브라켓 부착시 실런트 레진이 법랑질 탈회에 미치는 영향

윤영아,이기헌,황현식,홍석진 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.1

The purpose of this study was to evaluate the effects of a sealant resin on enamel demineralization in orthodontic bracket bonding. The forty eight extracted sound bovine teeth was subdivided into four groups and treated with Phase Ⅱ^(r) on the surface. Group 1 was not treated, Group 2 was acid etched with 37% phosphoric acid for 30 seconds, Group 3 was sealant applied after acid etching and Group 4 was resin paste applied after acid etching and sealant application. Each group was demineralized in artificial caries solution. Demineralized enamel depth was measured using by confocal laser scanning microscopy. The results were as follows. 1. The mean demineralized enamel depth was Group 1 (47.4㎛), Group 2 (61.8㎛), Group 3 (13.9㎛), Group 4 (8.2㎛). 2. The demineralized enamel depth was increased in Group 2 than Group 1 (p<0.05). 3. The demineralized enamel depth was reduced in Group 3 than Group1 and Group 2 with statistically significant differences (p<0.05). 4. Group 4 was very little demineralized. The results of the present study indicate that sealant application is useful for reducting enamel demineralization in orthodontic bracket bonding.

브라켓 부착 시 실런트 레진이 법랑질 탈회에 미치는 영향

윤영아,조진형,이기헌 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.1

본 연구는 교정용 브라켓 부착 시 사용되는 접착제 중 two paste type 의 실런트 레진 적용이 법랑질 탈회에 미치는 영향을 알아보고자 시행되었다. 건전한 표면을 가진 발치된 소의 상악절치 48개를 실험재료로 하여 법랑질 처리 방법에 따라 4개 군으로 분류하고 각 군을 Phase Ⅱ^(?) (Reliance, Itasca, Ⅲ) 를 이용하여 치면처리 하였다. 대조군으로서 아무런 처리를 하지 않은 Group 1, 37% 인산으로 39초간 산부식을 시행한 Group 2, 산부식 후 실런트 A와 B를 동량으로 혼합하여 도포한 Group 3과 산부식 후 실런트를 도포하고 레진 페이스트 A와 B를 동량으로 혼합하여 도포한 Group 4로 분류하여 각 군을 인공탈회용액에서 탈회시킨 다음 공초점 레이저 주사현미경을 이용하여 각각의 탈회된 깊이를 측정한 후 비교한 결과, 탈회된 법랑질의 평균 깊이는 47.4 ㎛ (Group 1), 61.8 ㎛ (Group 2), 13.9 ㎛ (Group 3), 8.2 ㎛ (Group 4) 로 나타났다. 산부식 후 인공탈회용액에 노출되는 군(Group 2)은 산부식 없이 노출되는 군 (Group 1) 에 비해 탈회된 깊이가 더 깊은 것으로 나타났으며 (p <0.55), 실런트 레진을 도포한 군 (Group 3) 은 산부식 없이 노출되는 군 (Group 1) 이나 산부식 후 노출되는 군 (Group 2) 에 비해 탈회된 법랑질 깊이가 유의성 있게 감소하였다 (p <0.55). 접착레진으로 부착된 군 (Group 4) 은 법랑질 탈회가 거의 나타나지 않았다. 이상의 연구결과는 교정지료 시 법랑질 탈회 가능성을 줄이기 위해서 브라켓 부착 시 실런트 레진의 도포가 유용함을 시사하였다. The purpose of this study was to evaluate the effects of a sealant resin on enamel demineralization in orthodontic bracket bonding. The forty eight extracted sound bovine teeth were subdivided into four groups and treated with Phase Ⅱ^(?) (Reliance, Itasca, Ⅲ) on the surface. Group 1 was not treated. Group 2 was acid etched with 37% phosphoric acid for 30 seconds. Group 3 was applied with sealant after acid etching. Group 4 was applied with resin paste after acid etching and sealant application. Each group was demineralized in artificial caries solution. Demineralized enamel depth was measured by confocal laser scanning microscopy. The results were as follows: the mean demineralized enamel depth was 47.4 ㎛ (Group 1), 61.8 ㎛ (Group 2), 13.9 ㎛ (Group 3), 8.2 ㎛ (Group 4) the demineralized enamel depth was increased in Group 2 than in Group 1 (p < 0.05) the demineralized enamel depth was reduced in Group 3 than in Group1 and Group 2 with statistically significant differences (p < 0.05) and demineralization in Group 4 was very little. The results of the present study indicate that sealant application is useful for reducing enamel demineralization in orthodontic bracket bonding.

