2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

저장안정성이 개선된 천연장 소시지의 제조를 위한 감마선 조사

이주운,조철훈,변명우 경산대학교 생명자원개발연구소 2001 생명자원과 산업 Vol.5 No.-

Quality properties in the sausage stuffed into the irradiated natural lamb and pork intestine for manufacturing the high quality emulsion-type meat produces were studied. The microbial changes of irradiated casings and the microbial growth of the sausages with gamma-irradiated natural casings were observed. Population of Total aerobia bacteria was decreased by gamma irradiation, dependent upon the irradiation dose. The number of microflora in lamb and pork casings was reduced by about 5.5 log cycle at 5kGy. Population of total aerobic bactelia of sausages stuffed in non-irradiated lamb and pork casing was about 3.6 log cfu/g after just manufacture and was about 7 log after 10 day storage. However, population of total aerobic bacteria of sausages with 3 key-irradiated and 5 kGy-irradiated casings was 2.48 and 0.32 log in lamb, and 2.78 and 0.60 log in pork respectively. The sausages vacuum-packaged and stored were shown no chance in the 2-thiobarbituric acid reactive substances value during storage. Irradiated sausage showed the higher TBARS value than that of nonirradiatd control at 5-day with pork casing and at 10day with lamb casing. Shear force of the sausages were decreased in both irradiated casings but the sensory evaluation showed no difference. Therefore, the gamma irradiation was a useful tool to sanitize the natural pork and lamb casings and extend the shelf-life of the high quality, value-added sausage made with those casings.

Oxide-CMP 연마 특성 개선을 위한 실리카 슬러리 온도 영향 분석

이우선,고필주,최창주 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.2

Chemical mechanical polishing (CMP) Process has been widely used to planarize dielectric layers, which can be applied to the integrated circuits for sub-micron technology. Despite the increased use of CMP process, it is difficult to accomplish the global planarization of in the defect-free inter-level dielectrics (ILD). In this paper, we have investigated slurry properties and CMP perfbrmance of silicon dioxide (oxide) as a function of different temperature of slurry. Thermal effects on the silica slurry properties such as pH, particle size, conductivity and zeta potential were studied. Moreover, the relationship between the removal rate (RR) with WIWNU and slurry properties caused by changes of temperature were investigated. Therefore, the understanding of these temperature effects provides a foundation to optimize an oxide CMP process for ULSI multi-level interconnection technology.

자동측정망 데이터를 이용한 국내 항공기소음 실태 조사

이주엽,전지현,이태강,김선우 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

Currently domestic criteria for the aircraft noise is being adapted WECPNL(weighted equivalent continuous perceived noise level), while internationally preferred method is L_(dn) which is originated from L_(eq) and can evaluate even environmental noise. WECPNL used in domestic as a evaluation method is only for the aircraft noise. It is, therefore, not adequate for the evaluation of residents' injury, moreover, it is very difficult to measure the aircraft noise with WECPNL due to the complicated calculating procedures as long as automatic measuring system is not used This study aims to propose alternative evaluation method for the aircraft noise. To achieve this purpose, the data measured by automatic measuring system in 5 places among domestic airports from 1998 to 2002 were gathered and calculated with three evaluation method ; WECPNL, L_(eq) and L_(dn) and the results calculated from different methods were compared and analyzed. At the same time, it was investigated problems generated from the actual operating of the automatic measuring system and that remedy was presented.

CMP 실리카 슬러리 노화 현상에 대한 연구

이우선,최권우,고필주,서용진 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1

As the integrated circuit device shrinks to the smaller dimension, the chemical mechanical polishing (CMP) process was required for the global planarization of inter-metal dielectric (IMD) layer with free-defect. However, as the IMD layer gets thinner, micro-scratches are becoming as major defects. Micro-scratches are generated by agglomerated slurry, solidified and attached slurry in pipe line of slurry supply system. It is well known that the presence of hard and larger size particles in the CMP slurries increases the defect density and surface roughness of the polished wafers. In this paper, we have studied aging effect the of CMP slurry as a function of particle size. We prepared and compared the self-developed silica slurry by adding of abrasives before and after annealing. As our preliminary experiment results, we could be obtained the relatively stable slurry characteristics comparable to original silica slurry in the slurry aging effect.

