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      • The Impacts and Countermeasures of Japan's Proposal to Release Nuclear-Contaminated Water into the Sea on Neighboring Countries

        Xuexi Zhang(Xuexi Zhang),Xi Chen(Xi Chen) 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.1

        Since 2020, the Japanese government has made great efforts to promote the discharge of nuclear-polluted water from the Fukushima nuclear power plant. Although it is strongly opposed by the Japanese and neighboring countries, the Japanese government still puts economic benefits first and does not fully consider the biological and chemical hazards that may be caused by the discharge of nuclear-polluted water into the sea, the impact on people's health, or whether it will pose a threat to Japan's offshore and neighboring countries' marine safety and food safety. As always, it is an obvious violation of the United Nations Convention on the Law of the Sea to choose the simplest, lowest-cost, and most irresponsible way to discharge nuclear-polluted water into the sea, which needs to be highly valued by neighboring countries and even all countries around the Pacific Ocean, and actively take measures to avoid the harm caused by Japan's nuclear-polluted water discharged into the sea to neighboring countries. To solve the current problems, it is necessary for the United Nations to actively play the role of central mediator and for neighboring countries to jointly create international public opinion on the harm caused by the discharge of nuclear-polluted water into the sea. At the same time, it is also necessary to call on non-governmental environmental protection organizations to protest and continuously increase internal pressure in Japan. In addition, the active resistance to importation of the fish resources from Japan and the reduction in the number of tourists to Japan are also important measures to prevent the Japanese government from dumping nuclear-polluted water. Therefore, actively calling on the Japanese government to cancel or terminate the dumping of nuclear-polluted water into the sea is not only the greatest protection of the lives and property of people in Japan and neighboring countries, but a responsible expression of ensuring that the world's maritime security is not threatened.

      • KCI등재

        Magnesium isoglycyrrhizinate inhibits L-type Ca2+ channels, Ca2+ transients, and contractility but not hERG K+ channels

        Yue Lin,Yuanyuan Zhang,Qiongtao Song,Tao Song,Xue Han,Ying Zhang,Xuan Zhang,Xi Chu,Fenghua Zhang,Li Chu,Jianping Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10

        To explore the cardiovascular protective effectsof Magnesium isoglycyrrhizinate (MI), especially theunderlying cellular mechanisms related to L-type calciumchannels and myocardial contractility, and to examine theeffects of MI on hERG K? current expressed in HEK293cells. We used the whole-cell patch clamp technique,video-based edge detection and dual excitation fluorescencephotomultiplier systems to explore the effect of MIon L-type Ca2? currents (ICa-L) and cell contraction in ratcardiomyocytes. We also examined the rapidly activatingdelayed rectifier potassium current (IKr) expressed inHEK293 cells using a perforated patch clamp. MI inhibitedICa-L in a dose-dependent manner, with a half-maximalinhibitory concentration (IC50) of 0.22 mg/ml, and themaximal inhibitory effect was 61.10 ± 0.59%. MI at aconcentration of 0.3 mg/ml reduced cell shortening by24.12 ± 3.97% and the peak value of the Ca2? transient by36.54 ± 4.96%. MI had no significant influence on hERGK? channels expressed in HEK293 cells at all testpotentials. MI exerts protective effects on the heart via theinhibition of ICa-L and cell shortening in rat cardiomyocytes. However, MI had no significant influence on IKr;thus, MI may exert cardioprotective effects without causingdrug-induced long QT syndrome.

      • KCI등재

        Experimental study on Chinese ancient timber-frame building by shaking table test

        Xi-cheng Zhang,Jian-yang Xue,Hong-tie Zhao,Yan Sui 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.4

        A one-story, wooden-frame, intermediate-bay model with Dou-Gon designed according to the Building Standards of the Song Dynasty (A.D.960-1279), was tested on a unidirectional shaking table. The main objectives of this experimental study were to investigate the seismic performance of Chinese historic wooden structure under various base input intensities. El Centro wave (N-S), Taft wave and Lanzhou wave were selected as input excitations. 27 seismic geophones were instrumented to measure the real-time displacement, velocity and acceleration respectively. Dynamic characteristics, failure mode and hysteretic energy dissipation performance of the model are analyzed. Test results indicate that the nature period and damping ratio of the model increase with the increasing magnitude of earthquake excitation. The nature period of the model is within 0.5~0.6 s, the damping ratio is 3~4%. The maximum acceleration dynamic magnification factor is less than 1 and decreases as the input seismic power increases. The frictional slippage of Dou-Gon layers (corbel brackets) between beams and plates dissipates a certain amount of seismic energy, and so does the slippage between posts and plinths. The mortise-tenon joint of the timber frame dissipates most of the seismic energy. Therefore, it plays a significant part in shock absorption and isolation.

      • Design of FIR Linear Phase Filters with Discrete Coefficients Using Hopfield Neural Networks

        Zhang, Xi,Iwakura, Hiroshi 대한전자공학회 1994 ISPACS:Intelligent Signal Processing and Communica Vol.1 No.1

        A novel method is presented for designing FIR linear phase filters with discrete coefficients using Hopfield neural networks. The proposed procedure is based on the minimization of the energy function of the Hopfield neural network, and can produce a good solution to the design of FIR linear phase filters with discrete coefficients. A design example is presented to demonstrate the effectiveness of the proposed method.

