http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes
Wu Long-Fei,Zhang Qin,Mo Xing-Bo,Lin Jun,Wu Yang-Lin,Lu Xin,He Pei,Wu Jian,Guo Yu-Fan,Wang Ming-Jun,Ren Wen-Yan,Deng Hong-Wen,Lei Shu-Feng,Deng Fei-Yan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Rheumatoid arthritis (RA) is an autoimmune disease characterized by infiltration of immune cells in the synovium. However, the crosstalk of immune cells and synovial fibroblasts is still largely unknown. Here, global miRNA screening in plasma exosomes was carried out with a custom microarray (RA patients vs. healthy controls = 9:9). A total of 14 exosomal miRNAs were abnormally expressed in the RA patients. Then, downregulated expression of exosomal miR-204-5p was confirmed in both the replication (RA patients vs. healthy controls = 30:30) and validation groups (RA patients vs. healthy controls = 56:60). Similar to the findings obtained in humans, a decreased abundance of exosomal miR-204-5p was observed in mice with collagen-induced arthritis (CIA). Furthermore, Spearman correlation analysis indicated that plasma exosomal miR-204-5p expression was inversely correlated with disease parameters of RA patients, such as rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein. In vitro, our data showed that human T lymphocytes released exosomes containing large amounts of miR-204-5p, which can be transferred into synovial fibroblasts, inhibiting cell proliferation. Overexpression of miR-204-5p in synovial fibroblasts suppressed synovial fibroblast activation by targeting genes related to cell proliferation and invasion. In vivo assays found that administration of lentiviruses expressing miR-204-5p markedly alleviated the disease progression of the mice with CIA. Collectively, this study identified a novel RA-associated plasma exosomal miRNA-204-5p that mediates the communication between immune cells and synovial fibroblasts and can be used as a potential biomarker for RA diagnosis and treatment.
Wu, Bo,Kwon, Sung Won,Hwang, Gwi Seo,Park, Jeong Hill WILEY‐VCH Verlag 2012 Helvetica chimica acta Vol.95 No.9
<P><B>Abstract</B></P><P>Eight new and eight known 2‐(2‐phenylethyl)chromone (=2‐(2‐phenylethyl)‐4<I>H</I>‐1‐benzopyran‐4‐one) derivatives, <I>i.e.</I>, <B>1</B>–<B>8</B> and <B>9</B>–<B>16</B>, respectively, together with the two known sesquiterpenoids <B>17</B> and <B>18</B> were isolated from a 70% MeOH extract of <I>Aquilaria malaccensis</I> (AM) agarwood chips. Their structures were determined based on extensive spectroscopic analysis and comparison with reported data.</P>
Bo Wu,Rui Wang,Guo Zheng,Cun Zhou 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
In this article, phosphate modified epoxy resin (PAEK) and polyethylene oxide (PEO) were used as the mainmonomers to fabricate a composite sizing agent (TPP) for carbon fiber (CF) surface treatment. The effects of TPP sizing onthe surface morphology, activity and wettability of CF were studied by FE-SEM, XPS and contact angle. In addition, frictioncoefficients, fuzz amount and the mechanical properties of CF filaments, as well as the interlaminar shear strength (ILSS) ofCF composites were analyzed. The results indicate that the defects of CF surface were completely repaired by TPPmolecules, the content of active groups increased by 24.8 % and the contact angle and the spreading time of EP on CF surfacereached respective minimum values of 43.5 o and 15 s, meanwhile, the friction coefficient and the fuzz amount of the treatedCF surface are reduced in the sizing quantity range of 3.0-4.0 mg/g. Thus, there were 36.1 % and 24.3 % enhancement in thebreaking strength and elongation of CF filament. In addition, the ILSS of composite prepared with TPP treated CFs wasincreased from 12.81 to 28.55 MPa.
The average trapping time for a weight-dependent walk on a weighted hierarchical graph
Wu Bo,Cao Fang,Chen Yun 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.78 No.12
A hierarchical graph is a kind of self-similar network, which is widely discussed and has a wide range of applications. In this paper, we introduce a class of weighted hierarchical graphs H (n, k), which is constructed using the hierarchical product of complete graphs. The weighted hierarchical graph depends on two parameters: the weighted factor r (0 < r ≤ 1) and the number k (k ≥ 3) of nodes of the complete graph K k . In addition, we also discuss the trapping problem and the average trapping time (ATT) for a weight-dependent walk on a weighted hierarchical graph. Based on the special structure of the weighted graph, we derived the exact expression of the ATT for a weighted hierarchical graph. The results show that the ATT obeys a power-law function with the exponent ln(kr) lnk < 1 , which is related to the factors k and r and indicate that for kr = k(r = 1) and 1 < kr < k , the ATT has a linear and sublinear relationship with the network order, respectively. Therefore, the smaller kr is, the more efficient the trapping process of the weighted hierarchical graph is. Compared with the unweighted hierarchical graph, the weighted hierarchical graph has a higher efficiency in the trapping process.
