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Dong-YoonLim,Eun-SookLee,Hyeon-GyoonPark,Byeong-CheolKim,Soon-PyoHong,EunBangLee 대한약학회 2003 Archives of Pharmacal Research Vol.26 No.3
The present study was conducted to investigate the effects of green tea extract (GTE) on arterial blood pressure and contractile responses of isolated aortic strips of the normotensive rats and to establish the mechanism of action. The phenylephrine (10-6~10-5 M)-induced contractile responses were greatly inhibited in the presence of GTE (0.3~1.2 mg/mL) in a dose-dependent fashion. Also, high potassium (3.5´10-2~5.6´10-2 M)-induced contractile responses were depressed in the presence of 0.6~1.2 mg/mL of GTE, but not affected in low concentration of GTE (0.3 mg/mL). However, epigallocatechin gallate (EGCG, 4~12 mg/mL) did not affect the contractile responses evoked by phenylephrine and high K+. GTE (5~20 mg/kg) given into a femoral vein of the normotensive rat produced a dose-dependent depressor response, which is transient. Interestingly, the infusion of a moderate dose of GTE (10 mg/kg/30 min) made a significant reduction in pressor responses induced by intravenous norepinephrine. However, EGCG (1 mg/kg/30 min) did not affect them. Collectively, these results obtained from the present study demonstrate that intravenous GTE causes a dose-dependent depressor action in the anesthetized rat at least partly through the blockade of adrenergic a1-receptors. GTE also causes the relaxation in the isolated aortic strips of the rat via the blockade of adrenergic a1-receptors, in addition to the unknown direct mechanism. It seems that there is a big difference in the vascular effect between GTE and EGCG.
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Chae-Wong Lim,Seajin Han,Bumseok Kim,Umanets Alexander,Young-Ran Lee,박태건,박겸준,Doo Nam Kim,손호선,Du- Hae An,Hyeon-CheolKIM,Cheolho Sim,SI-Yun Ryu,Bae-Keun PARK 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.3
The trematodes of Genus Nasitrema are the most common infection in the heads of small odontocetes. Five species of Nasitrema have been described in Asia. But those parasites has been not surveyed in the East Sea of Korean peninsula. There are no evidence of pathology associated with Nasitrema attenuate. To determine the infection ratio of N. attenuata in the dolphin, it was surveyed 9 long-beaked common dolphin, Delphinus capensis, caught incidentally from Samcheok to Pohang, East Sea, Korea. Five males and four females, estimated to be between 1 to 10 years old, were examined. The quantity of N. attenuata harvested by aspiration from pterygoid sinuses ranged from 10 to 100 with a 100% (9/9) infection with older dolphins exhibiting higher parasite counts. The body of trematoda was elongated with tegumental patches resembling the leaves of lilies and oral sucker located ventrally at the anterior terminal. Esophagus was absent and intestinal bifurcation arose immediately from the posterior of pharynx. The undulated intestinal caeca transversed the entire body and terminated at the posterior extremity of the worm. The genital pore opened anterior to the ventral sucker. This report confirms the prevalence and morphology of N. attenuata in the dolphins from the East Sea, Korea.
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