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김영준,류현모,김신윤,신홍인 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1
gp130,a subunit for serveral cytokine signal transducing receptors, mediates diverse activities including osteoclastogenesis. In vitro obaervations suggest that PTH also triggers the gp130-mediated signal for bone resorption by stimulating secretion of IL-6,IL-11 and LIF from osteoblast/stromal cells. Though this gp130 signaling is required for full activation of bone resporption by PTH in vitro, the relationship between PTH and gp130 signaling pathway in vitro is not yet clanified. To address the importance of gp130 as a mediator of PTH action in osteoclast activation, the blood ionized calium and blood serum PTH level was investigated in gp130-/- and wild type mice at E18.5 using a CIBA/Coming 634 Ca^+2/pH analyzer and rat intact PTH Kit, respectively.In addition, calium transport efficiency was assessed from gp130 mice at E17.5. The resorptive activity of osteoclasts from intact calvariae by a ^45Ca release assay and the osteoclastic developmental condition in tibiae were also analyzed, respectively.The gp130-/- micerevealed significantly lower ionized calcium level(1.44±0.03 vs1.77±0.03 mmol/ℓ, p<0.001)and significantly higher blood serum PTH(251.8±5.3 VS 20.5±5.3 pg/㎖,p<0.001) compared to wild type littermates.There was no remarkable pathologic change of placenta in gp130-/- and the ^45Ca transport though placenta was accelerated in gp130-/- compared to wild type littermates(%to Het 83%in -/- vs 148% in +/+).The gp130-/- embryos had small skeletons with bones containing little primary spongiosa, and large multinucleated TRAP+ cells along the lower border of the growth plate. Release of ^45Ca from prelableled calvarial bone(E18.5)in response to either 10^-7 M hpTH(1-34)or 20 ng/㎖ sRANKL was lower in gp130-/-calvarial bone compared to gp130+/+ calvarial bone (PTH 1.83±0.6 fold over basal in-/- vs 2.79±0.6 in +/+and sRANKL1.3±0.4 in -/- vs 2.79±0.6 in +/+ and sRANKL1.3±0.4 in -/- vs 2.0±0.4 in +/+,p<0.5). These result strongly support the hypothesis that PTH activates bone resortion,in part, by stimulating ostedtrophic cytokine secretiom from osteoblast/stromal cells, which tirggers gp130-mediated signaling for osteoclastic activation.
李鐵泰,柳榮鴻 단국대학교 1986 論文集 Vol.20 No.-
This study was carried out to investigate the separation of arsenic component from arsenic ore by roasting(lst process)under the inert gas atmosphere and water leaching(2nd process). The analyses of the roasting products and water leaching products were carried out by chemical analyses and X-ray diffraction analyses. The optimum conditions for the roasting of arsenic ore were that reaction temperatnre, reaction time, N_2 flow rate and panicle size of ore were 500℃, 1h, 10cm^3/min and -140 mesh, respectively. The optimum conditions for the water leaching of the roasting product were that leaching temperature: 99℃, amount of water per 1.0g of roasting product: 50ml, leaching time: 1h.
