성장호르몬 분비성 뇌하수체 선종에서 소마토스타틴 수용체 (제2아형, 제5아형), G_i2α 및 Pit-1 유전자 발현

류미숙,양인명,박철영,우정택,김성운,김진우,김영설,최영길,김은희,박승준,김국기 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Mutation of Gs protein subunit (gsp oncogene), detected in about 30∼40% of growth hormone (GH)-secreting pituitary tumors, is associated with an increased long-acting somatostatin analog octreotide sensitivity. However, the mRNA expression of somatostatin receptor (sst) was not changed in the GH-secreting pituitary tumor, regardless of whether they were gsp oncogene positive or negative. This suggests that the expression of genes coding for G_i2α, Pit-1 and the other factors involved in the regulation of secretory activity in somatotrophs is likely to be altered in gsp oncogene positive tumors. We observed the impact of the gsp oncogene on the expression of the genes coding for Gi2, Pit-1 and sst (2&5) in GH-secreting pituitary tumors. Methods: The GH response to octreotide was examined in 13 acromegalic patients before transsphenoidal adenomectomy. Genomic DNA and RNA were extracted from fresh frozen tumor tissues. PCR was performed to amplify and sequence the region between codon 184 and 251 that includes exons 8 and 9 of the Gs gene. Sst2, sst5, G_i2α and Pit-1 mRNA levels were measured by semi-quantitative RT-PCR. Results: Sst2 and sst5 mRNA transcripts were detected in all tumors (7 gsp +, 6 gsp-). The amount of sst transcripts varied considerably varied between the tumors. There were no significant differences in sex, age, tumor size, grade or basal GH levels. Pit-1 and sst2 mRNA levels were not different. In contrast, G_i2 mRNA levels were significantly higher in gsp (+) while sst5 mRNA levels were higher in gsp (-). Conclusion: These data suggests that gsp oncogene may increase Gi2α levels but decrease sst5 mRNA levels. However, Pit-1 and sst2 mRNA expression may not be affected by gsp oncogene. The increased expression of the G_i2α gene might be an inhibitory compensatory response to the action of gsp oncogene

아웃 블록을 찾기 위한 제약조건을 갖지 않는 상수시간 RMESH 알고리즘

우진운,김기원 단국대학교 1999 論文集 Vol.34 No.-

A linear quadtree representation as a way to store a quadtree is efficient to save space compared with other representations. It, therefore, has been widely studied to develop efficient algorithms to execute operations related with quadtrees. In this paper, we present an O(1) time algorithm without constraints for finding neighbor blocks of locational codes representing linear quadtrees, using three-dimensional n×n×n RMESH.

Big Y 전개를 통한 장치 Line의 Yield 향상

문기주,박우종 한국품질경영학회 2004 품질경영학회지 Vol.32 No.4

Current companies 집중 on how to operate and select projects to achieve the best result. 6Sigma projects are chosen in the best suitable concept, which are solved by the 6Sigma experts according to the priority. And every project has to be launched not the view of individual management factors but the total factors, Big Y. Therefore, a process needs to be treated to connect the vital few factors in various processes to improve the yield, which is the main performance criteria in a manufacturing industry This report is to make the total optimization through the Vital-Few mapping between quality characteristics and process factors in a manufacturing line. Accordingly, it means to secure lower variance by making the CTP(Critical To Process) optimization and finally to improve the yield.

