배달 미니 게임 개발:"최고의 웨이터를 꿈꾸며"

김정훈,정한교,김영옥,김중곤,박정윤,윤진성,김경식 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 미니 게임은 웨이터라는 직업을 모티브로 하여서 남녀노소 누구나 재미를 느낌과 동시에 기억력 향상시켜 주는 게임제작이라는 목적아래 제작되었다.본 논문에서는 이 게임의 제작과정을 기술하고자 한다.이 게임은 제3회 AGC(한국 아마추어 게임제작 공모전)에서 우수 작으로 선정되었다.

정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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學生 生活의 質 改善에 關한 硏究 : 大學生活 經驗에 따른 新入生의 意識變化 Changes in Freshmen's Expectations for Higher Education through Collegians' Experiences

김언주,박영철,김교헌,박동철,허윤근,사명규 충남대학교 1992 學生生活硏究 Vol.19 No.-

1. 인적사항 ‘부모님과의 가치관의 차이가 없다’가 48.2%이고 ‘가치관의 차이가 있다’가 51.8%로 나타났다. 한 학기를 지낸 후 부모님과의 가치관의 차이에는 별다른 변화를 보이지 않고 있다. 재학 중 침식형태를 보면, 전체 학생 중 약 39%가 자책이 아닌 하숙, 기숙사, 자취 또는 친척집에서 다니고 있었다. 신입생들은 대체로 원만한 인간관계를 유지하고 있는 것으로 나타났다. 대학별로는 예술대학이 가장 높았으며 약학대학이 평균보다 낮았다. 그런데 입학당시에 비해 한 학기를 지낸 후 원만한 인간관계를 유지하고 있다는 반응율이 낮아졌다. 이런 점은 다른 여러 가지 이유가 있겠으나 주된 이유는 대학사회라는 급격히 변화한 환경에 적응을 잘 하지 못한데서 연유된다고 생각된다. 이상과 같은 인적사항에 대한 분석 결과는 부모님과 자녀 또는 기성세대와 대학생들 간의 긴밀한 대화의 통로를 마련할 것과, 원만한 인간관계 개발을 위한 프로그램의 개발 및 종합적인 주거환경에 대한 대학교육목적 달성의 차원에서의 장기적인 대책 수립이 요망된다.

嫌氣性細菌 Erwinia carotovora subsp. carotovora에 의한 大麻皮의 精練

金永哲,金基淸,吳讚敎 全南大學校 農漁村開發硏究所 1991 農業科學技術硏究 Vol.26 No.-

後前의 Bacillus subtilis 菌에 의한 大麻皮의 纖維精練 方法을 改善하기 위해 Erwinia carotovora subsp. carotovora(植物 軟腐 病原菌)의 生育 培地別, 培地 pH別, 處理溫度別 및 處理時間別 pectin의 分解率과 現地 工場에서의 實用實驗의 精練程度 및 pectin 分解率에 基礎한 새로운 精練方法을 開發하였다. 1. 大麻皮 精練을 위한 E. carotovora의 利用에 있어서 母液培地로는 Nutrient broth나 0.5% pepton水보다는 最少無機염類培地가 pectin分解率에 있어서 가장 높았고 B. subtilis보다 pectin分解 活性이 훨씬 높았다. 2. Pectin分解率이 가장 높았던 E. carotovora 母液培地(最少無機염類培地)의 pH는 7.0에서 부터 8.0 사이였다. 3. E. carotovora를 利用한 大麻皮 精練 處理溫度는 30~35℃, 處理時間은 24~36時間이 合理的이었다. 4. 生産工場에서 實用試驗의 結果 B. subtilis 보다 E. carotovora가 精練效果에 있어서 越等히 좋았고, 1次 處理完了液을 그대로 2次 處理에 利用할 수 있었으며 보다 精練效率이 좋았다. 5. 以上의 結果에서 E. carotovora를 利用한 大麻皮 精練의 새로운 方法을 提示하면 다음과 같다. 菌母液으로는 最少無機염類培地(pH 7.0~8.0)를 利用하고 精練條件으로는 處理溫度 30℃, 處理時間 24~35時間, 連續 2回 處理하며, 强制합氣는 不必要하나 廢液의 滅菌處理가 必要하다. Fermentation conditions for the hemp refining by an anaerobic bacterium, Erwinia carotovora subsp. carotovora, were investigated. Percentage of the hemp pectin decomposition(% HPD) by the bacteria grown in the minimal broth, was measured as a indicator of fermentation since the % HPD was higher in the minimal broth than in the nutrient broth or 0.5% pepton water. The Optimal pH and temperature for the % HPD were pH 7.0~8.0 and 30~35℃, respectively. Fermentor test a factory demonstrated that E. carotovora is more effective organism than B. subtilis, which has been used up to now, for hemp refining at least in the condition of using minimal broth.

