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Acupuncture effect on Chemotherapy-induced Vomiting and Nausea: A case series
류현모,김대준 대한한의학회 2015 대한한의학회지 Vol.36 No.4
Objectives: We carried out an observational study of the effects of Nei Guan (P6) and Gong Sun (SP4) acupuncture for the treatment of CINV, preparing for further randomized controlled trial study. This is a case series to explore the changes in the incidence of CINV by acupuncture. Methods: Patients reported a Rhodex index indicating the severity of nausea and vomiting and loss of appetite, before acupuncture, after acupuncture and 1-week follow-up examination. Twelve patients with CINV participated in this study. We included patients receiving chemotherapeutic agents that might induce moderate or severe nausea and vomiting. We conducted 5 treatment sessions with P6 and SP4 acupuncture over the course of 5 days. Results: The median Rhodex score were decreased in 5 patients over time, while we observed loss of appetite of 6 patients were improved over time. During the study, the mean of Rhodex of total patients revealed a decrease of Day 1, Day 7, Day 14; 0.74, 0.68, 0.38, respectively, while the mean of loss of appetite showed a decrease of Day 1, Day 7, Day 14; 5.25, 4.08, 4.00, respectively. Conclusions: The study gives a preliminary data that manual acupuncture of P6 and SP4 may reduce the severity of CINV and loss of appetite, and justifies further study.
동종 골수이식 후 재발된 급성 림프구성 백혈병 환자에서 고식적 항암화학요법만으로 장기간 완전관해를 보이는 1례
류현모,이상엽,이경희,현명수 대한조혈모세포이식학회 2000 대한조혈모세포이식학회지 Vol.5 No.1
동종 골수이식 후 재발된 급성 백혈병의 치료에 대해서는 아직 확립된 표준요법은 없다. 골수이식 후 재발된 경우 일반적으로 시행하는 치료로서 고용량 화학요법 및 2차 골수이식을 들 수 있으며 최근 골수성 백혈병 특히 만성 골수성 백혈병에 효과가 있는 공여자 림프구 주입(Donor lymphocyte infusion, DLI)에 의한 이식편대 백혈병 효과(graft-versus-leukemia effect, GVL effect)를 얻고자 시도해 보지만 결과는 만족스럽지 못한 실정이다. 동종 골수이식 이후 이식편대 숙주질환이 발생한 경우 재발률이 낮다는 사실이 여러 연구에서 확인되어 이식편대 숙주질환이 항백혈병 효과가 있다는 사실이 증명되었다. 저자들은 동종골수이식 후 9개월 후 재발된 급성 림프구성 백혈병 환자에서 고식적 항암화학요법 1회 시행 후 동종골수이식 후에는 관찰할 수 없었던 간과 피부를 침범한 이식편대 숙주질환이 발생하였고 이 후 장기간 무병상태로 유지되는 1례를 경험하였기에 보고하는 바이다. 본 증례는 mixed chimerism 상태에서 고식적 항암화학요법으로 선택적으로 환자의 백혈세포나 림프구를 억압하거나 사망시켜 공여자의 T-cell이 우세하여 GVHD가 발생하면서 얻은 GVL 효과로 장기간의 관해 상태가 유지되는 것으로 사료된다. Graft-versus-host disease (GVHD) remains a major immunological complication after allogeneic bone marrow transplantation (allo-BMT), but also favors development of the beneficial graft-versus-leukemia (GVL) effect. A patient with ALL is described, who was given non-myeloablative remission reinduction therapy for leukemic relapse diagnosed on day 270 after HLA-compatible sibling BMT. On day 300, a clinical syndrome suggestive of acute GVHD had developed. Skin biopsy confirmed the clinical diagnosis of GVHD. The patient has since remained in complete remission with an excellent performance status for more than 3 years without an further chemotherapy. The case indicates that intensive non-myeloablative chemotherapy can cure AML relapsing after allo-BMT. The therapeutic effect in this case probably involved a direct pharmacological suppression of the leukemic clone followed by a GVL effect initiated by donor-derived alloreactive T lymphocytes.
류현모 서울市立大學校 經商大學 稅務學科 2005 稅務學論集 Vol.18 No.1
연금과세제도의 문제점과 그 개선방안에 관한 연구
可姙期 女性의 唾液中 Peroxidase, N-acetyl-β-D-glucosaminidase의 活性度 및 遊離 sialic acid 含量의 週期的 變動
柳顯模,卞鍾秀,曺準承 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.1
In order to determine the possible effects of hormonal changes on the salivary components, the activities of peroxidase and N-acetyl-β-D-glucosaminidase, and the content of free sialic acid were measured in saliva during menstrual cycles of 11 healthy women. Elevations of salivary peroxidase and N-acetyl-β-D-glucosaminidase activities were found around the time of ovulation in 8 cycling woment : the highest enzymatic activities which were measured 15.38, 14.63 days before menstruation were 118.76±10.01 Unit/min/g of protein, 21.95±1.04 nmol/min/mg of protein in peroxidase and N-acetyl-β-D-glucosaminidase, respectively. These value of highest activity significantly increased, compared to those of menstrual period, 38.24% and 21.48% in peroxidase and N-acetyl-β-D-glucosaminidase, resectively. Large cyclic variation without any clear tendency occured in the content of the free sialic acid. J. Kyungpook Univ. Sch. Dent. Vol. 7, No. 1,23∼32, 1990