Laproscopic Liver Resection for Hepatocellular Carcinoma: 5-Year Experience at a Single Center

( Yanjie Xu ),( Dong Hee Ryu ),( Jae-woon Choi ),( Hanlim Choi ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Laparoscopic liver resection for hepatocellular carcinoma(HCC) has become an increasingly popular operation, even in the presence of liver cirrhosis. Here we evaluate the outcomes of laparoscopic liver resection for HCC at a single center. Methods: From November 2011 to August 2016, 24 patients with HCC underwent various laparoscopic liver resection at a single institution. The operation was performed by one team of surgeons. The clinical data of these patients were retrospectively reviewed and analyzed by reviewing the medical records, radiologic images and pathologic reports. Results: The mean age of the patients was 58 years(range 41-80 years) and 22 patients were men. The types of resection were resection of one segment (7 cases), resection of two segments (9 cases), resection of three segments (2 cases) and four segments (6 cases). The mean tumor size was 3.4 cm (range 0.8-10 cm). The mean resection margin was 17.9 mm (range 1-50 mm). The median follow-up duration was 29 months (range 4-45 months). The 3-year overall survival rates were 83.3%. Conclusions: Laparoscopic liver resection for HCC is feasible, safe with good oncologic outcomes. Major liver resection is possible with improved surgeon’s skill and experience.

Multiple-shot People Re-identify based on Feature Selection with Sparsity

Dongping Zhang,Yanjie Li,Jiao Xu,Ye Shen 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

In a video surveillance network, it is always required to track and recognize people when they move through the environment. This paper presents a novel re-identification method for multiple-people using feature selection with sparsity. By using the multiple-shot approach, each of appearance models is created in this method. The human body is divided into five parts form which the features of color, height, gradient were extracted respectively. Our appearance model is represented by linear regression method. Experimental results show that our appearance model is robust and attain a high precision rate and processing performance.

Effects of Li2CO3 on the sintering behavior and piezoelectric properties of Bi2O3-excess (Bi0.5Na0.5)0.94Ba0.06TiO3 ceramics

Yanjie Zhang,Ruiqing Chu,Zhi-Jun Xu,Qian Chen,Yong Liu,Guangchao Zhang 한국물리학회 2012 Current Applied Physics Vol.12 No.1

(Bi0.5Na0.5)0.94Ba0.06TiO3 ceramics doped with Li2CO3 and Bi2O3 as sintering aids were manufactured, and their micro structural, dielectric and piezoelectric properties were investigated. All specimens could be well sintered at a low-temperature of 1080 ℃. The bulk density of the specimens doped with a small amount of Li2CO3 was enhanced. The dielectric and piezoelectric properties of ceramics were investigated with different amounts of Li2CO3 substitutions. High electrical properties of d33 ¼ 167 pC/N,kp ¼ 0.34, Pr ¼ 40 mC/cm2 and Ec ¼ 38 kV/cm were obtained from the specimen containing 0.1 mol% of Li2CO3 sintered at 1080 ℃.

Effects of Fish Oil Combined with Selenium and Zinc on Learning and Memory Impairment in Aging Mice and Amyloid Precursor Protein Processing

Yanji Xu 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Alzheimer’s disease is characterized by the aggregation of amyloid-beta (Aβ) peptide into plaques and neurofibrillary tangles. Aβ peptide is generated by the cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretase. The present study was conducted to investigate the effects of fish oil [or eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], selenium, and zinc on learning and memory impairment in an aging mouse model and on APP. We performed the Morris water maze and platform recorder tests on male Kunming mice (10/group) grouped as control and D-galactose-induced aging model mice treated with vehicle, fish oil, fish oil+selenium, fish oil+selenium+zinc, and positive control (red ginseng extract). Fish oil+zinc+selenium for 7 weeks significantly improved learning and memory impairments in aging model animals in the Morris water maze and platform recorder tests, as evidenced by shortened incubation periods and number of errors. In vitro analysis of Aβ1–40 content in APP695-transfected CHO cells revealed a decrease after treatment with EPA, DHA, and their combinations with selenium or selenium and zinc. Assaying β- and γ-secretase activities revealed a decrease in PC12 cells and mouse serum as well as a decrease in β-site APP-cleaving enzyme 1 and presenilin 1 protein levels in the PC12 cells and mouse serum. Taken together, our results show that fish oil combined with selenium and zinc inhibited APP processing and alleviated learning and memory impairment in a mouse model of aging.

