排卵湯이 白鼠의 排卵에 미치는 影響

황태원,박재웅,위석,조한백,유심근 한국전통의학연구소 2002 한국전통의학지 Vol.12 No.1

Baelantang(BLT) is used in female infertility caused by ovulation disorder. An attempt was to evaluate the influences, of BLT on the serum concentrations of FSH, LH, estradiol(E_(2)) and progesterone, the histological and optical changes of ovary, ovary weight of rats. The results of the study were as follows : 1. Blood FSH level increased experimental group as compared with control group on 7th day, which showed no efficacy. 2. Blood LH level increased in experimental group as compared with control group on 7th day and decreased 14th day, which showed no efficacy. 3. Blood E_(2) level decreased in experimental group as compared with control group on 7th day and increased 14th day, which showed no efficacy. 4. Blood progesterone level increased in experimental group as compared with control group on 7th day and decreased 14th day, which showed no efficacy. 5. In histological observations of ovary, ovulation increased in experimental group as compared control group on 7th day and on 14th day, which showed no efficacy. 6. In optically observations of ovary, weight of ovary increased in experimental group as compared with control group on 7th day and 14th day, which showed no efficacy. According to these results, BLT did not influence on the ovulation and ovary of rats.

Impact of fatty liver on long-term outcomes in chronic hepatitis B: a systematic review and matched analysis of individual patient data meta-analysis

Yu Jun Wong,Vy H. Nguyen,Hwai-I Yang,Jie Li,Michael Huan Le,Wan-Jung Wu,Nicole Xinrong Han,Khi Yung Fong,Elizabeth Chen,Connie Wong,Fajuan Rui,Xiaoming Xu,Qi Xue,Xin Yu Hu,Wei Qiang Leow,George Boon-B 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3

Background/Aims: Chronic hepatitis B (CHB) and fatty liver (FL) often co-exist, but natural history data of this dual condition (CHB-FL) are sparse. Via a systematic review, conventional meta-analysis (MA) and individual patient-level data MA (IPDMA), we compared liver-related outcomes and mortality between CHB-FL and CHB-no FL patients. Methods: We searched 4 databases from inception to December 2021 and pooled study-level estimates using a random- effects model for conventional MA. For IPDMA, we evaluated outcomes after balancing the two study groups with inverse probability treatment weighting (IPTW) on age, sex, cirrhosis, diabetes, ALT, HBeAg, HBV DNA, and antiviral treatment. Results: We screened 2,157 articles and included 19 eligible studies (17,955 patients: 11,908 CHB-no FL; 6,047 CHB-FL) in conventional MA, which found severe heterogeneity (I2=88–95%) and no significant differences in HCC, cirrhosis, mortality, or HBsAg seroclearance incidence (P=0.27–0.93). IPDMA included 13,262 patients: 8,625 CHB-no FL and 4,637 CHB-FL patients who differed in several characteristics. The IPTW cohort included 6,955 CHB-no FL and 3,346 CHB-FL well-matched patients. CHB-FL patients (vs. CHB-no FL) had significantly lower HCC, cirrhosis, mortality and higher HBsAg seroclearance incidence (all P≤0.002), with consistent results in subgroups. CHB-FL diagnosed by liver biopsy had a higher 10-year cumulative HCC incidence than CHB-FL diagnosed with non-invasive methods (63.6% vs. 4.3%, P<0.0001). Conclusions: IPDMA data with well-matched CHB patient groups showed that FL (vs. no FL) was associated with significantly lower HCC, cirrhosis, and mortality risk and higher HBsAg seroclearance probability.

