Systemic Family Therapy of Comorbidity of Anxiety and Depression with Epilepsy in Adolescents

Jing Li1,Xuefeng Wang,Huaqing Meng,Kebin Zeng,Fengying Quan,Fang Liu 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.3

ObjectiveaaThe aim of this study was to find if systemic family therapy (SFT) does work in anxiety and depression with epilepsy in adolescents (ADAE). Methodsaa104 adolescents with epilepsy, aged 13–20 years old, were included from December 2009 to December 2010, the enrolled patients were with anxiety [Hamilton Anxiety Scale (HAMA) score ≥14 points] or depression [Hamilton Depression Scale (HAMD) score ≥20 points]. The patients were randomly divided into the control group (n=52) treated with antiepileptic drugs (AED) and the intervention group (n=52) undergone Systemic Family Therapy (SFT) as well as AED. The AED improvements, anxiety and depression scores, Social Support Rating Scale (SSRS), Family Assessment Device (FAD) and scale of systemic family dynamics (SSFD) were observed after 3-month treatment. ResultsaaThe frequencies of epileptic seizures in intervention group was decreased much more significantly than the control group (4.22±3.54 times/month vs. 6.20±5.86 times/month, p=0.04); and the scores of anxiety (9.52±6.28 points vs. 13.48±8.47 points, p=0.01) and depression (13.86±9.17 points vs. 18.89±8.73 points, p=0.02) were significantly decreased than the control group; meanwhile, the family dynamics and family functions were significantly improved, and the social support was also increased (p<0.05). ConclusionaaSFT combined with AEDs had better efficacies than AEDs alone, not only the frequency of epileptic seizures was decreased, but also the patients’ anxiety and depression were improved, and the family dynamics, family functions and social support were improved.

Subproteomic profiling from renal cortices in OLETF rats reveals mutations of multiple novel genes in diabetic nephropathy

Li Zhiguo,Shen Hong,Liu Yeqiang,Zhou Xuefeng,Yan Meihua,He Hailan,Zhao Tingting,Zhang Haojun,Li Ping 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Ovarian cancer is a common gynecological malignancy among female patients and poses a serious threat to women's health. Although it has been established that Fos-like antigen 2 (FOSL2) is linked to ovarian cancer (OC), its exact role in the development of OC remains unknown. Objective: This article aims to investigate the role of FOSL2 in ovarian cancer development. Methods: FOSL2 expression in ovarian carcinoma and adjacent tissues was assessed using real-time fluorescent quantitative PCR and western blot. We constructed OE/sh-FOSL2 plasmids and Caspase-1 specific inhibitors (Yvad-CMK) and transfected A 2780 cells with them to identify the relevant cell functions. Furthermore, we used western blot assay to determine the changes in expression of apoptosis-associated speck-like protein containing a CARD (ASC), cysteine aspartate-specific proteasezymogen procaspase 1 (pro-caspase-1), cysteinyl aspartate-specific proteinase-1 (caspase-1), interleukin-1β precursor (pro-IL-1β), interleukin-1β (IL-1β), interleukin-18 precursor (pro-IL-18), and interleukin-18 (IL-18). In addition, we measured the concentration of IL-1β and IL-18 using an enzyme-linked immunosorbent assay (ELISA). Moreover, Tthe level of lactate dehydrogenase (LDH) in the cell supernatant was measured by LDH release assay kit. Results: The expression of FOSL2 was significantly higher compared with the surrounding tissues. The proliferation, migration, and invasion of A2780 cells were enhanced after transfection with OE-FOSL2 plasmids; however, the cell apoptosis was significantly decreased. When FOSL2 was overexpressed, the inflammasome-associated proteins such as ASC, caspase-1, IL-1β, and IL-18 were downregulated. Furthermore, FOSL2 induced apoptosis and activated the production of inflammasomes in A2780 cells. Co-therapy with Yvad-CMK and substantially inhibited apoptosis and activation of inflammasomes. Conclusions: Inhibition of FOSL2 promotes the apoptosis of OC cells by mediating the formation of an inflammasome.

