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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Yun, Ye-Rang,Jeon, Eunyi,Lee, Sujin,Kang, Wonmo,Kim, Sang-Gi,Kim, Hae-Won,Suh, Chang Kook,Jang, Jun-Hyeog Kluwer Academic/Plenum 2012 The Protein Journal Vol.31 No.6
<P>To investigate the functions of recombinant human dentin phosphoprotein (rhDPP), we examined cell adhesion, viability and the odontoblastic differentiation activity of human dental pulp cells (hDPCs). Firstly, rhDPP was constructed using pBAD-HisA plasmid in Escherichia coli. Cell adhesion and viability of hDPCs by rhDPP was examined using a crystal violet assay and a MTT assay, ALP, mineralization activity and odontoblastic differentiation-related mRNA levels of hDPCs were measured to elucidate the odontoblastic differentiation effect of rhDPP on hDPCs. Initially, rhDPP significantly and dose-dependently increased hDPCs adhesion versus the untreated control (p < 0.05). Cell viability was also significantly increased by rhDPP at 5 days (p < 0.001). Furthermore, the odontoblastic differentiation effect of rhDPP was verified by measuring ALP activity, mineralization activity and the mRNA levels of odontoblastic differentiation markers. Taken together, rhDPP is expected to play an important role on hDPCs, thereby suggesting its potential use for tooth repair and regeneration.</P>
A case of colovesical fistula complicated by sigmoid diverticulitis
( Yun Hyuk Yim ),( Hyo Keun Lee ),( June Sung Lee ),( Kyung Ah Kim ),( Nam Hoon Kim ),( Tae Jun Song ),( Won Ki Bae ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Colovesical fistula is a rare complication of inflammatory or neoplastic disease, and traumatic or iatrogenic injuries. Among them, sigmoid diverticulitis is the most frequent cause of colovesical fistula. There are few reported cases of the colovesical fistula in Korean literature, that is probably because the left colonic diverticulum is not common in Korea. We present here a case of patient with colovesical fistula complicated by sigmoid diverticulitis. A 66-year-old male patient was transferred to our hospital due to complaining of abdominal pain and mucoid stool. An abdominal and pelvic CT scan revealed diverticulitis and peridiverticular abscess in sigmoid colon. The patient was admitted and treated with intravenous antibiotic agents for four weeks, followed by oral antibiotic therapy. Six weeks after being discharged from the hospital, he was admitted again with complaints of pneumaturia, fecaluria, and dysuria. Follow up CT scan demonstrated fistula between sigmoid colon and bladder dome portion. Under the diagnosis of colovesical fistula due to diverticulitis of sigmoid colon, low anterior resection and partial cystectomy with cystostomy were performed.
( Yun Won Jo ),( Seung Suk Yoo ),( Sung Soo Kim ),( Jeong Mi Lee ),( Hyun Ju Min ),( Chang Yoon Ha ),( Hong Jun Kim ),( Woon Tae Jung ),( Ok Jae Lee ),( Hyun Jin Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Colonoscopic polypectomy is a commonly performed procedure in Korea, subsequently prevents colon cancer. The increase of therapeutic colonoscopy, polypectomy, results in inevitably various complications including bowel perforation that is rare and requires emergent decision of treatment modalities and timely treatment. The bowel perforation is usually diagnosed on the basis of pneumoperitoneum on simple X-ray images. Surgery is the treatment of choice for most cases of colonic perforation. A 58-year-old woman was referred to the gastroenterologist for endoscopic mucosal resection (EMR) of laterally spreading flat adenoma in the sigmoid colon. The EMR was performed with flexible and insulated tip knives. The patient was hospitalized for close observation of post-EMR complications. On the day of the polypectomy, simple X-ray images were taken to rule out colonic perforation, which revealed a large amount of intracolonic gas, but no free air in the subphrenic area. The next day of the procedure, subcutaneous emphysema was observed by the clinicians. Then abdomen computed tomography (CT) scan was performed, which showed diffuse bilateral retroperitoneal air extending to the mediastinum without intraperitoneal gas. The patient was discharged from the hospital after medical treatment and supportive care. We herein report a case of colonoscopic perforation in which pneumomediastinum, subcutaneous emphysema and peumoretroperitoneum occurred in the absence of pneumoperitoneum. The perforation was successfully treated with medical treatment and endoscopic clipping. Colonoscopists should not exclude colonic perforation even though free air on simple X-ray images is not visible.
( Yun Seon Choi ),( Jun Won Kim ),( Hye Jung Cha ),( Kwang Hyub Han ),( Jin Sil Seong ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Purpose: The aim of this study was to investigate prognostic significance of portal vein tumor thrombosis (PVTT) response in hepatocellular carcinoma (HCC) patients treated with concurrent chemoradiotherapy (CCRT). Methods and Materials: One hundred patients (28 with helical tomotherapy and 72 with 3-dimensional conformal radiotherapy) treated with CCRT for the International Union Against Cancer (UICC) stage T2-4N0M0 HCC with PVTT between 2002 and 2011 were analyzed retrospectively. The radiotherapy (RT) volume included primary tumor and PVTT, and median radiation dose was 45 Gy (range 45-60 Gy) delivered in 1.8 to 3 Gy per fraction. Treatment response was evaluated up to 6 months after RT. Results: Tumor thrombus in the main PV, first and second branches of PV were detected in 38 (38%), 44 (44.0%) and 18 (18.0%) patients, respectively. In terms of PVTT response to treatment, complete response (CR) and partial response (PR) were achieved in 14% and 51% of patients, respectively, giving objective response (OR) rate of 65.0%. Progression-free rate of PVTT was 91.0%. PVTT size (> 3 cm in diameter) was associated with the lower rate of complete response (CR) (p=0.001). Median overall survival (OS) was 10.5 months, and the 1- and 2-year survival rates were 42.8% and 20.3%, respectively. Significant variables associated with OS included alpha-fetoprotein level (400 ng/ml ≤), and OR of tumor to RT and CR of PVTT. Independent prognostic factors for OS were OR of tumor to RT and CR of PVTT. Achieving OR in both tumor and PVTT had significant correlation with improved survival (p=0.017). Conclusions: PVTT showed a substantial response (65%) to CCRT with a higher CR rate for PVTT smaller than 3 cm. CR of PVTT was associated with an improved overall survival. Patients achieving OR of both PVTT and tumor showed the best outcome (p=0.017).