Emotion Gesture Art

Han, Eunjung,Wong, Chee-Onn,Jung, Keechul,Lee, Kyung Ho MIT Press 2010 Leonardo Vol.43 No.3

PREPARATION AND EFFECT OF Mo-V-Cr-Bi-Si OXIDE CATALYSTS ON CONTROLLED OXIDATION OF METHANE TO METHANOL AND FORMALDEHYDE

Han, Zhan sheng,Pan, Wei,Pan, Wei xiong,Li, Jin-lu,Zhu, Qi ming,Tin, Kam chung,Wong, Ning bew 한국화학공학회 1998 Korean Journal of Chemical Engineering Vol.15 No.5

혈관평활근세포에서 산화에너지대사 억제에 의한 아밀로이드전구단백질 대사의 변화

한문구,최웅,김헌식,안희열,한설희 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: A reduction in the activity of cytochrome c oxidase(COX) has been recently identified in mitochondria from platelets and postmortem brain tissue of AD patients Sodium azide (NaN₃). a COX inhibitor, is an effective chemical agent producing energy shortage and oxidative stress both in vitro and in vivo system Furthermore it has been suggested that vascular compromise could be either directly involved AD pathogenesis or indirectly associated with triggering pathogenetic events leading to AD This study was performed to investigate amyloid precursor protein (APP) metabolism by inhibition of mitochondrial energy metabolism in cultured vascular smooth muslce cells (VSMCs) Materials and Methods: VSMCs isolated from the aorta of seven weeks old Spraque-Dawley rat were treated with NaN₃in a low concentration (100-500μM) or in a high concentration (1-100mM) Cellular proliferation and viability were determined by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenly)-2H-tetrazolium) assay Cellular APP was detected with N-terminal specific antibody 22C11. Celldeath was determined by observation of morphology and terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end labeling stain (TUNEL) We used ginkgo biloba extract(EGb761) and melatonin as anti-oxidants to investigate the mechanism of latered APP metabolism Results: The viability of VSMCs was increased after treatment with 1 mM and 10mM NaN₃(p<0.05) unitl 3 hr and then dimnished Many TUNEL positive cells were found in 10mM and 100mM treatment group. but were not apoptotic in nature 22C11 immunoreactivity was not changed at 3 hr, 6hr, 12hr Anti-oxidants reduced cellular proliferation (p<0.05). but did not block TUNEL positivities and did not influence the 22C11 immunoreactivity In a low concentration NaN₃ treatment group the viability of VSMCs was increased concentration dependently(p<0.05) Immunoblot with 22C11 showed the concentration dependent decrease at 145 kDa, 125 kDa. and high molecular weight range (>160kDa) TUNEL staining showed DNA fragmentations and condensations of nuclear chromatin suggesting apoptosis After treatment with anti-oxidants, the cellular proliferation was more decreased (p<0.05), and TUNEL positive cell deaths were blocked Immunoreactivities of 125 kDa (immature APP). 145 kDa (mature APP). and higher molecular weight bands were recovered below 400μM of NaN₃ Immunoreactivity of 145 kDa was recovered in 100 μM NaN₃ treated group Conclusions: The presumed mechanism of low concentration COX inhibitor is the overproduction of reactive oxygen species resulting from a depression of the mitochondiral electron transport chain. whereas potential consequence of high concentration COX inhibitor might be related to decreassion of ATP synthesis and bioenergetic impairment Reactive oxygen radicals in response to low concentration COX inhibitor alter the processing of APP in VSMCs This investigation demonstrated analtered APP metabolism as a peripheral marker of AD Therefore VSMCs treated with low concentration COX inhibitor could be concsidered as a novel in vitro model of AD.

Efficient page layout analysis on small devices

Han, E. j.,Wong, C. o.,Jung, K. c.,Lee, K. h.,Kim, E. y. Springer Science + Business Media 2009 Journal of Zhejiang University Vol.10 No.6

FeCo 합금의 상전이

한원근 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-

We studied the surface properties of FeCo alloys near the phase transition via Monte Carlo simmulation of Ising model Hamiltonians. We concluded that the surface field induced by surface segregation of Fe atoms is the surface induced order behavior observed in a recent experiment.

