Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors

Zhang, Ling-Qiang,Zhang, Xiu-De,Xu, Jia,Wan, Yong,Qu, Kai,Zhang, Jing-Yao,Wang, Zhi-Xin,Wei, Ji-Chao,Meng, Fan-Di,Tai, Ming-Hui,Zhou, Lei,Liu, Chang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.

Multi-Description Image Compression Coding Algorithm Based on Depth Learning

Yong Zhang,Guoteng Hui,Lei Zhang 한국정보처리학회 2023 Journal of information processing systems Vol.19 No.2

Aiming at the poor compression quality of traditional image compression coding (ICC) algorithm, a multidescriptionICC algorithm based on depth learning is put forward in this study. In this study, first an imagecompression algorithm was designed based on multi-description coding theory. Image compression sampleswere collected, and the measurement matrix was calculated. Then, it processed the multi-description ICCsample set by using the convolutional self-coding neural system in depth learning. Compressing the waveletcoefficients after coding and synthesizing the multi-description image band sparse matrix obtained the multidescriptionICC sequence. Averaging the multi-description image coding data in accordance with the effectivesingle point’s position could finally realize the compression coding of multi-description images. According toexperimental results, the designed algorithm consumes less time for image compression, and exhibits betterimage compression quality and better image reconstruction effect.

A novel recyclable nano-adsorbent for enhanced oil recovery with efficient removal of Ca2+ and Cr6+ from oilfield wastewater

Lei He,Yong Dai,Zhe Wang,Lutao Yang,Luxia Zhang,Pengpeng Hu,Yutian Lei,Hong Mo,Haomiao Zhu,Jun Zhang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.8

Oilfield wastewater has a significantly negative influence on the recovery efficiency due to its hypersalinity. Therefore, magnetic graphene oxide (GO) modified with ethylene diamine tetraacetic acid (EDTA) and grafted bypolyethylene glycol (PEG) nano-adsorbent was prepared to remove the Ca2+ and Cr6+ in Jidong Oilfield wastewaterspecifically. It was noteworthy that PEG-g-EDTA/Fe3O4/GO nano-adsorbent had excellent adsorption performance,with removal ratios up to 71.6% for Ca2+ and 42.7% for Cr6+ at 30 min. After the fifth recycling run, the nano-adsorbentstill remained with high removal ratios (69.3% for Ca2+ and 30.5% for Cr6+) and high reuse rates (89.4% for Ca2+and 95.2% for Cr6+), indicating that the nano-adsorbent had outstanding adsorption-desorption efficacy and high reusability. The adsorption test results demonstrated that the total salinity of the treated oilfield wastewater decreased byabout 5,000 ppm, and the displacement efficiency further increased by 12.5% by chemical flooding compared with theuntreated wastewater. Therefore, PEG-g-EDTA/Fe3O4/GO nano-adsorbent is an adsorbent with excellent potentialwhich can effectively remove Ca2+ and Cr6+ in oilfield wastewater to enhance oil recovery (EOR).

Effect of Vehicle-Bridge Interaction Vibration on Young Concrete

Xiong Zhang,Ming Zhao,Yong-juan Zhang,Zhou Lei,Yue-ran Zhang 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.1

The purpose of this investigation was to study the effect of vehicle-bridge interaction vibration on repairing concrete. A newlydeveloped systematic test was used to simulate the vibration and evaluate its effect. The results indicated that both external damageand internal damage were serious when the simulated vibration test was conducted during a special time period. And this special timeperiod was defined as the concrete disturbance sensitive period when the penetration resistance ranged from 3.5 MPa to 28 MPa. Anti-cracking fiber and self-healing admixture improved the vibration resistance of young concrete. When the dosage of anticrackingfiber came to 800 g/m3 by volume of concrete, the 3-day crack area on the concrete surface decreased over 50%. When 9%self-healing admixture was added to the concrete, the ultrasonic pulse velocity of concrete subjected to vibration was higher all thetime than without the admixture added. And the ultrasonic pulse velocity at the age of 28 days reached 95% of the control concretewhich suffered no vibration. Sand percentage and maximum aggregate size were found to significantly influence the vibrationresistance of concrete.

Minus-C odorant binding protein TcasOBP7G contributes to reproduction and defense against phytochemical in the red flour beetle, Tribolium castaneum

Gao Shanshan,Zhang Xinyi,Zhou Can,Zhang Guangyan,Zhang Yong-lei,Li Rui-min,Zhang Kun-peng 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

Insect odorant binding proteins (OBPs) paly an important role in the recognition and transmission signals. One odorant binding protein gene, TcasOBP7G, was significantly up-regulated after exposure to eucalyptol. Never theless, the causal role of TcasOBP7G in Tribolium castaneum is still unclear. Here, TcasOBP7G was cloned and characterized from T. castaneum, aligning with the typical characteristic of Minus-C OBPs. The analysis of gene expression profile showed that TcasOBP7G is highly expressed at late larval and adult stage, with particularly high expression levels in ovary and testis of adults, suggesting that TcasOBP7G might be associated with reproduction of T. castaneum. Furthermore, RNAi of TcasOBP7G led to a decrease in spawning, while the development of gonads was normal, suggesting that TcasOBP7G may medicate the reproduction of T. castaneum. Additionally, the mRNA level of TcasOBP7G was significantly increased after exposure to eucalyptol, and knockdown of TcasOBP7G resulted in an increased susceptibility of T. castaneum to eucalyptol, indicating that TcasOBP7G is associated with the tolerance of T. castaneum to eucalyptol. Altogether, these results indicate that TcasOBP7G is required for both reproduction and defense against phytochemical in T. castaneum. This study will provide a theoretical basis for the development of novel control strategies based on the olfaction of insects.