소 질병의 혈액화학적 연구

김덕환,이교영,이경갑,최희인,오사메 사토시,이찌조 시게루 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

In prder to clarify the changes of serum chemical values(AST, CPK and LDH activities)and LDH isoenzyme fractions in frequent occuring some diseases of dairy cows, total 48 cows(40 patients: 18 with downer cow syndrome, 17 with abomasal displacement and 5 with acute mastitis and 8 controls: clinically healthy cows) were examined. The results obtained were as follows: 1. In changes of total serum enzyme activities of patients group, increase of serum AST(P<0.001), CPK(P<0.01) and LDH activities(P<0.01)were observed in groups of downer cow syndrome and abomasal displacement, respectively by comparison with control group. Increase of AST only was found in group of acute mastitis(P<0.05). 2. In LDH isoenzyme fractions, increase of LDH₁(P<0.01), LDH₂(P<0.05), LDH₃(P<0.01), LDH₄(P<0.01) and LDH_5(P<0.01)fractiona was observed in group of downer cow syndrome and also marker increase of LDH4 and LDH5 fractions was noted in this group. The increase of LDH₁, LDH₂ amd LDH₃ (P<0.01)fractions was found in group of abomasal displacement, but group of acute mastitis showed similar result to that of control group.

산 처리가 상아질 접착에 미치는 영향

김영경,김성교,박진훈 大韓齒科保存學會 1993 Restorative Dentistry & Endodontics Vol.18 No.1

Calcitonin Gene Related Peptide에 의한 치수미세순환 조절

김성교,,김영경,진명욱 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.6

본 연구에서는 감각성 neuropeptide인 CGRP의 치수혈류 조절에 관해 교감신경과의 유기적 관계를 연구함으로써 CGRP의 치수혈류 조절기전을 밝히고자 하였다. 열두 마리의 전신마취된 고양이에서 실험하였으며 CGRP를 혈관을 통해 전신적 또는 국소적으로 투여하였다. 견치에서 치수혈류의 변화를 측정하고 paired t-test로 통계분석 하였으며 95% 수준에서 유의성을 검증하였다. CGRP (0.3㎍/㎏)를 전신정맥으로 주사시, 전신혈압에 현저한 영향을 나타내면서 치수혈류는 평균 68.85%의 일차적인 증가와 감소를 보였고 이차적으로 다시 평균 161.8% 증가하였다가 감소하였다. CGRP를 저용량 (0.3㎍/㎏)으로 국소적으로 투여시, 치수혈류는 평균 2.92%의 미약한 증가를 나타내었다. 교감신경을 전기자극시 (10 Hz, 4 V, 1.5 ms), 전신혈압은 영향을 받지 않으면서 치수혈류가 유의하게 평균57.88% 감소하였다. 교감신경 자극으로 치수혈류가 저하되어 있는 동안 주입한 CGRP는 저하된 치수혈류를 유의하게 회복시켰다. CGRP의 이 치수혈류 증가 효과는 CGRP_(8-37)에 의해 효과적으로 차단되었다. The purpose of this study was to investigate the function of calcitonin gene-related peptide (CGRP) in regulatory mechanism of pulpal microcirculation with the aim of elucidating neurogenic inflammation. Experiments were performed on twelve cats under general anesthesia. CGRP was administered through the femoral vein to see the systemic influence and through the external carotid artery to see the local effect. Sympathetic nerve to the dental pulp was stimulated electrically and pulpal blood flow (PBF) was measured with a laser Doppler flowmeter on the canine teeth to the drug administration. The paired variables of control and experimental data were compared by paired t-test and differences with p < 0.05 were considered statistically significant. Systemic administration of CGRP (0.3 ㎍/㎏) exerted decreases in systemic blood pressure and caused changes in PBF with an initial increase followed by decrease and a more marked second increase and decrease. Close intra-arterial (i.a.) injection of CGRP (0.03 ㎍/㎏) resulted in slight PBF increase. The effect of CGRP resulted in no significant increase in PBF in the presence of CGRP. The electrical stimulation of the sympathetic nerve alone resulted in PBF decreases. The i.a. administration of CGRP following the electrical stimulation of the sympathetic nerve compensated the decreased PBF. Therefore, CGRP effectively blocked the sympathetic nerve stimulation-induced PBF decrease. Results of the present study have provided evidences that even though the local vasodilatory function of CGRP are weak. CGRP is effectively involved in blocking the vasoconstriction caused by sympathetic nerve stimulation in the feline dental pulp.

개에서의 膀胱結石 手術3例

김명철,장석진,이교영,김남중,변홍섭,박명호 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

Three dogs which show clinical signs of cystic calculi with anorexia, hematuria, stranguria, dribbling of urine, and pain in posterior abdomen, were referred, and diagnosed as cystic calculi by radiography and ultrasonography. Removal of urinary cystic calculi was performed by urinary cystotomy. Calculi, removed surgically, were analyzed chemically and microscolically. Calculi from three patient dogs were calcium carbonate in all. After the removal of calculi recurrence of urolith were not observed up to nowadays for about 4-10 months.