Prediction of NOx Emission in Lean Premixed Gas Turbine Combustor Using a CFD - CRN Approach

Xiang Yu Hou,Seung Han Kim,Truc Huu Nguyen,Jung Kyu Park,Seung Chai Jung,Si Won Yang 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11

This works developed chemical reactor network approach (CRN) with a short time and precise result to predict NOx emissions from a gas turbine rapidly and precisely to amend the defect of the computed time and precision with traditional CFD method for combustor designs. The chemical reactor network with 4 PSRs and 2 PFRs is developed here based on the computational fluid dynamics (CFD). The predictions of exhaust emission in this CRN approach were carried out by using CHEMKIN code and full GRI 3.0 chemical kinetic mechanism. The model combustor tests were conducted at different equivalence ratios. The predicted temperature and NOx emission results closely matched the experimental data. Also NO formation pathway analysis was carried out for the deep understanding of the relative contribution of four NO formation mechanism.

MQL 알루미늄 선삭가공의 표면거칠기

후상우(Xiang-Yu Hou),정종윤(Jong-Yun Jung) 한국산업경영시스템학회 2011 한국산업경영시스템학회지 Vol.34 No.1

기계가공은 절삭 부위의 냉각작용과 윤활작용을 위해 절삭유를 많이 소모한다. 절삭유는 염소계의 극압첨가제 등이 함유되어 있어 작업자들에게 유독할 뿐만 아니라 대기의 오염을 초래하여 청정생산을 저해하게 되므로 이런 전통적인 방법은 작업자의 직업병으로부터 보호와 환경보호를 위하여 새로운 가공방법으로 변경되어야만 한다. MQL기계가공 방법은 절삭유를 아주 소량 소모하므로 청정생산을 위한 대안으로 떠오르고 있지만 많은 작업자들이 이에 대한 기술적인 확신이 부족하여 이 방식의 사용을 주저하고 있다. 본 연구는 MQL 가공 방식에서 가공의 특성을 파악하여 표면거칠기에 영향을 미치는 인자와 범위를 찾고자 다양한 실험을 계획하고 그 결과를 분석하였다. 실험의 계획에서는 각 가공의 특성을 잘 나타낼 수 있는 인자와 수준을 선정하고, 다양한 상황의 결과를 분석하여 MQL 가공의 특성과 최적의 가공조건을 도출하였다. 본 연구의 실험 및 분석의 결과로서, 절삭 파라미터와 그의 수준이 가공특성을 잘 반영할 수 있도록 적절히 선택된다면 MQL 기계가공은 표면거칠기 향상 및 원가절감이나 환경보호 측면에서 절삭유 윤활방식을 대체하는 green manufacturing을 위한 대안이 될 수 있음을 보였다.

Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate

Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.

Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis

Ding, Xiang,Cui, Feng-Mei,Xu, Song-Tao,Pu, Jin-Xian,Huang, Yu-Hua,Zhang, Jiang-Lei,Wei, Xue-Dong,Hou, Jian-Quan,Yan, Chun-Yin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Background: Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 on estrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results. Methods: A meta-analysis was here conducted to systematically evaluate the relationship of these two variants with prostate cancer susceptibility. Results: For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with a pooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but not statistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). Compared to the homozygous TT carriers, the allele C carriers showed a 31% increased risk for prostate cancer (pooled OR = 1.31, 95% CI = 1.06-1.63). No significant association between the rs2234693 and prostate cancer risk was found with the pooled OR of 1.15 (95% CI = 0.97-1.39, T/C and C/C vs. T/T) under the dominant genetic model. Compared to the homozygote T/T carriers, the heterozygous T/C carriers did not show any significantly different risk of prostate cancer (pooled OR = 1.13, 95% CI = 0.94-1.36) and the homozygous C/C carriers also did not show a significant change for prostate cancer risk compared to the wide-type T/T carriers (pooled OR = 1.26, 95% CI = 0.98-1.62). Conclusion: These data suggested that variant rs9340799, but not rs2234693, on ESR1 confers an elevated risk of prostate cancer.