李鐵泰,玄聖鎬,徐中錫,柳榮鴻 단국대학교 1992 論文集 Vol.26 No.-
The reactions between vanadium pentoxide and ammonium chloride were investigated to find a new separation method of NH_3 and HCl from ammonium chloride. In this NH_4Cl-V_2O_5 reaction systems, both chlorination and reduction of V_2O_5 were proceeded by HCl(g) and NH_3(g) from decomposed NH_4Cl, respectively. The experimental results showed the possibility for the separation of NH_3 and HCl from NH_4Cl. 84.85% of HCl was recovered from the decomposed NH_4Cl at the conditions of reaction temperature : 400℃, NH_4Cl weight raatio ; 8.0, Ar gas flow rate 100㎤/min
Ryoo, Jae-Jeong,Kim, Se-Hoon,Jeong, Young-Han,Do, Hwan-Suk,Ryu, Jeong-Eun,Kwon, Hae-Young,Jeong, Ji-Yoon,Park, Hye-Jin,Lee, Soon-Ho,Hong, Moo-Ki,Hong, Jong-Ki Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.5
Simultaneous determination of amitraz, bromopropylate, coumaphos, cymiazole and 2,4-dimethylaniline in 200 honey samples purchased in Korea was performed by reversed-phase high-performance liquid chromatography with multiple UV detection. 2% Acetone in hexane was used for a liquid-liquid extraction and 20-40% water in acetonitrile solutions were used as mobile phases. The LOD for the analytes varied between 0.4 and 1.5 $\mu$g/L and the recoveries were yielded between 64 and 94%. Relative standard deviation of the repeatability of the method is less than 15%. Amitraz was not present in amount above 10 $\mu$ g/L and one for coumaphos and cymiazole and two for bromopropylate, and three for 2,4-dimethylanilne were detected in amount above 10 $\mu$ g/ L. Levels of the acaricide residues found were less than 50 $\mu$ g/L.
하시모트 갑상선염과 동반된 갑상선 MALT 림프종(MALToma) 1 예
김영선,이태영,한찬희,유명희,김철희,변동원,진소영,남일송,류은상,홍기영,윤석기,서교일 대한내과학회 2001 대한내과학회지 Vol.61 No.3
Primary thyroid lymphomas constitute of up to 5% of all thyroid malignancies. Recently, mucosa-associated lymphoid tissue (MALT) lymphoma are relatively recognized as a B cell subset of non-Hodgkin's lymphoma. MALT-lymphomas are thought to develop from acquired lymphocytic tissue during the course of a chronic inflammatory or autoimmune process. In the thyroid , which is normally devoid of lymphocytic tissue, chronic autoimmune thyroiditis (Hashimoto's disease) has been associated with an increased risk of lymphoma, including MALT type. The clinical presentations include the enlarging of the neck mass, dysphagia, hoarsenes and choking or cold thyroid nodule. We report a case of MALToma of the thyroid accompanied by Hashimoto's thyroiditis with a review of the literature.(Korean J Med 61:281-285, 2001)
Yang Hong Jun,Hong Yeon Pyo,Yoon Tai-Young,Ryoo Jae-Hong,Choi Joong-Myung,Oh Chang-Mo 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.4
Background/Aims: This study aimed to examine the independent and synergistic association of aerobic physical activity and resistance exercise with nonalcoholic fatty liver disease (NAFLD) using a nationwide representative database. Methods: This was a cross-sectional study using data from the Korea National Health and Nutritional Examination Survey between 2007 and 2010. Multiple logistic regression models were used to examine the independent and synergistic (additive interaction) associations of aerobic physical activity and resistance exercise with NAFLD after adjusting for multiple covariates. Results: The prevalence of NAFLD was 26.2% for men and 17.6% for women. In the fully adjusted multiple logistic regression model to examine the independent association of aerobic physical activity or resistance exercise with NAFLD, the odds ratios for NAFLD were significantly decreased in both men (p=0.03) and women (p<0.01) who had highly active aerobic physical activity. Regarding the frequency of resistance exercise, the odds ratio for NAFLD was decreased in men who did resistance exercise ≥5 days per week (p=0.04), but not in women (p=0.19). However, when investigating the synergistic associations of aerobic physical activity and resistance exercise, the odds ratios for NAFLD significantly decreased when the frequency of both exercises increased together in both men (p for interaction <0.01) and women (p for interaction<0.01). Conclusions: Combining aerobic physical activity and resistance exercise had a synergistic preventive association for NAFLD in Korean men and women.
