Acetazolamide 의 Carbonic Anhydrase 활성 억제 작용에 대한 Testosterone 의 영향

장동원,이상복,조규철,Chang, Dong-Won,Lee, Sang-Bok,Cho, Kyu-Chul 대한약리학회 1975 대한약리학잡지 Vol.11 No.2

This study was carried out to observe the effect of testosterone on carbonic anhydrase inhibiting action of acetazolamide. Carbonic anhydrase activities in the kidneys of mice were measured by Philpot and Philpot method(1936) at 30, 90 and 150 minutes after intravenous administration of saline(0.5 ml/10 g) or acetazolamide (0.25 mg/10 g) in mice pretreated with testosterone (0.1 mg/10 g). The changes in volume and pH of urine as well as those in urinary electrolytes, such as $Na^+,\;K^+\;and\;Cl^-$ were measured at 15 minutes interval for 150 minutes in the rabbit pretreated with double administrations of testosterone(10 mg/kg), 1 hour and 18 hours, prior to the administration of acetazolamide (10 mg/kg). The results were as follows: 1. Carbonic anhydrase activities in the kidneys of mice of testosterone-pretreated groups were significantly higher than those of acetazolamide-treated group at 30 minutes. No significant changes of carbonic anhydrase activities were observed in testosterone-pretreated groups compared with saline-treated groups. 2. Combined administrations of acetazolamide and testosterone exhibited higher carbonic anhydrase activity than those group of acetazolamide alone in the kidney of mice through observed period of 150 minutes. 3. There were no significant changes in the excretion rate of urine and urinary electrolytes in the group of rabbits with testosterone administerone alone. Urine volume as well as $Na^+\;and\;Cl^-$ excretion rates in the combined treated group of acetazolamide and testosterone were significantly lower than that of acetazolamide group throughout experimental period except 15 minutes after drug administration at the time transient increase was shown. 4. Generally lower $K^+$ excretion rate was observed in the combined treated group of acetazolamide and testosterone compared with the single acetazolamide-treated group and the testosterone-pretreated group shows lowest excretion rate of potassium.

精神疾患과 犯罪

張東原(Chang, Dong Won) 한국형사법무정책연구원 1990 형사정책연구 Vol.1 No.-

精神疾患者의 犯罪性에 관한 硏究

張東原(Chang Dong Won) 한국형사법무정책연구원 1990 형사정책연구원 연구총서 Vol.- No.-

법정신의학의 개략

장동원(Dong Won Chang) 대한사회정신의학회 2000 사회정신의학 Vol.5 No.1

법정신의학은 법과 정신의학이라는 서로 다른 두 전문분야가 만나는 부분을 다루는 학문이다. 법정신의학은 크게 두 분야로 나눌 수 있는데 하나는 법의 집행에 정신의학이 관여하는 부분이고 다른 하나는 정신과 치료에 대한 법적인 규제가 된다. 현재 법정신의학에서 문제가 되는 주요 이슈로는 행위능력, 의료과오, 형사책임능력, 고지후 동의, 비자발적 입원, 비밀보장 등이 있다. Forensic psychiatry operates at the interface of two disparate disciplines:law and psychiatry. Although most cases in forensic psychiatry practice produce no conflicts, functioning at the interface of these two disciplines can lead to confusion and ethical dilemmas. Forensic psychiatry can be divided roughly as the psychiatry in the practice of the law and legal regulation of psychiatry. Some major issues in forensic psychiatry are reviewed briefly.

조영제 부작용 관리 프로그램 운용에서 조영제 재노출 환자 관리를 통한 조영제 부작용 사례 분석

장동원(Dong Won Chang),박영자(Yeong Ja Park),김성심(Tae Keun Lee),이대근(Seong Sim Kim) 대한CT영상기술학회 2012 대한CT영상기술학회지 Vol.14 No.1

