Risk Factors, Patterns, and Outcomes of Late Recurrence after Liver Resection for Patients with Hepatocellular Carcinoma (Analysis of a Multicenter Cohort over 15 Years)

( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Late recurrence (> 2 years) after liver resection of hepatocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recurrence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Multivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intrahepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treatments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The patterns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.

A dynamic asymmetrical crack model of bridging fiber pull-out in unidirectional composite materials

Xin-gang Li,Yun-hong Cheng,Nian-chun Lü,Guo-dong Hao,Jin Cheng 대한기계학회 2011 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.25 No.9

As a rule, when a crack happens in composite materials, the fibrous system will generate bridging fibers resulted in the asymmetrical extending of the crack. In this paper, a dynamic asymmetrical crack model of bridging fiber pull-out in unidirectional composite materials is built for analyzing the distributions stress and displacement with the internal asymmetrical crack under the loading conditions of an applied non- stress and the traction forces on crack faces yielded by the bridging fiber pull-out model. Thus the fiber failure is determined by the maximum tensile stress, the fiber ruptures, and hence the crack propagation should also occur in self-similar modality. The formulation involves the development of a Riemann-Hilbert problem. The analytical solution of an asymmetrical extension crack in unidirectional composite materials under the conditions of moving increasing loads Pt²/x² and Px²/t is concluded, respectively. Based on relative material properties, the variable law of dynamic stress intensity factors was depicted perfectly. After the conclusion of analytical solutions with the superposition theorem, the solutions of arbitrary complex problems could be acquired.

Fault identification of a chain conveyor based on functional data feature engineering and optimized multi-layer kernel extreme learning machine

Hao Wen,Baolin Hou,Xin Jin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5

The functional time series signals generated during the operation of electromechanical systems contain fault characteristic information. This study proposes a fault identification method for electromechanical systems based on functional data feature engineering and multi-layer kernel extreme learning machine (MLKELM) optimized by sparrow search algorithm (SSA). First, multiple time series signals under different fault conditions are functionalized under the B-spline basis function system, and the feature reduction space is constructed by functional principal component analysis (FPCA) and principal differential analysis (PDA) to extract fault features. Second, the minimum redundancy and maximum relevance (mRMR) method is performed on the initial feature set for feature selection. In addition, the size of the optimal feature subset is determined by the class separability of feature subset (CSFS) criterion. Finally, deep feature learning and fault identification are implemented by MLKELM and the pre-defined parameters are optimized based on the SSA in this process to improve its performance. The experimental results show that the proposed method can effectively extract the fault features of function time series signals, and then accurately identify the faults of electromechanical systems.

Experimental Comparison of Bernoulli Gripper and Vortex Gripper

Xin Li,Ning Li,Guoliang Tao,Hao Liu,Toshiharu Kagawa 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

A Bernoulli gripper and a vortex gripper are types of pneumatic grippers that have similar functions but different working principles. They are widely used for performing gripping, transferring, and placing operations in automated production lines. This study systematically compares the two grippers and provides an objective reference to enable users to choose an appropriate gripper. First, we present the working principles of both grippers. Then, we measure the curves of suction force, air consumption, and upstream pressure; furthermore, we analyze and compare the energy consumption from the viewpoint of the entire pneumatic system. The results reveal the relationships with the air consumption and total energy consumption. Next, we measure the pressure distribution formed on the upper surface of the workpiece. From the experimental results, the principles of the two grippers are stated and compared. Furthermore, we use the pressure distribution data to estimate the deformation and inner stress of the workpiece. The influence of the grippers on the workpiece are analyzed and compared from a material mechanics viewpoint. Finally, we use three types of rough surfaces to qualitatively evaluate and compare the performance of the grippers when gripping a workpiece with a rough surface

Multicomponent assessment and ginsenoside conversions of Panax quinquefolium L. roots before and after steaming by HPLC-MS<SUP>n</SUP>

Xin Huang,Yan Liu,Yong Zhang,Shuai-Ping Li,Hao Yue,Chang-Bao Chen,Shu-Ying Liu 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.1

Background: The structural conversions in ginsenosides induced by steaming or heating or acidic condition could improve red ginseng bioactivities significantly. In this paper, the chemical transformations of red American ginseng from fresh Panax quinquefolium L. under steaming were investigated, and the possible mechanisms were discussed. Methods: A method with reversed-phase high-performance liquid chromatography coupled with linear ion trap mass spectrometry (HPLC-MS<SUP>n</SUP>)-equipped electrospray ionization ion source was developed for structural analysis and quantitation of ginsenosides in dried and red American ginseng. Results: In total, 59 ginsenosides of protopanaxadiol, protopanaxatriol, oleanane, and ocotillol types were identified in American ginseng before and after steaming process by matching the molecular weight and/or comparing MS<SUP>n</SUP> fragmentation with that of standards and/or known published compounds, and some of them were determined to be disappeared or newly generated under different steaming time and temperature. The specific fragments of each aglycone-type ginsenosides were determined as well as aglycone hydrated and dehydrated ones. The mechanisms were deduced as hydrolysis, hydration, dehydration, and isomerization of neutral and acidic ginsenosides. Furthermore, the relative peak areas of detected compounds were calculated based on peak areas ratio. Conclusion: The multicomponent assessment of American ginseng was conducted by HPLC-MS<SUP>n</SUP>. The result is expected to provide possibility for holistic evaluation of the processing procedures of red American ginseng and a scientific basis for the usage of American ginseng in prescription.

