남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이

신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.

다당류를 이용한 생분해성 필름의 제조

신은경,김동운,김유은,나건,이기영 全南大學校 觸媒硏究所 1998 觸媒硏究 論文集 Vol.20 No.-

In this study, we prepared biodegradable polysaccharide films with pullulan, κ-carrageenan, curdlan and chitosan and measured physical properties and antibacterial activity All of polysaccharide films showed the high biodegradability but antibacterial activity on bacteria was only observed at chitosan film. The permeability of the gas(O₂and C0₂) of polysaccharide films besides chitosan film showed 50∼100 times lower than polyethylene(PE) film. Therefore, we prepared two film types to give low gas permeability and antibacterial property at polysaccharide film : one type was the physically mixed film(k-carrageenan +chitosan) and other type was the chitosan coated κ-carrageenan film. Chitosan coated κ-carrageenan film showed low gas permeability and antibacterial activity.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

유해화학물질의 계통분석

박성우,박유신,이진훈,김남이,김유나,임미애,이상기,유재훈,진광호,신호상,노동석 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

Detection of Near-membrane Calcium Ions in Live Tissues with a Two-Photon Fluorescent Probe

Shin, Yu-Na,Lim, Chang-Su,Tian, Yu Shun,Rho, Won-Young,Cho, Bong-Rae Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.3

A two-photon fluorescent probe (ACaCL) that can detect near-membrane $Ca^{2+}$ is reported. This probe can be excited by 780 nm fs pulses, shows high photostability and negligible toxicity, and can visualize near-membrane $Ca^{2+}$ in live cells and deep inside live tissues by two-photon microscopy.

Detection of Near-membrane Calcium Ions in Live Tissues with a Two-Photon Fluorescent Probe

Yu Na Shin,임창수,Yu Shun Tian,Won Young Rho,조봉래 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.3

A two-photon fluorescent probe (ACaCL) that can detect near-membrane Ca2+ is reported. This probe can be excited by 780 nm fs pulses, shows high photostability and negligible toxicity, and can visualize near-membrane Ca2+ in live cells and deep inside live tissues by two-photon microscopy.

간호사가 인식하는 간호 관리자와 동료간 돌봄 행위가 조직 사회화와 간호 업무 성과에 미치는 영향

신나연(Shin, Na Yeon),유소영(Yu, Soyoung),강성숙(Kang, Seong Suk),이승신(Lee, Seung Shin),박민정(Park, Min Jeung),이대연(Lee, DaeYeon),남선미(Nam, Sun Mi) 한국간호행정학회 2020 간호행정학회지 Vol.26 No.2

Purpose: The study was examined to investigate the influence of nurse manager and peer group caring behaviors on organizational socialization and nursing performance Methods: The subjects were 286 clinical nurses from a general hospital in S city. The collected data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation and hierarchical regression analysis with the SPSS 25.0 program. Nurse manager and peer group caring behaviors, organizational socialization, and nursing performance were measured using organizational climate for caring scale, peer group caring interaction scale, organizational socialization and performance measurement scale for hospital nurses. Results: There was no significant difference in organizational socialization between nurse manager and peer group caring behaviors. The significant predictors of nursing performance were position (β=-.26), nurse manager caring behaviors (β=.23), and peer group caring behaviors (β=.17). These variables explained 23% of the variance in nursing performance. Conclusion: The results suggest that it is necessary to increase both manager and peer group caring behaviors in order to improve nursing performance.

팔당호와 충주호의 Sediment Oxygen Demand (SOD) 변화

신유나 ( Yu Na Shin ),박혜경 ( Hae Kyung Park ),이상원 ( Sang Won Lee ),공동수 ( Dong Soo Kong ) 한국물환경학회 2006 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2006 No.-

