다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

리네졸리드와 반코마이신을 교대로 투여하여 치료한 지속성 메티실린 내성 황색포도알균 균혈증 1예

김낙현,김문석,장은선,강유민,김가연,장희창,박완범,김의종,김남중,오명돈 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for ≥7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic therapy. Vancomycin remains the antibiotic of choice in MRSA bacteremia. Alternative agents, linezolid or daptomycin, are available, but a consensus regarding management of persistent MRSA bacteremia on vancomycin failure is still lacking. We report a case of a 60-year-old male who received thoracoabdominal aorta replacement operation due to dissecting aneurysm of the ascending and descending aorta. Surgical site infection and bacteremia caused by MRSA occured, and wound debridement operations were performed. The patient was treated with vancomycin in therapeutic doses but MRSA bacteremia persisted for 168 days in a row. Although the inserted aortic graft was the most probable source of persistent bacteremia, surgical removal was impossible. Linezolid was administered as an alternative antibiotic but had to be discontinued from time to time due to thrombocytopenia induced by this agent. In the end, MRSA bacteremia was successfully managed by alternating vancomycin-linezolid therapy.

유색미에 관한 연구 : Ⅲ. 유색미 유망계통에 대한 주요 생육 특성

김광수,최윤표,김선택,최현구,정종태,김보경,유지홍,이희봉 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

국내외 유색미 수집종을 돌연변이원에 의해 유기된 우수 계통과 수집종간 상호교배에 의해 선발된 CNU 20계통을 파종하여 얻어진 주요 작물학적 특성을 살펴보면 다음과 같다. 1. 간장은 유색 메벼인 CNU126 계통이 대조품종인 동진벼와 같이 가장 컸고 메성인 CNU 128계통에서 가장 작았다. 2. 주당 분얼수는 CNU3, CNU50. CNU56, CNU112 계통에서 가장 많았고 대조품종과 CNU 128 계통에서 10개 미만으로 가장 적게 나타났다. 3. 수장은 육성 계통 중 CNU88 계통에서 가장 길었으나 대조구보다 짧고, 육성계통 중에서는 CNU 126 계통이 가장 짧았다. 4. 주당 영화수는 대조구인 동진벼보다 CNU50 계통에서 2배 이상 많았고, CNU158 계통에서 가장 적게 나타났다. 5. 천립중은 CNU113 계통에서 30g이상으로 대조구와 같이 가장 무거웠고, CNU128 계통에서 20g으로 가장 적었다. 6. 주당 수량은 대조구의 26.6g에 비해 CNU50, CNU112 계통에서 두배정도 높았고, CNU128, CNU158, CNU200 계통에서 가장 낮게 타나났다. Aims of this study were carried out to develop the useful lines induced from mutation and pedigree breeding methods among the collected genetic resources from national and domestic areas. In this study, Stem height of CNU126 line and check among them were high, while CNU128 was lower than other lines. Spiklet length of CNU88 was longer, but that of CNU126 was shorter than check. Number of spiklets per plant of CNU50 among lines have twice time than check. 1,000 grains weight of CNU113 was higher than check. In yield per plant, CNU50 and CNU112 were higher than check, Dongjinbyeo.

The Observation of Intermetallic Compound Microstructure Under Sn Whisker in Lead-free Finish

Yu, Chong-Hee The Korean Microelectronics and Packaging Society 2009 마이크로전자 및 패키징학회지 Vol.16 No.2

Sn whiskers can grow from the pure Sn and high Sn-based finish and cause the electrical shorts and failures. Even with the wealth of information on whiskers, we have neither the clear understanding of whisker growth nor methods for its prevention. In this study, the whisker grain roots which connected with intermetallic layer were analyzed by high-resolution transmission electron microscopy (HR-TEM). In the Sn-Cu plated leadframe (LF) that was stored at ambient condition for 540 days, filament-shaped whiskers were grown on the Sn-plated surface and ${\eta}'-Cu_6Sn_5$ precipitates were widely distributed along the grain boundaries at the Sn matrix. The measured of the lattice fringes at the ${\eta}'-Cu_6Sn_5$ was $4.71{\AA}$ at the coarse grain and $2.91{\AA}$ at the fine grain. The $Cu_3Sn$ which generates the tensile stresses was not observed. The formation of $Cu_6Sn_5$ precipitates and intermetallic layer were strongly related to whisker growth, but, the whisker growth tendency does not closely relate with the geometric morphology of irregularly grown intermetallic compound (lMC).

