정신분열병 환자를 위한 인지재활훈련 프로그램의 개발 : Korean-Cognitive Differentiation Program 한국형 인지분화훈련 프로그램

현명호,안석균,이만홍,조현상,최충식,이연희,송선미,유계준,김장우,김태용,이희상 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구배경 : 정신분열병 환자들은 인지장애를 보이는바, 저자들은 이들을 대상으로 한국형 인지분화훈련 프로그램을 개발하여 정신분열병 환자들을 대상으로 인지재활훈련을 실시한 후 환자들의 인지기능, 정신병리 및 문제해결기술에 미치는 효과를 조사하였다. 방 법 : 28명의 정신분열병 환자를 훈련군(n=14)과 대조군(n=14)으로 나누어 훈련군에게 한국형 인지분화훈련 프로그램을 1회 60분씩, 주당 2회씩, 11주간 총 22회를 실시하였다. 환자들의 인지기능은 K-WAIS의 산수, 빠진곳찾기, 어휘, 공통점찾기 소검사로 측정하였고 정신병리는 양성 및 음성증상 척도로 측정하였으며 문제해결기술은 사회문제해결척도로 평가하였다. 인지재활훈련의 효과를 평가하기 위해 훈련 전후의 인지기능, 정신병리 및 문제해결기술의 변화를 종속변수로 하고 훈련 유무를 독립변수로 하여 반복측정에 의한 변량분석으로 자료를 분석하였다. 결 과 : 한국형 인지분화훈련이 시간에 따른 인지기능검사 중 산수 소검사, 문제해결기술 중 시회문제해결척도의 전체 점수와 문제해결기술 소척도의 점수의 변화에 유의한 영향을 미쳤으나, 시각적 주의력, 개념화 능력 및 정신병리의 점수의 변화에 유의한 영향을 미치지 않았다. 결 론 : 한국형 인지분화훈련 프로그램은 정신분열병 환자에서 청각적 주의력 및 문제해결기술의 호전을 꾀할 가능성이 있음을 시사한다. Objectives : The purpose of this study was to investigate the effects of cognitive differentiation training program- Korean version(a training program of attention and conceptual abilities) on cognitive function, psychopathology and problem solving skills in patients with schizophrenia. Methods : A total of patients diagnosed as schizophrenia using DSM-Ⅳ were randomly assigned to 2 groups. The training group went through a total of 22 sessions of cognitive differentiation training(60 min/ session×2 sessions/wk×11 wks). The attention-placebo control group received psychoeducation program during the same period. Arithmetic, vocabulary, similarities, picture completion of Wechsler Adult Intelligence Scale-Korean version, Positive and Negative Syndrome Scale, and Social Problem Solving Scales were administered to all patients, both before and after the training program. Results : In the arithmetic scores(F=6.35, af=1, p=0.018) of Wechsler Adult Intelligence Scale-Korean version, and total scores(F=6.35, af=1, p=0.018) and problem solving skill scale scores(F=4.88, af=1, p=0.036) of social problem solving scale, interaction effects of training was significant. Conclusion : Our findings suggest that cognitive differentiation training program-Korean version is effective on improving auditory attention and problem solving skills in patients with schizophrenia.

신생혈관녹내장에서 광역학치료를 이용한 치험 1예

송유미,김준현,Yoo-Mi Song Joon-Hyun Kim 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To evaluate photodynamic therapy (PDT) with verteporfin for iris and angle neovascularization in eyes with neovascular glaucoma. Methods: We treat a patient who had neovascular glaucoma with iris and angle neovacularization and showed reduction of intraocular pressure (IOP) and the obliteration of neovascularization after PDT. PDT was performed following the treatment parameters used in age-related macular degeneration. The laser was directed at the anterior chamber angle and iris surface using a Goldmann three-mirror contact lens. Follow-up examination was performed 1, 2, 3, 5, 7, and 8 weeks after PDT, and included visual acuity, IOP, and iris fluorescein angiography (7 weeks after PDT). Results: Two months after PDT, we observed a reduction of IOP and the improvement of iris fluorescein leakage. IOP diminished considerably after 1 week, and showed subsequent tendency toward stabilization without additional antiglaucoma medicine. Conclusions: Photodynamic therapy can be used safely and effectively in the early phase of neovascular glaucoma to achieve the obliteration of iris and angle neovascularization and induce IOP reduction.

