Morphine의 血漿 Corticosterone 增加作用에 미치는 副交感神經系藥物의 影響

文永煥,全普權,申萬鍊 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

Buckingham suggested that the effects of opioid substances on CRF secretion are probably due partially to direct actions on the hypothatamus and partially to alterations in the activity of cholinergic and noradrenergic neurons in the central nervous system. In this paper, the influences of cholinergic and anticholinergic drugs on the morphine-induced increase of plasma corticotserone level was studied in male mice. The results obtained were summarized as follows; 1. The dose-dependent increasing effect of morphine on plasma corticosterone was significantly inhibited by naloxone. 2. Pilocarpine (0.1-2.0㎎/㎏), physostigmine(10-200㎍/㎏), carbachol(10-200㎍/), and nicotine(0.1-2.0㎎/㎏) induced the dose-dependent increase of plasma corticosterone level. Particularly, the increasing effect of physostigmine and carbachol was marked. 3. The increasing effect of morphine on plasma corticosterone was markedly enhanced by pilocarpine, physostigmine or carbachol and was slightly enhanced by nicotine. The combined effect of morphine with pilocarpine or nicotine showed a tendency to be strengthened by atropine. But the combined effect of morphine and physostigmine was little changed by atropine and the combined effect of morphine and carbachol was inclined to be decreased by atropine. 4. Atropine(1.0㎎/㎏)and hexamethonium(10㎎/㎏)induced the marked increase of plasma corticosterone level. But by the combined treatment of them, the plasma corticosterone level showed the initial marked increase followed by the abrupt decrease downward to the control level. The increase induced by the combined treatment of atropine or hexamethonium with morphine was rather lower than that induced by a single treatment of atropine or hexamethonium. These results suggest that the increasing effect of morphine on plasma corticosterone level is mediated rather by its direct action on hypothalamus and its indirect action on central noncholiergic neurones than by its action on central cholinergic neuronal function.

傳統餘暇에 關한 硏究

천영일,윤상문 중앙대학교 스포츠과학연구소 1998 體育硏究 Vol.- No.11

This study is executed with explanatory method research and analysis about documents. It is no doubt that every study should do as it but this study analyzed the content on the whole research of documents, and especially, it more considered the aspect of qhole society than aspect of individuality. It is suggested that specific problem and the background of this study, and mentioned about limitation quich has appeared in research. It is mentioned about understanding of the traditional culture and relation between leisure and traditional culture with general contemplation on the leisure theory.

패스트푸드점 서비스품질과 재구매의도의 결정요인에 관한 업체 간 비교연구

全永鎬,崔文摫 홍익대학교 과학기술연구소 2006 科學技術硏究論文集 Vol.17 No.-

In Korea, the number of family restaurants and fast food restaurants have increased rapidly. In particular, as the food service industry becomes large-scaled and organized, those restaurants are dominated by large capital group. The objective of this study is to conduct evaluation and investigation of fast food restaurants at the point of service quality. The evaluation criteria of service quality were identified for the customers to assess the fast food restaurants in an attempt to find the determinants of service quality affecting customer satisfaction. Factor analysis, t-test and multiple regression analysis were applied to 256 survey data. In conclusion, coefficient of correlation of the customer satisfaction and service quality were very high.

심상성 루프스에서 Nested-Primer Gene Amplification Assay에 의한 결핵균 DNA의 검출

신문석,전효진,김병천,이규석,김재룡,권호준,송준영 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Lupus vulgaris, which is a progressive form of postprimary tuberculosis in patients with a moderate to high degree of immunity and tuberculin sensitivity, is the most common, most serious, and most variable type of cutaneous and mucous membrane tuberculosis. Domonstration of M.tuberculosis directly or in culture in some of these eruptions can be difficult. It is essential to demonstrate the presence of M.tuberculosis in a clinical sample for a definitive diagnosis of tuberculosis. With the discovery of the polymerase chain reaction (PCR), the DNA diagnostic approach for infection has developed in a short period. With the dual purpose of definitive and rapid diagnosis of tuberculosis, this study examined the usefulness of a nested PCR for detection of M. turberculosis. Compared with a single-step PCR, the two-step PCR was able to enhance sensitivity approximately 1,000-fold on the basis of bacterial counts and DNA quantity. We concluded that two-step nested PCR appeared to be the most useful PCR protocol for early and sensitive diagnostic method detecting M.tuberculosis in acid-fast stain negative specimens.

공과대학 컴퓨터 교육 향상 연구

박영필,민병렬,문영현,김상식,조원철,홍준표,이홍림,김재희,오두환 연세대학교 산업기술연구소 1988 논문집 Vol.20 No.2

In accordance with the rapid advance of computer technologies, industries as well as the academic world become to apply the computer to various fields in engineering. Therefore, more realistic and effective computer educations should be provided in engineering colleges. This study proposes some schemes to elevate currently offered computer- related educations in engineering colleges. For this study, 10 major domestic and foreign engineering colleges were surveyed in the aspects of computer- related courses and computer systems offered by the colleges.

