A Case of Adjuvant Treatment with Sorafenib after Radiotherapy for Brain Metastasis from Poorly Differentiated Thyroid Carcinoma

Yejee Lim,김연실,정찬권,임동준 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.2

Sorafenib is an emerging therapeutic option for radioactive iodine (RAI)-refractory differentiated thyroid carcinoma. However, the effects of sorafenib as an adjuvant treatment following surgery or radiation on brain metastases from poorly differentiated thyroid carcinoma (PDTC) have never been reported. A 52-year-old patient underwent total thyroidectomy for follicular thyroid carcinoma. Despite high-dose RAI therapy, a neck mass and lung metastases were developed. PDTC was diagnosed by neck mass removal. During adjuvant external beam radiation therapy (EBRT) to the neck, brain metastases developed. After palliative EBRT for brain metastases, the brain tumor size decreased but lung metastases markedly progressed. Off-label sorafenib was used to treat progressive multiple metastatic lesions. Over five months of sorafenib treatment, the sum of the longest diameters for target lesions was decreased by 45% in brain and 13% in lung. Sorafenib can be considered a new adjuvant therapeutic option for metastatic brain lesions from PDTC after EBRT.

Remediation of heavy metal-contaminated soils using eco-friendly nano-scale chelators

Lim, Heejun,Park, Sungyoon,Yang, Jun Won,Cho, Wooyoun,Lim, Yejee,Park, Young Goo,Kwon, Dohyeong,Kim, Han S. Techno-Press 2018 Membrane water treatment Vol.9 No.3

Soil washing is one of the most frequently used remediation technologies for heavy metal-contaminated soils. Inorganic and organic acids and chelating agents that can enhance the removal of heavy metals from contaminated soils have been employed as soil washing agents. However, the toxicity, low removal efficiency and high cost of these chemicals limit their use. Given that humic substance (HS) can effectively chelate heavy metals, the development of an eco-friendly, performance-efficient and cost-effective soil washing agent using a nano-scale chelator composed of HS was examined in this study. Copper (Cu) and lead (Pb) were selected as target heavy metals. In soil washing experiments, HS concentration, pH, soil:washing solution ratio and extraction time were evaluated with regard to washing efficiency and the chelation effect. The highest removal rates by soil washing (69% for Cu and 56% for Pb) were achieved at an HS concentration of 1,000 mg/L and soil:washing solution ratio of 1:25. Washing with HS was found to be effective when the pH value was higher than 8, which can be attributed to the increased chelation effect between HS and heavy metals at the high pH range. In contrast, the washing efficiency decreased markedly in the low pH range due to HS precipitation. The chelation capacities for Cu and Pb in the aqueous phase were determined to be 0.547mmol-Cu/g-HS and 0.192mmol-Pb/g-HS, respectively.

뉴트로 트렌드를 반영한 어글리 슈즈의 색채 경향과 선호도

임예지(YeJee Lim),이윤진(YounJin Lee) 한국색채학회 2020 한국색채학회 학술대회 Vol.2020 No.5

소비자들은 시시각각 변화하는 트렌드에 관심을 가지고 집중하고 있는데 그 중에서도 뉴트로(New-tro)는 2018년부터 시작되어 현재까지 단순히 트렌드를 넘어서 하나의 문화로 자리 잡고 있다. 뉴트로 트렌드는 패션에서 가장 많이 나타나는데 그 중에서도 글로벌 스포츠 브랜드로 확장되며 나온 어글리 슈즈가 대표적이다. 급변하는 패션시장에서 아웃도어 브랜드의 재킷, 스포츠 웨어 브랜드에 대한 소비자 인지도, 선호도, 의류에 관련된 선행연구 사례는 많으나 스포츠 웨어브랜드 운동화 색채 경향에 관한 연구는 부족한 실정이다. 본 연구는 NCS 표색계를 사용하여 연도별 뉴트로 트렌드 색채 경향과 스포츠 웨어 브랜드의 어글리 슈즈 색채 특징에 대하여 연구하고 이에 대해 비교하였다. 색채 분석 결과 뉴트로 트렌드는 전체적으로 명도가 높은 쪽에 많이 분포되어 있는 반면, 스포츠 웨어 브랜드의 어글리 슈즈는 주조와 보조색의 명도가 대체로 낮았다. 또한, 색채 범위가 뉴트로 트렌드가 더욱 다양하게 나타났다. 하지만 전체적으로 스포츠 웨어 브랜드가 뉴트로 트렌드의 색채, 색조의 특징을 잘 반영하였다는 결과를 볼 수 있었다. 이를 바탕으로 소비자들에게 제품의 형태와 컬러의 조화도, 제품의 선호도를 SD척도법을 사용하여 설문조사 한 결과 조화도와 선호도 각 설문조사에서 평균값이 높게 나온 제품은 동일한 제품이었다. 본 연구에서는 제품의 가치와 형태를 이해하고 색채 트렌드를 반영해야 소비자들의 선호도에 영향을 줄 수 있다는 점을 시사하고 다양한 업계 및 분야에 도움이 되기를 바란다.