Wu, Ting-Ting,Wang, Zhi-Gang,Ou, Wu-Ling,Wang, Jun,Yao, Guo-Qing,Yang, Bo,Rao, Zhi-Guo,Gao, Jian-Fei,Zhang, Bi-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: The study aimed to investigate the analgesic effect of a combination of intravenous flurbiprofen axetil and opioids, and evaluate the relationship between refractory pain relief and plasma ${\beta}$-endorphin levels in cancer patients. Materials and Methods: A total of 120 cancer patients was randomly divided into two groups, 60 patients took orally morphine sulfate sustained-release tablets in group A, and another 60 patients receiving the combination treatment of intravenous flurbiprofen axetil and opioid drugs in group B. After 7 days, pain relief, quality of life improvement and side effects were evaluated. Furthermore, plasma ${\beta}$-endorphin levels were measured by radioimmunoassay. Results: With the combination treatment of intravenous intravenous flurbiprofen axetil and opioids, the total effective rate of pain relief rose to 91.4%, as compared to 82.1% when morphine sulfate sustained-release tablet was used alone. Compared with that of group A, the analgesic effect increased in group B (p=0.031). Moreover, satisfactory pain relief was associated with a significant increase in plasma ${\beta}$-endorphin levels. After the treatment, plasma ${\beta}$-endorphin level in group B was $62.4{\pm}13.5pg/ml$, which was higher than that in group A ($45.8{\pm}11.2pg/ml$) (p<0.05). Conclusions: Our results suggest the combination of intravenous flurbiprofen axetil and opioids can enhance the analgesic effect of opioid drugs by increasing plasma ${\beta}$-endorphin levels, which would offer a selected and reliable strategy for refractory cancer pain treatment.
Behavior of reinforced concrete beams filled with demolished concrete lumps
Wu, Bo,Xu, Zhe,Ma, Zhongguo John,Liu, Qiongxiang,Liu, Wei Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.3
In the past decades, recycling use of demolished concrete was almost limited to the types of recycled coarse aggregate with a size of about 5-40 mm and recycled fine aggregate with a size of about 0-5 mm for concrete structures, and reuse of demolished concrete lumps (DCLs) with a size much larger than that of recycled aggregate, e.g., 50-300 mm, has been limited to roadbed, backfilling materials, or discarded to landfills. Treatment processes of DCLs are much simpler than those of recycled aggregate, leading to less cost and more energy-saving. In the future, the amount of demolished concrete is estimated to be much higher, so reuse of DCLs for concrete structures will become necessary. The objectives of this paper are to document the process of making reinforced concrete beams with DCLs, and to discuss the flexural and shear behaviors of those reinforced DCL beams through an experimental program, which includes three beams filled with DCLs and one conventional beam for investigating the flexural strengths and deformations, and 12 beams filled with DCLs and two conventional beams for investigating the shear strengths and deformations. The authors hope that the proposed concept offers another sustainable solution to the concrete industry.
Behavior of reinforced concrete beams filled with demolished concrete lumps
Bo Wu,Zhe Xu,Zhongguo John Ma,Qiongxiang Liu,Wei Liu 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.3
In the past decades, recycling use of demolished concrete was almost limited to the types of recycled coarse aggregate with a size of about 5-40 mm and recycled fine aggregate with a size of about 0-5 mm for concrete structures, and reuse of demolished concrete lumps (DCLs) with a size much larger than that of recycled aggregate, e.g., 50-300 mm, has been limited to roadbed, backfilling materials, or discarded to landfills. Treatment processes of DCLs are much simpler than those of recycled aggregate, leading to less cost and more energy-saving. In the future, the amount of demolished concrete is estimated to be much higher, so reuse of DCLs for concrete structures will become necessary. The objectives of this paper are to document the process of making reinforced concrete beams with DCLs, and to discuss the flexural and shear behaviors of those reinforced DCL beams through an experimental program, which includes three beams filled with DCLs and one conventional beam for investigating the flexural strengths and deformations, and 12 beams filled with DCLs and two conventional beams for investigating the shear strengths and deformations. The authors hope that the proposed concept offers another sustainable solution to the concrete industry.