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등준걸(Jun Jie Deng),정홍인(Hong-In Cheng),고창성(Chang Seong Ko) 대한인간공학회 2021 대한인간공학회 학술대회논문집 Vol.2021 No.11
소형·소량의 운송물을 수탁하여 받는 사람의 주택, 사무실, 그 밖의 장소까지 운송하여 인도하는 것을 일반택배라고 한다. 택배업무에서 주요 작업은 화물분류작업(물류센터 작업), 차량운전, 집화·배송 등의 작업으로 이루어진다. 전세계의 택배 물량은 지속적으로 증가 추세에 있으며 특히 최근 코로나로 인해 급격하게 증가되었다. 국내의 택배업 종사자 수는 2019년 현재 약 6만명에 이르고 있고, 업체 간의 심한 경쟁과 낙후된 작업 환경 등으로 인해 2020년도에 16명의 택배 근로자가 과로사로 사망하였다. 2021년에는 생활물류서 비스산업발전법을 제정하기에 이르렀으나 택배 관련 인간공학적 연구는 미흡한 실정이다. 산업재해를 예방하고 업무의 효율성을 높이기 위해 안전한 택배 작업 방안을 마련하고 작업의 표준을 설정하는 것은 매우 필요하다. 이를 위해 택배와 연관된 인간공학 분야 연구에 관한 문헌 연구를 실시하였다. 이와 같은 연구를 통해 택배업무와 관련하여 이제까지 수행된 다양한 연구를 살펴보고 우리나라 택배와 관련해 추진해야 할 연구방향을 제시하고자 한다. 문헌연구는 국내외 학술 DB와 학위 논문들을 중심으로 수행하였으며 가능한 전반적인 인간공학 분야를 포함시키고자 하였다.
Jun Duan,Feng Deng,Wan-Shan Li,Xue-Lei Li,Lei-Lei Zheng,Gui-Yuan Li,Yan-Jie Bai 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.4
Objective: To compare the positions of the mandibular premolars in Angle Class I subjects according to vertical facial type. The results will provide a theoretical basis for predicting effective tooth movement in orthodontic treatment. Methods: Cephalometric parameters were determined using cone-beam computed tomography in 120 Angle Class I subjects. Subjects were categorized as short, normal, and long face types according to the Frankfort mandibular angle. Parameters indicating the position of the mandibular right premolars and the mandible were also measured. Results: The angle between the mandibular first premolar axis and buccal cortex, the distance between the root apex and buccal cortex, angle of vestibularization, arc of vestibularization, and root apex maximum movable distance were significantly greater in the short face type than in the long and norm face types. The angle between the mandibular second premolar axis and buccal cortex, the distance from root apex to buccal cortex, and the arc of vestibularization were significantly greater in the short face type than in the normal face type. Conclusions: There are significant differences in the mandibular premolar positions in Class I subjects according to vertical facial type.
Zhang Jie,Lin Xiao-Tong,Yu Hong-Qiang,Fang Lei,Wu Di,Luo Yuan-Deng,Zhang Yu-Jun,Xie Chuan-Ming 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Metastatic hepatocellular carcinoma (HCC) is the most lethal malignancy and lacks effective treatment. FBXL6 is overexpressed in human hepatocellular carcinoma (HCC), but whether this change drives liver tumorigenesis and lung metastasis in vivo remains unknown. In this study, we aimed to identify FBXL6 (F-Box and Leucine Rich Repeat Protein 6) as a key driver of HCC metastasis and to provide a new paradigm for HCC therapy. We found that elevated FBXL6 expression in hepatocytes drove HCC lung metastasis and was a much stronger driver than Kras mutation (KrasG12D/+;Alb-Cre), p53 haploinsufficiency (p53+/-) or Tsc1 loss (Tsc1fl/fl;Alb-Cre). Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation. Activated TKT further increased PD-L1 and VRK2 expression via the ROS-mTOR axis, leading to immune evasion and HCC metastasis. Targeting or knockdown of TKT significantly blocked FBXL6-driven immune evasion and HCC metastasis in vitro and in vivo. Notably, the level of active TKT (p-Thr287 TKT) was increased and was positively correlated with the FBXL6 and VRK2 expression levels in HCC patients. Our work provides novel mechanistic insights into FBXL6-driven HCC metastasis and suggests that targeting the TKT-ROS-mTOR-PD-L1/VRK2 axis is a new paradigm for treating patients with metastatic HCC with high FBXL6 expression.