HDPE 개질 아스팔트 혼합물의 강도 및 변형특성

김광우,이기호,권오선,고태영 강원대학교 부설 석재복합신소재 제품연구센터 2004 석재연 논문집 Vol.9 No.-

본 연구는 폐비닐 펠렛을 도로포장재료로 재활용하여 자원절약 및 아스팔트 혼합물의 품질향상을 위한 연구이다. 이를 위하여 폐비닐의 첨가량별 배합설계를 수행하여 적정 폐비닐 첨가량과 최적 아스팔트 함량으로 편마암과 화강암 2가지 골재와 폐비닐인 RHDPE의 함량을 4가지로 혼합물을 제작하여 8종류의 재질 혼합물과 2종류의 무개질 혼합물을 제작하였다. 그리고 이 공시체에 대하여 마샬안정도, 간접인장강도 및 Kim test와 반복주행시험 등 실내시험을 통하여 혼합물의 특성을 분석하였다. 폐비닐 첨가량은 RHDPE가 8%일 때 안정도와 간접인장강도 모두 가장 우수한 것으로 나타났고 취성도 나타나지 않았다. RHDPE를 첨가한 혼합물에 대하여 Kim test를 수행한 결과 DR과 DS 모두 높은 상관성을 보였다. 그리고 반복주행시험에서는 RHDPE를 첨가한 혼합물이 일반 혼합물보다 우수하였다. 향후 많은 실험을 통해 RHDPE의 우수성을 입증한다면 소성변형 저항성에 우수한 재료로 이용될 수 있을 것이다. This study is a fundamental research for recycled high-density polyethylene (RHDPE) in asphalt mixture for improving roadway pavement. Marshall mix design was conducted and optimum asphalt content(OAC) was determined for dense-graded surface course mixture by RHDPE content. Marshall stability test, indirect tensile strength (ITS) test, wheel tracking trest and Kim-test were carried out to measure the characteristics of RHDPE-added asphalt concretes. From the results of this study, RHDPE in asphalt mixture if possible. It could be considered that adding too much RHDPE in asphalt mixture is not proper. The optimum content of RHDPE was appeared to be 8%. In Kim-test, statistical analysis was performed for each loading head and aggregate to find out correlation between S_(D) values and each rut parameter. The analysis result showed that S_(D) had very high coefficient of determination with rut parameters on the average.

3차원 두부방사선규격사진의 정확성에 관한 연구

배기선,박수병,손우성 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.1

본 연구는 교정 임상에서 흔히 촬영되는 측모와 정모 두부방사선규격사진을 사용하여 3차원적인 두개안면 형태를 재현하였을 때 그 방법의 정확성을 고찰해 보고, 기존의 측모 두부방사선규격사진과 비교하여 어떠한 차이를 보이는지 알아보고자 하였다. 이를 위해 두개안면 골격모형의 3차원 두부방사선규격사진을 형성하고, 선 계측과 각도 계측을 시행하였다. 여기서 얻어진 계측치들을 실제 계측치 및 측모 두부방사선규격사진에서의 계측치와 비교하여 다음과 같은 결론을 얻었다. 1. 3차원 두부방사선규격사진의 선 계측 평균 오차는 0.94±0.62mm, 평균 확대율 100.31±0.91% 이었으며 실제 계측치와 차이를 보이지 않았다(α=0.1). 2. 측모 두부방사선규격사진은 선 계측에서 평균 오차 6.44±1.48mm, 평균 확대율 106.99±1.45%로서 하악체를 제외한 모든 선 계측에서 확대를 보였다(P<0.005). 3. 3차원 두부방사선규격사진에서의 각도 계측은 평균 오차 1.22±0.82°, 평균 확대율 105.72±12.07%로서 실제 계측치와 차이를 보이지 않았다.(α=0.1). 4. 측모 두부방사선규격사진은 평균 오차 1.70±0.94°, 평균 확대율 106.35±15.70%으로 실제 계측치와 차이를 보이지 않았다(α=0.1). Conventional cephalometrics have inherent errors because their evaluation is performed in two-dimension for three-dimensional object. To compensate these errors, three-dimensional cephalograms - derivation of three-dimensional data from conventional lateral and postero-anterior cephalograms - were developed. In this study, the accuracy and precision of three dimensional cephalograms were determined by means of 10 linear and 12 angular measurements on 36 acrylic skull models and by the comparison of conventional lateral cephalograms. The results were as follows : 1. Mean difference between three-dimensional cephalograms and actual models in linear measurements was 0.94±0.62mm and mean rate of magnification of three-dimensional cephalograms was 100.31±0.91%. There were no statistically significant differences between three-dimensional cephalograms and actual models in linear measurements(α=0.1). 2. Mean difference between conventional lateral cephalograms and actual models in linear measurements was 6.44±1.48mm and mean rate of magnification of lateral cephalograms was 106.99±1.45%. There were statistically significant differences between lateral cephalograms and actual models in linear measurements(P<0.005). 3. Mean difference between three-dimensional cephalograms and actual models in angular measurements was 1.22±0.82° and mean rate of magnification of three-dimensional cephalograms was 105.71±12.07%. There were no statistically significant differences between three-dimensional cephalograms and actual models in angular measurements(α=0.1). 4. Mean difference between conventional lateral cephalograms and actual models in angular measurements was 1.70±0.94° and mean rate of magnification of lateral cephalograms was 106.35±15.70%. There were no statistically significant differences between lateral cephalograms and actual models in angular measurements(α=0.1). There were similarity between three-dimensional and lateral cephalograms in angular measurements.