Polysomnography and Neuropsychological Analysis of Patients With Post-Traumatic Stress Disorder Two Years After the COVID-19 Pandemic in Wuhan

Junhua Mei,Yanjie Xu,Xue Gong,Jinmei Xu,Guohua Chen,Weiqi Chen,Yicong Wang,Zhaohong Kong,Yilong Wang,Qing Yang 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.3

Objective We used polysomnography (PSG) monitoring and neuropsychological scales to explore the characteristics of coronavirus disease-2019 (COVID-19) patients diagnosed with post-traumatic stress disorder (PTSD) in Wuhan, two years after the onset of the COVID-19 pandemic.Methods A total of 42 patients in the Sleep Medicine Center were diagnosed with insomnia between December 2021 and May 2022; they were divided into the PTSD group (patients with PTSD diagnosed with insomnia after COVID-19 infection) and the non-PTSD group (patients with insomnia without PTSD). A healthy control group was simultaneously included.Results The PTSD group was more significant than the non-PTSD group in partial manifestations of sleep disorders, neuropsychological clinical symptoms, and partial PSG data. Patients with different COVID-19 subtypes showed significant differences in the course of disease, sleep disorders, neuropsychological clinical symptoms, relevant scale scores, and PSG data analysis.Conclusion The emotional anxiety and depression of COVID-19 patients diagnosed with PTSD two years after the COVID-19 pandemic in Wuhan are more significant, and will not be self-alleviated with the passage of time. It is necessary to continue to pay attention to the PTSD symptoms and sleep psychology of COVID-19 infected patients, and take appropriate measures. Patients with severe and critical COVID-19 have more severe sleep and mental disorders, and there is a significant correlation between the duration of the disease and the severity of mental and mental disorders and sleep disorders after recovery.

Involvement of amygdaloid neuropeptide Y in the anxiolytic effects of acupuncture during ethanol withdrawal in rats

Zhao, ZhengLin,Kim, Sang Chan,Wu, YiYan,Zhang, Jie,Xu, YanJi,Cho, Il Je,Yang, Chae Ha,Lee, Bong Hyo,Zhao, RongJie Elsevier 2014 Neuroscience Letters Vol.567 No.-

The role of neuropeptide Y (NPY) in the central nucleus of amygdala (CeA) in the preventive effects of acupuncture against ethanol withdrawal-induced anxiety was investigated. Rats were treated with 3 g/kg/day of ethanol for 28 days, followed by 3 days of withdrawal. Bilateral acupuncture treatment at HT7 (Shen-Men), PC6 (Nei-Guan) or a non-acupoint was respectively added to the rats during the withdrawal once a day for three days. Enzyme-linked immunosorbent assays and real-time polymerase chain reaction analyses showed there was a significant decrease in NPY protein and mRNA expression in the CeA during ethanol withdrawal, which was reversed by acupuncture at HT7 but neither at PC6 nor at a non-acupoint. Acupuncture at HT7 also greatly inhibited the decrease in cAMP response element-binding protein (CREB) phosphorylation in the CeA. In elevated plus maze tests, a selective NPY Y1 receptor antagonist BIBP 3226 into the CeA before the acupuncture abolished almost completely the anxiolytic effect of acupuncture at HT7. These results suggest that acupuncture at HT7 rescues the depletion of amygdaloid NPY and reverses the decrease in CREB phosphorylation to produce anxiolytic effects during ethanol withdrawal. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Laparoscopic Management for Stump Appendicitis: A Case Series

Hanlim Choi,Jae-Woon Choi,Dong Hee Ryu,Yanjie Xu 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11

Amygdaloid Corticotropin-releasing Factor is Involved in the Anxiolytic Effect of Acupuncture during Ethanol Withdrawal in Rats

Zheng Lin Zhao,XiuDong Jin,Yi Yan Wu,Xu Dong Yang,YanJi Xu,James ZhongJian Jiang,김상찬,이봉효,양재하,조용걸 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.5