Antioxidant effect of 23-hydroxytormentic acid on human dermal fibroblasts

( Young Ah Cho ),( Ji Su Lee ),( Sung Min Kim ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Hae Jeong Youn ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Reactive oxygen species (ROS) are generated by Ultraviolet A (UVA) in the dermal layer of the skin. ROS causes inflammatory change of dermal tissue, photoaging, and alterations of gene expression. For this reason, how to protect skin from UVA has been continuously investigated. Objectives: This study aimed to investigate the effect of 23-Hydroxytormentic acid to UVA-irradiated human dermal fibroblasts in vitro. Methods: The antioxidant effect of 23-hydroxytormentic acid (23-HTA) was evaluated by using 2,7-dichlorofluorescin diacetate and 3-(4,5-dimethylthiazol- 2-yl)-2,5,diphenyltertazolium bromide. By using quantitative real-time polymerase chain reaction, mRNA levels of antioxidant molecule were investigated. Results: 23-HTA was associated with antioxidant effect on human dermal fibroblast from UVA by regulating antioxidant-related gene expression and ROS scavenging. In addition, the SA-β-gal analysis and results of mRNA levels of type I procollagen and matrix mellaoproteinases demonstrated that 23-HTA attenuates UVA-induced oxidative stress by regulating the extracellular matrix proteins gene expression and these results were statistically significant. Conclusion: This study suggests that 23-HTA has protecting effect against UVA-induced oxidation stress on human dermal fibroblast. In order to clarify the antioxidant effect of 23-HTA, in vivo study is needed in the future.

Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

Han Ah Lee,Young Chang,Pil Soo Sung,Eileen L. Yoon,Hye Won Lee,Jeong-Ju Yoo,Young-Sun Lee,Jihyun An,Do Seon Song,Young Youn Cho,Seung Up Kim,Yoon Jun Kim 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.3

The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non–antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl- 4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non–antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.

The Induction and Floral Scent Analysis of Calluses Derived from Petals of Rosa hybrida Breeding Line 15R-12-2

Ka Youn Lee,Ju Young Shin,Myung Suk Ahn,Young Ah Lee,Se Jin Kim,Yae Jin Kim,Pil Man Park,Hye Ryun An,Su Young Lee 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.11

Cortical network dynamics during source memory retrieval: Current density imaging with individual MRI

Kim, Young Youn,Roh, Ah Young,Namgoong, Yoon,Jo, Hang Joon,Lee, Jong-Min,Kwon, Jun Soo Wiley Subscription Services, Inc., A Wiley Company 2009 HUMAN BRAIN MAPPING Vol.30 No.1

<P>We investigated the neural correlates of source memory retrieval using low-resolution electromagnetic tomography (LORETA) with 64 channels EEG and individual MRI as a realistic head model. Event-related potentials (ERPs) were recorded while 13 healthy subjects performed the source memory task for the voice of the speaker in spoken words. The source correct condition of old words elicited more positive-going potentials than the correct rejection condition of new words at 400–700 ms post-stimulus and the old/new effects also appeared in the right anterior region between 1,000 and 1,200 ms. We conducted source reconstruction at mean latencies of 311, 604, 793, and 1,100 ms and used statistical parametric mapping for the statistical analysis. The results of source analysis suggest that the activation of the right inferior parietal region may reflect retrieval of source information. The source elicited by the difference ERPs between the source correct and source incorrect conditions exhibited dynamic change of current density activation in the overall cortices with time during source memory retrieval. These results indicate that multiple neural systems may underlie the ability to recollect context. Hum Brain Mapp 2009. © 2007 Wiley-Liss, Inc.</P>

The Induction and Floral Scent Analysis of Calluses Derived from Petals of Rosa hybrida Breeding Line 15R-12-2

Ka Youn Lee,Ju Young Shin,Myung Suk Ahn,Young Ah Lee,Se Jin Kim,Yae Jin Kim,Pil Man Park,Hye Ryun An,Su Young Lee 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.11

