The Transition of Learning Mode with NPD in Chinese Firms

Xiaobo Wu,Wei Dou 피터드러커 소사이어티 2009 창조와 혁신 Vol.2 No.1

Organizational learning is very important for innovative search performance in NPD activities. Most of Chinese firms started product innovation from foreign mature technology acquisition to adoption and finally innovated with own emerging technology. In this process, dominant learning mode should change from exploitation to exploration. This article provided a narrative of learning mode transition process and proposed propositions about this transition: 1)from knowledge exploitation to exploration is a process across innovation cycle, which can generate continuous innovation 2) exploitation is the dominant mode after the external technology acquisition and exploration is the dominant mode after own emerging tech R&D; 3) SBU management and R&D collaboration will be introduced in the period from exploitation to exploration 4) the time of product search across exploitation and exploration is much longer than the time of product search in one learning mode. Transition of learning mode is very important for innovative firms’ continuous innovation in developing countries like China and Korea.

Design and Realization of Intelligent Question Answering System Based on Ontology

Xiaobo Wang,Wei Cui,Weicun Zhang 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

This paper presents an intelligent question answering system based on ontology, which adopts Chinese natural language processing technology to generate concise and appropriate answers to the student’"s questions. The accuracy and intelligence of the system are guaranteed through ontology based knowledge description, word segmentation, and question pattern recognition.

BiFeO3 Thickness Dependence of the Exchange Bias in Polycrystalline BiFeO3/NiFe Bilayers

Xiaobo Xue,Biao You,Wenbing Rui,Wei Zhang,Jun Du,Xueyong Yuan,Qingyu Xu 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

A clear exchange bias has been observed at room temperature in a series of BiFeO3(t)/NiFe(3.6nm) bilayers, in which the BiFeO3 layers are single-phase polycrystalline with t varied from 8 nmto 240 nm. With increasing t, both the exchange bias field (HE) and the coercivity (HC) increasesharply and approach maxima when t is about 40 nm, which is close to one half the spin cycloidalmodulation period (64 nm) of the bulk BiFeO3 material. The oscillatory variations of HE and HCwith the BiFeO3 layer thickness suggest that the cycloidal spin structure may exist in polycrystallineBiFeO3 thin films. The angular dependence of the exchange bias exhibits collinear unidirectionaland uniaxial anisotropies in the present BiFeO3/NiFe bilayers.

Morphology and transcriptome differences between the haploid and diploid drones of Apis cerana

Wei-Yu Yan,Hai-Yan Gan,Shu-Yun Li,Jing-Hua Hu,ZilongWang,Xiaobo Wu,Zhi Jiang Zeng 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4

In general, drone honey bees are haploid and develop from unfertilized eggs. However, a diploid drone can arise in an inbred colony. In this study, the morphological characteristics and gene expression profile of the haploid and diploid drones of Apis cerana were analyzed to reveal the differences between them. The ploidy level of the droneswas identified by FlowCytometry (FCM). The characters of the forewings,wetweight of reproductive organs and of newly emerged drones, were investigated. Then, a high throughput transcriptomic analysis was performed using RNA-seq in diploid and haploid drones. The results showed that the wet weight and reproductive organs of diploid droneswere significantly lighter than those of haploid drones. About 201 million high-quality reads were generated from RNA-seq, and 75.99–78.12% of the data weremapped to Apis cerana genome. 360 genes were differentially expressed between diploid and haploid drone, with 152 up-regulated and 208 downregulated in the diploid drones. Functional analysis identified that these genes were significantly enriched in 28 pathways. Comparative transcriptomic analysis detected several differentially expressed genes, which lay a foundation for future studies on molecular mechanisms underlying biology difference in drones in Apis cerana.

The Simulation Analysis On Concrete Pump Truck Arm Device

ZhanGuo Wei,Zhuoxian Zhou,XiaoBo Wang 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.6

Reinforcing effect of Lewis acid–base interaction on the high-temperature colloidal stability and tribological performance of lubricating grease

Nan Xu,Wei-Min Liu,Ming Zhang,Xiaobo Wang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-

The high-temperature tribological performance of lithium grease is enhanced by addition of Lewis acidborate ester, which could interact with Lewis base RCO2of lithium 12-hydroxystearate (LHS, constitutethe thickenerfiber network of lithium grease) to form a Lewis acid–base complex. Important detailsabout the Lewis acid–base complex and its reinforcing effect on the tribological performance areelucidated by means of SRV oscillating friction and wear tester (SRV), Fourier transformation infraredspectroscopy (FTIR), TGA–DSC, and rheological methods. The experimental results strongly suggest thatthere is a Lewis base–acid interaction between the boron atom of borate ester or boric acid and theoxygen atom of RCO2. Lewis acid centers can serve as second-level linking points to reinforce thestrength of the thickenerfiber network and further improve the colloidal stability of lubricating grease. Compared with pure LHS, the Lewis acid–base complex displays higher thermal stability, allowinglithium grease to be applied to higher temperature. Because of the enhancement of thermal stability andcolloidal stability,film-forming property under high temperature can be greatly improved, resulting in>15% friction and >95% wear reductions.