Social Factors Influencing the Choice of Bicycle: Difference Analysis among Private Bike, Public Bike Sharing and Free-Floating Bike Sharing in Kunming, China

Xuefeng Li,Yong Zhang,Mingyang Du,Jingzong Yang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5

The emergence of free-floating bike sharing (FFBS) has made essential changes in urban bicycle travel. In order to explore the differences of travel behavior among private bicycle (PB), public bicycle sharing (PBS) and FFBS, a survey was conducted in Kunming, China in 2018. Firstly, the differences of travel characteristics among these three modes were analyzed based on 522 valid questionnaires. Then, a multinomial logistic model was applied to explore the influential factors among them. The results show that: 1) PB and FFBS are more attractive for long-distance travel enthusiasts compared with PBS, PB is rarely used for transfer in suburbs while FFBS is the most desirable in connecting other travel modes. The theft problem and high maintenance costs are main obstacles for PB. 2) The elderly, high-income and non-student groups in inflexible travel activities show a preference for PBS, while the young, low-income and student groups in flexible travel demands have a tendency towards FFBS. 3) PB and PBS imped the use of FFBS to a certain extent, while PB seems to have less impact on PBS. 4) FFBS is desirable in temporary travel demand while PBS is more preferable in fixed demand. Interestingly, residents with registered permanent residence tend to use PBS while those without registered permanent residence prefer FFBS. Finally, several management strategies and policy recommendations were proposed for the government and FFBS enterprises to improve the management of bicycles.

Privacy measurement method using a graph structure on online social networks

Li, XueFeng,Zhao, Chensu,Tian, Keke Electronics and Telecommunications Research Instit 2021 ETRI Journal Vol.43 No.5

Recently, with an increase in Internet usage, users of online social networks (OSNs) have increased. Consequently, privacy leakage has become more serious. However, few studies have investigated the difference between privacy and actual behaviors. In particular, users' desire to change their privacy status is not supported by their privacy literacy. Presenting an accurate measurement of users' privacy status can cultivate the privacy literacy of users. However, the highly interactive nature of interpersonal communication on OSNs has promoted privacy to be viewed as a communal issue. As a large number of redundant users on social networks are unrelated to the user's privacy, existing algorithms are no longer applicable. To solve this problem, we propose a structural similarity measurement method suitable for the characteristics of social networks. The proposed method excludes redundant users and combines the attribute information to measure the privacy status of users. Using this approach, users can intuitively recognize their privacy status on OSNs. Experiments using real data show that our method can effectively and accurately help users improve their privacy disclosures.

Recycling of Sintered Nd-Fe-B Magnets Doped with PrNd Nanoparticles

Xuefeng Zhang,Fei Liu,Yanli Liu,Qiang Ma,Yongfeng Li,Qian Zhao,Gaofeng Wang,Zhubai Li 한국자기학회 2015 Journal of Magnetics Vol.20 No.2

The waste of sintered Nd-Fe-B magnets was recycled using the method of dopingPrNd nanoparticles. The effect of PrNd nanoparticle doping on the magnetic properties of the regenerated magnets has been studied. As the content of the PrNd nanoparticles increases, the coercivity increases monotonically, whereas both the remanence and the maximum energy products reach the maximum values for 4 wt% PrNd doping. Microstructural observation reveals that the appropriate addition of PrNd nanoparticles improves the magnetic properties and refines the grain. Domain investigation shows that the self-pinning effect of the rare earth (Re)-rich phase is enhanced by PrNd nano-particle doping. Compared to the magnet with 4 wt% PrNd alloy prepared using the dual-alloy method, the regenerated magnet doped with the same number of PrNd nanoparticles exhibits better magnetic properties and a more homogeneous microstructure. Therefore, it is concluded that PrNd nanoparticle doping is an efficient method for recycling the leftover scraps of Nd-Fe-B magnets.

