Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism

( Sang Min Hong ),( Ae Rim Hong ),( Yun A Shin ) 한국운동영양학회 2014 Physical Activity and Nutrition (Phys Act Nutr) Vol.18 No.2

Sang Min Hong, Ae Rim Hong and Yun A Shin. Effects of detraining on motor unit potential area, muscle function and physicalperformance based on CNTF gene polymorphism. JENB., Vol. 18, No. 2, pp.151-160, 2014 [Purpose] The purpose of this studywas to identify the effect of detraining on motor unit potential area (SMUP), muscular function and physical performance, accordingto CNTF gene polymorphism. [Methods] For this study, GG (normal homozygote, n = 8) group and GA + AA (mutation heterozygoteand homozygote, n = 10) group were divided by CNTF gene polymorphism and both groups were performed detraining for 4weeks. The data was analyzed by two-way repeated measures ANOVA for verifying the differences between two groups andinteraction using SPSS(ver. 20.0) statistical program. [Results] The results were as follows. First, changes in body compositionwere measured but there was no significant interaction effect between time and group. Seconds, changes in SMUP were measuredby SEMG. Interaction effect between time and group was found lateral vastus during isokinetic exercise of 180°/sec (p<.05). Third, changes in isokinetic muscle strength of 60°/sec and 180°/sec were measured but there was no significant interaction effect. Fourth, significant statistical differences were not showed changes of sports performance after detraining. [Conclusion] In conclusion, there were no significantly differences between GG and GA + AA group after detraining, therefore, further study will be considereda matter in various its interventions such as serum levels of CNTF and changes in receptors and muscle fiber types. [Keyword]detraining, motor unit potential area, muscular function, physical fitness, CNTF gene polymorphism

Risk of cancer, cardiovascular disease, thromboembolism, and mortality in patients with rheumatoid arthritis receiving Janus kinase inhibitors: a real-world retrospective observational study using Korean health insurance data

Hong Ki Min,Hyeongsu Kim,Ho Jin Jeong,Se Hee Kim,Hae-Rim Kim,Sang-Heon Lee,KunSei Lee,Soon-Ae Shin,Jong Heon Park 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study investigated whether Janus kinase inhibitors (JAKis) raise the risk of cardiovascular disease (CVD), venous thromboembolism (VTE), and cancer in patients with rheumatoid arthritis (RA). METHODS: We conducted a real-world retrospective observational study using data obtained from the Korean National Health Insurance Service database. Two data sets were analyzed: tumor necrosis factor inhibitor (TNFi)/JAKi-naive RA patients (set 1) and all RA patients who used TNFis or JAKis (set 2). The incidence rate ratios (IRRs) and hazard ratios (HRs) for acute myocardial infarction (AMI), stroke, cardiovascular (CV)-related mortality, major adverse cardiovascular events (MACE), VTE, arterial thromboembolism (ATE), cancer, and all-cause mortality were compared between the JAKi and TNFi groups. RESULTS: Set 1 included 1,596 RA patients (JAKi group: 645; TNFi group: 951), and set 2 included 11,765 RA patients (JAKi group: 2,498; TNFi group: 9,267). No adverse events (AEs) showed significantly higher IRRs in the JAKi groups than in the TNFi groups of sets 1 and 2. The HRs for MACE in the JAKi groups of sets 1 and 2 were 0.59 (95% confidence [CI], 0.35 to 0.99) and 0.80 (95% CI, 0.67 to 0.97), respectively. The JAKi group of set 2 showed a significantly higher risk of all-cause mortality (HR, 1.71; 95% CI, 1.32 to 2.20), but the other AEs did not demonstrate increased risks in the JAKi groups. CONCLUSIONS: In this study, JAKis did not increase the risk of AMI, stroke, CV-related mortality, MACE, VTE, ATE, or cancer in Korean RA patients relative to TNFis.

