18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

素問·調經論에 대한 연구(Ⅱ)

鄭憲瑩,琴坰樹,朴炅 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2

'Joe'(調) implies the harmony or the regulation, and 'Kyung'(經) indicates a meridian on that is translating meridian blood and Meridian-Qi. The Meridian channel is opened to the Five viscera(五藏) and the Six bowels(六腑) internally and that is connected with three hundred and sixty five joints externally. The body never occurs disease until Qi-hyul(氣血) is harmonied and Yin-Yang(陰陽) is balanced. If the disease occurs by means of the internal cause-the eating and drinking, the living of dwelling space, the importance of the emotion etc, I or by means of the external cause- the wind and rain, and the cold and dampness, it has influence on the Qi-hyul(氣血) of the body. Therefore with disharmony of the body has Qi-hyul, each kind of the Hei-shil disease brake(&實病燮) occur. From this chapter, Joe kyung(調經) implies the regulation that each kind of Hei-shil disease brake with ocwrance of the disorder of the body Yin-Yang-Qi-hyul(陰陽氣血), the shortage(&) is supplied, and the surplus(R) is decreased. Summerizing the contents of the "Joe Kyung Ron(調經陰)" in reference to the contents of successive generation note, the contents were as follows; In chapter 1, it was made clear that the revelation of the body normal physiological function had an action that connected human being's inside with it's outside, and that play the part of a passage in Qi-hyul(氣血) risvolving. In chapter 2, it was made clear about the plentiful disease, and it's administration of the Shen-Qi-Hyul-Hyung-Zhi(神·氣·血·形·志) with kept in the five viscera. In chapter 3, it was made clear about the Hei-shil(虛實) of the cause of the disease(病機), Qi-Hyul(氣血) union malim(雅氣), that by Qi-Hyul(氣血) itself union how Hei syndrome(虛證) and Shil syndrome(#%) are? In chapter 4, it was made clear that cause of a disease about Hei-Shil(虛實) has an attack of disease by pung(風)·woo(雨)·han(寒)·seo(署), and by the eating and drinking, the living of dwelling space and it explained the cause of a disease. In chapter 5, it explained the cause of a disease about Yin-Yang-Han-Yul(陰陽寒熱). In chapter 6, it explained an acupuncture technique about Hei syndrome(虛證) and Shil syndrome(l實證). chapter 7, it explained the method of Joe Kyung(調經) through the region of the body. The above contents had significient influence on the assortment and demonstration of the method of the acupuncture and moxibustion and disease in the future.

고령자 급성 췌장염의 임상적 고찰

이진헌,강진경,박인서,송건훈,정재복,백용한,송시영,서정훈 대한소화기학회 1998 대한소화기학회지 Vol.32 No.3

Background/Aims: Inflammatory diseasas of the pancreas are not uncommon. The advanced age is one of the significant factors in assessing the severity of acute pancreatitis. It has been shown that the biliary tract disease is a more frequent cause of acute pancreatitis in the elderly than in the young. With the increased life span, the elderly are comprising a large proportion of the population. As a result, physicians are more often being faced with acute pancreatitis in the elderly. The purpose af this study was to evaluate clinical features of acute panereatitis in the elderly. Methods: A total of 188 patients with acute pancreatitis were reviewed. We investigated the differences of clinical characteristics between the elderly patients aged over 60 and the young patients aged under 60. Results: The sex distribution showed male preponderance in the young patients (M:F=2.4:1), but was nearly equal in the elderly patients (M:F=1.1:1). The most common cause of acute pancreatitis in the elderly was biliary tract disease (52.5%), while alcohol abuse was the most common cause in the young patients (38.8%), Local complications of acute pancreatitis, such as psuedocyst, necrosis, abscesses were not differently shown between the elderly (16.9%) and the young (20.2%) patients. Systemic complications including acute puhnonary failure occurred more frequently in the elderly patients than the young patients. The mortality rate of the elderly patients (5.1%) was not significantly different from that of the young patients (3.1%). Conclusions: To detect correctable underlying bihary tract diseases the elderly patients with acute pancreatitis should be completely investigated using endoscopic retrograde cholangiopancreatography (ERCP). In addition, the patient should be closely monitored for the development of the systemic complications during the disease process.

고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer

Kyung‑Yoon Jeon,Eun‑Ji Ko,Young Lim Oh,Hongbae Kim,Wan Kyu Eo,김아리,Han Gyu Sun,Meesun Ock,Ki Hyung Kim,Hee‑Jae Cha 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.