Low-Carbohydrate Diet and Genetic Risk Score Interaction of Hypo-HDL-Cholesterolemia among Korean Adult

SoHyun Park,Min-Jae Jang,Seong-Ah Kim,Byeong-hwi Lim,Sangwook Kim,Lijuan Tan,Jiaqi Zhang,Do-Young Kim,Chiwoong Lim,Seok-Won Lim,Yejee Park,Young-Jun Seo,Yoon-Been Park,Jun-Mo Kim,Sangah Shin 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

LTE 시스템 기반 SON 환경에서 Time-to-Trigger 파라미터가 Handover 성능에 미치는 영향

이예지(Yejee Lee),신봉진(Bongjhin Shin),홍대형(Daehyoung Hong),임재찬(Jaechan Lim) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.2

Roles of Follicle-Stimulating Hormone on Bone Metabolism in Late Postmenopausal Women

Chaiho Jeong,Jinyoung Kim,Yejee Lim,Jeonghoon Ha,Mee-Kyoung Kim,Hyuk-Sang Kwon,Ki-Ho Song,Moo-Il Kang,Ki-Hyun Baek 대한골대사학회 2022 대한골대사학회지 Vol.29 No.3

Background: The effects of elevated follicle-stimulating hormone (FSH) levels on physi- ological changes in the bone remain unclear. This study aimed to clarify the association between FSH concentrations and bone mineral density (BMD) and bone turnover mark- ers (BTM) in late postmenopausal women. Methods: A total of 169 Korean women were enrolled. The participants’ ages ranged from 60 to 84 years (mean age, 69.0±5.1) and reported a mean duration of 19.4±6.6 years since menopause (YSM). The participants showed an average body mass index (BMI) of 24.4±2.8 kg/m2. Age, YSM, estradiol, tes- tosterone, and BMI were confounders in the Pearson's partial correlation. A test for trends across the quartiles of FSH levels was performed for each variable. Results: The mean FSH and estradiol concentrations were 61.5 IU/L and 2.9 pg/mL, respectively. Serum FSH concentration was not significantly associated with BMD (lumbar, r = 0.09, P = 0.30; total hip, r = 0.00, P = 0.96; and femoral neck, r = 0.05, P = 0.62). BTM across the FSH quartiles did not show any trend association (bone-specific alkaline phosphate, P = 0.31; cross- linked C-terminal telopeptide of type I collagen, P = 0.90). Instead, FSH levels were nega- tively correlated with BMI (r = -0.34, P = 0.00). In the multivariate regression model ad- justed for age, testosterone, and estradiol, only BMI showed a negative value across the FSH quartiles (β coefficient -0.11, P = 0.00). Conclusions: This study identified that high FSH concentrations were not associated with bone loss or high bone turnover in women in the late postmenopausal period.

Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology

( Jeong-min Lee ),( Jeonghoon Ha ),( Kwanhoon Jo ),( Yejee Lim ),( Min-hee Kim ),( Chan-kwan Jung ),( So-lyung Jung ),( Moo-il Kang ),( Bong-yun Cha ),( Dong-jun Lim ) 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.6

Background/Aims: Lymphocytic thyroiditis as cytology diagnosis from fine needle aspiration (FNA) is frequently detected in patients with thyroid nodules. However, the clinical outcome for upcoming hypothyroid events has been rarely clarified in euthyroid patients. Methods: We retrospectively reviewed the data of patient who had lymphocytic thyroitidis on FNA cytology of thyroid nodule from January 2005 to December 2010 at a tertiary referral hospital. In total, 109 patients with follow-up thyroid function tests (TFT) were enrolled. Final outcomes included overt and subclinical hypothyroidism with thyroid stimulating hormone (TSH) levels ≥ 10 mIU/L. Potential parameters predicting clinical hypothyroidism were analyzed by multivariate analysis. Results: Over the mean follow-up duration of 51.6 months, 14 out of 109 patients (12.8%) developed clinical hypothyroidism that required thyroid hormone replacement. The median onset time to hypothyroidism was 16 months (range, 3 to 88) and ≥ 60% of patients experienced clinical hypothyroidism within 1 year. By multivariate analysis, background thyroiditis (relative risk [RR], 9.78; p = 0.004), thyroid peroxidase antibody positivity (RR, 9.90; p = 0.003), nodule size (RR, 1.24; p < 0.001), and initial TSH (RR, 1.47; p = 0.009) were the independent risk factors for predicting hypothyroidism in euthyroid patients. Conclusions: Hypothyroidism frequently occurs during the follow-up in euthyroid patients with thyroid nodules which show lymphocytic thyroiditis on FNA cytology. Close surveillance and regular TFT are needed in high-risk patients for upcoming clinical hypothyroidism.

Lowered cutoff of lymph node fine-needle aspiration thyroglobulin in thyroid cancer patients with serum anti-thyroglobulin antibody

Jo, Kwanhoon,Kim, Min-Hee,Lim, Yejee,Jung, So-Lyung,Bae, Ja-Seong,Jung, Chan-Kwon,Kang, Moo-Il,Cha, Bong-Yun,Lim, Dong-Jun BioScientifica Ltd. 2015 European journal of endocrinology Vol.173 No.4

<P><B>Objective</B></P><P>Fine needle aspiration cytology (FNAC) and measurement of thyroglobulin (Tg) in needle washout (FNA-Tg) are recommended for the diagnosis of metastatic or recurrent lymph nodes (LNs) in differentiated thyroid cancer (DTC). However, the effect of serum Tg antibody (TgAb) on FNA-Tg levels still remains unclear in the preoperative setting. We analyze the interference of serum TgAb on FNA-Tg levels as proof of concept in the diagnostic advantage of serum TgAb combined with FNA-Tg.</P><P><B>Subjects and methods</B></P><P>A total of 370 suspicious cervical LNs from 273 patients with DTC were included. The primary tumor was confirmed as DTC on preoperative pathology in all patients. We performed FNA-Tg measurement and FNAC on suspicious LNs and evaluated the diagnostic performance of FNAC and FNA-Tg according to TgAb status. Final diagnoses were confirmed by histological examination of excised specimens or by follow-up ultrasonography for at least 6 months.</P><P><B>Results</B></P><P>Data from 273 subjects with suspicious 370 LNs were evaluated. Fifty-five LNs (14.9%) were from TgAb+ positive serum TgAb (TgAb+) patients. Serum Tg and FNA-Tg levels were significantly lower in patients with TgAb+ than in those with TgAb-negative (TgAb−). Final pathology confirmed 109 LNs (29.5%) asmalignant. Diagnostic performance of FNA-Tg at the same cutoff level was lower in the TgAb+ than TgAb− group. FNA-Tg cutoff levels determined by ROC curve were lower in the TgAb+ group.</P><P><B>Conclusion</B></P><P>The results suggested that the cutoff value of FNA-Tg should be lowered in suspicious LN before thyroidectomy in thyroid cancer patients with TgAb.</P>