스퍼터로 제작된 WO ₃박막의 CMP 광역평탄화 특성

이우선,최창주,고필주,최권우 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.1

Chemical mechanical polishing (CMP) process has been widely used to planarize dielectric layers, which can be applied to the integrated circuits for sub-micron technology. Despite the increased use of CMP process, it is difficult to accomplish the global planarization of in the defect-free inter-level dielectrics (ILD). we investigated the performance of WO_(3) CMP used silica slurry, ceria slurry, tungsten slurry. In this paper, the effects of addition oxidizer on the WO_(3) CMP characteristics were investigated to obtain the higher removal rate and lower non-uniformity.

소아청소년과의사의 영유아기 구강건강 관리에 대한 인식도 조사

주태준,박호원,이주현,서현우 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

국민건강보험공단에서 실시하는 영유아 건강검진은 5회의 일반검진과 2회의 구강검진으로 구성되어 있다. 하지만 9개월 영유아 건강검진 시 구강건강 상담 및 교육은 일반의사가 담당하도록 되어 있어 이를 주로 담당하게 될 소아청소년과의사의 구강건강 상담 항목에 대한 지식이 필요한 상황이다. 이번 조사의 목적은 소아청소년과 전문의나 전공의를 대상으로 영유아기 구강건강교육에 대한 인식도를 알아보는 것으로 150명의 설문을 분석해 다음과 같은 결론을 얻었다. 1. 조사 대상자의 대부분은 유아기우식증으로 인한 치과 의뢰 경험이 있었고, 절반 이상의 응답자는 영유아 환자에 대해 구강검사를 시행하지 않고 있었다. 2. 조사 대상 소아청소년과의사들의 첫 치과방문 시기에 관한 적절한 인식도가 확립되지 않았다. 3. 영유아 건강검진 중 구강건강 교육 항목에 대한 인지도가 전반적으로 부족하였다. 이에 대한 교육의 강화가 필요하다. 4. 영유아 구강질환 예방을 위한 의과계의 관심과 더불어 치과계와의 협조가 필요하리라 생각 된다. For prevention of ECC, the Korean Academy Of Pediatric Dentistry(KAPD) advocate that Children should be seen as early as 6 months of age after the first tooth erupts, or 12 months of age. Pediatrics have increased access to new mothers and children 6 to 12 months while dentists does not see young children unless there are urgent problems. Therefore, they have an opportunity to impact infant oral health care. This study's purpose was to examine pediatricians' awareness and experience about infant oral health care. For the study, we surveyed of 150 pediatricians in korea. The survey comprised 10 questions related to infant oral health care and the recommended age a child go for their first dental visit. The results were as follows: 1. Most respondents had been referred children to a dentist for treating ECC and more than half of respondents reported that they did not do oral examination in their practice. 2. The majority of surveyed pediatricians are not advising patients to see the dentist by 1 year of age. 3. The surveyed pediatrician's awareness of infant oral health care is insufficient. The oral health education should be reinforced. 4. There is a need for increased infant oral health care education in the medical and dental communities.

레이저 간섭계(ESPI)에 의해 측정된 플립칩 열변형의 유한요소해석 모델링을 통한 솔더볼의 유동곡선 평가

이백우,김주영,나재웅,백경욱,권동일 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.6

The goal of this study was to determine the uniaxial flow curve for solder balls in a flip-chip from experimental-computational algorithms based on finite element modeling (FEM) of in-plane thermal displacement data measured by electronic speckle pattern interferometry (ESPI). In order to measure the deformation of such tiny components as the solder balls in the flip-chip, the spatial resolution of ESPI was increased to submicron scale by magnifying the areas studied. The flow curve for solder balls in the flip-chip was determined by the algorithm, which effectively matches the simulated solder deformation by FEM to the measured deformation by ESPI. The algorithms were applied to Sn-36Pb-2Ag flip-chip solder balls. The flow curve obtained for flip-chip solder was compared with those for bulk solder. The microstructure was also studied to clarify the flow curve results.