Fibular Lengthening for the Management of Translational Talus Instability in Hereditary Multiple Exostoses Patients

Lee, Dong Yeon,Kim, Joong Il,Song, Mi Hyun,Choi, Eun Seok,Park, Moon Seok,Yoo, Won Joon,Chung, Chin Youb,Choi, In Ho,Cho, Tae-Joon by Lippincott Williams Wilkins 2014 Journal of pediatric orthopedics Vol.34 No.7

Hereditary multiple exostoses (HME) patients frequently present with ankle valgus deformity and marked fibular shortening. Loss of the lateral buttress may cause translational talus instability (TTI) that manifests as ankle pain after physical exercise, medial clear space widening on plain radiographs, and gross translational movement of the talus within the mortise. Among 123 HME patients examined and/or surgically treated, 10 patients (14 ankles) with symptomatic TTI underwent fibular lengthening with osteochondroma excision. Twelve ankles of 9 patients were followed for >1 year after surgery. Total fibular length gain averaged 15.3 mm and distal migration of the distal fibular fragment averaged 5.5 mm. The mean medial clear space decreased from preoperative 6.7 mm to postlengthening 3.5 mm. Gross instability of the talus within the ankle mortise disappeared in all cases. AOFAS ankle-hindfoot score improved from preoperative 80.3 to 97.3 at the latest follow-up. The current study showed the fibular lengthening improved lateral ankle stability by providing lateral buttress on the talus and providing favorable short-term result by ameliorating exercise-induced ankle pain in TTI of HME. The authors carefully conclude that TTI is a rare but potentially disabling condition in HME patients, requiring special attention during follow-up of HME patients.Level of Evidence: Level IV.

전북 지역사회에서 천렵에 이용된 식물들의 전통지식에 관한 연구

천인옥(Inok Cheon),송미장(Mi-Jang Song),김현(Hyun Kim),이기훈(Ki Hoon Lee),유영준(Young Joon Yoo) 한국지역사회생활과학회 2015 한국지역사회생활과학회지 Vol.26 No.4

Development of a mixed-mode chromatography with tandem mass spectrometry method for the quantitative analysis of 23 underivatized amino acids in human serum

Choi, Min Sun,Rehman, Shaheed Ur,Kim, In Sook,Park, Hi-Joon,Song, Mi-Yeon,Yoo, Hye Hyun Elsevier 2017 Journal of pharmaceutical and biomedical analysis Vol.145 No.-

<P><B>Abstract</B></P> <P>In this study, a robust, selective and simplified method was developed and validated for the simultaneous quantitative analysis of 23 underivatized amino acids in human serum using mixed-mode chromatography with tandem mass spectrometry (LC–MS/MS). Serum samples were deproteinized with acetonitrile and subjected to LC–MS/MS analysis. The chromatographic separation of amino acids was achieved using a mixed-mode column (150×3mm, 3μm) with a gradient elution system; the mobile phase consisted of 50mM ammonium formate and 0.1% formic acid in acetonitrile. The total run time was 22min. Eluted compounds were detected in the electrospray ionization-positive mode with multiple reaction monitoring. The validation study evaluated linearity, repeatability, intra and inter-day accuracy and precision, and matrix effect. The validation results were satisfactory in all the tested parameters. This method was successfully applied to the analysis of amino acids in the clinical sample of human serum.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A simultaneous quantitative method for underivatized amino acids in human serum was developed. </LI> <LI> In this method, mixed-mode chromatography with tandem mass spectrometry was used. </LI> <LI> The analytical method validation was properly performed. </LI> <LI> This method was applied to the analysis of amino acids in the clinical samples of human serum. </LI> </UL> </P>

카드뮴에 의한 희돌기교세포의 손상에 대한 牛膝의 영향

이재규,이은미,오석규,손영우,유교상,김상수,이정헌,이강창,한두석,이승현,박승택,김요한,송호준 대한동의생리학회,대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.6

In order to clarify the cytotoxic effect of cadmium in cultured oligodendrocytes of neonatal mouse, the cytotoxicity was measured by MTX assay in cultured cells treated with 1∼20uM CdCl_2 for 24 hours. And also, the protective effect of Achyranthis Bidentazae Radix(ABR) was examined by cell viability in these cultures. Cell viability was significantly decreased in a dose-and time-dependent manner after exposure of cultured oligodendrocytes to 10uM CdCl_2 for 24 hours. Protective effect of ABR on CdCl_2-mediated toxicity was very effective in these cultures. From above the results, it suggests that CdCl_2 is toxic in cultured oligodendrocytes and selective herb extract such as ABR is effective in protection of the CdCl_2 -induced cytoxicity.