목적 CT검사에서 조영제는 반드시 필요하지만 독성으로 인해 조영제 과민 반응인 부작용이 발생하며, ‘조영제 부작용’(이하 ‘부작용’)은 사전에 알 수 있는 방법은 현재까지 알려져 있지 않다. ‘부작용 과거력이 있는 환자가 조영제에 재노출’(이하 재 ‘노출’)되는 경우에는 부작용 발생률이 상당히 높다고 보고 되고 있다. ‘강릉아산병원 영상의학과’(이하 ‘영상의학과’)에서는 ‘조영제 부작용 유형 관리 프로그램’(이하 ‘관리 프로그램’) 운용을 통해 예측할 수 없는 부작용 발생에 대한 정확한 기록의 과거력을 획득하고 있다. 획득한 과거력을 이용한 재노출 환자에 대한 적절한 처치(항 히스타민제)와 관리가 부작용 경감에 미치는 영향을 알아보고자 하였다. 대상 및 방법 2005년 5월 1일부터 현재까지 영상의학과에서 자체적으로 관리 프로그램을 개발하여 부작용 발생 환자에 대한 사례별 과거력 ‘Data Base’(이하 ‘DB’)를 구축하였다. DB화하여 등록된 부작용 내용을 2006년부터 2010년까지 연도별로 ‘조영제사용 CT검사(이하 ‘CT검사’), 부작용, 재노출 변화를 분석하였다. 결과 CT검사 건수는 2006년을 기준으로 2007년부터 2010년까지 각각 12,6, 21,5, 37.1, 51.5%씩 매년 증가하였다. 부작용 발생은 2006년을 기준으로 2007년부터 2010년까지 각각 36.9, 39.6, 46,8, 40,5%씩 감소하였다. 재노출 환자는 2006년 3명에서 2007년부터 2009년까지 대폭 증가하여 각각 14, 18, 23명으로 증가하였고 2010년에는 39명까지 증가하였다. 재노출 환자를 대상으로 적절한 처치 후 검사한 부작용 발생 현황은 2006년에서 2010년까지 각각 0, 2, 7, 16, 10건이었다. 결론 대상 기간 5년 동안 CT검사 건수는 꾸준히 증가되었으나 부작용 발생은 그에 반해 꾸준히 증가하지는 않았다. 2007년 이후로 재노출 환자 건수가 지속적 증가되고, 부작용 발생이 2007년 이후로 증가가 둔화되는 모습을 보이는 것은 재노출 환자의 적절한 처치와 관리가 부작용 경감에 기여되는 것으로 판단된다. I. Purpose The use of IV contrast in CT scan is necessary for depicting many pathologies but many patients have adverse side effects. The side effects of IV contrast injections are not predictable and typically only become apparent at the fun: of injection. According to published research patient who have a history of side effect to IV contrast are more likely to have repeat incidences of adverse contrast reactions. This paper will be demonstrate how patient with histories of IV contrast reactions can be effectively managed with proper care techniques thereby reducing the overall risk of IV contrast reactions. The paper will show how proper care management such as the use of antihistamine treatment and will show how to effectively reduce the risk of side effects of IV contrast with patient who have histories of contrast reactions. II. Material and Methods A data base was developed to gather research finding of patients’ histories of side effects to IV contrast injection from May 1st, 2005 to present. The study also evaluated cases of patients who required N contrast for CT scan studies from 2006 to 2010. III. Results The base period of 100% is 2006, the number of cases of CT has been increased from 2007 to 2010 ; 12.6%, 21.5%, 37.1%, 51.5%, and a number of side effect has been decreased such as 36.9%, 39.6%, 46.8%, 40.5%. The number of patient needed CT exam again increased from 3 people at 2006, to 14, 18, 23, 39 people at 2010. And their side effects -were reduced as 0, 2, 7, 16, 10 case after proper treatment. IV. Conclusion Management of the side effects of IV contrast showed significant statistical reduction in the overall occurrence rate of side effects to the use of contrast media with CT scan.

정신분열증, 알코올중독, 약물중독에서 도파민 $D_2$ 수용체 유전자의 조절유전자(modifying gene)로서의 역할 - 충동적.강박적.탐닉적 행동을 나타내는 정신질환들에서 도파민 $D_2$ 수용체의 조절유전자로서의 역할 -

정현모,이홍석,장동원,이민수,Jung, Hyun-Mo,Lee, Hong-Seock,Chang, Dong-Won,Lee, Min-Soo 대한생물정신의학회 1997 생물정신의학 Vol.4 No.2

The authors attempted to examine the allelic association between the A1 allele of Dopamine $D_2$ receptor and schizophrenia, alcoholism, drug addiction in Koreans. Schizophrenic patients(n=31), alcoholism(n=65), drug addiction(n=18) and controls(n=52) were examined by case-control study for distribution of the TaqI polymorphism of the dopamine $D_2$ receptor gene in Korean population to minimize the effect of racial differencies in gene frequencies. In schizophrenics, the numbers of schizophrenics with A1A1, A1A2, A2A2 were 9(29.0%), 15(48.4%) and 7(22.6%) respectively and in alcoholics with A1A1, A1A2, A2A2 were 14(21.5%), 36(55.4%) and 15(23.1%) respectively and in drug addiction with A1A1, A1A2, A2A2 were 2(11.1%), 10(55.6%) and 6(33.3%) respectively and in controls with A1A1, A1A2, A2A2 were 4(7.6%), 24(46.2%) and 24(46.2%) respectively. The prevalence of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 77%, 76.9%, 67% and 53.8% respectively. And the frequency of the A1 allele in schizophrenics, alcoholics, drug addiction and controls were 0.53, 0.49 0.39 and 0.31 respectively. There was significant difference in the frequency of the A1 allele between schizophrenics, alcoholics and controls. We also classified our alcoholic population. For classification by severity, we used the median MAST score 30 in our samples. There was also significant difference in the frequency of the A1 allele between less severe group(0.42) and more severe group(0.57). This data suggest that the A1 allele is associated with schizophrenia and alcoholism in Koreans. Furthermore the prevalence of the A1 allele increassed in more severely affected alcoholics. The authors conclude that our data support an allelic association between the A1 allele at dopamine $D_2$ receptor and schizophrenia, alcoholism. These results suggest the A1 allele of the $DRD_2$ gene is associated with a number of behavior disorders in which it may act as a modifying gene rather than as the primary etiological agent.