The efficacy of denosumab in Korean male patients with osteoporosis

Chaiho Jeong,Jeonghoon Ha,Jinyoung Kim,Yejee Lim,Mee Kyoung Kim,Hyuk-Sang Kwon,Ki-Ho Song,Moo-Il Kang,Ki-Hyun Baek 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Despite the prominence of denosumab as the number one prescribed anti-osteoporosis drug in Korea, the effects of denosumab in male osteoporosis patients were not researched sufficiently. Moreover, concerns on rebound vertebral fractures associated with poor denosumab adherence exist. Methods: We retrospectively evaluated 147 Korean male osteoporosis patients treated with denosumab. After 12 months of treatment, 60 patients were lost during follow-up, and eight were excluded due to missing data. Out of the initial 147 patients, 79 were considered eligible for the analysis of the efficacy of denosumab. 54 patients were initially drug-naïve, and 25 had previously received bisphosphonate therapy. Results: In 54 drug-naïve patients, significant increases in bone mineral density (BMD) were observed in all measurement sites: 5.2% ± 3.7% in the lumbar spine, 2.3% ± 2.8% in the femoral neck, and 1.9% ± 2.8% in the total hip (p < 0.01, respectively). Trabecular bone score showed an increase of 0.5% ± 5.8% in drug-naïve patients. Likewise, in 25 patients with previous bisphosphonate treatment, increase in BMD were observed as well: 4.8% ± 3.5% in the lumbar spine, 1.4% ± 3.6% in the femoral neck, and 0.8% ± 2.1% in the total hip (p < 0.01, p = 0.06, p = 0.06, respectively). Significant declines of –55.1% ± 31.8% in C-terminal telopeptide of type 1 collagen (CTX), and –62.9% ± 21.3% in total procollagen 1 N-terminal propeptide (P1NP), in drug-naïve patients; and –37.7% ± 41.5%, in CTX and –55.4% ± 30.1%, in P1NP in patients with previous bisphosphonate treatment were exhibited after 12 months of treatment. The adherence rates of the second and third dosing schedules were 79.9% and 56.8%, respectively. Conclusions: Our study indicates that denosumab is effective in increasing BMD in Korean osteoporosis males regardless of prior bisphosphonate treatment.

아동용 또래 거부민감성 단축형 척도의 타당화

최정원(Jungwon Choi),임정하(JungHa Lim),정예지(Yejee Jeong) 한국인간발달학회 2024 人間發達硏究 Vol.31 No.1

본 연구의 목적은 아동용 또래 거부민감성 척도(최정원, 2023)의 단축형을 구성하고, 단축형 척도의 심리측정학적 특성을 확인하는 것이다. 이를 위하여 초등학교 5, 6학년 아동 463명을 대상으로 또래 거부민감성과 친구와의 불안정애착, 또래관계문제에 대한 자기보고식 설문자료를 수집하였다. 주요 연구결과는 다음과 같다. 첫째, 탐색적 요인분석 결과 단축형 척도는 총 17문항으로 거부예상, 우울⋅분노, 해석편향, 불안⋅위축의 네 가지 하위요인으로 구성되었다. 둘째, 원척도와 단축형 척도의 상관분석 결과 두 점수의 동질성이 매우 높았다. 셋째, 단축형 척도의 신뢰도는 높게 나타났다. 넷째, 단축형 척도는 CRSQ와 높은 관련성을 보여 준거관련 타당도가 적절하였다. 친구와의 불안정애착 및 또래관계문제 상위 30%집단이 하위 30%집단보다 또래 거부민감성 점수가 높은 것으로 나타나 단축형 척도의 집단비교 타당도를 확인하였다. 또래 거부민감성 단축형 척도는 아동 연구 및 상담현장에서 편리하게 활용될 수 있을 것으로 기대된다. This study aims to develop a short form of the Peer Rejection Sensitivity Questionnaire (PRSQ; Choi, 2023) and assess its psychometric properties. A sample of 463 children in the 5th and 6th grades from elementary schools participated in the study. Self-report data were collected using questionnaires on peer rejection sensitivity, in-secure friendship attachment, and peer relationship problems. Exploratory factor analyses yielded a short form of the PRSQ consisting of 17 items with four factors including re-jection expectation, anger/depression, interpretation bias, and anxiety/withdrawal. Correlation analyses demonstrated strong associations between scores of the original and the short forms. The short form of the PRSQ exhibited high internal consistency and split-half reliability. Furthermore, it displayed appropriate criterion-related validity, with substantial associations with the CRSQ. Children in the top 30 percent of insecure friend-ship attachment and peer relationship problems scored significantly and practically higher on peer rejection sensitivity than those in the bottom 30%, supporting the known-group validity of the short form. The short form of the PRSQ serves as a valuable instrument for measuring peer rejection sensitivity of school-age children within research and counsel-ing settings.