항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

호밀 (Secale cereale L.)유식물의 질산환원효소의 활량과 단백질함량에 관한 Cycloheximide의 영향

권오용,이영하,오희목,박흥순,이진철 충남대학교 자연과학연구소 1988 忠南科學硏究誌 Vol.15 No.2

This work was accomplished with 6 day-old rye (Secale cereale L.) seedlings to determine the effect of the antibiotics by cycloheximide on in vivo nitrate reductase activity, protein and RNA content. The nitrate reductase activity by treating 0.1μM and 0.1 mM cycloheximide was lower than that of the control group. The optimum pH for the nitrate reductase of the control group was 7.6 in the range of pH 5.6-8.0, but, in the case of 0.1mM cycloheximide treatment group, the optimum pH was decreased to 6.8 within the weak the acid region. The protein content of shoot and root in the 0.1μM and 0.1 mM cycloheximide treatment groups were respectively found at the 96%, 82% level of that in the control group. In the higher cycloheximide treatment (0.1 mM CH), not only nitrate reductase activity and protein content but also RNA content was greatly decreased. In this fact, it was suggested that the 0.1 mM cycloheximide had affected on the RNA polymerase. On the basis of there results, it was concluded that the decreased nitrate reductase activity by treating cycloheximide occurred primarily according to the decreased nitrate uptake, and the decreased protein and RNA content depended upon the results of the direct and indirect effect of cycloheximide on the protein synthesis.

남부지역에서의 양파 수확, 저장 및 유통실태

권병선,이을태,오용비,정동희,이조진 順天大學校 師範大學 附屬 科學敎育硏究所 1996 科學과 敎育 Vol.4 No.-

This study was carried out to find marketing, storage and harvest of onion in southern parts of Korea from Jan. 1994 to Apr. 1994. Early maturing cultivar harvest between 10th and 20th of May but late maturing cultivar harvest between 10th and 20th of June, this period was busy farming season with a shortage of labor. Early maturing cultivar was send out good directly but late maturing cultivar was send out good after shortage the simple store house with the period 7-9 month, and professional seed production farmer are not in here. We hope that this report stimulates research to investigate for the establishment of not only harvesting practices such as varietal improvement, machanical harvesting and disease resistant variety for the storage.

수정된 DP 정합을 이용한 필기체 한자 인식

권희용,전상엽 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

온라인 필기체 한자는 동일인의 동일 문자조차도 획수, 획순 및 형태의 변화가 다양할 뿐만 아니라 인식 대상이 방대하여 인식이 매우 어렵다. 또한 한자는 기본 자소의 조합에 의한 글자가 아닌 각각의 글자가 독립적으로 이루어져 있어 연속된 획들 간의 관련도를 파악하기 어렵고 획수도 1획에서 28획까지 다양하게 분포를 한다. 따라서 본 연구에서는 대분류 단계로 시작 획 비교를 하고 이어진 세 분류 단계에서 문자의 특징으로 방향코드와 특이점을 추출해내고 획수 및 각 획의 특징을 고려하여 DP 정합을 하는 2단계 인식 시스템을 제안하였다. 이로써 최적의 속도로 입력한 문자를 찾아낼 수 있도록 하였다. In this paper, we propose two step handwriting chinese character recognition system. It is very difficult to recognize them because there are many variations on the number of strokes, orders and shapes even in a character written by a person, and there are too many characters about 100 thousand and strokes from 1 to 28, to classify. And also, Chinese characters are not composed of basic components like consonants and vowels, but independent simple units. So it is hard to analyze the relationship among the consecutive strokes. We propose a new two step recognition system; In the class classifying step, we compare the first stroke of an input character with that of models and classify the class, in the recognizing step, we extract the direction codes and characteristic points from strokes as a character's features, then matches them with those of model patterns using DP algorithm considering with the numbers of strokes and the features. In the experiments, we show that the proposed algorithm effectively classifies the input characters.

Film중감지와 Film의 활용에 따른 화질특성의 고찰

권용재,이상모,김순희,김도형,최태균 한국건강관리협회 2000 건협 Report Vol.3 No.-

신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구

權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.

Bacillus cereus에 있어서 Phospholipase C활량에 관한 몇가지 계면활성제의 영향

권오용,윤희주,한수자 충남대학교 자연과학연구소 1987 忠南科學硏究誌 Vol.14 No.2

This study demonstrates the effects of four detergents and three on the activity change of phospholipase C which is prepared from the cultural broth of Bacillus cereus. This assay of phospholipase C activity was carried out with phosphatidylcholine micelles which were mixed with the detergents and sterols, with increase a molar ratio of these compounds to phosphatidylcholine. Phospholipase C was highly activated at 0.5 molar ratio of Tween 80-mixed micelles. In the case of Triton X-100, it was activated at higher molar ratio indicated 1.0. Sodium dodecyl sulfate was more effective than that of the other detergents at lower molar ratio. However sodium deoxycholate-mixed micelles increased the activity more 7 times than that of the control group. This maximum activation was occurred at 2.5 molar ratio and the turbidity was gradually decreased. Cholesterol and ergosterol increased the activity until molar ratio reached up to 0.9. But the activity was higher at 0.3 molar ratio for stigmasterol. Consequently, it was indicated that phospholipase C was activated with the supplement of detergents until the mixed micelles made a number of small and spherical shape.

시민․전문가 경관 인식에 근거한 통합경관마스터플랜 수립 방안 연구

김용진, 권일, 김성희 한국교통대학교 2016 한국교통대학교 논문집 Vol.51 No.-

The need for a unified landscape starts from cities that are thus spatially and functionally linked together. It is necessary to plan and manage the city landscape more integrally because the administrative regions are different but functional and spatial closely in addition to the case of restructuring the cities into a unified form by being bound by a single living zone. This study is a basic research for establishing a comprehensive and systematic landscape plan of urban landscape over the whole city integrated in 2010, centered on integrated municipalities. For this purpose, this study conducted a survey of residents' awareness of the landscape, and based on the results, we propose implications for the establishment of a master plan integrated landscape. As a result of the analysis, the shipping factors such as roads, pedestrian roads, rivers and green spaces were found to be important factors for landscape formation for both residents and professionals. In the direction of establishing the integrated landscape master plan, it is necessary to establish the unity of the whole city and strengthen the inherent characteristics of each of the existing cities.

웨이브렛 변환을 이용한 내용 기반 영상 검색 시스템

권희용 안양대학교 자연과학연구소 1997 自然科學硏究 Vol.4 No.-

본 논문에서는 최근 영상 처리 분야에서 널리 사용되고있는 웨이브렛 변환을 사용하여 내용에 기반한 영상 검색을 하기 위한 4가지 정합 방법을 제시하고자 한다. 이들은 각각 윤곽선 추출과 웨이브렛 변환의 중간 단계를 이용한 정합, 변환 결과의 중간 부분을 이용한 정합, 반경 개념을 도입한 정합의 4가지 방법이다. 실험 결과 윤곽선을 추출한 후 중간 단계 변환 결과중 중간 부분 만을 정합에 사용하는 경우가 내용에 기반한 영상 검색에 효율적임을 보인다. In this paper, we propose four matching methods for a implementation of a content-based image retrieval system using wavelet transform. The four matching methods use edge drawing out, intermediate wavelet transform level matching, wavelet transformed middle part matching and matching with radius. The intermediate wavelet transform level matching with wavelet transformed middle part matching shows good searching results in the content-based image retrieval.