In a previous study, acupuncture at acupoint HT7 attenuated ethanol withdrawal-induced anxiety-like behavior in rats by normalizing amygdaloid catecholamines. In the present study, the involvement of amygdaloid corticotropin-releasing factor (CRF) in the anxiolytic effect of acupuncture was investigated during ethanol withdrawal. Rats were intraperitoneally treated with 3 g /kg/day of ethanol for 28 days, and the CRF mRNA levels in the central nucleus of the amygdala (CEA) were measured by using a RT-PCR analysis 72 hours after the last dose of ethanol. During ethanol withdrawal, the rats were bilaterally treated with acupuncture at acupoints HT7, PC6 or at a non-acupoint (Tail) for one min/day for three days. Also, rats were bilaterally injected with CRF into the CEA five minutes after the third acupuncture treatment , after which followed by the elevated-plus maze (EPM) test and the plasma corticosterone radioimmunoassay (RIA) were administered. The RT-PCR analysis showed a significant increase in the amygdaloid CRF mRNA levels in the ethanol-withdrawn rats compared with both the saline-treated rats and the rats treated with acupuncture at HT7, but neither acupuncture at PC6 nor acupuncture at a non-acupoint significantly inhibited the increased mRNA expression. The EPM test and the RIA also showed that the post-acupuncture infusion of CRF greatly reduced the anxiolytic effect of acupuncture at HT7. These results suggest that during ethanol withdrawal, the anxiolytic effect of acupuncture may be mediated through the modulation of amydaloid CRF during ethanol withdrawal.

Effects of Nicotine on Aβ or CT_(105)-induced Toxicity

Seo, Ji-Heui,Chang, Keun-A,Kim, Hye-Sun,Park, Cheol Hyoung,Kim, Seong Han,Lee, Me Jeong,Jeong, Sung-Jin,Choi, Se Hoon,Rah, Jong-Cheol,Koo, Jawook,Kim, Eun-Mee,Xu, Yanji,--,Choi, Jun Ho,Shin, Jae Kyung 한국뇌학회 2001 한국뇌학회지 Vol.1 No.1

알츠하이머 치매의 병인기전에서 아밀로이드 베타 펩티드는 중요한 역할을 할 것이라는 연구결과가 많이 보고되어있다. 그러나 알츠하이머 치매의 진행과 아밀로이드 베타 펩티드의 생성에는 여러 가지 모순도 보고되었다. 그러므로 아밀로이드 전구단백질에서 생성된 아밀로이드 베타 펩티드 외에 여러 가지 대사물들이 알츠하이머 치매의 병인기전과 관련이 있으리라 여겨진다. 이미 본 연구팀은 니코틴이 신경보호효과가 있다고 알려진 분비형 아밀로이드 전구단백질의 발현을 시간, 농도 의존적으로 증가시킨다는 연구결과를 보고하였다. 이번 논문에서는 니코틴의 전처리로 아밀로이드 베타 펩티드 및 아밀로이드 C단 단백질에 의한 1차 신경세포에서의 세포독성 효과가 억제되며, 이러한 효과는 니코틴의 길항제인 알파붕가로톡신에 의해 상쇄된다는 연구결과를 얻었다. 뿐만 아니라 C단 단백질을 PC12세포에 유전자를 이입시켰을 때, 니코틴에 의하며 세포 독성이 억제되는 결과를 얻었다. 이러한 연구결과로 볼 때, 니코틴이나 니코틴 수용체는 콜린성 신경전달 물질 보상 뿐만 아니라 아밀로이드 베타 펩티드, 아밀로이드 C단 단백질의 독성을 저해함으로써 인지기능 향상에 영향을 줄 것으로 예상된다. Several lines of evidence indicate that Aβ may play an important role in the pathogenesis of AD. However, there are several discrepancies between the production of Aβ and the development of the disease. Thus, Aβ may not be the sole active fragment of β-amyloid precursor protein (βAPP) in the neurotoxicity associated with AD. Previously, findings from our experiments have shown that nicotine enhances the release of APPs, which has neurotrophic and neuroprotective activities in concentration and time-dependent manners. In this study, our results showed that Pretreatment of nicotine (>10μM, for 24hr) partially prevented Aβ or CT_(105)-induced cytotoxicity in primary cultured neuronal cells, and the effects of nicotine-induced protection was inhibited by the pretreatment with a nicotine receptor antagonist α-bungarotoxin. Nicotine (>10μM, for 24hr) partially inhibited CT_(105)-induced cytotoxicity when PC12 cells was transfected with CT_(105). From these results, we proposed that treatment of nicotine or nicotinic receptor agonist might improve the cognitive functions not only by supplementation of cholinergic neurotransmission but also by protecting Aβ-or CT_(105)-induced neurotoxicity probably through the increased release of APPs and the activation of nicotinic receptor.