Epidemiology of Esophageal Cancer in Yanting - Regional Report of a National Screening Programme in China

Wang, Xiao,Fan, Jin-Chuan,Wang, An-Rong,Leng, Yue,Li, Jun,Bao, Yu,Wang, Ying,Yang, Qing-Feng,Ren, Yu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.

A native Trichoderma harzianum strain Th62 displays antagonistic activities against phytopathogenic fungi and promotes the growth of Celosia cristata

Yue-Feng Wang,Xue-Yue Hou,Chuan-Ying Jiang,Tong-Tong Zhai,Rui Miao,Jun-Jie Deng,Zhi-Hong Yao,Rongshu Zhang 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2

Trichoderma spp. are widely applied, eco-friendly mycofungicides and plant growth promoters. Native Trichoderma strainsare likely to have more productive, stable biocontrol and biofertilizer activities since they are well adapted to the local environment. In this study, we isolated a native Trichoderma strain ‘Th62’ from the rhizosphere soil of wild Chelidonium majusplants in Harbin, China (126.6341°E, 45.7242°N). The isolated Trichoderma strain was identifi ed as a T. harzianum strainvia morphological observation and molecular methods based on the rDNA internal transcribed spacer region and elongationfactor-1α gene sequences. Signifi cant antagonistic activities of Th62 against fi ve soil-borne fungal phytopathogens,Fusarium oxysporum , Sclerotinia sclerotiorum , Alternaria alternata , Cytospora chrysosperma, and Rhizoctonia solani ,were confi rmed by dual-culture assays. Furthermore, the crude fermentation products of Th62 also displayed antifungalactivities against these fi ve pathogens. To evaluate the function of Th62 as a biofertilizer, we subsequently applied Th62on cockscomb ( Celosia cristata L), a plant species with both ornamental and medicinal values, by inoculation with Th62conidia at diff erent concentrations, 1 × 10 10 cfu mL −1 , 1 × 10 11 cfu mL −1 , and 1 × 10 12 cfu mL −1 . The benefi cial eff ects ofTh62 were evaluated by measuring the growth and photosynthetic traits of the inoculated cockscomb plants, and the resultsdemonstrated that Th62 signifi cantly improved the photosynthetic effi ciency, photosynthetic capacity, and the adaptabilityto intense light of the inoculated cockscomb plants compared to the controls. Consistently, Th62 inoculation signifi cantlyimproved the growth and fl ower yield of cockscomb. We presented a positive case of isolating and applying native microbialresources on local plantation practices.

Expression of CDX2 and Villin in Gastric Cardiac Intestinal Metaplasia and the Relation with Gastric Cardiac Carcinogenesis

Xiao, Zhong-Yue,Ru, Yi,Sun, Jiang-Tao,Gao, She-Gan,Wang, Yu-Feng,Wang, Li-Dong,Feng, Xiao-Shan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Objective: To determine whether CDX2 and villin protein expression are associated with intestinal metaplasia (IM) in gastric cardiac mucosa and to explore the relationship with evolution of gastric cardiac adenocarcinoma (GCA). Methods: We studied 143 gastric cardiac biopsy or resection specimens from Henan province China, including 25 cardiac gastritis specimens with IM, 65 dysplasia specimens with IM and 35 gastric cardiac adenocarcinoma specimens and stained them for CDX2 and villin by the immunohistochemical SP method. 15 normal gastric cardiac biopsy specimens were also collected as control. Results: (1) Normal gastric mucosa presented no CDX2 and villin expression. The positive rates of CDX2 protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 84.0% (21/25), 66.7% (32/48) and 36.4% (20/55), respectively. While the positive rates of villin protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 76.0% (19/25), 70.8% (34/48) and 45.5% (25/55), respectively. There were significant differences among the three groups for both CDX2 and villin (P<0.01). Spearman's rank correlation coefficient(rho) showed a close correlation between the two proteins (r=0.843, P<0.01) and both were positively related with tumor differentiation (both P<0.05), but not associated with age, sex, invasion and metastasis of lymph node (P>0.05). Conclusion: Our results suggest that ectopic expression of CDX2 and villin may be involved in early-stage IM and tumorigenesis in gastric cardia and the expression of villin may be regulated by CDX2.