폐경전 자궁적출술을 시행받은 여성과 자연폐경 여성에서 에스트로겐 단독투여와에스트로겐+프로게스틴의 지속적 병합투여시 지질 및 고밀도의 변화에 대한 연구

김희옥(Hee Ok Kim),유민영(Min Young Yoo),김연정(Youn Jung Kim),박지은(Ji Eun Park),양훈진(Hoon Jin Yang),유은희(Eun Hee Yoo),전선희(Sun Hee Chun),김종일(Chong Il Kim),유한기(Han Ki Yu) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

목적 : 폐경전 자궁적출술을 시행받은 여성과 자연폐경 여성에서 에스트로겐 단독투여시와 에스트로겐과 프로게스테론의 지속적 병합투여시 지질 및 골밀도의 변화에 대한 차이를 비교하기 위한 연구이다. 연구방법 : 총 80명의 환자중 치료 1군(50명)은 폐경전 자궁적출술을 시행받은 환자로 접합 에스트로겐 0.625mg을 48개월간 지속적으로 투여받았고, 치료 2군(30명)은 접합 에스트로겐 0.625mg과 MPA 2.5mg을 지속적으로 병합 투여 받았다. 투여전과 투여후 6개월, 12개월, 24개월, 36개월, 48개월 후에 혈청 지질 및 지단백과 골밀도의 변화를 측정하였다.결과 : 총콜레스테롤치는 두 군에서 각각 치료 48개월후 9.9%, 10.8% 감소하였고, LDL-콜레스테롤치는 20.1%, 16.3% 감소하였다. HDL-콜레스테롤치는 각각 21%, 31.9% 증가하였다. 척추골 골밀도는 두 군에서 각각 치료 48개월후 11.6%, 14.9% 증가하였고, 대퇴골 골밀도는 12.9%, 14.9% 증가하였다.두 군 사이의 통계적 유의한 차이는 없었다.결론 : 에스트로겐 단독 투여와 에스트로겐과 프로게스테론의 지속적 병합 투여는 모두 심혈관질환과 골다공증에 유익한 효과가 있다. 자연 폐경 여성에서는 에스트로겐 단독 투여보다 에스트로겐과 프로게스테론의 지속적 병합 요법이 더 바람직하다고 할 수 있다. Objective : Our purpose was to investigate the effect of single estrogen and continuous combined estrogen + progestin on lipid profile and bone mineral density.Method : We have treated two groups of menopausal women for 4 years, ; Group 1(hysterectomised women) received conjugated equine estrogen(CEE) 0.625mg per day for 30 days ; Group 2(natural menopausal women) received continuous combined therapy(CEE 0.625mg and MPA 2.5mg per day) for 30 days.We compared pre-and poststudy serum lipid profile and bone mineral density in two groups.Result : The data demonstrated a beneficial effect in lipoprotein profile that total cholestrol decreased in two groups by 9.9% and 10.8% from the baseline values. Low density lipoproten(LDL)-cholesterol decreased in two groups by 20.1% and 16.3% in post HRT 48 months, high density lipoproten(HDL)-cholesterol increased in two groups by 21% and 31.9%. And HRT shows the beneficial effect in bone mineral densities. Lumbar BMD increased in two groups by 11.6% and 14.9% and femur BMD increased in two groups by 12.9% and 14.9% from the baseline value.Conclusion : Our result suggest that single estrogen therapy and continuous combined estrogen-progestin therapy has beneficial effect on cardiovascular disease and osteoporosis. Their effects were not significantly different among two groups. So we suggest that continuous combined estrogen-progestin therapy is preferable to single estrogen therapy.

Invasive Hormographiella aspergillata Infection Identified Using DNA Sequencing

Chong Eunbin,Yu Hui-Jin,Kim Tae Yeul,Yoo Keon Hee,김예진,Huh Hee Jae,Lee Nam Yong 대한진단검사의학회 2022 Annals of Laboratory Medicine Vol.42 No.3

RTA-Treated Carbon Fiber/Copper Core/Shell Hybrid for Thermally Conductive Composites

Yu, Seunggun,Park, Bo-In,Park, Cheolmin,Hong, Soon Man,Han, Tae Hee,Koo, Chong Min American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.10