A Comparative Study on European Container Terminal Operation System

Han, Chul-Hwan,Kim, Yong-Wong Korean Institute of Navigation and Port Research 2003 한국항해항만학회지 Vol.27 No.3

As the competition in the liner shipping industry is becoming fiercer, the shipping company is trying to find the way to keep the best competitive position by reducing the cost level as low as possible and offering the best quality of service to their customer. In order to achieve this goal, the selection of port and terminal that have the best quality of service and cost effective structure is essential for the shipping line, where they can only have a chance to save the money. In this context, the paper compares three European container terminals in order to understand the factors that have to be considered in the decision making process for the selection of terminal. And its advantages and disadvantages of each type of container terminal operation system were analyzed from the liner shipping company's point of view in terms of cost, time, flexibility, stability, hinterland connection, geographical position and terminal productivity. It is obvious that the cost factors are very important for liner shipping company to select their terminal. However, there might be even more important factors than the cost factors, such as quality of port and terminal service, mutual trust, and possibility of future development.

Characteristic Uptake Pattern of Bone Scintigraphy in Patients with Hepatocellular Carcinoma Following Treatment with High-Intensity Focused Ultrasound

Wai-Han Ma,Wai-Yin Ho,Andrew S. H. Lai,Kwong-Kuen Wong,Martin Law 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.4

Purpose This study retrospectively reviews the characteristic bone scintigraphic findings in 18 patients with hepatocellular carcinoma (HCC) following treatment with high-intensity focused ultrasound (HIFU). A potential complication of HIFU is damage to the tissues along the path of the ultrasound beam and structures superficial to the lesion of interest. Methods Patientswith hepatocellular carcinomawho underwent a bone scan between 1st December 2005 and 31st December 2011 were considered for this study. Among these patients, only those who had bone scans after the HIFU treatment were included. The time between HIFU treatment and bone scans, HIFU energy, HCC sites, tumour sizes and related radiological findings were evaluated. Results In total, 20 bone scans of 18 patients were reviewed. Of these scans, two patients were normal; three patients showed decreased uptake, four patients showed increased uptake and nine patients showed mixed uptakes of the bony tracer in their rib cages. The defects were located in the anterior, lateral, anterolateral or posterolateral aspects of the rib cage. The majority of those cold defects were in the right anterior rib cages. SPECT/CT was used to localise the decreased uptake in ribs. The magnetic resonance imaging in individual patients invariably showed ill-defined rimenhancement along the right chest wall, signifying chest wall injury. Conclusions The results showed that tissue ablation using HIFU caused tissue injury along the pathway of highintensity ultrasound beams. The harm to tissues is presented as photopenic area on the rib cages due to necrosis or hot spots due to rib fractures in the bone scan. Since these cold defects are subtle, they are easily overlooked or mistaken as aggressive bony metastasis.

Nasitrema attenuata (Digenia: Nasitrematidae) Infection of Long-beaked Common Dolphin (Delphius capensis) in the East Sea, Korea

Chae-Wong Lim,Seajin Han,Bumseok Kim,Umanets Alexander,Young-Ran Lee,박태건,박겸준,Doo Nam Kim,손호선,Du- Hae An,Hyeon-CheolKIM,Cheolho Sim,SI-Yun Ryu,Bae-Keun PARK 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.3

The trematodes of Genus Nasitrema are the most common infection in the heads of small odontocetes. Five species of Nasitrema have been described in Asia. But those parasites has been not surveyed in the East Sea of Korean peninsula. There are no evidence of pathology associated with Nasitrema attenuate. To determine the infection ratio of N. attenuata in the dolphin, it was surveyed 9 long-beaked common dolphin, Delphinus capensis, caught incidentally from Samcheok to Pohang, East Sea, Korea. Five males and four females, estimated to be between 1 to 10 years old, were examined. The quantity of N. attenuata harvested by aspiration from pterygoid sinuses ranged from 10 to 100 with a 100% (9/9) infection with older dolphins exhibiting higher parasite counts. The body of trematoda was elongated with tegumental patches resembling the leaves of lilies and oral sucker located ventrally at the anterior terminal. Esophagus was absent and intestinal bifurcation arose immediately from the posterior of pharynx. The undulated intestinal caeca transversed the entire body and terminated at the posterior extremity of the worm. The genital pore opened anterior to the ventral sucker. This report confirms the prevalence and morphology of N. attenuata in the dolphins from the East Sea, Korea.