저항운동이 CNTF 유전자 다형성에 따른 하지의 운동단위 동원능력, 근기능 및 운동수행능력에 미치는 영향

홍애림(Ae Rim Hong),신윤아(Yun A Shin),조은효(Eun Hyo Cho) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.57

The purpose of this study was to identify the effects of resistance exercise on motor unit recruitment, muscularstrength, muscular endurance, and exercise performance acording to CNTF gene polymorphism. Thesubjects of this study covered 8 normal homozygote GG group and 10 mutation heterozygote and homozygoteGA/AA group according to CNTF gene polymorphism. They performed resistance exercise during 8weeks. Comparative analysis of the results following conclusions were obtained by measuring body compositionand muscular function variables. Muscle mass(p<.001), fat free mass(p<.001), and body fat(p<.001)significantly improved in the GG and GA/AA groups. SUMP area o fvastus medialis during isokinetic exerciseof 180°/sec(p<.05), peak torque per body weight of knee joint extensor durin gisokinetic exercise of60°/sec(p<.001), peak torque per body weight of knee joint extensor during isokinetic exercise of 180°/sec(p<.001), reaction rate(p<.01), vertical jump(p<.001), side step(p<.001), 50m running time(p<.01), significantlyimproved in the GG and GA/AA groups. The changes opf eak torque per body weight of knee join textensor during isokinetic exercise of 60°/sec(p<.05) in the GA/AA group were significant higher than in th eGG group. In summary, resistance exercise had positive effect on motor unit recruitment, muscular endurance,and exercise performance regardless of CNTF gene polymorphism.H owever, muscle strength showed thedifference according to CNTF gene polymorphism.

Radiotherapy for pituitary adenomas: long-term outcome and complications

Rim, Chai-Hong,Yang, Dae-Sik,Park, Young-Je,Yoon, Won-Sup,Lee, Jung-Ae,Kim, Chul-Yong The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.3

Purpose: To evaluate long-term local control rate and toxicity in patients treated with external beam radiotherapy (EBRT) for pituitary adenomas. Materials and Methods: We retrospectively reviewed the medical records of 60 patients treated with EBRT for pituitary adenoma at Korea University Medical Center from 1996 and 2006. Thirty-five patients had hormone secreting tumors, 25 patients had non-secreting tumors. Fifty-seven patients had received postoperative radiotherapy (RT), and 3 had received RT alone. Median total dose was 54 Gy (range, 36 to 61.2 Gy). The definition of tumor progression were as follows: evidence of tumor progression on computed tomography or magnetic resonance imaging, worsening of clinical sign requiring additional operation or others, rising serum hormone level against a previously stable or falling value, and failure of controlling serum hormone level so that the hormone level had been far from optimal range until last follow-up. Age, sex, hormone secretion, tumor extension, tumor size, and radiation dose were analyzed for prognostic significance in tumor control. Results: Median follow-up was 5.7 years (range, 2 to 14.4 years). The 10-year actuarial local control rates for non-secreting and secreting adenomas were 96% and 66%, respectively. In univariate analysis, hormone secretion was significant prognostic factor (p = 0.042) and cavernous sinus extension was marginally significant factor (p = 0.054) for adverse local control. All other factors were not significant. In multivariate analysis, hormone secretion and gender were significant. Fifty-three patients had mass-effect symptoms (headache, dizziness, visual disturbance, hypopituitarism, loss of consciousness, and cranial nerve palsy). A total of 17 of 23 patients with headache and 27 of 34 patients with visual impairment were improved. Twenty-seven patients experienced symptoms of endocrine hypersecretion (galactorrhea, amenorrhea, irregular menstruation, decreased libido, gynecomastia, acromegaly, and Cushing's disease). Amenorrhea was abated in 7 of 10 patients, galactorrhea in 8 of 8 patients, acromegaly in 7 of 11 patients, Cushing's disease in 4 of 4 patients. Long-term complication was observed in 4 patients; 3 patients with cerebrovascular accident, 1 patient developed dementia. Of these patients, 3 of 4 received more than 60 Gy of irradiation. Conclusion: EBRT is highly effective in preventing recurrence and reducing mass effect of non-secreting adenoma. Effort to improve tumor control of secreting adenoma is required. Careful long-term follow-up is required when relatively high dose is applied. Modern radiosurgery or proton RT may be options to decrease late complications.