A Ripple-free Input Current Interleaved Converter with Dual Coupled Inductors for High Step-up Applications

Xuefeng Hu,Meng Zhang,Yongchao Li,Linpeng Li,Guiyang Wu 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.3

This paper presents a ripple-free input current modified interleaved boost converter for high step-up applications. By integrating dual coupled inductors and voltage multiplier techniques, the proposed converter can reach a high step-up gain without an extremely high turn-ON period. In addition, a very small auxiliary inductor employed in series to the input dc source makes the input current ripple theoretically decreased to zero, which simplifies the design of the electromagnetic interference (EMI) filter. In addition, the voltage stresses on the semiconductor devices of the proposed converter are efficiently reduced, which makes high performance MOSFETs with low voltage rated and low resistance rDS(ON) available to reduce the cost and conduction loss. The operating principles and steady-state analyses of the proposed converter are introduced in detail. Finally, a prototype circuit rated at 400W with a 42-50V input voltage and a 400V output voltage is built and tested to verify the effectiveness of theoretical analysis. Experimental results show that an efficiency of 95.3% can be achieved.

Shear-strain induced structural relaxation of Cu Σ3 [110](112) symmetric tilt grain boundary: The role of foreign atoms and temperature

Li Yang,Xue Hongtao,Zhou Xin,Tang Fuling,Li Xiuyan,Ren Junqiang,Lu Xuefeng 한국물리학회 2021 Current Applied Physics Vol.28 No.-

Grain boundaries (GBs) relaxation is a promising and effective strategy to improving GB stability or stabilizing nanocrystalline metals. However, previous studies mainly focused on nanocrystalline pure metals and GB behaviors therein, without considering the role of foreign atoms such as impurity or alloying atoms in GB relaxation. In this work, the shear-strain induced structural relaxation of pure Cu Σ3 [110](112) symmetric tilt GBs (STGBs), and the effects of foreign elements (Fe and Ni) and temperature on the GB relaxation were investigated in detail by molecular dynamics method. The results show that shear strain can trigger the structural relaxation of pure, Fe- and Ni-containing Cu GBs by the emission of Shockley partial dislocations from Cu GBs. Both Fe and Ni have impediment effects on the shear-strain induced GB relaxation, though the content of Fe or Ni atom (0.00165 at.%) is quite low in the GB model. The temperature cannot trigger GB relaxation independently within the considered temperature range, but play a positive role in the shear-strain induced structural relaxations of pure, Fe- and Ni-containing Cu Σ3 [110](112) STGBs. Our work might gain new insights into the mechanically induced GB relaxation in nanocrystalline copper and could be beneficial for improving the stability of Cu GBs.

A Ripple-free Input Current Interleaved Converter with Dual Coupled Inductors for High Step-up Applications

Hu, Xuefeng,Zhang, Meng,Li, Yongchao,Li, Linpeng,Wu, Guiyang The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.3

This paper presents a ripple-free input current modified interleaved boost converter for high step-up applications. By integrating dual coupled inductors and voltage multiplier techniques, the proposed converter can reach a high step-up gain without an extremely high turn-ON period. In addition, a very small auxiliary inductor employed in series to the input dc source makes the input current ripple theoretically decreased to zero, which simplifies the design of the electromagnetic interference (EMI) filter. In addition, the voltage stresses on the semiconductor devices of the proposed converter are efficiently reduced, which makes high performance MOSFETs with low voltage rated and low resistance $r_{DS}$(ON) available to reduce the cost and conduction loss. The operating principles and steady-state analyses of the proposed converter are introduced in detail. Finally, a prototype circuit rated at 400W with a 42-50V input voltage and a 400V output voltage is built and tested to verify the effectiveness of theoretical analysis. Experimental results show that an efficiency of 95.3% can be achieved.