Structural Deformation Sensing Based on Distributed Optical Fiber Monitoring Technology and Neural Network

Gong-Yu Hou,Zi-Xiang Li,Kai-Di Wang,Jin-Xin Hu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11

Structural deformation monitoring is vital to the safety of concrete structures. However, the distributed deformation of structures cannot be easily obtained using existing monitoring methods in civil engineering. To this end, this paper proposes a method to estimate the continuous deformation of concrete beams by utilizing the distributed optical fiber monitoring technology. In this method, optical fibers and a total station are used to obtain the strain and deformation distribution curves of a concrete beam, respectively. Subsequently, these curves are inputted to a back propagation network as training samples to learn their relationships. The results show that the deformation value of trained neural network is very close to that of the total station, with a maximum error of only 2.7% (0.3 mm). The linear regression analysis shows a goodness of fit R2 greater than 0.98, which confirms the reliability of the simulations results.

Relation between the local structure and solid solubility of the layered material LiMO2 (M=Co, Ni, Fe) in Li2MnO3

Chen Hou,Xiang Xiao,Yi-Ran Xing,Le-Le Yu,Yong-Heng Si,Han Lu,Yu-Juan Zhao 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.1

Although low solid solubility and activity of LiFeO2in xLi2MnO3·(1–x)LiFeO2 limit its practical application, it still has thepotential to become a new-generation cathode material without cobalt or nickel for Li-ion batteries. In order to understand theeffects of the local structures of different LiMO2(M = Co, Ni, Fe) layered materials on their solid solubility in Li2MnO3,partialdensities of states are calculated to determine the Jahn–Teller distortion in the layered cathode material, and the first-principlescalculation method based on density functional theory is used to optimize and compare the local structures of LiCoO2,LiNiO2,LiFeO2,LiMnO2,and Li2MnO3. The degrees of distortion of the transition metal–oxygen (M–O) and lithium–oxygen (Li–O)octahedra in the crystal structure of the material are evaluated. It is clear that the solid solubility of layered materials is relatedto the bond lengths and degrees of distortion of the M–O and Li–O octahedra. Among them, the similar bond length of LiNiO2and Li2MnO3and the high distortion of NiO6enhance the solid solubility of LiNiO2in Li2MnO3. Owing to the absence ofJahn–Teller distortion in LiFeO2and LiCoO2,the FeO6and CoO6octahedra are slightly distorted, thereby decreasing thesolid solubility of LiMO2(M = Fe, Co) in Li2MnO3. Understanding the relation between intra-octahedral distortion and solidsolubility provides simple and efficient evidence for comparing the solid solubilities of different LiMO2layered materials inthe Li2MnO3of Li-rich cathode materials. This study can be used as a reference for component design in Li-rich materials.

Genetic Diversity of a Chinese Native Chicken Breed, Bian Chicken, Based on Twenty-nine Microsatellite Markers

Ding, Fu-Xiang,Zhang, Gen-Xi,Wang, Jin-Yu,Li, Yuan,Zhang, Li-Jun,Wei, Yue,Wang, Hui-Hua,Zhang, Li,Hou, Qi-Rui Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.2

The level of genetic differentiation and genetic structure in a Chinese native chicken breed, Bian chicken, and two controlled chicken populations (Jinghai chicken and Youxi chicken in China) were analysed based on 29 microsatellite markers. A total of 166 distinct alleles were observed across the 3 breeds, and 32 of these alleles (19.3%) were unique to only 1 breed. Bian chicken carried the largest number of private alleles at 15 (46.9%), followed by the Jinghai chicken with 12 private alleles (37.5%). The average polymorphism information content (0.5168) and the average expected heterozygote frequency (0.5750) of the Bian chicken were the highest, and those of the Jinghai chicken were 0.4915 and 0.5505, respectively, which were the lowest. Among 29 microsatellite loci, there were 15 highly informative loci in Bian chicken, and the other 14 were reasonably informative loci. The highly informative loci in Jinghai chicken and Youxi chicken were 17 and 14 respectively. Significant deviations from the Hardy-Weinberg equilibrium were observed at several locus-breed combinations, showing a deficit of heterozygotes in many cases. As a whole, genetic differentiation among the breeds estimated by the fixation index (Fst) were at 6.7% (p<0.001). The heterozygote deficit within population (Fis) was 22.2% (p<0.001), with the highest (0.249) in Bian chicken and lowest (0.159) in Youxi chicken. These results serve as an initial step in the plan for genetic characterization and conservation of the Chinese chicken genetic resource of Bian, as well as Jinghai and Youxi chickens.