Effects of Ohmic Area Etching on Buffer Breakdown Voltage of AlGaN/GaN HEMT

Wang, Chong,Wel, Xiao-Xiao,Zhao, Meng-Di,He, Yun-Long,Zheng, Xue-Feng,Mao, Wei,Ma, Xiao-Hua,Zhang, Jin-Cheng,Hao, Yue The Korean Institute of Electrical and Electronic 2017 Transactions on Electrical and Electronic Material Vol.18 No.3

This study is on how ohmic area etching affects the buffer breakdown voltage of AlGaN/GaN HEMT. The surface morphology of the ohmic metal can be improved by whole etching on the ohmic area. The buffer breakdown voltages of the samples with whole etching on the ohmic area were improved by the suppression of the metal spikes formed under the ohmic contact regions during high-temperature annealing. The samples with selective etching on the ohmic area were investigated for comparison. In addition, the buffer leakage currents were measured on the different radii of the wafer, and the uniformity of the buffer leakage currents on the wafer were investigated by PL mapping measurement.

More precise determination of V_cb & V_ub and direct CP violation in charmless B decays

Yue-liang Wu,Yu-Feng Zhou,YWhen-Yu Wang 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2

More precise extractions on the two important CKM matrix elements jVcbj and jVubj are presented up to 1=m2 Q corrections, based on the complete heavy-quark eective eld theory (HQEFT) of QCD. The HQEFT as a large component QCD provides us with a complete theoretical framework for correctly and systematically evaluating the subleading and higher-order contributions in 1=mQ expansion of heavy quarks. A global analysis on charmless B decays is made, based on the isospin and SU(3) avor symmetry. An isospin relation is found to be very useful for studying SU(3) symmetry-breaking eects of strong phases and exploring new types of electroweak penguin eects. The direct CP violation in charmless B decays is predicted, and its precise measurement is helpful either for testing SU(3) symmetry breaking eects of strong phases or for probing new physics beyond standard model.

Associations of ABCB1 and XPC Genetic Polymorphisms with Susceptibility to Colorectal Cancer and Therapeutic Prognosis in a Chinese Population

Yue, Ai-Min,Xie, Zhen-Bin,Zhao, Hong-Feng,Guo, Shu-Ping,Shen, Yu-Hou,Wang, Hai-Pu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Associations between ABCB1 and XPC genetic polymorphisms and risk of developing colorectal cancer (CRC) as well as clinical outcomes in CRCs with chemotherapy were investigated. A case-control study was performed on the ABCB1 C3435T, G2677T/A and XPC Lys939Gln polymorphisms in 428 CRC cases and 450 hospitalbased, age and sex frequency-matched controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. We observed that the ABCB1 3435CT or CC+CT variants were significantly linked with increasing risk of developing CRC (adjusted OR (95% CI): 1.814 (1.237-2.660), P=0.0022; adjusted OR (95% CI): 1.605 (1.117-2.306), P=0.0102, respectively). Moreover, the distribution frequency of XPC AC genotype or AC+CC genotypes also showed a tendency towards increasing the suscepbility for CRC (P=0.0759 and P=0.0903, respectively). Kaplan-Meier curves showed that the ABCB1 C3435T variant was associated with a tendency toward longer progression-free survival (PFS) (n=343, Log-rank test: P=0.063), and the G2677T/A variant genotypes (GT+TT+GA+AA) with a tendency for longer OS in postoperative oxaliplatin-based patients (n=343, Log-rank test: P=0.082). However, no correlation of the XPC Lys939Gln polymorphism was found with PFS and OS in patients with postoperative oxaliplatin-based chemotherapy (n=343). Our study indicated that ABCB1 polymorphisms might be candidate pharmacogenomic factors for the prediction of CRC susceptibility, but not for prognosis with oxaliplatin chemosensitivity in CRC patients.

Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite Surface Protein 1, from Worldwide Isolates.

Wang, Yue,Kaneko, Osamu,Sattabongkot, Jetsumon,Chen, Jun-Hu,Lu, Feng,Chai, Jong-Yil,Takeo, Satoru,Tsuboi, Takafumi,Ayala, Francisco J,Chen, Yong,Lim, Chae Seung,Han, Eun-Taek Allen Press, etc.] 2011 The American journal of tropical medicine and hygi Vol.84 No.2

<P>Abstract. Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P. vivax merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor-like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P. yoelii, P. berghei, and P. falciparum during their evolutionary history. Full-length sequences of the msp1p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.</P>

A Youla-parameterized Gap Control for Next Generation of Optical Storage Systems

Tengfei Yue,Zhizheng Wu,Feng Li,Tao Wang,Lu Wang,Dziki Mbemba 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6

With the development of ultra-high-density optical storage technology, the density of storage media is getting higher and higher, but the increase of the capacity of the optical disk leads to the reduce of the lens-disk interface gap and the tolerance of the focus error dramatically. In the case of extremely small spacing, various external disturbances are highly likely to cause a collision between the optical lens and the disc. In order to avoid the collision between the optical lens and disk, effectively eliminate the deterministic disturbance and suppress the unknown random disturbance, in this paper a multi-objective optimal output feedback controller design approach is proposed within the Q (Youla)-parameterized regulator scheme. The optimal Q parameter in the controller is obtained by solving the properly formulated linear matrix inequalities (LMIs). The experimental results show that the designed Q-parameterized controller can eliminate the influence of various disturbances and suppress the occurrence of collisions effectively.

Effects of Ohmic Area Etching on Buffer Breakdown Voltage of AlGaN/GaN HEMT

Chong Wang,Xiao-Xiao Wel,Meng-Di Zhao,Yun-Long He,Xue-Feng Zheng,Wei Mao,Xiao-Hua Ma,Jin-Cheng Zhang,Yue Hao 한국전기전자재료학회 2017 Transactions on Electrical and Electronic Material Vol.18 No.3

This study is on how ohmic area etching affects the buffer breakdown voltage of AlGaN/GaN HEMT. The surfacemorphology of the ohmic metal can be improved by whole etching on the ohmic area. The buffer breakdown voltagesof the samples with whole etching on the ohmic area were improved by the suppression of the metal spikes formedunder the ohmic contact regions during high-temperature annealing. The samples with selective etching on theohmic area were investigated for comparison. In addition, the buffer leakage currents were measured on the differentradii of the wafer, and the uniformity of the buffer leakage currents on the wafer were investigated by PL mappingmeasurement.

Application of response surface methodology to the decolorization by the electrochemical process using FePMo12O40 catalyst

Lin Yue,Li Wang,Feng Shi,Jianbo Guo,Jingliang Yang,Jing Lian,Xiao Luo 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

In order to optimize the experimental conditions, the decolorization of Acid Red 3R by electrochemicaloxidation process with catalyst FePMo12-APS-MS4A as packing was performed using response surfacemethodology (RSM). The microstructure and morphology of FePMo12-APS-MS4A were characterizedwith Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electronmicroscopy (SEM) and X-ray fluorescence spectroscopy (XRF). Four control factors were throughlyanalyzed by means of RSM based on Box–Behnken design (BBD). Taking the decolorization efficiency asresponse value, a second order polynomial model was established. The model and analysis stronglyindicated that the cell voltage and airflow caused positive, and the initial pH and inter-electrode distancecaused negative effect on the decolorization efficiency. The interaction between cell voltage and initialpH, initial pH and airflow were also revealed. Under the optimal conditions, the color, COD and TOCremoval efficiency reached 67.3%, 58.4% and 47.9% after 60 min. Liquid chromatography–massspectrometry (LC–MS) analysis revealed that the dye molecule underwent a series of reduction andoxidation steps, including azo bond fracture, desulfonation and denitrogenation. The possiblemechanisms involving in this reaction process were proposed.