Efficient Public Verification on the Integrity of Multi-Owner Data in the Cloud

Boyang Wang,Hui Li,Xuefeng Liu,Fenghua Li,Xiaoqing Li 한국통신학회 2014 Journal of communications and networks Vol.16 No.6

Cloud computing enables users to easily store their dataand simply share data with others. Due to the security threats inan untrusted cloud, users are recommended to compute verificationmetadata, such as signatures, on their data to protect the integrity. Many mechanisms have been proposed to allow a publicverifier to efficiently audit cloud data integrity without receivingthe entire data from the cloud. However, to the best of our knowledge,none of them has considered about the efficiency of publicverification on multi-owner data, where each block in data issigned by multiple owners. In this paper, we propose a novel publicverification mechanism to audit the integrity of multi-ownerdata in an untrusted cloud by taking the advantage of multisignatures. With our mechanism, the verification time and storageoverhead of signatures on multi-owner data in the cloud are independentwith the number of owners. In addition, we demonstratethe security of our scheme with rigorous proofs. Compared to thestraightforward extension of previousmechanisms, ourmechanismshows a better performance in experiments.

Epigenetic silencing of UBXN8 contributes to leukemogenesis in t(8;21) acute myeloid leukemia

Yang Erna,Guan Wei,Gong Desheng,Li Jieying,Han Caixia,Zhang Juan,Wang Hong,Kang Synat,Gao Xuefeng,Li Yonghui,Yu Li 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

The formation of the RUNX1-RUNX1T1 fusion protein, resulting from the t(8;21) translocation, is considered to be one of the initiating events of t(8;21) acute myeloid leukemia (AML). However, the mechanisms of the oncogenic mechanism of RUNX1- RUNX1T1 remain unclear. In this study, we found that RUNX1-RUNX1T1 triggers the heterochromatic silencing of UBXN8 by recognizing the RUNX1-binding sites and recruiting chromatin-remodeling enzymes to the UBXN8 promoter region. Decitabine, a specific inhibitor of DNA methylation, upregulated the expression of UBXN8 in RUNX1-RUNX1T1+ AML cell lines. Overexpression of UBXN8 inhibited the proliferation and colony-forming ability of and promoted cell cycle arrest in t(8;21) AML cell lines. Enhancing UBXN8 levels can significantly inhibit tumor proliferation and promote the differentiation of RUNX1-RUNX1T1+ cells in vivo. In conclusion, our results indicated that epigenetic silencing of UBXN8 via methylation of its promoter region mediated by the RUNX1- RUNX1T1 fusion protein contributes to the leukemogenesis of t(8;21) AML and that UBXN8 targeting may be a potential therapeutic strategy for t(8;21) AML. The formation of the RUNX1-RUNX1T1 fusion protein, resulting from the t(8;21) translocation, is considered to be one of the initiating events of t(8;21) acute myeloid leukemia (AML). However, the mechanisms of the oncogenic mechanism of RUNX1-RUNX1T1 remain unclear. In this study, we found that RUNX1-RUNX1T1 triggers the heterochromatic silencing of UBXN8 by recognizing the RUNX1-binding sites and recruiting chromatin-remodeling enzymes to the UBXN8 promoter region. Decitabine, a specific inhibitor of DNA methylation, upregulated the expression of UBXN8 in RUNX1-RUNX1T1 + AML cell lines. Overexpression of UBXN8 inhibited the proliferation and colony-forming ability of and promoted cell cycle arrest in t(8;21) AML cell lines. Enhancing UBXN8 levels can significantly inhibit tumor proliferation and promote the differentiation of RUNX1-RUNX1T1 + cells in vivo. In conclusion, our results indicated that epigenetic silencing of UBXN8 via methylation of its promoter region mediated by the RUNX1-RUNX1T1 fusion protein contributes to the leukemogenesis of t(8;21) AML and that UBXN8 targeting may be a potential therapeutic strategy for t(8;21) AML.