Aerodynamic Design of the Supersonic Aircraft Wing-Shape and Wing-Twist Optimization

Li Li,Junqiang Bai,Tongbiao Guo,Xiaolong He,Ziyuan Fu 한국항공우주학회 2018 International Journal of Aeronautical and Space Sc Vol.19 No.2

This paper builds an aerodynamic optimization design system by coupling the free form deformation parameterization technique,thedynamicmeshtechniquebasedoninversedistanceweightinginterpolationmethodandparticleswarmoptimization algorithm,Krigingsurrogatemodel,withthecomputationalfluiddynamicssolverbasedonReynolds-averagedNavier–Stokes equations. And it carries out aerodynamic optimization designs with a supersonic transport aircraft configuration. The wing shape is parameterized by defining 60 design variables and the wing twist is by four design variables. Meanwhile, the wing thickness constraints are considered. Afterwards, a single-point optimization design aiming at minimum of the supersonic cruise drag is conducted, and in order to consider the transonic cruise condition, a multipoint aerodynamic optimization design aiming at minimum of a weighted drag for the supersonic cruise drag and transonic cruise drag is performed. The analyses of optimization results illustrate the specific drag reduction, the characteristics of pressure distributions for both the supersonic cruise condition and transonic cruise condition, and how the shock wave region and strength have improved on thesupersoniccruisecondition.Theoptimizationdesignthispaperpresentsrealizingthedragreductionisquitepracticaland effective, which is instructive in supersonic aircraft design.

Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes

Xiaolong Li,Yan Cai,Zuo Zhang,Jiyin Zhou 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.2

As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and astrocytic end feet. BBB impairment is a distinguishing and pathogenic factor in diabetic encephalopathy. Diabetes causes leakage of the BBB through downregulation of tight junction proteins, resulting in impaired functioning of endothelial cells, pericytes, astrocytes, microglia, nerve/glial antigen 2-glia, and oligodendrocytes. However, the temporal regulation, mechanisms of molecular and signaling pathways, and consequences of BBB impairment in diabetes are not well understood. Consequently, the efficacy of therapies diabetes targeting BBB leakage still lags behind the requirements. This review summarizes the recent research on the effects of diabetes on BBB composition and the potential roles of glial and vascular cells as therapeutic targets for BBB disruption in diabetic encephalopathy.

Mass trapping of apple leafminer, Phyllonorycter ringoniella with sex pheromone traps in apple orchards

Xiaolong Li,Shubao Geng,Hanjie Chen,정철의,Chunliang Wang,Hongtao Tu,Jinyong Zhang 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.1

The apple leafminer, Phyllonorycter ringoniella Matsumura (Lepidoptera: Gracillariidae), is an important insect pest of apple, with four to six generations a year in Korea, Japan, and China. The effect of mass trapping with sex pheromone traps on P. ringoniellawas investigated in apple orchards in 2015 in Yinchuan, China. Trap density treatments were 0, 75, 150, and 225/ha in the Control, T1, T2, and T3 orchard blocks, respectively. Average numbers of male catches permonitoring trapwere significantly lower in T2 and T3 treatments and highest in the control. Control efficiencies estimated fromthe leaf damage were 86.67±4.71, 97.23±3.93, and 100% in T1, T2, and T3, respectively. Significant within-tree migration of the moths from the lower part to the upper part was indicated by the shift of trap catches from lower (1–2 m high) to upper portions (3 m high) of the tree from early August. Mass trapping with sex pheromone traps can be one effective and environmentally friendly method to reduce the P. ringoniella populations in apple orchards. Trap density of 150/ha and hanging at 2 m height was recommended for growers to control and monitor its population, respectively

Coal dust exposure induces proliferation and migration of human bronchial epithelial cells

Li Amin,Zhang Yinci,Wang Ruikai,Xu Ruyue,Ma Yongfang,Song Li,Cao Weiya,Xiaolong Tang 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2

Background Coal dust exposure has caused a variety of lung diseases. In addition to genotoxicity and cytotoxicity, other biological changes caused by coal dust (CD) exposure need further study. Objective To observe the cellular transformation eff ects of CD exposure and explore its underlying molecular mechanism, human bronchial epithelial cells (BEAS-2B) were cultured with continuous CD exposure. Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay, colony formation assay, wound healing assay, next-generation sequencing (NGS) and western blotting were performed to observe the cell proliferation, migration, genomic transcription and pathological signaling pathways. Results We demonstrated that BEAS-2B cells with long-term chronic CD exposure show accelerated proliferation rate and enhanced migration ability, and have altered gene expression profi les and aberrant activation of EGFR/Raf/ERK and PI3K/ AKT/mTOR pathways. Conclusions The results indicate that chronic CD exposure could induce abnormal proliferation and migration of BEAS-2B cells, lead to the transformation potential of human bronchial epithelial cells.