An Approach to Nearest Neighboring Search for Multi-dimensional Data

Yong Shi,Li Zhang,Lei Zhu 보안공학연구지원센터 2011 International Journal of Future Generation Communi Vol.4 No.1

Core/Shell Molecular Imprinting Microparticles Prepared Using RAFT Technology for Degradation of Paraoxon

Yong Guo,Tian Ying Guo,Ying Yang,Lei Zhang 한국고분자학회 2011 Macromolecular Research Vol.19 No.11

We have developed a uniform core-shell structured surface hydrogel imprinted molecular imprinting polymer (MIP). This was achieved by surface grafting on a disulfide ester modified polystyrene core, using reversible addition-fragmentation transfer polymerization (RAFT) with N-methacryloyl-histidine-Cu2^+ complex (MAHCu ^2+) as the functional monomer and methyl paraoxon as the template to simulate phosphotriesterase (PTE). Subsequently,we investigated the catalytic (hydrolytic) activities of MIP to the template methyl paraoxon and the template analogue ethyl paraoxon. The results showed that the catalytic (hydrolytic) activity of MIP to the template methyl paraoxon was the highest, and the value of k was 8.67×10^-5 mM·L^-1·min^-1, which was 3.89-fold higher than MIP to ethyl paraoxon and 2.79-fold higher than the non-imprinting polymer (NIP) to methyl paraoxon. The K_m and r_m of MIP were also determined: the K_m was 3.95×10-4 M and the r_m 2.12 μM/min. The MIP can be reused with only lose 7% of catalytic activity for four cycles.

Multi-domain Security Authentication Protocol for Hybrid Cloud

Zhang Qikun,Zhang Lei,Gan Yong,Duan zhaolei,Zheng Jun 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.8

In recent years, with the high-speed development of cloud computing and its universal application, the cloud security technology is more and more important. In cloud computing, it is mainly through the resource sharing and collaborative action to meet the demand for an unlimited access speed, unlimited storage space and a reliable resource protection for users. For the secure access resources among different domains in cloud network, today most Cloud Computing Systems provide data security and mutual authentication with asymmetric and traditional public key cryptography. For these researches, the authentication process is cumbersome, and the certificate management is complex, which would bring some inconvenience for mutual authentication among servers or users in a Hybrid Cloud. This paper provides a security authentication protocol among multiple domains. It adopts the direct product decomposition and linear mapping technology of cyclic group to achieve mutual authentication between members in multi-domain systems or heterogeneous networks. Extensive security and performance analysis show that the proposed schemes have the advantages of in security, computation consumption and Communication consumption. It is suitable for safety authentication in large-scale Cloud computing environment.

Design and testing of CFRP sleeve for a high-speed permanent magnet synchronous motor with surface-mounted rotor

Yong Zhou,Lei Tian,Sheng-Hua Gao,Jing-Wei Zhang,Lin-Ke Yang,Rui-Guang Xie 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.1

A high-speed (HS) permanent magnet (PM) synchronous motor (HSPMSM) with a carbon fiber-reinforced plastic (CFRP) protective sleeve in the surface-mounted rotor was explored in this study. In view of retaining the PMs at HS operations, the high-strength CFRP sleeve was designed on the basis of a process that could be summarized as follows. First, a multi-physics analysis of the rotor was conducted. The requirements to the CFRP sleeve were obtained from electromagnetic analysis, loss analysis, heat flow coupling computational fluid dynamics analysis, structural analysis, and rotor dynamics analysis. Second, the CFRP sleeve was designed by theoretical analysis. From the results, the thickness values of the carbon fibers in the circumferential and helical directions were chosen to be 4 and 1 mm, respectively, while the helical angle of carbon fibers was chosen to be 70°. Then, a plateshaped CFRP product and a cylindrical CFRP product were fabricated to verify the strength and stiffness of the CFRP sleeve. The performance test results show that the hoop strength and elastic modulus and the axial strength and elastic modulus of the plate-shaped CFRP products at 20 °C are 1963 MPa @ 156 GPa and 550 MPa @ 36 GPa, respectively. The hoop strain and axial strain of the cylindrical CFRP product under 35 MPa are about 3000 and 1900 με, which meet the design requirements of the HSPMSM.

Molecular Analysis of the Copper-Responsive CopRSCD of a Pathogenic Pseudomonas fluorescens Strain

Yong-hua Hu,Hua-lei Wang,Min Zhang,Li Sun 한국미생물학회 2009 The journal of microbiology Vol.47 No.3

CopRS/CopABCD is one of the known systems that control copper homeostasis in bacteria. Although CopRS/CopABCD homologues are found to exist in Pseudomonas fluorescens, the potential role of this system in P. fluorescens has not been investigated. In this study a genetic cluster, consisting of copR, S, C, and D but lacking copAB, was identified in a pathogenic P. fluorescens strain (TSS) isolated from diseased fish. The copRSCD cluster was demonstrated to be required for full copper resistance and regulated at the transcription level by Cu. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression. Interruption of the regulated expression of copR affected bacterial growth, biofilm formation, and tissue dissemination and survival. A mutant CopR, which lacks the N-terminal signal receiver domain and is constitutively active, was found to have an attenuating effect on bacterial virulence when expressed in TSS. To our knowledge, this is the first report that suggests a link between CopR and bacterial pathogenicity in P. fluorescens.