Efficient and Precise Construction of Markerless Manipulations in the Bacillus subtilis Genome

Hao Jie Yu,Xin Yan,Wei Ling Shen,Yu Jia Shen,Ji Zhang,Shun Peng Li 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.1

Design of 1500V solar inverter stack beyond megawatt in NPC1 topology

Xin Hao,Kwok-Wai Ma,Jia Zhao,Xin-Yu Sun 전력전자학회 2017 전력전자학술대회 논문집 Vol.2017 No.7

This paper describes a design concept of NPC1 power stack for 1500VDC megawatt level solar inverter. This stack uses three latest half-bridge IGBT modules with highest power density and operation junction temperature, which enable realization of power level beyond 1MW without paralleling. Critical design concept on loop inductance is explained. Dynamic characteristics are verified by double-pulse test. Thermal characteristics and output power limits are verified by thermal test. Temperature-sensitive component on PCB as output power constraint is identified. Different PCB repositioning solutions are tested to give the overall output power thermal derating curves, which enable output power of 1.15MW at TA=55°C with 15°C thermal margin. The power stack characteristic and performance change under different thermal environment is further analyzed.

Hydration, Compressive Strength and Durability of Eco-friendly Cement Mortars Containing Recycled Brick Powder and Metakaolin

Hao Wang,Liang Wang,Xin Qian,Ke Cao,Ying Xu,Yi Fang,Liyun Cui 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9

Grinding brick waste into powder for use as a supplementary cementitious material has shown to be a promising recycling method for the reuse of construction and demolition waste.However, the strength and durability of concrete containing recycled brick powder (RBP) will significantly decrease due to the poor pozzolanic activity of RBP, limiting its wider applications. This study attempted to overcome these defects through metakaolin (MK) addition. The hydration, compressive strength, durability, and environmental impact of eco-friendly mortars containing RBP and MK were investigated. The results showed that MK promoted the early-stage hydration of cement, creating a suitable hydration environment for the hydration of RBP at a later age. As a result, the volume fractions of low-density calcium silicate hydrate (C-S-H) and high-density C-S-H increased according to the nanoindentation test results. In addition, the strength, chloride penetration resistance, and reinforcement bar corrosion resistance of the blended mortars obviously improved due to the synergistic effect of RBP and MK. Lastly, we achieved CO2 emissions that were 22.1 – 30.2% lower and energy consumption that was 21.4 – 27.0% lower by incorporating 20% RBP and 5 – 15% MK.

Indirect displacement monitoring of high-speed railway box girders consider bending and torsion coupling effects

Xin Wang,Zhonglong Li,Yi Zhuo,Hao Di,Jianfeng Wei,Yuchen Li,Shunlong Li 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.6

The dynamic displacement is considered to be an important indicator of structural safety, and becomes an indispensable part of Structural Health Monitoring (SHM) system for high-speed railway bridges. This paper proposes an indirect strain based dynamic displacement reconstruction methodology for high-speed railway box girders. For the typical box girders under eccentric train load, the plane section assumption and elementary beam theory is no longer applicable due to the bend-torsion coupling effects. The monitored strain was decoupled into bend and torsion induced strain, pre-trained multi-output support vector regression (M-SVR) model was employed for such decoupling process considering the sensor layout cost and reconstruction accuracy. The decoupled strained based displacement could be reconstructed respectively using box girder plate element analysis and mode superposition principle. For the transformation modal matrix has a significant impact on the reconstructed displacement accuracy, the modal order would be optimized using particle swarm algorithm (PSO), aiming to minimize the ill conditioned degree of transformation modal matrix and the displacement reconstruction error. Numerical simulation and dynamic load testing results show that the reconstructed displacement was in good agreement with the simulated or measured results, which verifies the validity and accuracy of the algorithm proposed in this paper.

Identification and Mapping of a Thermo-Sensitive Genic Self-Incompatibility Gene in Maize

Xin Ge Lin,Hui Ling Xie,Zhang Ying Xi,Yan Min Hu,Guang Yuan Zhao,Liu Jing Duan,Zong You Hao,Zong Hua Liu,Ji Hua Tang 한국유전학회 2009 Genes & Genomics Vol.31 No.3

In this study, we describe a novel ecological self-incompatibility (SI) line HE97 in maize. The main environmental factors influencing the inbred line characteristics were identified through field sowing trials during a two-year study period (2001 and 2002). The results showed that daily minimum temperature had the greatest effect on floral morphology and breeding system of the SI line. In staminate floret differentiation, when the daily minimum temperature exceeded 24℃, the line exhibited complete self-compatibility; however SI was observed when the daily minimum temperature was below 20℃. Therefore, we characterized the line as exhibiting thermo-sensitive genic self-incompatibility (TGSI). A set of F2 and F2:3 populations, derived from the inbred lines HE97 and Z58, were evaluated for two years to elucidate the TGSI line patterns of inheritance. Classical genetic analyses and QTL mapping results revealed that HE97 self-incompatibility was governed by a single allele, named here as tgsi1. The tgsi1 gene was mapped to chromosome 2 between SSR markers nc131 and bnlg1633, with a distance of 2.40 cM from nc131 and 2.44 cM from bnlg1633.