The XPD Lys751Gln Polymorphism has Predictive Value in Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Systemic Review and Meta-analysis

Qian, Ying-Ying,Liu, Xin-You,Pei, Dong,Xu, Jia-Li,Shen, Hua,Chen, Xiao-Feng,Liu, Yi-Qian,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: The predictive value of the xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism regarding clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, but the results remain inconclusive. Therefore, we performed a meta-analysis to determine the precise role of the XPD Lys751Gln polymorphism in this clinical situation and optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs), generalized odds ratio (ORG) and their 95% confidence intervals (CIs) were used to estimate the objective response, while hazard ratios (HRs) with 95%CIs were used for progression-free survival (PFS) and overall survival (OS). Results: A total of 17 studies including 2,286 patients met the inclusion criteria. Overall, the XPD 751Gln allele was associated with a non-significant reduced objective response to oxaliplatin-based chemotherapy in all patients or in the Asian and Caucasian subgroups. However, poor PFS and OS of CRC patients treated with oxaliplatin-based regimens were significantly related to the XPD 751Gln allele in the dominant model (PFS: HR=2.10, 95%CI: 1.65-2.67; OS: HR=3.18, 95%CI: 1.57-6.47). On stratified analysis by ethnicity, these relationships were more pronounced in Asians (PFS: HR=2.49, 95%CI: 1.79-3.47; OS: HR=5.25, 95%CI: 3.46-7.94) than in Caucasians (PFS: HR=1.73, 95%CI: 1.22-2.46; OS: HR=1.78, 95%CI: 1.06-2.99). Conclusions: The XPD Lys751Gln polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

The ERCC1 C118T Polymorphism Predicts Clinical Outcomes of Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Meta-analysis Based on 22 Studies

Qian, Ying-Ying,Liu, Xin-You,Wu, Qian,Song, Xian,Chen, Xiao-Feng,Liu, Yi-Qian,Pei, Dong,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1) C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, the conclusions are conflicting. Therefore, we performed the present meta-analysis to determine the precise role of the ERCC1 C118T polymorphism in this clinical situation and help optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were used to estimate objective response and oxaliplatin-induced toxicity, with hazard ratios (HRs) with 95%CIs for progression-free survival (PFS) and overall survival (OS). Results: A total of 22 studies including 2,846 CRC patients were eligible in the analysis. Overall, no significant correlation was found between the ERCC1 C118T polymorphism and objective response to oxaliplatin-based chemotherapy, in all patients or in the Asian and Caucasian subgroups. However, the pooled analysis showed that the PFS and OS were significantly shorter in patients who carried T/T or T/C genotypes of ERCC1 C118T as compared to the C/C genotype. On stratified analysis by ethnicity, the ERCC1 118T allele was associated with a favorable prognosis in Caucasians (PFS, HR=0.58, 95%CI: 0.24-1.44; OS, HR=0.38, 95%CI: 0.22-0.64) but an unfavorable prognosis in Asians (PFS, HR=2.49, 95%CI: 1.87-3.33; OS, HR=2.63, 95%CI: 1.87-3.69) based on a dominant model. In addition, we failed to find a statistically significant impact of ERCC1 C118T polymorphism on oxaliplatin-induced toxicity. Conclusions: The ERCC1 C118T polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

Detection and Analysis of Residual Pesticides Based On Surface Raman Spectra of Spinach

Liu Ying-Nan,Yi Shu-Juan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.12

This paper with spinach as the research object, to chlorpyrifos pesticide as detection object, using Raman spectroscopy technique surface pesticides in spinach residual detection method and rapid detection research. Starting from the detection method, study of the classic method and method for rapid detection of current situation of the development, Raman spectroscopy detection method as a means of detection, the selected object of study; master the Raman spectroscopy for rapid detection of the basic principles and originpro 9.0 software acquisition function using, lay the foundation for the subsequent detection of. After the actual test to determine Raman spectroscopy instrument laser wavelength to 473nm, acquisition time 2s spinach sample testing effect Best result. After no medicine Raman spectra to obtain the surface of spinach were denoising analysis results show that wavelet de noise method compared to the adjacent averaging, savitzky Golay method smoothing, median method effect better. On Spinach with different concentrations of chlorpyrifos Raman spectroscopy analysis that accorded with the residual linear relationship. The peak intensity method were selected to establish models were detected in spinach surface of pesticide chlorpyrifos. Raman spectroscopy detection method can of spinach surface of pesticide residues detection analysis. It solves the traditional measurement method for sample pretreatment is complex and long detection time, low efficiency of the measured defect

Stress Model of Axial Flow Threshing & Separating Device and Trajectory Simulation of Rice Grains

Liu Ying-Nan,Yi Shu-Juan 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.11

To reveal stress distribution rules of grain separating process in assembled axial flow threshing and separating device, regarding assembled axial flow threshing and separating device as object, High speed imaging technology is adopted in the shooting technique, stress model was set based on the stress principle, and stress distribution rules was obtained by simulation technology. Grain, broken ear movement and the movement as a whole and free movement of the grain threshing process is through the analysis of the EXCEL drawing, The test results show that distribution rules is irregular in grain separating process, is that, stress fluctuates at axial direction, and two peak values appear at early and middle threshing stage respectively; threshing and separating process finishes about 2.35 meters from the feeding mouth at axial direction. Off the spike in threshing and separating space motion unstable trajectory is a parabola, the speed decreased with the passage of time. No outside interference in the most free grain for approximate straight movement, in the medium of motion state, and axis direction and a certain angle.Therefore, grain rotors distribute at axial direction and rest results are consistent with theory analysis.