Dynamics of microbiome composition from placenta to fetus and neonate
( Da Young Kang ),( Moon Yeon Hwang ),( Sun Woo Choi ),( So Young Kim ),( Ji Eun Jung ),( Jae Hong Ryoo ),( Woo Yeon Hwang ),( Young Joo Lee ),( Byung Su Kwon ),( Young Sun Kim ),( Min Hyung Jung ) 대한산부인과학회 2023 대한산부인과학회 학술대회 Vol.109 No.-
김선영 ( Seon Young Kim ),권중구 ( Joong Goo Kwon ),김명환 ( Myung Hwan Kim ),오재영 ( Jae Young Oh ),박진홍 ( Jin Hong Park ),박경찬 ( Kyung Chan Park ),류정일 ( Jung Il Ryoo ),류헌모 ( Hun Mo Ryoo ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.5
Protein-losing enteropathy (PLE) is a syndrome characterized by excessive gastrointestinal protein loss, resulting in hypoproteinemia and edema. A variety of benign and malignant conditions can be associated with PLE and acute leukemia is a very rare cause of PLE. We report a case of PLE associated with acute lymphoblastic leukemia. A 27-year-old man was admitted due to watery diarrhea, epigastric pain and bilateral leg edema. Laboratory findings showed hypoproteinemia and polycythemia. The diagnosis of PLE and acute lymphoblastic leukemia were confirmed on the measurement of fecal α1-antitrypsin clearance and bone marrow examination. After systemic chemotherapy and autologous stem cell transplantation, his clinical symptoms and abnormal laboratory findings were gradually improved. (Korean J Gastroenterol 2012;60:320-324)
The association between insulin resistance and depression in the Korean general population
Lee, Jae-Hon,Park, Sung Keun,Ryoo, Jae-Hong,Oh, Chang-Mo,Mansur, Rodrigo B.,Alfonsi, Jeffrey E.,Cha, Danielle S.,Lee, Yena,McIntyre, Roger S.,Jung, Ju Young Elsevier 2017 Journal of affective disorders Vol.208 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Previous studies showed that the insulin resistance (IR) could be related to depression. However, this association is still equivocal in the general population. Herein, we aimed to investigate the association between IR and depressive symptoms in a large sample in South Korea.</P> <P><B>Methods</B></P> <P>A cross-sectional study was carried out for 165,443 Korean men and women who received a health checkup including various clinical parameters and the Center for Epidemiologic Studies Depression scales (CES-D). Subjects were stratified into subgroups by CES-D score, sex, age, and presence of diabetes. The odd ratios (ORs) for homeostasis model assessment of insulin resistance (HOMA-IR) were compared between groups using multivariable logistic regression analyses.</P> <P><B>Results</B></P> <P>After adjusting covariates (e.g. smoking, family income, marriage state, unemployment status, average alcohol use, BMI, physical activity, systolic blood pressure, diabetes), increased IR was weakly associated with greater depressive symptoms (adjusted OR=1.01 [95% CI 1.0001–1.03]). Subgroup analysis revealed this association was statistically significant in females (adjusted OR=1.03, [95% CI 1.001–1.06]), non-diabetic group (adjusted OR=1.04, [95% CI 1.02–1.06]), and young participants under the age of thirty (adjusted OR=1.17, [95% CI 1.07–1.27]). But we couldn’t find significant association in diabetic and middle to elderly participants.</P> <P><B>Conclusions</B></P> <P>This study demonstrates that there is a relationship between IR and depressive symptoms in the Korean general population. Results from this epidemiological study revealed that young adults and non-diabetic individuals with increased IR may be related with depressive symptoms.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Increased insulin resistance was associated with depressive symptoms in the Korean general population (N=165,443). </LI> <LI> The subgroup analysis revealed the association was statistically significant in female, non-diabetic and young groups. </LI> <LI> Increased insulin resistance in non-diabetic participants was more strongly associated with depressive symptoms. </LI> <LI> These findings suggest that early management of insulin resistance may prevent progression toward depressive symptoms. </LI> </UL> </P>