늑막삼출 유무에 따른 마이코플라즈마 폐렴의 임상 양상의 비교

변신연 ( Shin Yun Byun ),배윤진 ( Yun Jin Bae ),유재호 ( Jae Ho Yoo ),정진아 ( Jin A Jung ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2006 소아알레르기 및 호흡기학회지 Vol.16 No.4

목적: Mycoplasma pneumoniae는 학동기 소아에서 호흡기 감염의 주된 원인균이며, 마이코플라즈마 폐렴의 호흡기 합병증으로는 무기폐, 늑막 삼출, 폐농양, 폐기종, 기관지 확장증 등이 있다. 이번 연구에서는 마이코플라즈마 폐렴에서 늑막 삼출 유무에 따른 임상 양상의 특징을 비교해보고자 하였다. 방법: 2000년 1월부터 2004년 12월까지 동아대학교의료원 소아과에 입원한 마이코플라즈마 폐렴 환자 210명을 대상으로 입원 기록을 후향적으로 비교분석하였다. 마이코플라즈마 폐렴의 진단기준은 항 마이코플라즈마 항체역가가 1:320 이상인 경우로 하였으며 늑막 삼출을 동반한 경우(A군)와 동반하지 않은 경우(B군)로 나누어 성별, 연령, 발생시기, 증상, 이학적 소견, 검사 소견, 흉부 방사선 소견을 비교하였다. 결과: A군과 B군 간의 연령, 성별, 발생시기, 증상 및 청진 소견에서는 유의한 차이는 없었다. 발열기간과 입원기간은 A군이 B군보다 의미있게 길었다.(P<0.001) 적혈구 침강속도는 A군에서 49.6±32.9㎜/hr로, B군의 28.7±20.4㎜/hr보다 의미있게 높았으며(P=0.001), C-반응성 단백은 A군에서 23.0±60.4㎎/dL로, B군의 8.7±30.9㎎/dL보다 의미있게 높았고(P=0.004), SGOT와 SGPT는 A군이 각각 67±74.2 IU/L와 53.6±60.0 IU/L로, B군의 37.4±18.6 IU/L와 26.2±16.9 IU/L보다 의미있게 높았다. (P<0.001) 늑막 삼출 유무와 항 마이코플라즈마 항체역가 사이의 유의성은 없었다. 결론: 늑막 삼출이 동반된 마이코플라즈마 폐렴군에서 발열기간, 입원기간, 적혈구 침강속도, C-반응성 단백, SGOT, SGPT가 늑막 삼출이 동반되지 않은 군에 비해 유의하게 증가되어 있어, 이러한 검사 소견들을 통하여 치료 경과를 예측할 수 있을 것으로 생각한다. Purpose: Mycoplasma pneumoniae (M. pneumoniae) is a major cause of respiratory infections in school-aged children. Complications of M. pneumoniae pneumonia include atelectasis, pleural effusion, empyema, pneumothorax and bronchiectasis. We evaluated the clinical characteristics of M. pneumoniae pneumonia with pleural effusion. Methods: A total of 210 medical records of children who were admitted to the Dong-A University hospital due to M. pneumoniae pneumonia from 2000 to 2004 were retrospectively analyzed. Diagnosis of M. pneumoniae pneumonia was based on the single titer of antimycoplasmal antibody higher than 1:320. Enrolled children were divided into Group A (with pleural effusion) and Group B (without effusion). We analysed the differences between the two groups according to sex, age, onset, symptoms, clinical manifestations, laboratory findings and chest x-rays. Results: There were no significant differences in age, sex and clinical manifestations between the two groups. Group A had longer fever durations (9.3±7.8 days vs 5.0±3.7 days), and a longer duration of hospitalization (10.4±6.3 days vs 6.9±6.3 days) compare to Group B. Also, compared to the Group B, Group A had higher ESR (49.6±32.9㎜/hr vs 28.7±20.4㎜/hr), CRP (23.0±60.4㎎/dL vs 8.7±30.9㎎/dL), SGOT (67±74.2 IU/L vs 53.6±60.0 IU/L), SGPT (37.4±18.6 IU/L vs 26.2±16.9 IU/L). There was no significance between antimycoplasmal antibody titer and pleural effusion. Conclusion: This study shows that M. pneumoniae pneumonia with pleural effusion has a longer duration of fever and hospitalization, higher ESR, CRP, SGOT, SGPT compare to the M. pneumoniae pneumonia without pleural effusion. We conclude that these findings could be used as the prognostic factors in M. pneumoniae pneumonia with pleural effusion. [Pediatr Allergy Respir Dis(Korea) 2006;16:327-334]

