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Effects of a chitosan nanoparticles encapsulation on the properties of litchi polyphenols
Xingan Cheng,Qiwen Zou,Hanhui Zhang,Jianwei Zhu,Murtaza Hasan,Fangyun Dong,Xin Liu,Junjie Li,Yuehua Wu,Xiaojing Lv,Keqiang Wang,Xiangling Deng,Zhanmei Liu,Xuhong Jiang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.13
Litchi polyphenols have very specific biological activities. Nevertheless, the low and inconsistent oral bioavailability and instability hinder the further application of litchi polyphenols in food systems. This work prepared litchi polyphenols loaded chitosan nanoparticles (LP-CSNPs) by ionic gelation method to enhance the encapsulation on the properties of litchi polyphenols. The optimum conditions of formation via single factors and the Box–Behnken design were chitosan (CS) concentration 1.065 mg/mL, sodium tripolyphosphate (TPP) concentration 0.975 mg/mL, and the mass ratios of polyphenols and CS 1:1 with encapsulation efficiency (EE%) of 45.53%. LP-CSNPs presented the nanosized range of particle size (mean 170 nm), excellent polydispersity index (PDI) (0.156 ± 0.025), and zeta potential values (+ 35.44 ± 0.59). The in vitro release in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 6.8) during 100 h was 58.34% and 81.68%, respectively. LP-CSNPs could effectively improve the storage stability and had great antibacterial activity compared with unencapsulated litchi polyphenols.
Xiaoyu Chen,Jiagang Wu,Xiaojing Cheng,Bo Wu,Wenjuan Wu,Dingquan Xiao,Jianguo Zhu 한국물리학회 2012 Current Applied Physics Vol.12 No.3
[Li0.03(K0.48Na0.52)0.97](Nb0.97Sb0.03)O3-(Ba0.85Ca0.15)(Ti0.90Zr0.10)O3 [(1-x)LKNNS-xBCTZ] lead-free piezoelectric ceramics were prepared by the conventional solid state method, and effects of BCTZ content on the piezoelectric properties of LKNNS ceramics were mainly investigated. A stable solid solution has been formed between LKNNS and BCTZ, and a morphotropic phase boundary of (1-x)LKNNS-xBCTZ ceramics is identified in the range of 0 < x ≤ 0.02. The Curie temperature of (1-x)LKNNS-xBCTZ ceramics decreases with increasing BCTZ content. A higher εr value and a lower tan d value are demonstrated for the (1-x)LKNNS-xBCTZ ceramic with x = 0.02. The (1-x)LKNNS-xBCTZ ceramic with x = 0.02 has an enhanced electrical behavior of d33w237 pC/N, kpw 48.6%, 3 rw1451, tan d w0.037, and Tcw335 ℃. As a result, (1-x)LKNNS-xBCTZ ceramics are promising candidate materials for the field of lead-free piezoelectric materials.
Xiaopeng Wang,Jia-gang Wu,Ting Zheng,Xiaojing Cheng,Binyu Zhang,Dingquan Xiao,Jian-guo Zhu 한국물리학회 2014 Current Applied Physics Vol.14 No.5
In this work, 0.96(K0.48Na0.52)1xLixNbO3e0.04Bi0.5Na0.5ZrO3 lead-free piezoceramics were prepared using the conventional solid state reaction method in order to attain both a high TC and an enhanced d33. The effect of Li content on their phase structure, electrical properties, and stability was systematically investigated. These results indicate that adding Li could result in the increase of TC and the decrease of TOeT. Here we obtain the ceramics with an orthogonaletetragonal phase boundary in the composition of x ¼ 0.02, and then enhanced piezoelectric properties and a high Curie temperature (i.e., d33 w 255 pC/N, kp w 41%, and TC w 360 C) were observed, showing the realization of our objective. In addition, a good stability of piezoelectric and ferroelectric properties has been shown in such a material system.
Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity
Xiang Yang,Zhang Xiaoshun,Tian Zhiling,Cheng Yibin,Liu Ningguo,Meng Xiaojing 한국독성학회 2023 Toxicological Research Vol.39 No.4
The production of industrial solvents and adhesives often utilizes 1,2-dichloroethane (1,2-DCE), a highly toxic halogenated hydrocarbon compound. Occupational 1,2-DCE poisoning occurs frequently and is a public health concern. Exposure to 1,2-DCE can damage the brain, liver, and kidneys. The main and most severe damage caused by exposure to 1,2-DCE is to the nervous system, especially the central nervous system. Current research on 1,2-DCE mainly focuses on the mechanism of brain edema. Several possible mechanisms of 1,2-DCE neurotoxicity have been proposed, including oxidative stress, calcium overload, blood–brain barrier damage, and neurotransmitter changes. This article reviews the research progress on 1,2-DCE neurotoxicity and the mechanism behind it to provide a scientific basis for the prevention and treatment of 1,2-DCE poisoning.
