http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Jun-Hyeong Kim,Jin-Joo Hue,Bong Su Kang,Hyunji Park,Sang Yoon Nam,Young Won Yun,Jong-Soo Kim,Beom Jun Lee 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.1
Selenium (Se) is known to prevent several cancers while the relationship between high iron and the risk of colorectal cancer is controversial. To investigate the effects of Se in colon carcinogenesis, we subjected three different levels of Se and high-iron diet to a mouse model of colon cancer in which animals were treated with three azoxymethane (AOM) injections followed by dextran sodium sulfate (DSS) administration. There were five experimental groups including vehicle group [normal-Fe (NFe, 45 ppm)+medium-Se (MSe, 0.1 ppm)], positive control group (AOM/DSS+NFe+MSe), AOM/DSS+high-Fe (HFe, 450 ppm)+low-Se (LSe, 0.02 ppm), AOM/DSS+HFe+MSe, and AOM/DSS+HFe+high-Se (HSe, 0.5 ppm). The animals were fed on the three different Se diets for 24 weeks. The incidence of colon tumor in the high-Se diet group (AOM/DSS+HFe+HSe) showed 19.4% lower than positive control group, 5.9% lower than AOM/DSS+HFe+MSe diet group, and 11.1% lower than AOM/DSS+HFe+LSe group. The tumor multiplicity was significantly higher in the low-Se diet group (AOM/DSS+HFe+LSe) compare to all other AOM/DSS treated groups. In the high-Se diet group, the activity of hepatic GPx was comparable to that of positive control group, and significantly higher than those of low-Se or medium-Se diet groups. Expression level of hepatic GPx-1 showed similar results. Hepatic malondialdehyde (MDA) level (indicator of oxidative stress) in the low-Se diet group showed the highest compared to the other groups, and it was significantly higher than positive control group. In the high-Se diet group the level of MDA in the liver was significantly lower than all other AOM/DSS treated groups. High-Se diet group showed significantly lower proliferative index than low-Se and medium-Se groups. The apoptotic indices in low-Se group and medium-Se group were significantly lower than positive control group. However, apoptotic index of high-Se diet group was significantly higher than all other AOM/DSS treated groups. These findings suggest that dietary Se supplement may have protective effect against colon cancer by decreasing proliferation, increasing apoptosis of tumor cells, and reducing oxidative stress in mice with high iron diet.
Yun, Hyung Jun,Ko, Jang Myoun,Kim, Dong Won 한밭대학교 2003 한밭대학교 논문집 Vol.20 No.-
각기 다른 코팅 층 두께를 갖는 다공성 고분자가 코팅된 세퍼레이터를 담금 코팅과 상전이 방법에 의하여 제조하였다. 폴리올레핀 세퍼레이터에 코팅된 고분자는 전해액 침적에 의하여 겔화되었다. 전해액에 의해 겔화된 고분자 코팅 세퍼레이터는 상온에서 10^(-3) S/cm의 높은 이온 전도도를 나타내었고, Li 전극을 기준으로 하여 5.0V까지 전기화학적으로 안정하였다. 그라파이트 음극과 리튬코발트옥사이드 양극을 이용한 리튬이온폴리머 전지를 제조한 후, 그들의 율 특성을 폴리올레핀 세퍼레이터에 코팅된 고분자 층 두께에 따라 평가하였다. Porous polymer-coated separators with different thickness of coating layer were prepared by dip coating and phase inversion method. Polymer coated onto polyolefin separator was gelled by soaking in an electrolyte solution. The polymer-coated separators gelled by electrolyte solution exhibited high ionic conductivity in order of 10^(-3) S/cm at room temperature and were electrochemically stable up to 5.0 V against Li^(+)/Li. Lithium-ion polymer batteries composed of a graphite anode and a lithium-cobalt oxide cathode were assembled, and their rate performances were evaluated in terms of thickness of polymer layer coated on polyolefin separator.
Yun, Young Jin,Kim, Han-Jun,Lee, Deok-Won,Um, Sewook,Chun, Heung Jae Elsevier 2018 Journal of industrial and engineering chemistry Vol.67 No.-
<P><B>Abstract</B></P> <P>Surface modified poly <SMALL>L</SMALL>-lactic acid (PLLA) samples with hydroxyapatite (HA), heparin and bone morphogenetic protein-2 (BMP-2) mediated by polydopamine (pDA) coating (PLLA/pDA/HA/Hep/BMP-2) were prepared, and their effects on the enhancements of bone formation and osseointegration were evaluated <I>in vitro</I> and <I>in vivo</I> as compared to PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. The changes in surface chemical compositions, morphologies and wettabilities were observed by X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and water contact angle measurements. Pre-coating of HA particles with pDA provided uniform and homogeneous anchoring of particles to PLLA surface. In addition, the strong ionic interaction between heparin and pDA led PLLA surface readily heparinized for loading of BMP-2. <I>In vitro</I> experiments revealed that the levels of alkaline phosphatase (ALP) activity, calcium deposition, and osteocalcin (OCN) gene expression were higher in MG-63 human osteosarcoma cell lines grown on PLLA/pDA/HA/Hep/BMP-2 than on control PLLA, PLLA/pDA/HA, and PLLA/pDA/Hep/BMP-2. <I>In vivo</I> studies using micro-computed tomography (micro-CT) also showed that PLLA/pDA/HA/Hep/BMP-2 screw exhibited greatest value of bone volume (BV) and bone volume/tissue volume (BV/TV) among samples. Histological evaluations with H&E and Von Kossa staining demonstrated that a combination of HA and BMP-2 contributed to the strong osseointegration.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Comparison with 3 High-Fat Diet for Studying Obesity in C57BL/6 Mouse
Jun-Won Yun,Byoung-Seok Lee,Chae-Wook Kim,Bae-Hwan Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
Obesity is an abnormal condition in adipose tissue, which is the main site of lipid storage and plays a critical role in the regulation of energy balance. Although obesity is caused by various environmental and genetic factors, the consumption of high-fat diet (HFD) is thought to be one of the main factors. This study was designed to evaluate 3 HFD in C57BL/6 mouse for studying obesity. The final body weight in all HFD groups was higher than those in all control groups. And, all HFD groups had a significant increment of epididymal fat pad weights than all control groups. Therefore, all 3 HFD in model of diet-induced obesity are useful diets for studying obesity. However, when it was compared with ALH (23.9% HFD supplemented with lard) group and ASH (40% HFD supplemented with shortening) group, DH (23.6% HFD supplemented with lard) group had significant increment of body weight in the early stage of treatment, and markedly showed high increment rate of body weight. And, AC group, control group, showed increasing tendency in serum AST levels and revealed slight altered liver structure with vacuolation disseminated in the portal space. This result may be correlation with slight accumulation of fat due to AIN93G diet itself intake. Consequently, considering results of body weight and epididymal fat weight, 3 HFD are useful diets for diet-induced obesity model. However, 23.6% HFD supplemented with lard (DH group) is better choice for obesity studies with laboratory rodents.
( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confidence interval, 1.144-7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no significant difference in severity of the airflow limitation, presence of bronchiectasis, previous COPD medication including inhaled corticosteroids, or pathogens was identified between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.