한국인 남성 알코올 의존 환자에서 제2알데히드 탈수소 효소 유전자형과 도파민 D2 수용체 A1 대립유전자의 빈도에 관한 비교 연구

김신태(Shin-Tae Kim),정혜경(Hae-Gyung Chung),백용수(Yong-Sue Paik),이경아(Kyung-A Lee),윤갑준(Kab-Jun Yun),장동원(Dong-Won Chang),손봉기(Bong-Ki Son) 한국중독정신의학회 1999 중독정신의학 Vol.3 No.2

The purpose of this study is to evaluate the association polymorphic patterns of DRD2 and ALDH2 gene with alcohol dependence. The patient group consisted of 47 male patients with alcohol dependence and the control group consisted of 20 healthy male volunteers without alcohol dependence. Polymorphic patterns of ALDH2 gene and DRD2 gene were determined by PCR method. And then we compared allele frequencies of two loci between patient and control groups. The results were as follows:1) The frequencies of ALDH2*1/1 in patient group were significantly higher than those in the healthy controls. The frequencies of mutant ALDH2 (ALDH2* 1/2 and ALDH2*2/2) were significantly lower in patient group than those in healthy controls. 2) There was no significant difference in A1A1 A1A2 A2A2 genotype frequencies in DRD2 gene between patient group and healthy controls. 3) In patient group with A1 allele, frequencies of ALDH2*1/1, ALDH2*1/2, ALDH2*2/2 were 61.7%, 3%, 0%, respectively. In patient group without A1 allele, frequencies of ALDH genotypes were 29%, 2%, 0%, respectively. In conclusion, mutant ALDH2 genotype seems to have influence on the occurrence of alcohol dependence. The interaction of DRD2 A1 alleles and ALDH2 alleles should be studied to find some effect on pathogenesis of alcohol dependence.

OGLE-2017-BLG-1049: ANOTHER GIANT PLANET MICROLENSING EVENT

Kim, Yun Hak,Chung, Sun-Ju,Udalski, A.,Bond, Ian A.,Jung, Youn Kil,Gould, Andrew,Albrow, Michael D.,Han, Cheongho,Hwang, Kyu-Ha,Ryu, Yoon-Hyun,Shin, In-Gu,Shvartzvald, Yossi,Yee, Jennifer C.,Zang, Wei The Korean Astronomical Society 2020 Journal of The Korean Astronomical Society Vol.53 No.6

We report the discovery of a giant exoplanet in the microlensing event OGLE-2017-BLG-1049, with a planet-host star mass ratio of q = 9.53 ± 0.39 × 10-3 and a caustic crossing feature in Korea Microlensing Telescope Network (KMTNet) observations. The caustic crossing feature yields an angular Einstein radius of θE = 0.52 ± 0.11 mas. However, the microlens parallax is not measured because the time scale of the event, tE ≃ 29 days, is too short. Thus, we perform a Bayesian analysis to estimate physical quantities of the lens system. We find that the lens system has a star with mass Mh = 0.55+0.36-0.29 M⊙ hosting a giant planet with Mp = 5.53+3.62-2.87 MJup, at a distance of DL = 5.67+1.11-1.52 kpc. The projected star-planet separation is a⊥ = 3.92+1.10-1.32 au. This means that the planet is located beyond the snow line of the host. The relative lens-source proper motion is μrel ~ 7 mas yr-1, thus the lens and source will be separated from each other within 10 years. After this, it will be possible to measure the flux of the host star with 30 meter class telescopes and to determine its mass.