형질전환 벼 현탁세포 배양에서 투과성 증진을 통한 hCTLA4Ig의 생산성 증대

최홍열(Hong-Yeol Choi),전수환(Su-Hwan Cheon),권준영(Jun-Young Kwon),임정애( Jung-Ae Lim),박혜림(Hye-Rim Park),김동일(Dong-Il Kim) 한국생물공학회 2016 KSBB Journal Vol.31 No.4

In this system, rice cells were genetically modified to express human cytotoxic T-lymphocyte antigen 4-immunoglobulin (hCTLA4Ig) using RAmy3D promoter induced by sugar depletion. Even though the target protein fused with signal sequence peptide, plant cell wall can be a barrier against secretion of recombinant proteins. Therefore, hCTLA4Ig can be trapped inside cell wall or remained in intracellular space. In this study, to enhance the secretion of hCTLA4Ig from cytoplasm and cell walls into the medium, permeabilizing agents, such as dimethyl sulfoxide (DMSO), Triton X-100 and Tween 20, were applied in transgenic rice cell cultures. When 0.5% (v/v) of DMSO was added in sugar-free medium, intracellullar hCTLA4Ig was increased, on the other hand, the secreted extracellular hCTLA4Ig was lower than that of control. DMSO did not give permeable effects on transgenic rice cell cultures. And Triton X-100 was toxic to rice cells and also did not give enhancing permeability of cells. When 0.05% (v/v) Tween 20 was added in rice cell cultures, however, intracellular hCTLA-4Ig was lower than that of control cultures. And the maximum 44.76 mg/L hCTLA4Ig was produced for 10 days after induction, which was 1.4-fold increase compared to that of control cultures. Especially, Tween 20 at 0.05% (v/v) showed the positive effect on the secretion of hCTLA4Ig though the decrease of intracellular hCTLA4Ig. Also, Tween 20 as a non-toxic surfactant did not affect the cell growth, cell viability and protease activity. In conclusion, secretion of hCTLA4Ig could be increased by enhancing permeability of cells regardless of the cell growth, cell viability and protease activity.

MODIS LAI (엽면적지수) Product의 활용성 평가

하림 ( Rim Ha ),신형진 ( Hyung Jin Shin ),박근애 ( Geun Ae Park ),홍우용 ( Woo Yong Hong ),김성준 ( Seong Joon Kim ) 한국지리정보학회 2008 한국지리정보학회지 Vol.11 No.2

엽면적 지수(LAI)는 지표 환경에 영향을 미치는 광합성, 증발, 그리고 에너지 균형과 같은 생물물리학적 변화 과정에 있어 매우 중요한 인자이며, 여러 가지 생태학적 모델의 입력 자료로서도 필수적이다. 이러한 중요성에 근거하여 더욱 정확하고 유용한 LAI 추정 기법의 개발이 요구되지만, 현실적으로 LAI는 광역적 실측이 어렵기 때문에 대부분 LAI 연구에서는 정규화식생지수(NDVI)와의 단순 관계식을 통해 추정되어져 왔다. 본 연구에서는 경안천 유역(561.12 ㎢)을 대상으로 MODIS LAI Product의 활용성을 평가하고자 NOAA AVHRR NDVI와의 관계식으로 추정된 LAI와 국립산림과학원의 실측 LAI (2003, 2004)를 MODIS LAI와 비교 분석하였다. 그 결과 MODIS LAI는 활엽수림에서는 실측치보다 약 14% 높게, NOAA LAI보다 약 15~30% 높게 추정되었다. 침엽수림에서는 2003년 실측치가 약 5% 높게 추정되었으며, NOAA는 4월을 제외하고 약 7%의 차이를 보였다. 이러한 결과는 일부 지점에서 이루어지는 실측과 MODIS LAI 추출 시 기준자료가 포함하는 공간해상도의 한계 및 토지피복분류의 부정확성 등으로부터 발생한다. 따라서 실측자료에 근거한 MODIS자료의 보정기술을 향상시킴으로써 향후 광역적인 식생정보 제공 및 물수지 모의를 위한 생태학 및 수문학적 모형의 입력자료 등으로의 활용범위가 더욱 확대 가능할 것이다. Leaf area index (LAI) is a key biophysical variable influencing land surface processes such as photosynthesis, transpiration and energy balance, and is a required input to estimate evapotranspiration in various ecological and hydrological models. The development of more correct and useful LAIs estimation techniques is required by these importance, but LAIs had been assumed in most LAI research through simple relations with the normalized difference vegetation index (NDVI) because the field measurement is difficult on wide area. This paper is to evaluate the MODIS LAI Product`s practical use by comparing with LAIs that is derived from NOAA AVHRR NDVIs and the 2 years (2003-2004) measured LAIs of Korea Forest Research Institute in Gyeongancheon watershed (561.12 ㎢). As a result, the MODIS LAIs of deciduous forests showed higher values about 14 % and 15∼30% than the measured LAIs and NOAA LAIs. In the year of 2003, the MODIS LAIs in coniferous forests were 5% higher than the measured LAIs, and showed about 7% differences comparing with the NOAA LAIs except April. These differences come from the insufficient field data measured in partial points of the target area, and the extracted reference data from MODIS LAIs include the limits of spatial resolution and the error of incorrect land cover classification. Thus, using the MODIS data by the proper correction with the measured data can be useful as an input data for ecological and hydrological models which offers the vegetation information and simulates the water balance of a given watershed.