24시간 뇌파 감시로 진단된 복성 간질 1례

윤영아(Young Ah Youn),조선영(Sun Young Cho),이경일(Kyung Yil Lee),이인구(In Goo Lee),이준성(Joon Sung Lee) 대한소아신경학회 2006 대한소아신경학회지 Vol.14 No.2

복성 간질은 경련의 한 형태로 반복되는 복통이 나타나는 드문 질환이다. 이 질환은 위장관의 병변이 없는 복통 발작, 이에 뒤따르는 경련 등의 신경학적 증상, 이상 뇌파 및 항경련제에 대한 반응이 특징적이다. 저자들은 반복되는 복통, 과호흡 및 의식 상태 변화를 보이면서 수차례 뇌파 검사에서 정상을 보였던 14세 남아에 대해 24시간 뇌파 감시를 통해 진단하고, 항경련제로 치료한 증례를 문헌고찰과 함께 보고한다. Abdominal epilepsy is an infrequent syndrome which occurrs with gastrointestinal complaints caused by a seizure activity. It is characterized by paroxysmal onset of abdominal pain without visceral disorders, but comes along with the alteration of awareness during the attack and abnormal electroencephalogram(EEG) findings. Like other epilepsies, this abdominal epilepsy is improved with anticonvulsant medication. We present a 14 year-old boy who had recurrent episodes of abdominal pain for 2 months, accompanied by hyperventilation and alteration of awareness. His interictal EEG findings were normal, but 24 hour EEG monitoring showed multifocal spikes and generalized epileptiform discharges when abdominal pain developed. After the medication with valproate, he became free of symptoms and signs.

Utility of RT-PCR-based Dot-blot Hybridization for Detecting and Genotyping Echoviruses

Kim, Ah-Youn,Choi, Woo-Young,Chung, Yoon-Seok,Kim, Ki-Soon,Jee, Young-Mee,Cho, Hae-Wol,Lee, Joo-Shil The Korean Society for Microbiology 2007 Journal of Bacteriology and Virology Vol.37 No.3

We attempted to detect and identify virus types quickly by improving an RT-PCR-based dot-blot hybridization test for echoviruses, important human pathogens mainly causing aseptic meningitis. This test was applied to reference viruses of seven echovirus serotypes prevalent in Korea (E6, 7, 9, 11, 13, 25, and 30) and seventy isolates of echovirus isolated in Korea between 2002 and 2004. The primers for target DNA and hybridization probes (25mer, 50mer, and 70mer) were designed within the VP1 region of the echovirus. In RT-PCR, a nonradioactive digoxigenin-DNA labeling mix was added instead of dNTP to initiate PCR. The PCR product was then hybridized against 25mer, 50mer, and 70mer probe DNA spotted on nylon membranes and the reaction was observed. To investigate the optimal conditions for hybridization, various concentrations of target DNA (0.1, 1, 10, and $100\;ng/{\mu}l$), size of probe DNA (25mer, 50mer, and 70mer), concentrations of probe DNA ($10{\sim}50\;pM$), and reaction time were included. In the test zone, the optimal condition in terms of time and cost was a reaction time of 1 h with $10\;ng/{\mu}l$target DNA concentration and 10 pM of a 50mer probe. We found 100% diagnosis of the serotypes for seven reference echoviruses and 90% (63/70) sensitivity for clinical isolates. Also, tests with this probe for reactivity with seven reference echoviruses by using DNA chips showed that diagnostic identification was possible without other serotype cross-reactivity. Therefore, efficiency analysis of probe and target DNA on clinical specimens by using dot-blot analysis indicated that this system can be applied to the prestages of the DNA chip and that the dot blot analysis itself can be used in applications to develop a tool for diagnosing specific viral serotypes.

수신증을 동반한 요관의 자궁내막증

김창영 ( Chang Young Kim ),송경아 ( Kyoung Ah Song ),안미정 ( Mi Joung Ahn ),송민경 ( Min Kyung Song ),김연정 ( Youn Jung Kim ),김병창 ( Byung Chang Kim ),최현일 ( Hyun Il Choi ),강영수 ( Young Soo Kang ),황영희 ( Young Hee Hwa 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9