침수식 초음파 검사와 부분결합간섭 검사를 이용한 공식의 정확성 비교

윤일석(Il Suk Yun),박아람(A ram Park),최신영(Shin Young Choi),양홍석(Hong Seok Yang) 대한안과학회 2016 대한안과학회지 Vol.57 No.6

목적: 침수성 초음파 장치와 수동 각막곡률계를 이용한 인공수정체 계산공식과 IOL MasterⓇ를 이용한 계산공식의 예측오차를 비교하여 안축장과 전방 깊이, 각막곡률에 따른 침수성 초음파 검사와 수동각막곡률계를 이용한 인공수정체 검사의 정확성에 대해 보고하고자 하였다. 대상과 방법: 단일 술자에 의해 백내장수술을 받은 환자 65명 82안의 의무기록을 후향적으로 검토하였다. 생체계측은 IOL MasterⓇ, 수동각막곡률계, 침수식 방식의 초음파 검사를 순서대로 시행하여 측정하였다. 초음파 방식과 수동각막곡률계로 구한 생체계측 값을 SRK-T, Holladay 1 공식에 대입하였고 IOL MasterⓇ를 이용한 생체계측 값을 장비에 내장되어 있는 SRK-T, Holladay 2 공식에 대입하여 백내장 수술 후 굴절력을 예측하였다. 백내장 수술 후 7주 이상 지난 시점에 현성 굴절 검사를 시행하여 최종 굴절력을 구하였고, 각 공식들의 예측치와 이를 비교하였다. 결과: 평균 안축장과 평균 각막곡률값은 계측기기 간에 의미 있는 차이를 보였다. 그러나 평균절대오차는 두 계측방식 간에, 그리고 공식들 간에 안축장과 전방 깊이, 각막곡률에 따라서 의미 있는 차이가 관찰되지 않았다. 그러나 안축장과 전방 깊이, 각막곡률에 따라서 예측오차가 ±0.5디옵터 이내에 속하는 백분율은 4가지 공식들 간에 차이를 보였다. 결론: 침수식 초음파와 수동 각막곡률계를 이용한 생체계측 방식은 IOL MasterⓇ 방식과 비교하여 그 정확성이 떨어지지 않는 것으로 보인다. 그러나 더 정확한 인공수정체의 선택을 위해서는 안축장, 전방 깊이, 각막곡률에 따라서 더 적절한 인공수정체 공식을 선택하는 것이 필요할 것으로 생각된다. <대한안과학회지 2016;57(6):905-916> Purpose: To report the accuracy of intraocular lens (IOL) formulas according to axial length, anterior chamber depth, and mean corneal curvature when performing biometry with an immersion type A-scan with mannual keratomery and an IOL Master??. Methods: Retrospective medical chart reviews were carried out for 82 eyes of 65 patients who underwent cataract surgery performed by a single surgeon. Biometry was performed using IOL Master??, mannual keratometry, and immersion type A-scan ultrasound in sequence. Prediction diopter was obtained using Sanders-Retzlaff-Kraff/Theoretical (SRK-T) and Holladay 1 formulas calculated with the biometric value measured by mannual keratomery and A-scan, and using SRK-T and, Holladay 2 formulas with IOL Master??. The final refractive outcome was determined as manifested refraction at least 7 weeks after the surgery, and it was compared with the preoperative prediction dipoter (D) of the IOL formulas. Results: Mean axial length and mean keratomtric measurements as determined by A-scan with mannual keratomery showed significant statistical differences from those of IOL Master??. However, there was no difference in postoperative mean absolute error between biometric measurements, or among formulas according to axial length, anterior chamber depth, or mean corneal curvature. However, the percentage of actual refraction within ±0.50 D of the intended refraction was dirrerent among the four formalas according to axial length, anterior chamber dept, mean corneal curvature. Conclusions: Biometry measurement using the immersion-type A-scan with mannual keratomery is as accurate as that using IOL Master?? for predicting the postoperative refractive state of cataract surgery. However, it is suggested that the best IOL formula be chosen according to axial length, anterior chamber depth, and mean corneal curvature. J Korean Ophthalmol Soc 2016;57(6):905-916

