간호정보의 처리, 분석, 관리 기술개발-인공신경망을 이용한 간호진단시스템 구현-

유지수,유황빈,박지원,고일선 대한의료정보학회 1998 Healthcare Informatics Research Vol.4 No.2

닭 점막 및 표피조직내의 Transferrin Receptor의 분포에 대한 면역조직화학적 연구

조사선,유영복,이경훈,김지윤,이병란,차중익,백상호 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.4

분자구조적으로 설계된 폴리옥사다이아졸의 합성 및 성질

유지강,이법원,김선일 조선대학교 생산기술연구소 2000 生産技術硏究 Vol.22 No.1

Polyhydrazide was prepared by solution polycondensation of an aromatic dihydrazide, bis (2-hydroxy ethyl terephthalic mono-hydrazido) fumarate (BHF) and an isophthaloyl chloride in N-methyl pyrrolidinone (NMP) in the presence of pyridine as an acid acceptor. The polymer was converted into oxadiazole-containing polymer, POD by chemical cyclodehydration with thionyl chloride. In this work, isophthaloyl chloride was introduced t o enhance solubility. The POD can be dissolved in aprotic polar solvents such as NMP and organic solvents such as chloroform/trifluoroacetic acid (TFA) mixed solvent The POD having molecularly designed structure of the fixed conjugation length shows photoluminescence(PL) at about 440 nm which corresponds t o blue color, and Δλ l/2 is about 80 nm which means it emits relatively pure light.

병원중심 가정간호중재 분석 : NIC 체계 적용

용진선,유인자,유지연 성인간호학회 2000 성인간호학회지 Vol.12 No.4

The purpose of the study was to investigate the characteristics of the clients registered in the department of home health care nursing in a hospital and to analyze nursing intervention activities recorded in charts by application of Nursing Intervention Classification (NIC) system For the descriptive survey study, data were collected by reviewing charts of 572 home health care clients between May. 1997 and July, 2000 at K hospital in Seoul. The average alee of the clients was 66 years and the number of clients in their 70s ranted first with 28.2 percent(158 people). The mean length of home care servile was 47 days with the highest frequency of less than four weeks(56 %). With regard to medical diagnosis, cancer showed the highest frequency (48%. 271 people) fellowed by cerebrovascular disease (19%). anti pulmonary disease (6.9%). According to analysis of nursing interventions by the NIC system, the most frequently used nursing interventions in level 1 were interventions in the Physiological: Complex domain which were used 3.663 times (33%) among 11.107 total interventions. The Safety domain was the second most frequently used intervention, followed by the Physiological Basic, and the Behavioral domains. In level 2. the Risk Management class was the most frequently used interventions with 3,108 interventions (27.9%). followed by Drug Management, and Tissue Perfusion Management classes. In level 3 interventions. Vital Sign Monitoring was the most frequently used intervention. 569 times (5.1%) followed by Health Screening, and Neurological Monitoring interventions. In sum, half of the clients in the study had cancer and were in their 70s. The most frequent reason for ending home care was death(40%). followed by readmission (28%). These findings represent clients with severe conditions referred to the home care nursing decal-foment as it was a University leaching hospital. Further research on analyzing nursing interventions performed in earth institution needs to be conducted to develop a standardized list of nursing interventions to use in home health care settings.

알부민이 첨가된 시험관내 약역학 감염모델을 이용한 폐렴알균 치료에서 Ceftriaxone 일일 1회 요법

허지안,전혜선,박선희,최수미,김시현,이동건,최정현,유진홍,신완식 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

배경 : Penicillin 내성 폐렴알균이 증가하는 지역에서 대안 중의 하나로 사용되는 ceftriaxone (CTR)의 적절한 용법, 용량을 파악하는 것이 중요하다. 본 연구는 임상에서 분리된 폐렴알균을 대상으로 시험관내 약역학 감염모델을 이용하여 알부민이 첨가된 경우와 첨가되지 않은 경우 CTR의 일일 1회 요법의 효과를 비교해 보고자 하였다. 재료 및 방법 : Penicillin 감수성(SM24), 중간내성(SM47), 내성(SM60)주를 대상으로 2-구획 시험관내 약역학 감염모델을 적용하였다. CTR 주입은 2 g씩 24시간마다로 사람의 약동학을 모의하였다. 알부민은 모델에서 4g/ dL가 유지되도록 하였다. 살균효과는 0, 2, 4, 6, 24, 30, 48시간째 집락수 변화로 측정하였다. 결과 : 모든 균주에서 알부민이 첨가되지 않은 경우 6시간 이내에 살균력이 관찰되었다. 최저억제농도 및 알부민 첨가유무에 관계없이 3주 모두 24시간째 살균력이 관찰되었고, 48시간째는 모두 측정한계 이하의 집락수로 감소하였다. 전 실험과정에서 CTR에 대한 내성주는 출현하지 않았다. 결론 : CTR의 일일 1회 요법은 알부민이 첨가되었을 때, 감수성, 중간내성, 내성주 모두에서 살균력 발현이 지연되었으나 최종효과는 알부민이 없을 때와 다르지 않았다. 앞으로 알부민 결합효과와 관련된 기초적인 추가 연구가 필요할 것으로 생각된다. Background : During the era of increasing penicillin resistant Streptococcus pneumoniae, it is important to have knowledge about adequate dosage and dosing interval of ceftriaxone (CTR). We examined efficacies of once-daily CTR and compared results in an in vitro pharmacodynamic infection model (IVPDIM) supplemented with albumin and those without albumin. Methods : Using three clinically isolated S. pneumoniae that were susceptible (SM24), intermediate (SM47) and resistant (SM60) against CTR, we utilized a two-compartment IVPDIM. CTR 2 g was administered intravenously every 24 h. Human albumin was added with concentration of 4 g/dL. Samples were removed at multiple time points over a 48-h period to determine the colony counts. Results : In SM24 and SM60, bactericidal effects were observed within 6 hours in groups without albumin. The number of colonies during 1st 6 hours were more decreased in albumin-free groups than in albumin-supplemented groups (P<0.05). In SM47, similar results were found during 1st 6 hours (P=0.03). But, regrowth was observed in albumin supplemented group at 30 h. Irrespective of results of minimal inhibitory concentrations and albumin supplementation, bactericidal effects were shown at 24 h in all 3 strains. All groups were decreased below the detection limit at 48 h. Development of resistance was not detected throughout the entire study period in either strain. Conclusions : Although extents of killing in albumin supplemented broth of once-daily CTR dosing were delayed in all 3 strains compared with those of albumin free broth, final efficacies were not different between the two groups.

졸-겔법에 의해 합성한 실리카 졸의 GC 및 GC/MASS 분석

김선일,김준섭,유지강 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The optimal condition for reaction of silica sol at room temperature(25±1℃) was identified when the mole ratio of TEOS : EtOH : H₂0 : HCl was 0.345 : 0.390 : 0.612 : 1.21 x 10^(-3). The equilibrium state reached when the hydrolysis for TEOS was proceeded for 40~50 minutes at the room temperature, and the volume percent of ethanol which was detected from GC column reached to 61.6%. In order to identify the path for the molecular growth of intermediate, hydroxyl group of intermediate was change into TMS by the. TMCS, so that monomer and tetrasilicate were 92% based on the amount of TEOS by the GC/MASS.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

감염조절 코스웨어 개발

강규숙,유지수,고일선 대한의료정보학회 1998 Healthcare Informatics Research Vol.4 No.2