항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

Hirayama Disease with Isolated Spinal Cord Atrophy

Kyung-won Lee,Taewon Kim,Seong-Hoon Kim,Yun Jeong Hong,Jae Young An 대한신경초음파학회 2023 대한신경초음파학회지 (JNN) Vol.15 No.2

This report presents a young-aged man with Hirayama disease who had muscle atrophy and weakness strictly confined to the C8/T1 myotome that consistently accorded with electromyographic results. In the magnetic resonance imaging (MRI) evaluation, there was only a prominent isolated spinal cord atrophy without any typical flexion MRI features of Hirayama disease. We speculate that it may be possible to have only isolated spinal cord atrophy as a limited form in Hirayama disease even in the absence of anterior displacement of the dura in the flexed position. These findings emphasize the importance of understanding both typical and atypical limited findings of the MRI imaging features of Hirayama disease, because it’s critical to distinguish Hirayama disease, mostly showing benign course, from fatal conditions like amyotrophic lateral sclerosis.

경희대학교 서울캠퍼스 진입로 및 주변 보행공간 기본계획

김동찬,김영준,마원,김충희,노경식,이가영 경희대학교 부설 디자인연구원 2008 예술· 디자인학연구 Vol.11 No.1

Kyung-Hee University in Seoul accept changing of education environment to deal with World's information technology society so that school had preparing the Masterplan to grow up campus's vision since 2006th. Finally we finish up this plan. However, realization of the Masterplan need a lot of financial resources, much times and phases in improvement. Especially, our school needs symbolized business in 2009 due to school of 60th anniversary. So we made a plan that to construct by design which is going to reshape campus's main road and westside afforest place for future. As a result, purpose of research is to improve an atmosphere conducive to academic pursuit, to show up greatness of school and to deal with changing school's environment rapidlly. That is why the Masterplan is trying to find school of superb scenic and developing of environment to congratulate of our school's 60th anniversary main approach and walking spaces.

靈樞·五邪에 對한 硏究

李載胎,鄭憲瑩,琴坰樹,朴炅 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2

Young Chou O Sa(靈樞 五邪) described the symptoms of a disease when injurious factors permeated the five viscera and the location of a meridian point and the acupuncture in curing them according to the five viscera. When there are injurious factors within the lungs, you ought to acupuncture Woon Moon Hul(雲門穴), Joong Bu Hul(中府혈穴), Pae Soo HuI(肺輸穴 B13), and Geol Boon Hul(缺盆穴 S12), when there are injurious factors within the liver, acupuncture Hang Gan HuI(行間穴 LIV2) and Jok Sam Ri HuI(尺三里穴 S36), within the spleen, do acupuncture Yong Chul HuI(湧泉穴 K1) and Gon Ryun HuI(崑崙穴 B60), and when there are injurious factors within the heart, do so in the place of Shin Moon Hul(神門穴 H7).

Erosive adenomatosis of the nipple presenting early improvement after short-term cryotherapy

( Kyung-nam Bae ),( Kihyuk Shin ),( Woo-il Kim ),( Min-young ),( Yang Won-ku Lee ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Erosive adenomatosis of the nipple (EAN) is a rare benign neoplasm characterized by the erosion of the nipple forming crust with serous or bloody discharge. Although there is no pronounced link between its nature course with the malignant transformation, the erosive deformity is directly related to the recurrent functional discomfort and cosmetic problem, resulting in deterioration of the quality of life. A 22-year old woman visited the breast clinic for her persistent deformity of the left nipple. She underwent a core-needle biopsy of a breast mass, which was incidentally found during a breast examination. However, no additional abnormalities were found except for fibrocystic change, and then visited to our clinic for evaluation of the skin lesion. The physical examination revealed serous and bloody erosion on top of the nipple with loss of half of its normal structure. The skin biopsy showed hyperplasia of the tubular structure composed of layers of cuboidal cells, but no atypia or pleomorphism. Then she received four times of cryosurgery every six-weeks, and after 6 months the nipple almost completely healed only remaining a tiny slit-like hole. Although the first choice of treatment for EAN is local excision, it is not quite feasible approach in young-aged female patients given the unsatifactory cosmetical outcomes and the anxiety for invasive procedure. Cryotherapy could be one of the acceptable option for the treatment of EAN.