Radiotherapy for pituitary adenomas

Chai Hong Rim,Dae Sik Yang,Young Je Park,Won Sup Yoon,Jung Ae Lee,Chul Yong Kim 대한방사선종양학회 2011 Radiation Oncology Journal Vol.29 No.3

Purpose: To evaluate long-term local control rate and toxicity in patients treated with external beam radiotherapy (EBRT) for pituitary adenomas. Materials and Methods: We retrospectively reviewed the medical records of 60 patients treated with EBRT for pituitary adenoma at Korea University Medical Center from 1996 and 2006. Thirty-five patients had hormone secreting tumors, 25 patients had non-secreting tumors. Fifty-seven patients had received postoperative radiotherapy (RT), and 3 had received RT alone. Median total dose was 54 Gy (range, 36 to 61.2 Gy). The definition of tumor progression were as follows: evidence of tumor progression on computed tomography or magnetic resonance imaging, worsening of clinical sign requiring additional operation or others, rising serum hormone level against a previously stable or falling value, and failure of controlling serum hormone level so that the hormone level had been far from optimal range until last follow-up. Age, sex, hormone secretion, tumor extension, tumor size, and radiation dose were analyzed for prognostic significance in tumor control. Results: Median follow-up was 5.7 years (range, 2 to 14.4 years). The 10-year actuarial local control rates for non-secreting and secreting adenomas were 96% and 66%, respectively. In univariate analysis, hormone secretion was signifi cant prognostic factor (p = 0.042) and cavernous sinus extension was marginally signifi cant factor (p = 0.054) for adverse local control. All other factors were not signifi cant. In multivariate analysis, hormone secretion and gender were signifi cant. Fifty-three patients had mass-effect symptoms (headache, dizziness, visual disturbance, hypopituitarism, loss of consciousness, and cranial nerve palsy). A total of 17 of 23 patients with headache and 27 of 34 patients with visual impairment were improved. Twenty-seven patients experienced symptoms of endocrine hypersecretion (galactorrhea, amenorrhea, irregular menstruation, decreased libido, gynecomastia, acromegaly, and Cushing’s disease). Amenorrhea was abated in 7 of 10 patients, galactorrhea in 8 of 8 patients, acromegaly in 7 of 11 patients, Cushing’s disease in 4 of 4 patients. Long-term complication was observed in 4 patients; 3 patients with cerebrovascular accident, 1 patient developed dementia. Of these patients, 3 of 4 received more than 60 Gy of irradiation. Conclusion: EBRT is highly effective in preventing recurrence and reducing mass effect of non-secreting adenoma. Effort to improve tumor control of secreting adenoma is required. Careful long-term follow-up is required when relatively high dose is applied. Modern radiosurgery or proton RT may be options to decrease late complications.