모자보건법 제14조(인공임신중절수술의 허용한계)의 역사 : 인구정책변화에 따른 의미 변화와 ‘사회경제적 이유’ 포함 논쟁을 중심으로

신유나(Yu Na Shin),최규진(Kyu Jin Choi) 비판과 대안을 위한 사회복지학회 2020 비판사회정책 Vol.- No.66

본 연구는 인공임신중절 허용사유 중 하나로 논의되었던 ‘사회경제적 이유’ 포함 논쟁을 중심으로 모자보건법 제14조의 역사를 정리한 것이다. 모자보건법은 인구정책의 변화에 따라 제 · 개정되었다. 특히, 이 과정에서 제14조의 ‘사회경제적 이유’를 포함하려는 목적도 변화되었다. 1960년대부터 1980년대까지는 ‘경제개발’을 위해 인구를 억제시켜야 한다는 이유로 모자보건법 인공임신중절수술의 허용한계에 사회경제적 이유를 포함시키려 했다. 그러나 장기집권을 위해 보수층의 눈치를 봐야 했던 박정희 정권은 이를 포함시키지 못한 채 낙태죄를 단속하지 않는 방식을 취했고, 이러한 방향은 전두환, 노태우 정권까지 이어졌다. 그러나 군사정권을 벗어난 이후에도 모자보건법 인공임신중절수술의 허용한계에 사회경제적 이유는 포함되지 못했다. 이는 1990년대에 인구정책 기조가 바뀌기 시작해, 2000년대에 인구증가정책이 대두된 배경이 크게 작용했다. 즉, 진보적인 정부하에서조차 인구증가정책이라는 국가주의적 틀에 갇혀 피임 강화와 캠페인 등 우회적인 방법으로 낙태를 예방하는 데 급급했다. 그러나 2010년 진오비(프로라이프 의사회) 사건을 필두로 보수정권의 퇴행적 정책에 대한 사회운동의 대응이 이루어지며 낙태죄 폐지와 인공임신중절수술의 허용한계에 사회경제적 이유를 포함시켜야 한다는 목소리가 높아져왔다. 하지만 국제적 흐름은 인공임신중절 허용사유에 사회경제적 이유를 포함시키는 논의를 훨씬 넘어서고 있다. 따라서 이 인공임신중절 허용사유의 사회경제적 이유 포함 여부를 둘러싼 논쟁의 역사를 보다 비판적으로 고찰할 필요가 있다. 다시 말해, 헌법재판소의 낙태죄 헌법불합치 판결 이후의 논의에서 인공임신중절 허용사유의 사회경제적 이유 포함 여부가 논의의 핵심이 되어선 안 된다. 오히려 모자보건법 제14조의 탄생과 그것이 활용되온 역사가 절대적으로 국가주의적인 틀 속에서 이루어졌음을 인식하고, 보다 근본적인 논의를 진행할 필요가 있다. This study summarized the history of Article 14 of the Mother and Child Health Law, focusing on “socioeconomic reasons” discussed as one of the grounds for permissible induced abortion. As a result, the Mother and Child Health Law was enacted and revised according to the change of the population policy. Especially, in this process, the purpose of the intended inclusion of ‘socioeconomic reasons” in Article 14 also changed. From the 1960s through the 1980s, the government would include socioeconomic reasons in the Mother and Child Health Law for the reason that it is necessary to control the population for ‘economic development.’ However, the Park Chung-hee regime that had to read the conservative class for a prolonged rule adopted the way of not cracking down on criminal abortion operation, without including them. This direction continued until the 1980s. Even after leaving the military regime, the socioeconomic reasons were not included in Article 14. This was largely attributed to the rise of population growth policies in the 2000s. In other words, even under progressive government, they were locked in the nationalistic framework of population growth policy. In 2010, the Pro-Life Medical Association event triggered a response from the social movement. And it has been reiterated that socioeconomic reasons should be included in reasons for allowing abortions However, the international trend goes far beyond the discussion of including socioeconomic reasons in reasons for allowing abortions. Therefore, it is necessary to consider more critically the history of the debate over whether to include the socioeconomic reasons for allowing abortions. In other words, in the recent discussions after the Korean Constitutional Court"s decision about the abortion, whether to include the socioeconomic reasons for allowing abortions should not be at the heart of the debate. Rather, it is necessary to recognize that the birth of Article 14 of the Maternal and Child Health Act and the history of its use have taken place within an absolutely nationalistic framework, and to proceed with more fundamental discussions. The international trend goes far beyond the discussion of incorporating socioeconomic reasons into the reasons for abortion. Thus, in the discussions after the Korean Constitutional Court"s decision about abortion, the inclusion of socio-economic reasons for abortion should not be at the heart of the debate. Rather, it is necessary to recognize that the birth of Article 14 of the Maternal and Child Health Act and the history of its use have taken place in an absolutely nationalist framework, and to proceed with more open and fundamental discussions.

주의분산 과제에 따른 말소리장애 아동과 일반 아동의 자음정확도 비교

신유나(Yu Na Shin),하지완(Ji Wan Ha) 한국언어치료학회 2022 한국언어치료학회 학술발표대회 논문집 Vol.2022 No.11