Analysis of transient flow in a pump-turbine during the load rejection process

Xiaolong Fu,Deyou Li,Hongjie Wang,Guanghui Zhang,Zhenggui Li,Xianzhu Wei 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.5

The transient flow in pump-turbines during the load rejection process is very complex. However, few studies have been conducted on three-dimensional (3-D) numerical simulation. Hence, we simulated 3-D transient turbulent flow in a pump-turbine during the load rejection process using the calculation method of coupling the flow with the rotor motion of rigid body. To simulate the unsteady boundary conditions, the dynamic closing process of the guide vanes was simulated with the dynamic mesh technology. The boundary conditions at the spiral-casing inlet and the draft tube outlet were determined using the user defined functions (UDF) according to the experimental data. The numerical results of the rotational speeds show a good agreement with the experimental data. Then, the complex transient flow in the pump-turbine during the load rejection process was analyzed based on the numerical results. The results show that there are severe unsteady vortex flows in the vaneless space near the conditions under which the hydraulic torque on the runner equals to zero. When the pump-turbine operates into the maximum reverse discharge condition in the reverse pump operating process, the unsteady vortex flows in the vaneless space are instantaneously impacted into the region between the guide vanes and the stay vanes by the sudden reverse flows. The formation and development mechanism of the unsteady vortex flow in the vaneless space is associated with the distribution characteristic of the velocity field.

A DQN-based Two-Stage Scheduling Method for Real-Time Large-Scale EVs Charging Service

Tianyang Li,Yingnan Han,Xiaolong Li 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.3

With the rapid development of electric vehicles (EVs) industry, EV charging service becomes more and more important. Especially, in the case of suddenly drop of air temperature or open holidays that large-scale EVs seeking for charging devices (CDs) in a short time. In such scenario, inefficient EV charging scheduling algorithm might lead to a bad service quality, for example, long queueing times for EVs and unreasonable idling time for charging devices. To deal with this issue, this paper propose a Deep-Q-Network (DQN) based two-stage scheduling method for the large-scale EVs charging service. Fine-grained states with two delicate neural networks are proposed to optimize the sequencing of EVs and charging station (CS) arrangement. Two efficient algorithms are presented to obtain the optimal EVs charging scheduling scheme for large-scale EVs charging demand. Three case studies show the superiority of our proposal, in terms of a high service quality (minimized average queuing time of EVs and maximized charging performance at both EV and CS sides) and achieve greater scheduling efficiency. The code and data are available at THE CODE AND DATA.

CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin

Jingbo Ma,Xiaolong Xu,Chunjin Fu,Peng Xia,Ming Tian,Liuhai Zheng,Kun Chen,Xiaolian Liu,Yilei Li,Le Yu,Qinchang Zhu,Yangyang Yu,Rongrong Fan,Haibo Jiang,Zhifen Li,Chuanbin Yang,Chengchao Xu,Ying Long,J 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Background: It is highly desirable to develop new therapeutic strategies for gastric cancer given the low survival rate despite improvement in the past decades. Cadherin 17 (CDH17) is a membrane protein highly expressed in cancers of digestive system. Nanobody represents a novel antibody format for cancer targeted imaging and drug delivery. Nanobody targeting CHD17 as an imaging probe and a delivery vehicle of toxin remains to be explored for its theragnostic potential in gastric cancer. Methods: Naïve nanobody phage library was screened against CDH17 Domain 1-3 and identified nanobodies were extensively characterized with various assays. Nanobodies labeled with imaging probe were tested in vitro and in vivo for gastric cancer detection. A CDH17 Nanobody fused with toxin PE38 was evaluated for gastric cancer inhibition in vitro and in vivo. Results: Two nanobodies (A1 and E8) against human CDH17 with high affinity and high specificity were successfully obtained. These nanobodies could specifically bind to CDH17 protein and CDH17-positive gastric cancer cells. E8 nanobody as a lead was extensively determined for tumor imaging and drug delivery. It could efficiently co-localize with CDH17-positive gastric cancer cells in zebrafish embryos and rapidly visualize the tumor mass in mice within 3 h when conjugated with imaging dyes. E8 nanobody fused with toxin PE38 showed excellent anti-tumor effect and remarkably improved the mice survival in cell-derived (CDX) and patient-derived xenograft (PDX) models. The immunotoxin also enhanced the anti-tumor effect of clinical drug 5-Fluorouracil. Conclusions: The study presents a novel imaging and drug delivery strategy by targeting CDH17. CDH17 nanobodybased immunotoxin is potentially a promising therapeutic modality for clinical translation against gastric cancer.