Poster Presentation : A Case of an Ovarian Papillary Adenocarcinoma in a Dog

( Kyung Sook Hong ),( Jin Kyu Park ),( Il Hwa Hong ),( Dong Wei Yuan ),( Moon Jung Goo ),( Mi Ran Ki ),( Hye Rim Lee ),( Ok Kyung Hwang ),( Jung Youn Han ),( Ae Ri Ji ),( Tae Hwan Kim ),( Sun Hee Do ) 한국수의병리학회 2008 학술대회 Vol.12 No.2

The Differences in Sleep Skills between Insomnia Patients with and without Need of Hypnotics

Kong Byunghoon,Ko Mi Ae,Chang Jhin Goo,Hong Minha,김우정,Lee Su Young,Kim Hyun Soo,Song Hoo Rim 대한수면학회 2020 sleep medicine research Vol.11 No.2

Background and ObjectiveaaHypnotics are widely prescribed for the treatment of insomnia; however, cognitive behavioral therapy for insomnia (CBT-I) is considered as a primary treatment. We checked ordinary sleep skills of insomnia patients and changes in sleep skills after CBT-I, and evaluated the difference in sleep skills between patients with and without need of hypnotics. MethodsaaA total of 131 outpatients who had visited our sleep clinic with insomnia were recruited. Enrollment criteria included at least 12 weeks of insomnia periods, less than 16 in Beck Depression Inventory score, and agreement to receive 9 sessions of CBT-I for 12 weeks. After 12 weeks of CBT-I, patients were divided into two groups: still in need and no need of hypnotics. Changes in sleep skills were compared between these groups. ResultsaaSleep hygiene, sleep stimulus-control skills, and sleep Visual Analogue Scales (VAS) were statistically improved after CBT-I (all, p < 0.001). Forty-six (35.1%) patients did not need hypnotics anymore; however, 85 (64.9%) still needed hypnotics after CBT-I. Sleep VAS (25.26 ± 8.52 vs. 32.64 ± 8.95, p < 0.001), practicing regular moderate exercise (3.67 ± 0.92 vs. 2.76 ± 1.06, p = 0.030), and having a relaxing bedtime routine (4.08 ± 0.55 vs. 2.76 ± 0.76, p < 0.001) were different in the two groups. ConclusionsaaAmong CBT-I skills, regular moderate exercise and a relaxing bedtime routine seem to be key components. For reducing chronic use of hypnotics, and better outcome of CBT-I, clinicians should focus more on these two components.

견갑골 안정화 운동이 야구선수의 견갑골 관절가동범위, 근력 및근 활성도에 미치는 영향

홍은아(Eun Ah Hong),신윤아(Yun A Shin),홍애림(Ae Rim Hong) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.57

The purpose of this research was to study the effect of scapular stability exercise training on scapular position and scapular muscle activity in baseball player with scapular dyskinesis. The scapular stability exercise was equally applied on both dominant and non-dominant arms of subjects for 8 weeks. Shoulder Range of Motion, adduction and internal/external rotation in both dominant and non-dominant arm showed significant increases after scapular stability exercise training. Muscle strength showed significant differences among internal/external rotation, adduction and grip strength after scapular stability exercise training. Moreover, internal rotation and grip strength showed a significant interaction effect between time and group. Additionally, the muscle activity of upper trapezius muscle showed significant difference in dynamic hug, push up plus, push-up on the ball, and press-up with scapular retraction during scapular stability exercise before and after 8 weeks training. Lower trapezius muscle showed significant differences in push up plus, push-up on the ball motion, and press-up with scapular retraction movements. The muscle activity of serratus anterior muscle showed significant differences in dynamic hug and push up plus movements. Therefore, these data show that scapular stability exercise training has improved the shoulder range of motion, shoulder strength and grip strength in amateur baseball players with scapular dyskinesis despite the relatively short rehabilitation period. Especially, dynamic hug and press-up with scapular retraction were a effective movement for anterior serratus and push-up on the ball motion is a effective movement for lower trapezius.