<P>In this paper, we demonstrate a facile route to produce epoxy/carbon fiber composites providing continuous heat conduction pathway of Cu with a high degree of crystal perfection via electroplating, followed by rapid thermal annealing (RTA) treatment and compression molding. Copper shells on carbon fibers were coated through electroplating method and post-treated via RTA technique to reduce the degree of imperfection in the Cu crystal. The epoxy/Cu-plated carbon fiber composites with Cu shell of 12.0 vol % prepared via simple compression molding, revealed 18 times larger thermal conductivity (47.2 W m<SUP>–1</SUP> K<SUP>–1</SUP>) in parallel direction and 6 times larger thermal conductivity (3.9 W m<SUP>–1</SUP> K<SUP>–1</SUP>) in perpendicular direction than epoxy/carbon fiber composite. Our novel composites with RTA-treated carbon fiber/Cu core/shell hybrid showed heat conduction behavior of an excellent polymeric composite thermal conductor with continuous heat conduction pathway, comparable to theoretical values obtained from Hatta and Taya model.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-10/am500871b/production/images/medium/am-2014-00871b_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am500871b'>ACS Electronic Supporting Info</A></P>

Copper Shell Networks in Polymer Composites for Efficient Thermal Conduction

Yu, Seunggun,Lee, Jang-Woo,Han, Tae Hee,Park, Cheolmin,Kwon, Youngdon,Hong, Soon Man,Koo, Chong Min American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.22

<P>Thermal management of polymeric composites is a crucial issue to determine the performance and reliability of the devices. Here, we report a straightforward route to prepare polymeric composites with Cu thin film networks. Taking advantage of the fluidity of polymer melt and the ductile properties of Cu films, the polymeric composites were created by the Cu metallization of PS bead and the hot press molding of Cu-plated PS beads. The unique three-dimensional Cu shell-networks in the PS matrix demonstrated isotropic and ideal conductive performance at even extremely low Cu contents. In contrast to the conventional simple melt-mixed Cu beads/PS composites at the same concentration of 23.0 vol %, the PS composites with Cu shell networks indeed revealed 60 times larger thermal conductivity and 8 orders of magnitude larger electrical conductivity. Our strategy offers a straightforward and high-throughput route for the isotropic thermal and electrical conductive composites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-22/am4030406/production/images/medium/am-2013-030406_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am4030406'>ACS Electronic Supporting Info</A></P>

만성 신부전의 빈혈에 대한 유전자 재조합인 애리쓰로포이에틴(에포론�)의 유효성 및안전성 평가를 위한 연구 : 제 Ⅲ상 임상시험

유석희,강종명,강경원,이호영,노현진,신석균 대한신장학회 2000 대한신장학회잡지 Vol.19 No.6

Spine Metastasis Practice Patterns among Korean, Chinese, and Japanese Radiation Oncologists: A Multinational Online Survey Study

Yu, Jeong Il,Park, Hee Chul,Ahn, Yong Chan,Gao, Xian-Shu,Wang, Jun-Jie,Zeng, Zhao-Chong,Ito, Yoshinori,Ohno, Tatsuya,Nishimura, Yasumasa Oxford University Press 2017 Journal of radiation research Vol.58 No.1

<P>This online survey of practising radiation oncologists from Korea, China and Japan was conducted to investigate the current practices in radiotherapy (RT) for spine metastasis and to compare these practices across the three countries. The questionnaire included nine general information questions and two clinical scenarios (representing ‘typical’ and ‘good’ prognosis spine metastasis), with seven questions for each scenario. An anonymous web-based survey using Google Docs® was undertaken from 2 September 2014 to 9 April 2015. A total of 54 Korean, 107 Chinese and 104 Japanese radiation oncologists participated in the study. The first scenario involved a typical case of spine metastasis (~25% expected 1-year survival rate), and the preferred fractionation scheme was 10 fractions of 3 Gy, though the pattern was slightly different in each country. The second scenario involved a good prognosis case (>50% expected 1-year survival rate), and 10 fractions of 3 Gy was the preferred practice in all three countries (however, use of a larger fraction dose with a smaller fraction number was more common in Korea). A more conformal RT technique was more prominent in China and Korea, especially for patients with a good prognosis. Avoidance of reirradiation was notable in China. In summary, a preference for multiple fractionation in RT for spine metastasis was observed in the majority of Korean, Chinese and Japanese radiation oncologists, although there were slight differences in practice preferences, especially for patients with a favorable prognosis.</P>