Bacterial Community Structure and Function Shift in Rhizosphere Soil of Tobacco Plants Infected by Meloidogyne incognita

Wenjie Tong(Wenjie Tong),Junying Li(Junying Li),Wenfeng Cong(Wenfeng Cong),Cuiping Zhang(Cuiping Zhang),Zhaoli Xu(Zhaoli Xu),Xiaolong Chen(Xiaolong Chen),Min Yang(Min Yang),Jiani Liu(Jiani Liu),Lei Yu 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.6

Root-knot nematode disease is a widespread and catastrophic disease of tobacco. However, little is known about the relationship between rhizosphere bacterial community and root-knot nematode disease. This study used 16S rRNA gene sequencing and PICRUSt to assess bacterial community structure and function changes in rhizosphere soil from Meloidogyne incognita-infected tobacco plants. We studied the rhizosphere bacterial community structure of M. incognita-infected and uninfected tobacco plants through a paired comparison design in two regions of tobacco planting area, Yuxi and Jiuxiang of Yunnan Province, southwest China. According to the findings, M. incognita infection can alter the bacterial population in the soil. Uninfested soil has more operational taxonomic unit numbers and richness than infested soil. Principal Coordinate Analysis revealed clear separations between bacterial communities from infested and uninfested soil, indicating that different infection conditions resulted in significantly different bacterial community structures in soils. Firmicutes was prevalent in infested soil, but Chloroflexi and Acidobacteria were prevalent in uninfested soil. Sphingomonas, Streptomyces, and Bradyrhizobium were the dominant bacteria genera, and their abundance were higher in infested soil. By PICRUSt analysis, some metabolism-related functions and signal transduction functions of the rhizosphere bacterial community in the M. incognita infection-tobacco plants had a higher relative abundance than those uninfected. As a result, rhizosphere soils from tobacco plants infected with M. incognita showed considerable bacterial community structure and function alterations.

Design and Numerical Study of Hybrid Magnetic Source Disc-type Magnetorheological Valve

Xiaolong Yang,Yan Li,Youming Zhou,Shiying Zhou,Jiehong Zhu 한국자기학회 2023 Journal of Magnetics Vol.28 No.2

Magnetorheological valves are important components in hydraulic systems that provide precise position control. At present, the low-pressure drop performance of magnetorheological valves is the main problem limiting their application. To improve the pressure drop performance of magnetorheological valves, a hybrid magnetic source disc magnetorheological valve is proposed. The magnetic pressure drop model and viscous pressure drop model of the hybrid magnet source disc type magnetorheological valve based on the Bingham model are Derived. Magnetic field distributions in the damping channel of the hybrid magnet source disc type magnetorheological valve are obtained by using ANSYS finite element analysis software. The mathematical model of the relationship between pressure drop and magnetic induction intensity was established using Matlab software, and the effects of parameters such as effective current, axial damping gap, radial damping gap, and coil width on the pressure drop performance of disc-type magnetorheological valves with hybrid magnetic sources were numerically analyzed. The results show that the pressure drop of the disc magnetorheological valve with a hybrid magnetic source can reach 10.9935 MPa at the current I=3A, axial damping gap ga=1 mm, and radial damping gap gr=1.5 mm. Compared with the conventional disc magnetorheological valve, the pressure drop performance of the hybrid magnetic source disc magnetorheological valve is improved by 28 %, which provides ideas on how to improve the pressure drop performance of the magnetorheological valve.

Rapid recycling of waste salt core materials in foundry industry using fractional crystallization

Xiaolong Gong,Xiongjie Xiao,Qianqian Li,Jianwei Zhao,Zitian Fan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

The water-soluble composite salt core materials have attracted increasing interest in the manufacture ofhollow castings with complex structures due to their high strength and excellent water solubility, whilethe treatment of waste brine generated from the salt core represents a major pain point for its large-scaleapplication. To change the above situation, the recycling technology of the waste brine from compositesalt core materials was developed using cooling crystallization combined with solvent-driven crystallization. The influences of dissolution temperature and solvent content on the recovery rate of the compositesalt core materials, including inorganic salt and fortifier, were investigated. In addition, the mechanicalproperties and microstructures of the composite salt core with multiple cycles were compared and analyzed. The results show that the fortifier material of corundum powder exhibits excellent chemical andthermal stability with a 100% recovery rate, and the recovery rate of inorganic salt material can reach79.31% with a 40 C dissolution temperature and a 1.0 mass ratio of methanol to brine. The microstructures,phase compositions and mechanical properties of the multi-recycled composite salt core have notchanged, demonstrating that the recycling of the water-soluble composite salt core is feasible, and favoringthe green development of the foundry industry.