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RISS 인기검색어
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- 저자 : Yulei Zhu (검색결과 3 건)
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Linyue Pan,Yuting Tan,Bin Wang,Wenjia Qiu,Yulei Yin,Haiyan Ge,Huili Zhu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant pleural effusion compared with benign pleural effusion. So we investigated the role of CARD9 in non-small cell lung cancer (NSCLC) and its working mechanism. Materials and Methods Immunohistochemistry, western blot, and quantitative real-time polymerase chain reaction were used to detect the expression of CARD9 in specimens of NSCLC patients. The Cancer Genome Atlas (TCGA) database was also used to analyze the expression of CARD9 in NSCLC and its predicting value for prognosis. Immunofluorescence was used for CARD9 cellular location. Cell growth assay, clonal formation assay, wound healing assay, matrigel invasion assay, and flow cytometry were used to test cell proliferation, migration, invasion, apoptosis, and cycle progression of NSCLC cells with CARD9 knockdown or CARD9 overexpression. Co-immunoprecipitation was used to identify the interaction between CARD9 and B-cell lymphoma 10 (BCL10). SB203580 was used to inhibit p38 activation. Results CARD9 was decreased in NSCLC tissues compared with normal tissues; low CARD9 expression was associated with poor survival. CARD9 was expressed both in tumor cells and macrophages. Downregulation of CARD9 in NSCLC cells enhanced the abilities of proliferation, invasion, and migration via activated mitogen-activated protein kinases (MAPK)/p38 signaling, while overexpression of CARD9 presented antitumor effects. BCL10 was identified to interact with CARD9. Conclusion We demonstrate that CARD9 is an independent prognostic factor in NSCLC patients and inhibits proliferation, migration, and invasion by suppressing MAPK/p38 pathway in NSCLC cells.
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Mediatory role of K, Cu and Mo over Ru/SiO2 catalysts for glycerol hydrogenolysis
Xiaoyuan Liao,Kewen Li,Xiaomin Xiang,Sheng-Guang Wang,Xichun She,Yulei Zhu,Yongwang Li 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.2
SiO2 supported ruthenium catalysts with and without modifiers were prepared, characterized and tested for glycerol hydrogenation. Addition of K, Cu and Mo affects the reducibility and acidity of the Ru/SiO2catalyst. Characterization data shows that Cu and Mo-modified Ru/SiO2 have stronger acidity. On the contrary, K element on a passive effect on the acidity of Ru based catalyst had been observed. A comparison with the pure Ru/SiO2 indicates the Cu-promoted specimen has better selective to the desired products, acetol, 1,2-propanediol and ethyl glycol, although the reactivity is slightly lower.
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Zhenmin Liu,Junwei Wang,Mao-qing Kang,Ning Yin,Xin-kui Wang,Yisheng Tan,Yulei Zhu 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
MgAl hydrotalcite synthesized via co-precipitation method from magnesium and aluminum nitrateswas calcined to produce Mg4AlO5.5 mixed oxides. The oxides were modified by introducing LiNO3 andapplied to the synthesis of glycerol carbonate from glycerol and dimethyl carbonate. The research resultsindicated that LiNO3/Mg4AlO5.5 was an efficient catalyst for the synthesis of glycerol carbonate. The fullconversion of glycerol and 96.28% yield of glycerol carbonate were obtained after reacting at 80 8C for1.5 h in the presence of LiNO3/Mg4AlO5.5. The structure and properties of the catalysts were studied bymeans of XRD, TGA, BET, CO2-TPD and Hammett indicator method. It was found that the basic strengthand the basicity of the catalysts were enhanced after addition of LiNO3. Over Mg4AlO5.5 oxides, LiNO3 waseasily converted to LiAlO2 which constituted new strong basic sites. Too high basic strength and basicityof catalysts may improve the conversion of glycerol at the cost of GC selectivity reduction.
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