Synchronization for a Class of Fractional-order Linear Complex Networks via Impulsive Control
Na Liu,Jie Fang,Wei Deng,Zhen-Jun Wu,Guo-Qiang Ding 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.6
Up to now, the research topic about fractional-order complex networks is mainly focused on the synchronization. In this paper, synchronization for a class of fractional-order linear complex networks is realized via impulsive control. The general expression of solution for a fractional-order impulsive error system is deduced by utilizing iteration algorithm. Some inequality conditions are established to guarantee that the largest Lyapunov exponents of each node are negative, which means that the corresponding error system is asymptotic stable and synchronization is realized. It is the first time to achieve the synchronization of fractional-order systems based on the largest Lyapunov exponent. Finally, examples are present to illustrate the validity and effectiveness of proposed conclusions. Numerical simulations also indicate that the fractional-order parameter has a great influence on the largest Lyapunov exponent, although it is not reflected in the theoretical analysis.
( Xiang Cheng ),( Jun Hua Li ),( Jie Deng ),( Zhen Zhen Li ),( Shu Yan Meng ),( Hua Yan Wang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2012 BMB Reports Vol.45 No.1
The present study aimed to investigate the function of translationally controlled tumor protein (TCTP) in the regulation of Oct4 in mouse embryonic carcinoma P19 cells and mouse J1 embryonic stem (ES) cells. The mRNA level of endogenous TCTP in somatic cells was 2-4 folds higher than that in pluripotent P19 and J1 ES cells. Overexpression of TCTP in mouse pluripotent cells not only reduced the level of Oct4 transcription, but also decreased the pluripotency of stem cells. The N-terminal end of TCTP (amino acids 1-60) played an important role in suppressing the Oct4 promoter. Moreover, overexpression of TCTP in P19 cells suppressed the Oct4 promoter activity in a dose- and a time-dependent manner. In addition, knockdown of TCTP by small interfering RNA increased the expression of Oct4. Our study indicates that TCTP downregulates the Oct4 expression by binding the Sf1 site of Oct4 promoter in mouse pluripotent cells. [BMB reports 2012; 45(1): 20-25]
In Vitro and In Vivo Studies of Different Liposomes Containing Topotecan
Hao, Yan-Li,Deng, Ying-Jie,Chen, Yan,Wang, Xiu-Min,Zhong, Hai-Jun,Suo, Xu-Bin The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
Liposome as a carrier of topotecan (TPT), a promising anticancer drug, has been reported in attempt to improve the stability and antitumor activity of TPT. However, the biodistr ibution pattern of TPT liposome in vivo and PEG-modified liposome containing TPT have not been studied systemically. In this paper, the in vitro stability and in vivo biodistribution behavior of several liposomes containing TPT with different lipid compositions and PEG-modification were studied. Compared with the 'fluid' liposome (S-Lip) composed of soybean phosphatidylcholine (SPC), the 'solid' liposome (H-Lip) composed of hydrogenated soybean phosphatidylcholine HSPC decreased the leaking efficiency of TPT from liposome and enhanced the stability of liposome in fetal bovine serum (FBS) or human blood plasma (HBP). The results of biodistribution studies in S$_{180}$ tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. Compared with free TPT, S-Lip and H-Lip resulted in 5- and 19- fold increase in the area under the curve (AUC$_{0\rightarrow\propto}$), respectively. PEG- modified H-Lip (H-PEG) showed 3.7-fold increase in AUC$_{0\rightarrow\propto}$ compared with H-Lip, but there was no significant increase in t$_{1/2}$ and AUC$_{0\rightarrow\propto}$ for PEG-modified S-Lip (S-PEG) compared with S-Lip. Moreover, the liposomal encapsulation changed the biodistribution behavior, and H-Lip and H-PEG dramatically increased the accumulation of TPT in tumor, and the relative tumor uptake ratios were 3.4 and 4.3 compared with free drug, respectively. There was also a marked increase in the distribution of TPT in lung when the drug was encapsulated into H-Lip and H-PEG. Moreover, H-PEG decreased the accumulation of TPT in bore marrow compared with unmodified H-Lip. All these results indicated that the membrane fluidity of liposome has an important effect on in vitro stability and in vivo biodistribution pattern of liposomes containing TPT, and PEG-modified 'solid' liposome may be an efficient carrier of TPT.