치근관 내 편성 혐기성 세균에 대한 서양산 고추냉이 뿌리 추출물의 항균효과

이원주,박호원,신일식,이주현,서현우 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

치근단 감염 시 물리적인 작용으로 증상이 완화되지 않을 때, 근관 내 세균을 제거하기 위해 항균성을 지닌 소독제나 세척제가 필요하다. 천연항균제에 대한 관심이 증가하면서 여러 연구들에 의해 고추냉이 추출물의 구성 성분 중 하나인 allyl isothiocyanate에 대한 항균성이 밝혀졌다. 이에 본 연구에서는 근관내 감염시 자주 발견되는 세균들 중 편성혐기성 세균인 Fusobacterium nucleatum, Prevotella nigrescence, 그리고 항생제에 내성이 커서 항균 작용 실험 시 대조균으로 자주 사용되는 Clostidial perfringens에 대한 서양산 고추냉이 뿌리 추출물의 항균효과를 알아보고, 대표적인 항균제인 클로르헥시딘과 비교하여 다음과 같은 결과를 얻었다. 1. 본 연구에 사용된 3종의 편성 혐기성 세균에 대한 서양산 고추냉이 뿌리 추출물의 최소 억제 농도는 평균 87-470 ppm, 최소 살균 농도는 평균 156-625 ppm으로 F.nucleatum에 대해 가장 강한 항균효과를 나타내었으며, 항균제에 저항성이 큰 C. perfringens에도 항균효과를 나타내었다. 2. 본 연구에 사용된 3종의 편성 혐기성 세균에 대한 클로르헥시딘의 최소억제 농도는 평균 3.12-6.25 ppm, 최소 살균 농도는 평균 10.94 ppm이었다. 3. 서양산 고추냉이 뿌리 추출물은 87-470 ppm의 농도에서 3.12-6.25 ppm의 클로르헥시딘과 비슷한 세균성장 억제 효과를 가지며 156-625 ppm의 서양산 고추냉이 뿌리 추출물은 10.94 ppm의 클로르헥시딘과 비슷한 살균 효과를 보였다. When the symptom of periapical infection is not released by mechanical instrumentation, anti-microbial agents including antibiosis become necessary in order to remove microorganisms from the root canal. Since anti-microbial agents of natural origins are currently popular, more natural remedies are being sought out. As it turns out, it is welll known isothiocyanates (ITCs) in horseradish root extract have anti-microbial activity from many studies. In this research, anti-microbial effects of horseradish root extract and chlorhexidine, a typical anti-microbial agent, were investigated and compared against two kinds of obligate anaerobes, Fusobacterium nucleatum and Prevotella nigrescens, that are often discovered in infected root canal, and Clostridium perfringens, which is resistant to antibiotics and frequently used as a control strain for antibacterial studies. 1. The MIC and MBC of horseradish root extract were ranged from 87 to 470 ppm and from 156 to 625 ppm against three kinds of obligate anaerobes, respectively. Horseradish root extract showed the strongest anti-bacterial activity (MBC, 156 ppm) against F. nucleatum and also showed anti-bacterial activity against antibiotic resistant obligate anaerobes, C. perfringens. 2. The MIC and MBC of chlorhexidine were ranged from 3.12 to 6.25 ppm and 10.94 ppm aginst three kinds of obligate anaerobes, respectively. 3. The MIC with 87-470 ppm of horseradish root exact has the same growth inhibiting effect as the one of 3.12-6.25 ppm of chlorhexidine. Likewise, the MBC with 156-625 ppm of horseradish has the similar bactericidal effect as 10.94 ppm of chlorhexidine.