Eicosanoid 유도체가 흰쥐 혈압 변화에 미치는 영향

윤재순,윤연숙,신정희,최현진,최진아 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

Arachidonic acid (AA, C20:4, w-6) and eicosapentanoic acid (EPA,C20:5, w-3), which are polyunsaturated fatty acids forming eicosanoids, were tested for their effects on blood pressure in Wistar rats and SHR. AA is the most important precursor for the biosynthesis of eicosanoids which include the prostaglandins, prostacyclin (PGI_2), thromboxane A_2 (TXA_2) and the leukotriens. TXA_2 is a potent vasoconstrictor and a powerful inducer of platelet aggregation causing myocardial infarction and hypertention. In contrast, PGI_2 induces vasodilation and inhibits platelet aggregation. In this study, AA markedly increased blood pressure, but its effect was antagonized by both EPA a structural analog of AA, and dazmegrel, a TX synthetase inhibitor. Also, AA enhanced the antihypertensive effects of hydralazine and captopril, and EPA reduced TXA_2 production. These results indicate that the hypotensive effects of EPA might be closely related to the decrease in TXA_2 biosynthesis due to competitive inhibition by structural similarity of the EPA to the AA, the precursor of TXA_2.

제2형 당뇨병환자에서 족부병변의 발생률 및 위험인자 분석: 5년 관찰연구

박신애 ( Shin Ae Park ),고승현 ( Seung Hyun Ko ),이승환 ( Seung Hwan Lee ),조재형 ( Jae Hyoung Cho ),문성대 ( Sung Dae Moon ),장상아 ( Sang A Jang ),손현식 ( Hyun Shik Son ),송기호 ( Ki Ho Song ),차봉연 ( Bong Yun Cha ),손호영 ( H 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.4

연구배경: 제 2형 당뇨병환자에서 당뇨병성 족부병변에 의한 하지절단은 지속적으로 증가하고 있다. 또한 당뇨병성 족부궤양 단계에서의 적절한 예방과 치료가 하지절단의 위험성을 50%나 감소시킨다고 보고된 바 있다. 본 연구는 당뇨병성 족부병변의 발생률과 임상양상 그리고 위험인자들을 살펴보고자 하였다. 방법: 2003년 1월부터 12월까지 가톨릭대학교 성빈센트병원에 내원한 제2형 당뇨병환자를 2008년까지 5년간 관찰하였다. 족부병변의 위험인자를 확인하기 위해 6개월 마다당화혈색소를 반복 측정하였고, 당뇨병성 합병증을 조사하였다. 자율신경병증은 Ewing 방법에 따라 반복적인 심호흡호기와 흡기 시 (E/I 비), 체위 변화 시(30:15 비), 발살바 수기 시 심박동수의 변화를 측정하였다. 신기능 저하를 확인하기 위해 단백뇨 여부와 MDRD GFR를 이용하였다. 결과: 총 646명의 대상 환자 중에서 연구기간을 완료한 환자는 508명(82.9%)이었고, 이 중 32명(6.3%)에서 당뇨병성 족부병변이 발생하였다. 당뇨병성 족부병변이 발생한 군에서는 당뇨병 유병기간이 길었고, 고혈압 동반률이 높았으며, 망막병증 동반율도 높았다. 연구기간 동안의 평균 당화혈색소도 발생군에서 높게 측정되었다. Lipoprotein (a)가 증가되거나 신기능이 저하된 경우 당뇨병성 족부병변의 발생이 증가함을 확인하였다. 무엇보다 심혈관계 자율신경병증의 동반은 당뇨병성 족부병변의 발생을 4배 가까이 증가시킴을 확인하였고, 이는 말초신경병증 못지않게 중요함을 알 수 있었다. 결론: 당뇨병성 족부병변의 발생과 가장 밀접한 관련이 있는 것은 평균 당화혈색소임을 확인하였다. 또한 신기능의 저하와 심혈관계 자율신경병증이 중요한 유발인자임을 확인하였다. 따라서 당뇨병성 족부병변의 발생을 예방하기 위해서는 엄격한 혈당조절뿐만 아니라 정기적인 신기능과 자율신경병증에 대한 정기적인 평가가 이뤄져야 할 것이다. Background: The frequency of lower extremity amputation due to diabetic foot has been increasing in type 2 diabetic patients. The aim of this study was to observe the incidence, clinical aspects and associated risk factors for diabetic foot. Methods: We evaluated the incidence of diabetic foot through a five-year observation of type 2 diabetic patients who presented to St. vincent`s Hospital between January and December 2003. To identify the risk factors for diabetic foot, we evaluated mean glycosylated hemoglobin A1c (HbA1c) every six months and assessed renal function based on the existence of proteinuria and estimated glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) equation. Patients were also evaluated for retinopathy, peripheral neuropathy and autonomic neuropathy using Ewing`s method. Results: From an initial pool of 613 patients, the observational study of 508 patients (82.9%) was completed. The mean age, duration of diabetes and HbA1c were 50.3±10.6 yrs, 7.2±6.5 yrs and 8.8±2.1%, respectively. Diabetic foot occurred in 32 patients (6.3%). The incidence of diabetic foot increased when diabetic retinopathy (OR=6.707, 2.314~19.439), peripheral neuropathy (OR=2.949, 1.075~8.090), and autonomic neuropathy (OR=3.967, 1.476~10.660) were present and when the MDRD GFR (OR=5.089, 1.712~15.130) decreased. Mean HbA1c (OR=12.013, 1.470~98.179) was found to be an independent risk factor for diabetic foot. Conclusion: The present study confirmed the importance of intensive glycemic control and the role of autonomic dysfunction in the development of diabetic foot. In addition, diabetic retinopathy and impaired renal function proved to be factors associated with the occurrence of diabetic foot. Therefore, intensive glycemic control, as well as periodic examination of renal function, are essential for the prevention of diabetic foot. (Korean Diabetes J 33:315-323, 2009)