정신분열병 환자에 대한 통합심리치료의 효과

이만홍,이희상,조현상,현명호,안석균,유상우,박지환,한승진,현용호,구민성,손석한,김세주,이현주,박소라,송선미,안혜리,최정아,남궁기,유계준 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.6

목 적: 본 연구는 인지재활이 강화된 통합심리치료를 정 신분열병 환자에게 시행하여 그 결과를 평가하고 행상의 문제점을 분석하여 정신분열병 환자의 재활을 위한 한국형 통합심치료를 개발하기 위한 목적으로 실시되었다 . 방 법. 정신분열병으로 입원한 환자에게 인지분화,사회지각, 언어소통,사회기술, 문제해결기술의 5단계 구성된 통합심리치료를 12주간 주3회 실시하였고 치료 전후에 저자들이 개발한 인지분화평가척도, 사회기술평가척로,문제해결기술척도와Positive And Negative Syndrome Scale로 치료효과를 평가하였다. 집단내의 상호작용과 사회적 관심과 같은 비특이적인 간섭변인을 배제하기 위하여 정신건강교육에 의한 관심 -위약 대조군을 설정하여 비교하였다. 결 과: 통합심리치료를 시행한 군은 대조군에 비해 일반정신병리점수와 임상중상 총점수의 유의미한 호전이 있었고 인지기능의 호전은 인지분화 소프로그램후에서만 관찰되었으며 사회기술 소프로그램후의 사회기술기능은 제한적 효과만 있었다. 그러나 통합심리치료 시행군내에서는 12주후 양성증상. 음성증상. 일반 정신병리 모두에서 호전되었다. 결 론: 본 결과는 통할심리치료가 정신분열병 환자에게 임상 중상 영역의 치료효과가 있음을 지지하지만 인지 영역 훈련이 갖는 특정 효과는 보여주지 않았다 한편으로는 치료 프로그램의 사회문화적이고도 언어적인 배경의 차이. 치료기간, 집단구성원의 기능 동질화, 정서 처리, 인지영역 훈련에 대한 치료자의 숙련도 등의 시행상의 문제가 있어 우리나라 환자에의 적용을 위해서는 통합심리치료 원저의 수정이 요구된다. 0bjectives : This study, as a preliminary one attempting to develop the Korean version of Integrated Therapy for the rehabilitation of schizophrenic patients, was designed to investigate the results of Integrated Psychological Therapy(IPT) and review the problems during the program application. Methods : Cognitive Differentiation Scale, problem-Solving Scale, and PANSS(Positive And Negative Syndrome ScalE) were administered to schizophrenic inpatients before and after IPT incorporating cognitive diffirentiation, social perception, verbal communication, social skill and interpersonal Problem-solving skill subprograms. The therapy groups were offered activities three times per week during the 12-week program. The control groups were attention-placebo groups for control ling factors such as group interaction and social attention, and were offered psychoeducation. Results : The 12-week IPT groups, compared with the control groups, demonstrated sign-nificant improvements in the general psychopathology and the total symptoms of PANSS, but did not in cognitive functions and problem-solving skill. Significant improvements in cognitive functions were found only artier cognitive differentiation subprogram and social skill subprogram had limited effects on social skills. But within 12-week IPT groups significant improvements in the positive symptoms, negative symptoms and general psychopathology werc found. Conclusion : These findings support some effectiveness of IPT, but do not address the unique contribution by cognitive components. Applied to schizophrenic patients in this country, this modality had the problems such as differences in sociocultural and lingual background, duration of treatment, homogeneity in the level of the functioning among group members, management of emotions in activities, and the therapists'skill in the training of cognitive components. So the modification of this modality will be required.