Binyu Zhang,Jiagang Wu,Xiaopeng Wang,Xiaojing Cheng,Jianguo Zhu,Dingquan Xiao 한국물리학회 2013 Current Applied Physics Vol.13 No.8
The BaZrO3 and Ta have been used to improve piezoelectric properties of (K, Na)NbO3 ceramics by the construction of the phase boundary, and (1 x)K0.48Na0.52(Nb0.95Ta0.05)O3exBaZrO3 [(1 x)KNNTexBZ]ceramics were prepared by the conventional solid-state method. The effect of BZ content on their phase structure, microstructure, and electrical properties has been investigated. A rhombohedral and orthorhombic phase coexistence has been observed in the compositional range of 0.05 x 0.07. With increasing BZ content, their Tc and Toet values decrease gradually, and the dielectric constant increases linearly. The ceramic with x ¼ 0.06 exhibits an enhanced piezoelectric behavior (d33 w 193 pC/N and kp w 32.6%) because of the coexistence of two phases together with a dense microstructure. As a result,the construction of a rhombohedral and orthorhombic phase boundary is an effective way to improve the piezoelectric properties of KNN-based ceramics.
TsMIP6 enhances the tolerance of transgenic rice to salt stress and interacts with target proteins
Linlin Sun,Guohong Yu,Xiaori Han,Shichao Xin,Xiaojing Qiang,Linlin Jiang,Shuhui Zhang,Xian-guo Cheng 한국식물학회 2015 Journal of Plant Biology Vol.58 No.5
Aquaporins (AQPs), a large family of channel proteins in plants, play an important role in regulating the balance of osmotic potential in cells. We isolated an AQP gene, TsMIP6, from the halophyte Thellungiella salsuginea and functionally characterized it in transgenic rice (Oryza sativa). This gene belongs to a subfamily of tonoplast intrinsic proteins and is localized at the plasma membrane. Real-time PCR showed that expression of TsMIP6 in shoots or roots of T. salsuginea was markedly induced by salinity, whereas its ectopic expression in ‘Kitaake’ lines of rice significantly increased plant tolerance to salt stress. Physiological data suggested that TsMIP6 is involved in regulating ion homeostasis and water channel activity in salt-stressed transgenic rice. Heterologous expression analysis indicated that TsMIP6 specifically interacts with a member of the glycoside hydrolase family 64 protein #617 in yeast cells. This suggests that the relationship between TsMIP6 and #617 has a crucial role in mediating osmotic balance in plant cells. Moreover, TsMIP6 might help to modulate the transport of some neutral molecules and may function through a pathway regulating solute equilibrium to maintain osmotic potential.
Tian Guozhong,Zhang Li,Li Machao,Wang Xiaolei,Zheng Yuhong,Li Xiaojing,Huang Cheng,Li Xuechun,Xie Yongqiong,Xu Li,Ren Hongyu,Shao Zhujun 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
Two hundred and seventy-three Haemophilus influenzae strains isolated from pediatric pneumonia patients in China were studied. We used Multilocus Sequence Typing (MLST) to analyze genotypic characteristics. All strains were biotyped and serotyped. Relatedness and patterns of genes among isolates were determined by the analysis of MLST and eBURST. H. influenzae primarily causes acute pneumonia in children under 1 year old. Nontypeable H. influenzae was responsible for most cases of pediatric pneumonia. All 273 strains were classified into eight biotypes. They mostly belonged to the I, II, and III biotypes (17.6%, 43.6%, and 22.7%, respectively). 62 strains (22.7%) produced β-lactamase. We found 28 novel alleles. Fifty different STs were found by MLST, of which 39 were novel. These were ST477 through ST508 and ST521 through ST527. Group 17 and predicted founders 503 were new groups in this study. No STs correlated with strains from Korea, which is adjacent to China. The H. influenzae strains from China appeared to have heterogeneous ST types patterns which may be the reason no outbreaks or epidemics of H. influenzae infections have occurred in Chengdu city, Sichuan, China.
HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
( Xueliang Yang ),( Ming Han ),( Shunai Liu ),( Xiaoxue Yuan ),( Xiaojing Liu ),( Shenghu Feng ),( Li Zhou ),( Yaru Li ),( Hongping Lu ),( Jun Cheng ),( Shumei Lin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.1
Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the -139- to +359-bp region). Moreover, we observed that HCBP6 interacted with C/EBPβ-binding site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the C/EBPβ-binding site in the SREBP1c promoter. [BMB Reports 2018; 51(1): 33-38]