수중 운동 수행 시 숙련자와 비숙련자의 면역글로불린 A와 코티졸 반응 비교

신윤아(Yun A Shin),유연주(Yeon Joo Yu),석민화(Min Hwa Suk) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.30

The purpose of this study was to compare the stress and immune response between aquarobic experts and novices during cardio-aquarobic exercise. Immunogloblin(IgA), cortisol, Rating of Perceived Exertion(RPE), and heart rate were measured to identify the response of stress and immune in accordance with the levels of cardiovascular fitness during cardio-aquarobic exercise. Expert group(n=9) had 56 months of experience and novice group(n=8) had one month of experience in the aquatic exercise field. The heart rate showed significant difference in group(p<.05) and time(p<.001), and RPE showed significant differences in group(p<.05), time(p<.001), and interactions between group and time(p<.001). IgA and cortisol showed significant differences in time(before and after aquarobic exercise)(p<.01, p<.001, respectively). The response of immune and stress did not show any significant difference both rest and post exercise condition between groups. Therefore, we think that aquarobic exercise is the moderate intensity of exercise which reduced the impact of the muscloskeletal system in body and the psychological stress and increased the immune system. Our results demonstrated that the expert group in aquarobic exercise only showed significant differences in the heart rate and RPE. Therefore further study may investigate the response of immune and stress in different intensity, levels, and conditions of aquarobic exercise.

