Zhang, Yuanyuan,McKay, Timothy A.,Bertin, Emmanuel,Jeltema, Tesla,Miller, Christopher J.,Rykoff, Eli,Song, Jeeseon Astronomical Society of the Pacific 2015 Publications of the Astronomical Society of the Pa Vol.127 No.957
Yuanyuan Zhang,Jun Li,Mingyun Lv,Dongjie Tan,Weiyu Zhu,Kangwen Sun 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.3
Solar energy is the ideal power choice for long-endurance stratospheric airships. The output performance of solar array on stratospheric airship is affected by several major factors: flying latitude, flight date, airship’s attitude and the temperature of solar cell, but the research on the effect of these factors on output performance is rare. This paper establishes a new simplified analytical model with thermal effects to analyze the output performance of the solar array. This model consisting of the geometric model of stratospheric airship, solar radiation model and incident solar radiation model is developed using MATLAB computer program. Based on this model, the effects of the major factors on the output performance of the solar array are investigated expediently and easily. In the course of the research, the output power of solar array is calculated for five airship’s latitudes of 0°, 15°, 30°, 45° and 60°, four special dates and different attitudes of five pitch angles and four yaw angles. The effect of these factors on output performance is discussed in detail. The results are helpful for solving the energy problem of the long endurance airship and planning the airline.
Oil film stiffness and damping in an elastohydrodynamic lubrication line contact-vibration
Yuanyuan Zhang,Hua iju Liu,Caichao Zhu,Mingyong Liu,Chaosheng Song 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.7
An elastohydrodynamic lubrication line contact-vibration model is proposed to study the stiffness and damping of the oil film existed in the EHL contact region. An initial mutual approach between interacting surfaces, which deviates from the steady-state balanced position, is assumed under the free contact-vibration to predict the response of the mutual approach. An inertia term, which represents the acceleration of the gap motion, is added to the classical force balance equation to form the equation of motion of the mutual approach. Response of the mutual approach is solved based upon the solving of the contact-dynamic model. The oil stiffness is calculated according to the natural frequency of the response under damped and non-damped conditions, the latter of which represents dry contact conditions. The oil film damping is calculated in terms of the principle of the energy conservation which utilizes the whole history of response compared with the log decrement method. Effect of the normal load, the rolling speed and the amplitude of the regular sinusoidal surface waviness on the oil film stiffness, the contact stiffness and the oil film damping are studied. The study provides an insight on the oil film dynamic characteristics of lubricated contact-vibration problems which appear in gears, bearings, etc. The results show that the oil film damping factor decreases with the increasing normal load as well as the increasing rolling speed. The oil film stiffness increases with the normal load and decreases with the rolling speed. Also, compared to the contact stiffness, the oil film stiffness makes less contribution to the total stiffness. The surface waviness amplitude has little effect on the oil film stiffness and the oil film damping.
Yuanyuan Zhang,Qiuxiang Zhao,Hui Tang,Huiling Li,Depeng Li,Zhiyong Wang,Xin Gao,Fanye Wang 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.5
Enantiopure esomeprazole is an important drug in the treatment of gastric ulcer. The asymmetric sulfoxidation of omeprazole thioether was catalyzed by immobilized cells of a mutant of Rhodococcus rhodocrous ATCC 4276 to synthesize esomeprazole. The bioreaction was carried out in a biphasic system (chloroform-water), at a high substrate concentration (200mM), and optimized using response surface methodology (RSM). The optimal yield of esomeprazole obtained was 94.8% with e.e. (>99%) without the formation of the sulfone form as a byproduct, under the optimal conditions: the concentration of immobilized cells, 283.5 g/L, the incubation temperature, 37.05 oC, and pH of phosphate buffer, 7.35, respectively. A quadratic polynomial model was developed with R2 of 0.9998, which indicates that the model predicts the observed data with very high accuracy. The mutant exhibited a high enantioselective activity and substrate and product tolerance. The small size of immobilized cell beads (0.5-1 mm) creates a large reaction interface. The aerated flask provides enough oxygen for a high concentration of cells. The significant improvement of substrate tolerance may mainly be attributed to employing the chloroform-water biphasic system because organic substrates may be partitioned in the organic phase, eliminating potential damage and inhibition to cells. Based on the above, the asymmetric sulfoxidation catalyzed by immobilized bacterial cells is therefore more promising for efficient synthesis of chiral sulfoxides.
An Optimal Joint Call Admission Control Policy in Heterogeneous Wireless Networks
YuanYuan ZHANG,Chuang-bai XIAO,Jian WANG 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.1
In heterogeneous wireless networks (HWNs), a scheme called Joint Call Admission Control (JCAC) is demanding for deciding whether or not an incoming service request will be accepted. In this paper, we propose an optimal JCAC policy for HWNs based on semi-Markov decision process (SMDP) to achieve the optimal resource management scheme in terms of minimal the network cost and acquire the required quality of service (QoS) of mobile user. Furthermore, an improved value iteration algorithm with multi-dimensional threshold structure is presented. Numerical results show that the proposed JCAC policy is the overall optimal policy. The proposed algorithm is effective for high QoS performance by reducing the probabilities of dropping and blocking calls. The optimal JCAC policy is ratified by the current trend in the design of next generation wireless networks (NGWNs).
유아 교육용 어플리케이션 동향분석 및 발전방향에 관한 연구
ZHANG YUANYUAN,KUO CHUNCHENG,여등승(YU DENGSHENG) 한국IT서비스학회 2018 한국IT서비스학회 학술대회 논문집 Vol.2018 No.-
2015년까지 교육용 어플리케이션의 규모는 애플 스토어 중 게임 다음으로 두 번째를 기록하며 약 15억 위안을 넘어 약 70,000여개의 어플리케이션이 차지하고 있다. 교육용 어플리케이션에서 인기 다운로드의 80%이상이 유아 대상이다. 본 논문에서는 중국에 유아 교육용 어플리케이션을 대상으로 살펴보고 개발자를 위한 유아 교육용 어플리케이션의 발전방향을 논의하는데 그 목적이다. 연구결과, MAU 상위 50개의 유아 교육용 어플리케이션의 내용은 언어를 바탕으로 나타났으며, 인앱 구매는 32%인 것으로 나타났다. 또는 유아 교육용 어플리케이션의 내용과 평가, 내용과 사용자, 내용과 지불 여부, 사용자와 평가 사이 유의한 것으로 나타났다.