Spermatozoa cryopreservation alters pronuclear fomation and zygotic DNA demethylation in mice

Gong-Xue Jia,Xiang-Wei Fu,Ke-Ren Cheng,Ming-Xing Yue,Bao-Yu Jia,Yun-Peng Hou,Shi-en Zhu 한국동물생명공학회(구 한국동물번식학회) 2014 한국동물번식학회 한중일 심포지엄 Vol.2014 No.1

Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

Jia Hu,Li Liu,Xiang Chen,Ping Chen,Guang-li Yang,Wen-li Hou,Ming-hai Tang,Fan Zhang,Xian-huo Wang,Xia Zhao,Yu-quan Wei,Li-juan Chen 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.6

Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in combination with chemotherapeutic agents in several mouse xenograft models. Our goal was to investigate the radiosensitization effect of honokiol on lung carcinoma. The radiosensitization effect of liposomal honokiol in Lewis lung carcinoma cells (LL/2) was analyzed using an in vitro clonogenic survival assay. For an in vivo study, Lewis lung carcinoma-bearing C57BL/6 mice were treated with either liposomal honokiol at 25 mg/kg or 5 Gy of single tumor radiation, or a combination of both over 12 days of treatment. The tumor growth delay and the survival time were evaluated. In addition, histological analysis of tumor sections was performed to examine changes by detecting the microvessel density and apoptosis in tumor tissues. In the clonogenic survival assay, LL/2 cells treated with IC50 Lipo-HNK for 24 h showed a radiation enhancement ratio of 1.9. After 12 days of combination treatment, the tumor volume decreased 78% and produced an anti-tumor activity 1.3-fold greater than a predicted additive effect of honokiol and radiation alone. This combination treatment also caused an 8.7 day delay in tumor growth. The cell cycle distribution and histological analysis demonstrated that liposomal honokiol has an anti-tumor effect via inducing apoptosis and inhibiting angiogenesis. Liposomal honokiol can enhance tumor cell radiosensitivity in vitro and in vivo, indicating that radiotherapy combined with liposomal honokiol can lead to greater anti-tumor efficacy. Honokiol is an active compound purified from magnolia that has been shown to induce cell differentiation, apoptosis, and anti-angiogenesis effects, as well as an enhancement in tumor growth delay in combination with chemotherapeutic agents in several mouse xenograft models. Our goal was to investigate the radiosensitization effect of honokiol on lung carcinoma. The radiosensitization effect of liposomal honokiol in Lewis lung carcinoma cells (LL/2) was analyzed using an in vitro clonogenic survival assay. For an in vivo study, Lewis lung carcinoma-bearing C57BL/6 mice were treated with either liposomal honokiol at 25 mg/kg or 5 Gy of single tumor radiation, or a combination of both over 12 days of treatment. The tumor growth delay and the survival time were evaluated. In addition, histological analysis of tumor sections was performed to examine changes by detecting the microvessel density and apoptosis in tumor tissues. In the clonogenic survival assay, LL/2 cells treated with IC50 Lipo-HNK for 24 h showed a radiation enhancement ratio of 1.9. After 12 days of combination treatment, the tumor volume decreased 78% and produced an anti-tumor activity 1.3-fold greater than a predicted additive effect of honokiol and radiation alone. This combination treatment also caused an 8.7 day delay in tumor growth. The cell cycle distribution and histological analysis demonstrated that liposomal honokiol has an anti-tumor effect via inducing apoptosis and inhibiting angiogenesis. Liposomal honokiol can enhance tumor cell radiosensitivity in vitro and in vivo, indicating that radiotherapy combined with liposomal honokiol can lead to greater anti-tumor efficacy.

Distinct bacterial community of a solid-state fermented Chinese traditional food huase sufu revealed by high-throughput sequencing

Zhang Zhen-dong,Wang Yu-rong,Xiang Fan-shu,Hou Qiang-chuan,Guo Zhuang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.9

Sufu is a common solid-state traditional fermentedfood made from soybean. Huase sufu is a typicaltype found in several provinces of China, especially inHubei. However, little is known about the bacterial community. High-throughput sequencing technology revealedthat the dominant taxa at phylum level were: Firmicutes,Proteobacteria and Bacteroides, and at the genus levelwere: Pseudomonas, Lactococcus, Acinetobacter, etc. Additionally, LEfSe revealed that compared with the bacterialcommunity of red sufu and white sufu, the biomarkergenera for both huase sufu were Enterococcus, and Myroides. Moreover, there were twenty-eight hubs for thehuase sufu samples, and four of them were dominantgenera: Citrobacter, Myroides, Vagococcus, and Enterococcus. These results provide a new insight into ourunderstanding of the bacterial diversity of huase sufu, andwill facilitate the isolation, screening, and developmentpotential bacterial strains for production of huase sufu.