Combinatorial Interactions of Two cis-Acting Elements, AT-Rich Regions and HSEs, in the Expression of Tomato Lehsp23.8 upon Heat and Non-Heat Stresses

Shu-ying Yi,Jian Liu 한국식물학회 2009 Journal of Plant Biology Vol.52 No.6

We previously cloned and analyzed the 1,893-bp promoter region (−1,915 to −23) of the tomato (Lycopersicon esculentum) Lehsp23.8 gene, whose expression is induced by treatment with high or low temperatures, heavy metal, or abscisic acid (ABA). In our present work, we examined how this expression is regulated. A comprehensive quantitative promoter deletion and base-substitution analysis was conducted under various environmental conditions. The proximal region (−565 to −23 bp) of the Lehsp23.8 promoter harbors cis-regulatory elements that conferred high levels of heat-induced expression in transgenic tobacco. Mutation of the five proximal HSEs (HSE1 to 5) of that promoter led to an absence of heat inducibility. The AT-rich regions between −255 bp and −565 bp (AT-rich1 to 4) in the promoter might serve as enhancers for such heat-induced expression. Deletion and HSE mutation analysis indicated that other cis-acting elements also function in response to low temperature, heavy metal, and ABA and that HSE1 to 5 act at least as cis-acting elements in multiple-stress responses of Lehsp23.8. These results reveal that those five proximal HSEs and AT-rich regions function interdependently in the expression of Lehsp23.8 in response to non-heat stresses. Furthermore, the putative elements CRT/DRE, AP-1, and ABRE in that promoter are not required for multiple-stress induction.

Highly Nitrogen-Doped Porous Carbon Obtained Using Nicotinic Acid by a Template Carbonization Approach for Supercapacitors

Ying Jiang,Jiewu Cui,Jiaqin Liu,Yan Wang,Xia Shu,Yong Zhang,Yucheng Wu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3

Nitrogen-enriched porous carbon materials have been successfully synthesized via a template carbonization method, in which nicotinic acid acts as carbon/nitrogen sources, and Ca(OAc)2 · H2O as a template. It reveals that the mass ratio of Ca(OAc)2 · H2O-to-nicotinic acid and the carbonization temperature dominate the morphology of carbon materials as well as capacitive performances. The sample obtained with the ratio of Ca(OAc)2 · H2O-to-nicotinic acid as 1.5 at 800℃, namely the C-1.5-800 sample, displays the optimum capacitive behavior. It is amorphous with low-graphitization degree, possessing hierarchical porous structure, high nitrogen content (14.5%), large specific surface area (788 m2 g-1) and high total pore volume (3.56 cm3 g-1). As a result, the as-made C-1.5-800 electrode exhibits a maximum specific capacitance of 216 F g-1 at a current density of 1 A g-1 in 6 M KOH aqueous solution. It also displays a maximum energy density of 45.9 Wh kg-1 at 2050 W kg-1 and a maximum power density of 20100 W kg-1 at 19.2 Wh kg-1 at operation temperature of 50℃ in [EMIm]BF4/AN organic electrolyte. More importantly, the C-1.5-800 electrode exhibits an excellent cycling stability within 5000 cycles at 5 A g-1. This work may enrich and broaden the field of porous carbon and its potential application for supercapacitors under high temperature.

The Influence of Resilience on the Coping Strategies in Patients with Primary Brain Tumors

Shu-Yuan Liang,Hui-Chun Liu,Yu-Ying Lu,Shu-Fang Wu,Ching-Hui Chien,Shiow-Luan Tsay 한국간호과학회 2020 Asian Nursing Research Vol.14 No.1

Purpose: The purpose of this study was to assess the amount of variance in the coping strategies of patients with brain tumors that could be accounted for by resilience. Methods: This cross-sectional survey involved 95 patients who had experienced surgical, chemotherapy, or radiotherapy therapies for their brain tumors at least 1 month before data collection. The investigator collected data using the scales of the Ways of Coping Checklist-Revised and Resilience Scale. Data were analyzed using descriptive statistics, t tests, analysis of variance, Pearson product–moment correlation, and hierarchical multiple regression. Results: The results revealed that resilience was significantly positively associated with patients' problem-focused coping (r = .65, p < .001) and total coping (r = .49, p < .001). In addition, resilience accounted for 27% (R2inc = .27, p < .001) and 16% (R2inc = .16, p < .001) of the distinct variances in predicting patients’ problem-focused coping and total coping. Conclusion: The current results provide evidence to support the importance of resilience in shaping the coping strategies of relevant patients. As resilience shows a crucial element in patient coping with brain tumors, health team members should develop and employ appropriate strategies to improve the resilience of patients with brain tumors.