Characterization of secondary metabolite compounds correlated with the seasons in Artemisia princeps var. orientalis (Pamp.) H. Hara leaves using direct sample injection and gas chromatography-mass spectrometry: contribution to phytotoxicity

Mamun, M.I.R.,Abd El-Aty, A.M.,Musfiqur Rahman, Md.,Choi, Jeong-Heui,Yun, Kyeong Won,Shin, Ho-Chul,Shim, Jae-Han The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.2

Leaves from a natural population of Artemisia princeps var. orientalis (Pamp.) H. Hara were collected monthly from April through October and characterized for composition of secondary metabolite compounds and their phytotoxic effects on seed germination and seedling growth of Achyranthes japonica and Lactuca sativa. The compounds were identified using gas chromatography/mass spectrometry (GC/MS) coupled with a solvent-free solid injector (SFSI). GC/MS analyses of all samples revealed qualitative variability in the composition of secondary metabolites. The greatest number of compounds was identified in July (56) followed by September (30) and April (24), and the lowest number was found in June (2) and August (2). Among 92 compounds, the major compounds were various terpenes (23) (mono-, sesqui, di-, and tri-terpenes) followed by heterocyclic compounds (18) and hydrocarbons (14). The higher the concentration of the secondary metabolites, the lower the seed germination and seedling growth of A. japonica and L. sativa. Plant samples collected in July and August were most detrimental. Taken together, variability in the secondary metabolites compounds of A. princeps var. orientalis was verified during different seasons, and the compounds were successfully identified by a combination of SFSI and GC/MS. Notably, the antimicrobial and antioxidative effects were inconsistent throughout the various seasons.

Eicosanoid 유도체가 흰쥐 혈압 변화에 미치는 영향

윤재순(Jae S . Yun),윤연숙(Yeon S . Yun),신정희(Jeung Hee Shin),최현진(Hyun J Choi),최진아(Jin A Choi) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2

Arachidonic acid (AA, C20 : 4, ω-6) and eicosapentanoic acid (EPA,C20: 5, ω-3), which are polyunsaturated fatty acids forming eicosanoids, were tested for their effects on blood pressure in Wistar rats and SHR. AA is the most important precursor for the biosynthesis of eicosanoids which include the prostaglandins, prostacyclin (PGI₂), thromboxane A₂ (TXA₂) and the leukotriens. TXA₂ is a potent vasoconstrictor and a powerful inducer of platelet aggregation causing myocardial infarction and hypertention. In contrast, PGI₂ induces vasodilation and inhibits platelet aggregation. In this study, AA markedly increased blood pressure, but its effect was antagonized by both EPA, a structural analog of AA, and dazmegrel, a TX synthetase inhibitor. Also, AA enhanced the antihypertensive effects of hydralazine and captopril, and EPA reduced TXA₂ production. These results indicate that the hypotensive effects of EPA might be closely related to the decrease in TXA-2 biosynthesis due to competitive inhibition by structural similarity of the EPA to the AA, the precursor of TXA₂.

Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism

( Sang Min Hong ),( Ae Rim Hong ),( Yun A Shin ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.2

Sang Min Hong, Ae Rim Hong and Yun A Shin. Effects of detraining on motor unit potential area, muscle function and physicalperformance based on CNTF gene polymorphism. JENB., Vol. 18, No. 2, pp.151-160, 2014 [Purpose] The purpose of this studywas to identify the effect of detraining on motor unit potential area (SMUP), muscular function and physical performance, accordingto CNTF gene polymorphism. [Methods] For this study, GG (normal homozygote, n = 8) group and GA + AA (mutation heterozygoteand homozygote, n = 10) group were divided by CNTF gene polymorphism and both groups were performed detraining for 4weeks. The data was analyzed by two-way repeated measures ANOVA for verifying the differences between two groups andinteraction using SPSS(ver. 20.0) statistical program. [Results] The results were as follows. First, changes in body compositionwere measured but there was no significant interaction effect between time and group. Seconds, changes in SMUP were measuredby SEMG. Interaction effect between time and group was found lateral vastus during isokinetic exercise of 180°/sec (p<.05). Third, changes in isokinetic muscle strength of 60°/sec and 180°/sec were measured but there was no significant interaction effect. Fourth, significant statistical differences were not showed changes of sports performance after detraining. [Conclusion] In conclusion, there were no significantly differences between GG and GA + AA group after detraining, therefore, further study will be considereda matter in various its interventions such as serum levels of CNTF and changes in receptors and muscle fiber types. [Keyword]detraining, motor unit potential area, muscular function, physical fitness, CNTF gene polymorphism