균일 마이크로 스트립 선로에서 디지털 펄스 신호의 시간영역 전송 특성 해석

김기래,노철우 신라대학교 자연과학연구소 1999 自然科學論文集 Vol.7 No.-

Recently the necessity of MMIC is increasing because clock frequency goes up by digital data transmission of Gbps class being demanded and the density of circuits gets high for the purpose of lightening and miniaturizing system, owing to the development of ultra high speed. In this paper, the distortion of square pulse and Gaussian pulse caused by dispersion as it propagates along a uniform microstrip line is investigated. A model dispersion of the phase constant proposed by Kirchning-Jansen is used to meet the frequency, accuracy, and microstrip parametric requirements. Numerical integration technique which has high accuracy and is easily simulated, is used to obtain the time domain response of pulse signals. The dispersion of pulse signals is analyzed regarding to the relative permittivity, substrate height, strip width of the microstrip line and pulse width of signal pulse. The simulation results show that small relative permittivity and small w/h ratio are advantageous for the dispersion of the pulse signals, and that pulse signals bandwidth cause smaller dispersion. The results of this paper are compatible to the trade-off determination of relative permittivity, substrate height, strip width and pulse width of signal pulse when a design of MIC and MMIC is necessary.

WWW 기반의 질의 및 튜닝 지원 시스템

장기화,우용태 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

In this paper, we propose a new type of gateway system for WWW-Oracle interface. It supports various types of relational queries on the WWW such as join between two tables, one level nested queries, ORDER BY and GROUP BY operations in conditional clause. In addition, an application designer can suggest an access method for a table by query selection with a hint option on the WWW. It causes the Oracle optimizer to chose the specified access path. By this function, an application designer can choose more efficient way than the optimizer can determine. The designer can also check the execution time of the SQL statement on the WWW.

효율적인 컴포넌트 개발을 위한 확장 객체지향 분석 및 설계

왕기철,박경우,고형대 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-

Component Based Development(CBD) is an emerging paradigm of software development. Its goal is composing an application with plug & play software components on the frameworks. This CBD requires existing software analysis and design approaches to be reconsidered. In this paper. we present the extended method from Object-Oriented Analysis and Design. To provide a clear separation of component specification form its design and implementation. we add interface design step and component implementation design step to the process of Object-Oriented Methodology. To provide a method of tracking each step in the development process, we add "use case-behavior-control object-interface mapping table", "component-interface-implementation class mapping table", and "interface-implementation class-integrated implementation class mapping table" to the Object-Oriented Models. Object-Oriented Models could be easily re-engineered to Component System Models by the proposed method. Component System Models also could be easily back tracked by the proposed method.

배추좀나방(Plutella Xylostella Linnaeus)에 대한 새로운 살충활성 분자의 설계

조윤기,최우영,성낙도 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2

The new insecticidal active molecules from the based on the holographic quantitative structure-activity relationships (HQSAR) between a series of 1-(R₁)-2-(n-octyl)-3-(R₂), 3-(R₃)-pseudothiourea derivatives and their insecticidal activities against Diamond-back moth (Plutella Xylostella Linnaeus) were designed and discussed quantitatively. The most active molecule from the based graphical analyses of atomic contribution maps with the optimized HQSAR C-1 model (q²=0.764 & r²_(ncv)=0.942) was 1-(n-butyl)-2-(t-butyl)-3,3-diisopropylpseudothiourea (P1: pI_(50)=5.30, IC_(50)=1.397 ppm). Therefore, it is suggested that the new designed molecule would increased the activity as much as 23.5 times as compared to X=n-octyl substituent 17(pI_(50)=4.00, IC_(50)=32.86 ppm) which was the highest active molecule in training set compounds.

미세공정상에서 전가산기의 해석 및 비교

이우기,김정범 강원대학교 정보통신연구소 2004 정보통신논문지 Vol.8 No.-

In this paper the main topologies of one-bit full adders, including the most interesting of those recently proposed, are analyzed and compared for speed, power consumption, and power-delay product. The comparison has been performed on circuits, optimized transistor dimension to minimize power-delay product. The investigation has been carried out with properly defined simulation runs on a Cadence environment using a 0.25-μw process, also including the parasitics derived from layout. Performance has been also compared for different supply voltage values. Thus design guidelines have been derived to select the most suitable topology for the design features required. This paper also proposes a novel figure of merit to realistically compare n-bit adders implemented as a chain of one-bit full adders. The results differ from those previously published both for the more realistic simulations carried out and the more appropriate figure of merit used. They show that, except for short chains of blocks or for cases where minimum power consumption is desired, topologies with only pass transistors or transmission gates are not attractive. In contrast. the most interesting implementations in terms of trade off between power and delay are the traditional CMOS and Mirror topologies. Moreover, the CPL allow the best speed performance.