메가프로젝트 사업에서의 기획/계획단계 사례기반추론 기반 공사비 예측모델 개발

현창택(Hyun Chang-Taek),홍태훈(Hong Tae-Hoon),손명진(Son Myung-Jin),김윤식(Kim Yun-Sik),장동원(Jang Dong-Won) 대한건축학회 2009 大韓建築學會論文集 : 構造系 Vol.25 No.9

Unlike the normal project-leveled construction projects, MXD(Mixed Used Development) projects considering the stakeholder, cost, and duration, require the higher level of strategy and skill for successful completion of the project. MXD projects found to have a couple of problems, such as the complicated relationship of stakeholder, unclear business field between the public and private sectors, unestablished project process, insufficient experience and human resources, and the solutions for them, such as a supporting tool, are urgently required. In case of mega projects with a large scale of project cost and duration, more accurate project feasibility should be studied so that construction cost at planning phase is predicted and either owners or developing companies could make a better decision. However, both the existing and on-going researches on predicting construction cost are focusing on normal project-leveled project, which identifies that more researches predicting the program-leveled projects' construction cost, such as MXD, should be done. Therefore, this study intended to develop a construction cost prediction model based on CBR (Case-Based Reasoning) methodology so that it could possibly support a decision-making specifically at the pre-construction phase (defined as planning phase in this study). Also, it is expected that historical construction cost could be collected and utilized much more efficiently by developing construction Cost's Breakdown Structure(CBS) and Data Base(DB) which are essentially necessary for the CBR prediction model.

PM -Store을 ISO/IEEE 11073 PHD 표준의 구현을 위해 필요한 메모리 공간에 대한 연구

이창기(Lee Chang Ki),김상곤(Kim Sang Kon),장동원(Jang Dong Won),김태곤(Kim Tae Kon) 한국통신학회 2013 한국통신학회 학술대회논문집 Vol.2013 No.11

정신분열증으로 진단 받았던 양극성장에 환자의 특성에 관한 연구

김봉준(Bong Jun Kim),송인권(In Kuan Song),장동원(Dong Won Chang) 한국정신병리진단분류학회 1996 精神病理學 Vol.5 No.1

N/A N/A

금주중인 알코올 의존 환자의 인지기능 회복에 관한 연구

임중현(Jung-Hyun Lim),김규현(Kyu-Hyun Kim),서동수(Dong-Soo Suh),장동원(Dong-Won Chang) 한국중독정신의학회 2000 중독정신의학 Vol.4 No.2

Objectives:This study was performed to evaluate the cognitive deficit in alcoholic patients and the cognitive improvement during the course of abstinence. Subjects and Method: Subjects participated in the study were 32 alcoholic patients and 35 normal control group. Their alcoholic history and demographic data were taken and they were tested on cognitive assessment consists of Digit span, Paired association learning test, Digit symbol substitution test, Trail making B test, ReyOsterrith complex figure test. Patients were tested in 3 weeks and 6 months later. Results:In summary, the results of this study were as follows:1) In the comparison between alcohol group (3 weeks after abstinence) and normal control group, normal control group was superior to patient group in almost all the test except for first Paired association learning test. 2) In the comparison between serial cognitive follow-up test in alcohol group, there was significant cognitive improvement in almost all the test except for second Paired association learning test. 3) In the comparison between alcohol group (6 months after abstinence) and normal control group, there was no significant difference except for Trail making B test. 4) There was no significant correlation between cognitive function change and alcohol related factor. Conclusion:The results suggest that the cognitive deficit in alcoholic patients and cognitive improvement during the course of abstinence. Significant recovery of cognitive function can occur but may be contingent on the factors such as age and continued abstinence. On the other hand, when we consider the limitation of this study, more precise and standard test method and more longer follow up duration may be required.