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Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Jin Yong Kim,Jae-Hoon Ko,김예진,Yae-Jean Kim,Jeong-Min Kim,Yoon-Seok Chung,Heui Man Kim,Myung-Guk Han,So Yeon Kim,Bum Sik Chin 대한의학회 2020 Journal of Korean medical science Vol.35 No.7
As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.
The Changes in Respiratory and Enteric Adenovirus Epidemiology in Korea From 2017 to June 2022
Kim Kyung-Ran,Won Jisu,Kim Hyungjun,Kim Bryan Inho,Kim Mi Jin,Kim Jae Young,Gwack Jin,Kim Yae-Jean 대한의학회 2023 Journal of Korean medical science Vol.38 No.9
Since October 2021, severe acute hepatitis of unknown etiology in pediatric patients has been observed in many countries around the world. Adenovirus (mainly enteric adenovirus) was detected in more than 50% of the cases. Nationwide surveillance on acute hepatitis of unknown etiology in pediatric patients was started in May 2022 in Korea. Taking into account the severity of the illness and the urgency of the epidemiological situation worldwide, we report a summary of changes in adenovirus epidemiology during the past five years and six months in Korea.
한약재 천궁, 당귀의 상온보관에 따른 권연벌레 번식과 품질변화
Yong Il Kim,Sang Won Lee,Yae Jin Kim,Tae Jin An,Young Guk Kim,Jae Ki Chang,Jin Won Kim 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.05
Background : The practice of keeping the medicinal herbs at room temperature causes many problems, but due to lack of sufficient field research and study, it is difficult to improve related regulations and safety management. Methods and Results : The Cnidium Rhizome and Angelica gigas Root were inoculated with Lasioderma serricorne F. and incubated at 28℃ for 2.5 months and 5 months. After five months, the number of Lasioderma serricorne F. in Cnidium Rhizome increased from 30 to 1,429 (about 47 times). In the same period, the number of insects in Angelica gigas Root increased from 30 to 663 (about 22 times). Due to the rapid increase in pest population, hygiene deteriorated, changes in the active ingredient and appearance quality of the herbal medicines, which greatly damaged the value of the herbal medicine. Conclusions : These results show that current regulation requiring only sealing and not specifying the storage temperature do not guarantee quality safety. Therefore, it is necessary to establish appropriate preservation standards and improve management regulations in order to preserve safety.
Lee Kyung Jae,Ko Jae Sung,Park Kie Young,Kang Ki Soo,Lee Kunsong,Hong Jeana,Kim Soon Chul,Lee Yoon,Kang Ben,Kim Yu Bin,Kim Hyun Jin,Eun Byung Wook,Cho Hye-Kyung,Kim Yae-Jean,Kim Mi Jin,Lee Jin,Lee Tae 대한의학회 2023 Journal of Korean medical science Vol.38 No.47
Background: Several cases of pediatric acute hepatitis of unknown etiology related to adenoviral infections have been reported in Europe since January 2022. The aim of this study was to compare the incidence, severity, possible etiology, and prognosis of the disease with those in the past in Korea. Methods: The surveillance group collected data between May and November 2022 using a surveillance system. Acute hepatitis of unknown etiology was defined in patients aged < 16 years with a serum transaminase level > 500 IU/L, not due to hepatitis A-E or other underlying causes. For comparison, data from 18 university hospitals were retrospectively collected as a control group between January 2021 and April 2022. Results: We enrolled 270 patients (mean age, 5 years). The most common symptom was fever. However, the incidence was similar between 2021 and 2022. Liver function test results, number of patients with acute liver failure (ALF), liver transplantation (LT), death, and adenovirus detection rates did not differ between the two groups. None of the adenoviruspositive patients in either group experienced ALF, LT, or death. In the surveillance group, adenovirus-associated virus-2 was detected in four patients, one of whom underwent LT. Patients with an unknown etiology showed significantly higher bilirubin levels, a lower platelet count, and a higher LT rate than patients with a possible etiology. Conclusion: The incidence of pediatric acute hepatitis of unknown etiology and adenovirus detection rate have not increased in Korea.
Kim, Young Hwan,Yoon, Yae Jin,Lee, Yu-Jin,Kim, Cheol-Hee,Lee, Sangku,Choung, Dong Ho,Han, Dong Cho,Kwon, Byoung-Mog Elsevier 2018 Bioorganic & medicinal chemistry letters Vol.28 No.14
<P><B>Abstract</B></P> <P>Piperlongumine (PL), isolated from <I>Piper longum</I> L., is receiving intense interest due to its selectively ability to kill cancer cells but not normal cells. We synthesized a number of analogues by replacing the cyclic amide of PL with aliphatic amides to explore structural diversity. Compound <B>CG-06</B> had the strongest cytotoxic profile of this series, showing potent effects in human prostate cancer DU-145 cells, in which signal transducer and activator of transcription 3 (STAT3) is constitutively active. <B>CG-06</B> inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU-145 cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in DU-145 and LNCaP cell lines. <B>CG-06</B> decreased the expression levels of STAT3 target genes, such as cyclin A, Bcl-2, and survivin. Notably, we used drug affinity responsive target stability (DARTS) to show that <B>CG-06</B> binds directly to STAT3, and the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) rescued the <B>CG-06</B>-induced suppression p-STAT3. Our results suggest that <B>CG-06</B> is a novel inhibitor of STAT3 and may be a useful lead molecule for the development of a therapeutic STAT3 inhibitor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Piperlongumine (PL) derivative with aliphatic amide was synthesized. </LI> <LI> <B>CG-06</B> is showing potent effects in human prostate cancer DU-145 cells. </LI> <LI> <B>CG-06</B> inhibits STAT3 activity through binding directly to STAT3 and inducing ROS. </LI> <LI> <B>CG-06</B> strongly inhibits the cell growth of DU-145 cells compared to PL. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Myositis as an Initial Presentation of Ulcerative Colitis before Gastrointestinal Symptoms
Kim, Doo Ri,Kim, DongSub,Choi, SangJoon,Suh, Yeon-Lim,Yoo, So-Young,Kim, Mi Jin,Choe, Yon Ho,Kim, Yae-Jean The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.3
The musculoskeletal system can be involved as an extra-intestinal manifestation of inflammatory bowel disease. Among these, myositis in ulcerative colitis (UC) is very rare. A 14-year-old girl was admitted due to severe shoulder tenderness. She had complained of left jaw pain and swelling for the past 10 days. Inflammatory markers were elevated with no evidence of infectious etiology. Myositis was suspected by shoulder magnetic resonance imaging. Three days after admission, she developed hematochezia. Muscle biopsy and colonoscopy was performed due to worsening left mandibular area pain and persistent hematochezia. Colonoscopy showed consistent findings with UC. She was finally diagnosed with UC with myositis as an extra-intestinal manifestation. She showed a dramatic response to UC treatment. Gastrointestinal symptoms were well-controlled. After 14 months, UC symptoms and muscle pain were aggravated, which were relieved after steroid and cyclosporin treatment. We report a unique case of UC initially presented with myositis, preceding gastrointestinal symptoms.