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Improved Inventory Management for Retail Stores based on Intelligent Demand Forecasts
Xiaomin Zhu,Xi Xiang,Donghua Chen 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.8
In order to meet the increasing daily demands of customers and reduce the unnecessary cost in retail stores as far as possible, the inventory management of retail stores becoming more and more important. However, because of various characteristics of demand in retail stores, the traditional demand forecasting technologies can’t work well. In this paper, we use the modified K-means clustering analysis to help determine the groups with different characteristics of demand. In addition, a demand forecasting model integrated BP neural networks and grey model is proposed to make the prediction more intelligent and general. The example illustrates that the proposed method for forecast is feasible by the comparative analysis between the predicted values and the actual values.
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Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse
Xinyu Wan,Xiaomin Yang,Fan Yang,Tianyi Wang,Lixia Ding,Lili Song,Yan Miao,Xiang Wang,Yani Ma,Chengjuan Luo,Jingyan Tang,Longjun Gu,Jing Chen,Yanjing Tang,Jun Lu,Benshang Li 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3
PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.
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Liping Chen,Xiaomin Li,Xiang Li,Min Zhu,Ranchao Wu,António M. Lopes 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11
This work investigates the guaranteed cost leader-following consensus of a class of uncertain fractionalorder (FO) multi-agent systems (FOMASs) affected by state time delay. The leader and following group are exposed to norm-bounded time-varying parametric uncertainty and time-delay. A delay- and order-dependent consensus protocol is developed which guarantees robust stability of the controlled system and ensures that the effect of uncertainty on the system performance is below some prescribed index. The FO Razumikhin theorem and the linear matrix inequality approach are adopted to derive the method that can be applied to FOMASs with deterministic parameters. The analysis can be extended to distinct consensus problems for different types of FOMASs. Three numerical examples illustrate the effectiveness and feasibility of the approach.
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Mediatory role of K, Cu and Mo over Ru/SiO2 catalysts for glycerol hydrogenolysis
Xiaoyuan Liao,Kewen Li,Xiaomin Xiang,Sheng-Guang Wang,Xichun She,Yulei Zhu,Yongwang Li 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.2
SiO2 supported ruthenium catalysts with and without modifiers were prepared, characterized and tested for glycerol hydrogenation. Addition of K, Cu and Mo affects the reducibility and acidity of the Ru/SiO2catalyst. Characterization data shows that Cu and Mo-modified Ru/SiO2 have stronger acidity. On the contrary, K element on a passive effect on the acidity of Ru based catalyst had been observed. A comparison with the pure Ru/SiO2 indicates the Cu-promoted specimen has better selective to the desired products, acetol, 1,2-propanediol and ethyl glycol, although the reactivity is slightly lower.
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Shih-Ku Lin,Shu-Yu Yang,Seon-Cheol Park,Ok-Jin Jang,Xiaomin Zhu,Yu-Tao Xiang,Wen-Chen Ouyang,Afzal Javed,M. Nasar Sayeed Khan,Sandeep Grover,Ajit Avasthi,Roy Abraham Kallivayalil,Kok Yoon Chee,Norliza 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.1
Objective: Pharmacotherapy including mood stabilizers and antipsychotics are frequently used in bipolar disorder (BD); however, the lack of consensus regarding the definition of polypharmacy hinders conducting comparative studies across different settings and countries. Research on Asian Prescription Pattern (REAP) is the largest and the longest lasting international collaborative research in psychiatry in Asia. The objective of REAP BD was to investigate the prescription patterns of psychotropic medications across Asian countries. The rates of polypharmacy and psychotropic drug load were also analyzed. Methods: The data collection was web-based. Prescription patterns were categorized as (1) mood stabilizer monotherapy: one mood stabilizer; (2) antipsychotic monotherapy: one antipsychotic; (3) simple polypharmacy: one mood stabilizer and one antipsychotic; and (4) complex polypharmacy: ≥ 2 mood stabilizers or/and antipsychotics. The psychotropic drug load in each patient was calculated using the defined daily dose method. Results: Among 2003 patients with BD (52.1% female, 42.4 years) from 12 countries, 1,619 (80.8%) patients received mood stabilizers, 1,644 (82.14%) received antipsychotics, and 424 (21.2%) received antidepressants, with 14.7% mood stabilizer monotherapy, 13.4% antipsychotic monotherapy, 48.9% simple polypharmacy, 20.3% complex polypharmacy, and 2.6% other therapy. The average psychotropic drug load was 2.05 ± 1.40. Results varied widely between countries. Conclusion: Over 70% of psychotropic regimens involved polypharmacy, which accords with the high prevalence of polypharmacy in BD under a permissive criterion (2 or more core psychotropic drugs) worldwide. Notably, ≥ 80% of our sample received antipsychotics, which may indicate an increasing trend in antipsychotic use for BD treatment.
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