Appropriate Soil Heat Treatment Promotes Growth and Disease Suppression of Panax notoginseng by Interfering with the Bacterial Community

( Ying-bin Li ),( Zhi-ping Zhang ),( Ye Yuan ),( Hui-chuan Huang ),( Xin-yue Mei ),( Fen Du ),( Min Yang ),( Yi-xiang Liu ),( Shu-sheng Zhu ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.3

In our greenhouse experiment, soil heat treatment groups (50, 80, and 121°C) significantly promoted growth and disease suppression of Panax notoginseng in consecutively cultivated soil (CCS) samples (p < 0.01), and 80°C worked better than 50°C and 121°C (p < 0.01). Furthermore, we found that heat treatment at 80°C changes the microbial diversity in CCS, and the inhibition ratios of culturable microorganisms, such as fungi and actinomycetes, were nearly 100%. However, the heat-tolerant bacterial community was preserved. The 16S rRNA gene and internal transcribed spacer (ITS) sequencing analyses indicated that the soil heat treatment had a greater effect on the Chao1 index and Shannon’s diversity index of bacteria than fungi, and the relative abundances of Firmicutes and Proteobacteria were significantly higher than without heating (80 and 121°C, p < 0.05). Soil probiotic bacteria, such as Bacillus (67%), Sporosarcina (9%), Paenibacillus (6%), Paenisporosarcina (6%), and Cohnella (4%), remained in the soil after the 80°C and 121°C heat treatments. Although steam increased the relative abundances of most of the heat-tolerant microbes before sowing, richness and diversity gradually recovered to the level of CCS, regardless of fungi or bacteria, after replanting. Thus, we added heat-tolerant microbes (such as Bacillus) after steaming, which reduced the relative abundance of pathogens, recruited antagonistic bacteria, and provided a long-term protective effect compared to the steaming and Bacillus alone (p < 0.05). Taken together, the current study provides novel insight into sustainable agriculture in a consecutively cultivated system.

Taiwanese Parents’ Experience of Making a “Do Not Resuscitate” Decision for Their Child in Pediatric Intensive Care Unit

Shu-Mei Liu,Hung-Ru Lin,Frank L. Lu,Tzu-Ying Lee 한국간호과학회 2014 Asian Nursing Research Vol.8 No.1

Purpose: The purpose of this project was to explore the parental experience of making a “do not resuscitate” (DNR) decision for their child who is or was cared for in a pediatric intensive care unit in Taiwan. Methods: A descriptive qualitative study was conducted following parental signing of a standard hospital DNR form on behalf of their critically ill child. Sixteen Taiwanese parents of 11 children aged 1 month to 18 years were interviewed. Interviews were recorded, transcribed, analyzed and sorted into themes by the sole interviewer plus other researchers. Results: Three major themes were identified: (a) “convincing points to sign”, (b) “feelings immediately after signing”, and (c) “postsigning relief or regret”. Feelings following signing the DNR form were mixed and included “frustration”, “guilt”, and “conflicting hope”. Parents adjusted their attitudes to thoughts such as “I have done my best,” and “the child’s life is beyond my control.” Some parents whose child had died before the time of the interview expressed among other things “regret not having enough time to be with and talk to my child”. Conclusion: Open family visiting hours plus staff sensitivity and communication skills training are needed. To help parents with this difficult signing process, nurses and other professionals in the pediatric intensive care unit need education on initiating the conversation, guiding the parents in expressing their fears, and providing continuing support to parents and children throughout the child’s end of life process.

The Lived Experience of First-time Mothers with Congenital Heart Disease

Liu Yu-Ting,Lu Chun-Wei,Mu Pei-Fan,Shu Ying-Mei,Chen Chi-Wen 한국간호과학회 2022 Asian Nursing Research Vol.16 No.3

Purpose: Nowadays most children with congenital heart disease (CHD) are expected to survive to adulthood. The healthcare focus needs to pay close attention to the important developmental tasks during their growth process. The women with CHD face some challenges in their critically developmental stages during pregnancy, delivery, and even motherhood. The lived experience of being a mother needs to be further concerned. This study aimed to explore the lived experience of first-time mothers with CHD. Methods: Descriptive phenomenological design was adopted. Semi-structured interviews were conducted from April to August 2018 with 11 primiparous women with CHD, who were recruited from the pediatric and adult cardiology outpatient departments at a medical center and who had a child aged between 6 months and 3 years. Giorgi's phenomenological analysis method was employed. Results: Six main themes arose from the analysis: (1) recognizing pregnancy risks, (2) performing selfcare for health, (3) building self-worth from my baby, (4) adapting to postpartum life and adjusting priorities, (5) enjoying being a first-time mother, and (6) the factors contributing to success in high-risk childbirth. Conclusions: The experiences that occurred prior to and after labor that were identified in this study can assist women with CHD to more capably prepare for and understand the process of becoming a mother, including recognition of the importance of a prepregnancy evaluation. The findings of this study can help women with CHD to better understand the path to becoming a mother and prepare themselves for the challenges that lie ahead.