진행암 환자에서 Cisplatin 병용화학요법 시 Ondansetron의 오심 구토 조절 효과

조문준,윤환중,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ondansetron is a novel agent that selectively binds to the 5-hydroxytryptamine_3 receptor, and has been reported to have a prominent effect in the prevention of anti-neoplastic agent induced nausea and vomiting. Twenty solid tumor patients who were scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively open-labeled study to evaluate the antiernetic efficacy and safety of ondansetron. The male to female ratio was 11 : 9 and median age was 49(16-70). The sites of primary neoplasms and number of patients were as following : head and neck 4, metastatic carcinoma of unknown primary site 3, stomach 3, osteosarcoma 2, ovary 2, esophagus 1, melanoma 1, penile 1, bladder 1, cervix 1, and extragonadal germ cell 1. Ondansetron was given as an 8mg loading dose IV before chemotherapy followed by 8mg IV every 8 hours until 24 hours after chemotherapy completion. Complete or major control(0 to 2 emetic episodes) of emesis was achieved in 17 of 20 patients(85%;complete 50%, major 35%) receiving ondansetron during the first 24hrs of chemotherapy. During the period of day 2 through clay 5 of chemotherapy, 14 of 20(75%) patients had complete or major control of emesis(complete 35%, major 35%). No severe side reactions were recorded in ondansetron treated patients, while mild to moderate headache was noted in 20% of patients. These results show that ondansetron is effective in the control of cisplatin induced nausea and emesis, and can be administered safely with minimal side effects.

나트형 불소 4규소운문[NaMg_2.5(Si_4O_10)F_2]의 이온교환(Ⅱ)

崔世千,宋宗澤,申榮文 단국대학교 대학원 1984 學術論叢 Vol.8 No.-

Ion exchange of Na­fluor­tetrasilicic Mica (Na­TSM) by univalent cations of Li^+, K^-, and bivalent cations of Mg^2+, Ca^2+, Ba^2+, was studied to investigate the fundamental properties of cation exchangability of it. The absorbed equivalents of the alkali and alkali earth metal ions were smaller than Na^2+ ion equivalents dissolved from the Na­TSM. The difference of their ion exchange capacities was changed by the kind and concentration of the cations and was considered that H^+ ions from the dissociation of water were absorbed in the surface of the Na­TSM. H^+ ion and cation exchange capacities were about 80% of the interlayer Na^+ ion in the Na­TSM, and it was considered in terms of the particle size and the drying condition of the starting material.

걷기운동이 비만중년여성의 건강관련체력과 피하지방두께변화에 미치는 영향

원영두,문현화,정천모,신명건 朝鮮大學校 스포츠科學硏究所 2007 스포츠科學硏究 Vol.18 No.-

The purpose of this study was to analyze the effect of walking exercise on health-related physical fitness and Subcutaneous fat thickness in obese middle-aged women. SPSS 11.0 was used to calculate mean and SD, and ANCOVA was conducted to examine the group difference between paired sample t-test and pre-test and post-test. The level of significance was set at a=.05. 1. The change of health-related physical fitness was examined, In the EG, there was no statistically significant difference in muscular strength, but there was statistically significant difference in muscle endurance(p<.05), f1exibi1ity(p<.01), and cardivascular endurance(p<.OOl). In the CG, there was no statistically significant difference in all factors. 2. The change of body composition was examined. In the EG, there was statistically significant difference in weight(p<.001) and % body fat(p(.001), but 3. The change of skinfold thickness was examined. In the EG. there was statistically significant difference in triceps. subscapular, midaxillary, abdominal, suprailliac, and popliteal muscles(p<.001) and front thigh(p(.01), but there was no statistically significant difference in medial calf. In the CG, there was no statistically significant difference in all regions. In conclusion, as results of conducting the 12-week walking exercise program for obese middle-aged women, it was found that the program improved health-related and effectively reduced % body fat and skinfold thickness. It is recommended that middle-aged women should do low intensity endurance exercise rather than excessive exercise. Further study should conduct a walking exercise program and a dietary cure together to provide obese middle-aged women with a more effective program.

β-agarase를 생산하는 해양균의 분리 및 효소 특성연구

김문수,김도만,박혜영,강미화,천종훈 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

An agar degrading bacteria was isolated from the south ocean of Korea and was identified as Aeromonas sp. This strain produced the amount of agarase (1.4U/ml) with agar as a carbon source and casamino acid as a nitrogen source. The optimum concentration of NaCl for both cell growth and enzyme activity was 2.5%. The agarase was purified by DEAE-cellulose and hydroxyapatite column chro-matograpy. The purified agarase showed a single protein band upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) and its molecular weight was estimated to be 50 KDa. The optimal temperature and pH for the enzyme activity were 28℃ and 7.2, respectively. The agarase was stable at pH 6.5 - 8 and 22 - 37℃. The agarase activity was notably inhibited by EDTA, Mn2+, Hg2+, Fe2+ and slightly activated by Na+ and Ba2+.

노인의 식이 콜레스테롤 및 식이섬유 섭취가 혈중지질과 체중에 미치는 영향

양춘호,문용식,김중언 群山大學校 1997 論文集 Vol.25 No.-

The purpose of this study was to investigate the effects of dietary cholesterol and dietary fiber on blood liquid component and body weight of 60's older. The subjects were 12 of older. The subjects were ranomly assigned to one two group( experimental and control). Each group ender up with 6 subject. The measurement items were total cholesterol, TG, HDL, LDL, body weight. The entire investigation period was 8wks The subject in the utitlized the 2×5 factorial repeated measure The results were as follows: First, There were statistically significant difference between cholesterol, TG, HDL, body weight of the control group and the experimental group. Second, There were statistically significant difference among Cholesterol, TG, HDL, LDL, and body weight means of treatment period. Third, There were not show statistically significant difference between group and treatment period.