One-step solvothermal synthesis of poly(arylene ether nitrile) decorated magnetic composite for methylene blue adsorption from aqueous solution

Zhou Xuefei,Miao Wei,Cheng Wenxi,Lin Haowei,Lin Haowei,Zheng Hongjuan,Cheng Qiaohuan,Wang Renjie,Yao Chenxue,Liu Xiaobo 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.6

A series of poly(arylene ether nitrile) containing versatile carboxyl and sulfonic groups (CSPEN) were magnetically functionalized by ferroferric oxide (Fe3O4), and the obtained magnetic adsorbents (Fe3O4/CSPEN) were used to remove methylene blue (MB) dye from aqueous solution. The systematical characterizations that including scanning electron microscope (SEM), X-ray powder diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), Fourier transform infrared (FTIR) certified that the Fe3O4/CSPEN possessed versatile functional groups and magnetic separation properties. The batch adsorption studies revealed that the Fe3O4/CSPEN not only displayed high selective adsorption ability for cationic MB in the presence of anionic MO, but also exhibited a removal efficiency as high as 98.2%. Besides, the adsorption kinetics and isotherm matched well with pseudo-second-order model and Langmuir model, respectively, and the maximum adsorption capacity of Fe3O4/CSPEN for MB was 92.029 mg/g. The FTIR and Brunauer-Emmett-Teller (BET) analyses confirmed that the outstanding adsorption capacity of Fe3O4/CSPEN was attributed to their own microporous structure and the electrostatic interaction with MB. Therefore, the modified magnetic adsorbent can be used to selectively remove cationic dye from aqueous solution.

Attrition behavior of fine particles in a fluidized bed with bimodal particles: Influence of particle density and size ratio

Zeeshan Nawaz,Tang Xiaoping,Xiaobo Wei,Fei Wei 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.5

To process the solid particulates in fluidized bed and slurry phase reactors, attrition is an inevitable consequence and is therefore one of the preliminary parameters for the catalyst design. In this paper, the mechanical degradation propensity of the zeolite catalysts (particles) was investigated in a bimodal distribution environment using a Gas Jet Attrition - ASTM standard fluidized bed test (D-5757). The experimentation was conducted in order to explore parameters affecting attrition phenomena in a bimodal fluidization. In a bimodal fluidization system, two different types of particles are co-fluidized isothermally. The air jet attrition index (AJI) showed distinct increases in the attrition rate of small particles in a bimodal fluidization environment under standard operating conditions, in comparison with single particle. A series of experiments were conducted using particles of various sizes, with large particles of different densities and sizes. Experimental results suggest that the relative density and particle size ratio have a significant influence on attrition behavior during co-fluidization. Therefore a generalized relationship has been drawn using Gwyn constants;those defined material properties of small particles. Moreover, distinct attrition incremental phenomenon was observed during co-fluidization owing to the change in collision pattern and impact, which was associated with relative particle density and size ratios.

Suppression of Aurora-A oncogenic potential by c-Myc downregulation

Shangbin Yang,Shun He,Xiaobo Zhou,Mei Liu,Hongxia Zhu,Yihua Wang,Wei Zhang,Shuang Yan,Lanping Quan,Jingfeng Bai,Ningzhi Xu 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.11

The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together,our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.

Identification of Medium-Length Antineurofilament Autoantibodies in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Shisi Wang,Cancan Xu,Xiaobo Sun,Yifan Zhou,Yaqing Shu,Shangzhou Xia,Zhengqi Lu,Wei Qiu,Xiaofen Zhong,Lisheng Peng 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.3

Background and Purpose Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe central nervous system disorder mediated by NMDAR antibodies that damages neurons. We investigated the correlation between cytoskeletal autoantibodies and the clinical severity in patients with anti-NMDAR encephalitis. Methods Non-NMDAR autoantibodies were identified by screening matched cerebrospinal fluid (CSF) and the serum samples of 45 consecutive patients with anti-NMDAR encephalitis and 60 healthy individuals against N-methyl-D-aspartate receptor 1-transfected and nontransfected human embryonic kidney 293T cells. Immunocytochemistry was performed to assess antibody binding in rat brain sections and primary cortical neurons. Cell-based assays and Western blotting were applied to identify autoantibodies targeting medium neurofilaments (NFMs). We compared clinical characteristics between patients with NMDAR encephalitis who were positive and negative for anti-NFM-autoantibodies. Results Anti-NFM autoantibodies were detected in both the serum and CSF in one patient (2%) and in the serum only in six patients (13%). No antibodies were detected in the serum of healthy controls (7/45 vs. 0/60, p=0.0016). Four of the seven patients with anti-NFM autoantibodies in serum were children (57%), and three (43%) had abnormalities in brain magnetic resonance imaging. These patients responded well to immunotherapy, and either no significant or only mild disability was observed at the last follow-up. Anti-NMDAR encephalitis did not differ with the presence of anti-NFM autoantibodies. Conclusions Anti-NFM autoantibodies may be present in patients with anti-NMDAR encephalitis, indicating underlying neuronal damage. A large cohort study is warranted to investigate the clinical differences between patients with NMDAR encephalitis according to their anti- NFM antibody status.