      • SCIESCOPUS

        Effect of joint gap on bead formation in laser butt welding of stainless steel

        Zhang, Yan-Xi,Han, Sang-Woo,Cheon, Jason,Na, Suck-Joo,Gao, Xiang-Dong Elsevier 2017 Journal of materials processing technology Vol.249 No.-

        <P>Simulations and experiments of laser butt welding are presented in the paper with the laser beam traveling along an inclined line across the gap. Full penetration was observed when the laser beam focused on the gap, while partial penetration was achieved when the laser beam deviated from the gap. A three-dimensional numerical model coupled with a ray tracing algorithm was established to investigate and compare the transient dynamics of the keyhole, molten pool and laser induced plume. The shape of the simulation cross-sections of the welds show good agreement with the experimental results. The gap contributed to transmission of laser beam energy deep into the inner part of the workpiece. The absorbed energy by the workpiece decreased when the laser beam was focused on the gap as some rays escaped through the opening gap. The decrease in absorbed energy resulted in a lower velocity of the molten pool and lower average pressure on the free surface. The velocity and volume of the plume on the top side of the workpiece also decreased. Flow patterns in the molten pool were also identified and discussed.</P>

      • KCI등재

        Design-Oriented Stability of Outer Voltage Loop in Capacitor Current Controlled Buck Converters

        Xi Zhang,Zhongwei Zhang,Bocheng Bao,Han Bao,Zhimin Wu,Kaiwen Yao,Jing Wu 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.4

        Due to the inherent feedforward of load current, capacitor current (CC) control shows a fast transient response that makes itsuitable for the power supplies used in various portable electronic devices. However, considering the effect of the outer voltageloop, the stable range of the duty-cycle is significantly diminished in CC controlled buck converters. To investigate the stabilityeffect of the outer voltage loop on buck converters, a CC controlled buck converter with a proportion-integral (PI) compensatoris taken as an example, and its second-order discrete-time model is established. Based on this model, the instability caused by theduty-cycle is discussed with consideration of the outer voltage loop. Then the dynamical effects of the feedback gain of the PIcompensator and the equivalent series resistance (ESR) of the output capacitor on the CC controlled buck converter with a PIcompensator are studied. Furthermore, the design-oriented closed-loop stability criterion is derived. Finally, PSIM simulationsand experimental results are supplied to verify the theoretical analyses.

      • Silver nanoparticles cause complications in pregnant mice

        Zhang, Xi-Feng,Park, Jung-Hyun,Choi, Yun-Jung,Kang, Min-Hee,Gurunathan, Sangiliyandi,Kim, Jin-Hoi Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-

        <P><B>Background</B></P><P>Silver nanoparticles (AgNPs) have attracted much interest and have been used for antibacterial, antifungal, anticancer, and antiangiogenic applications because of their unique properties. The increased usage of AgNPs leads to a potential hazard to human health. However, the potential effects of AgNPs on animal models are not clear. This study was designed to investigate the potential impact of AgNPs on pregnant mice.</P><P><B>Methods</B></P><P>The synthesis of AgNPs was performed using culture extracts of <I>Bacillus cereus</I>. The synthesized AgNPs were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. AgNPs were administrated into pregnant mice via intravenous infusion at 1.0 mg/kg doses at 6.5 days postcoitum (dpc). At 13.5, 15.5, and 17.5 dpc, the pregnant mice were euthanized, and the embryo and placenta were isolated. The meiotic status of oocytes was evaluated. DNA methylation studies were performed, and aberrant imprinting disrupted fetal, placental, and postnatal development. Quantitative real-time polymerase chain reaction analysis and Western blot were used to analyze various gene expressions.</P><P><B>Results</B></P><P>The synthesized AgNPs were uniformly distributed and were spherical in shape with an average size of 8 nm. AgNPs exposure increased the meiotic progression of female germ cells in the fetal mouse ovaries, and maternal AgNP exposure significantly disrupted imprinted gene expression in 15.5 dpc embryos and placentas, such as <I>Ascl2</I>, <I>Snrpn</I>, <I>Kcnq1ot1</I>, <I>Peg3</I>, <I>Zac1</I>, <I>H19</I>, <I>Igf2r</I>, and <I>Igf2</I>; DNA methylation studies revealed that AgNPs exposure significantly altered the methylation levels of differentially methylated regions of <I>Zac1</I>.</P><P><B>Conclusion</B></P><P>The results from this study indicated that early exposure to AgNPs has the potential to disrupt fetal and postnatal health through epigenetic changes in the embryo and abnormal development of the placenta. These results can contribute to research involved in the safe use of various biomedical applications of AgNPs and improves the understanding of the development of AgNPs in biomedical applications.</P>

      • KCI등재

        Reduced-order Mapping and Design-oriented Instability for Constant On-time Current-mode Controlled Buck Converters with a PI Compensator

        Xi Zhang,Jianping Xu,Jiahui Wu,Bocheng Bao,Guohua Zhou,Kaitun Zhang 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.5

        The constant on-time current-mode controlled (COT-CMC) switching dc-dc converter is stable, with no subharmonic oscillation in its current loop when a voltage ripple in its outer voltage loop is ignored. However, when its output capacitance is small or its feedback gain is high, subharmonic oscillation may occur in a COT-CMC buck converter with a proportional-integral (PI) compensator. To investigate the subharmonic instability of COT-CMC buck converters with a PI compensator, an accurate reduced-order asynchronous-switching map model of a COT-CMC buck converter with a PI compensator is established. Based on this, the instability behaviors caused by output capacitance and feedback gain are investigated. Furthermore, an approximate instability condition is obtained and design-oriented stability boundaries in different circuit parameter spaces are yielded. The analysis results show that the instability of COT-CMC buck converters with a PI compensator is mainly affected by the output capacitance, output capacitor equivalent series resistance (ESR), feedback gain, current-sensing gain and constant on-time. The study results of this paper are helpful for the circuit parameter design of COT-CMC switching dc-dc converters. Experimental results are provided to verify the analysis results.

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