http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Xue‑Lian Song,Fei‑Fei Zhang,Wen‑Jing Wang,Xin‑Ning Li,Yi Dang,Ying‑Xiao Li,Qian Yang,Mei‑Jing Shi,Xiao‑Yong Qi 한국유전학회 2020 Genes & Genomics Vol.42 No.12
Background: Myocardial ischemia and reperfusion injury (MI/RI) is a complex pathophysiological process, which can lead to severe myocardial injury. The long noncoding RNA alpha-2-macroglobulin antisense RNA 1 (A2M-AS1) has been revealed to be abnormally expressed in MI, However, its function in MI and the potential mechanism are still unclear. Objective: To evaluate the functional role of A2M-AS1 in hypoxia/reoxygenation (H/R)-induced neonatal cardiomyocytes and its potential molecular mechanism. Methods: Dataset GSE66360 was obtained from GEO database for analyzing the RNA expression of A2M-AS1 and interleukin 1 receptor type 2 (IL1R2). KEGG pathway enrichment analysis of the genes that co-expressed with A2M-AS1 was performed. Human neonatal cardiomyocytes were subjected to H/R to construct in vitro models. QRT-PCR and Western blot were adopted to test the levels of mRNA and protein. The viability and apoptosis of cardiomyocytes were tested by CCK-8 and flow cytometry assays, respectively. Results: The expression of A2M-AS1 was notably downregulated in H/R-treated cardiomyocytes. Overexpression of A2M-AS1 can notably enhance the cell viability of H/R-damaged cardiomyocytes, whereas knockdown of A2M-AS1 showed the opposite outcomes. Besides, a negative correlation was showed between A2M-AS1 and IL1R2 expression. In H/R-treated cardiomyocytes, overexpression of IL1R2 weakened the promoting proliferation and anti-apoptosis effects caused by overexpressing A2M-AS1, however, IL1R2-knockdown abolished the anti-proliferation and pro-apoptosis effects caused by silencing A2M-AS1. Conclusion: This study demonstrates the potential regulatory role of A2M-AS1/ IL1R2 axis in cardiomyocytes suffered from H/R, and provides insight into the protection of MI/RI.
Qi Fei-Yan,Zhu Zhou-Hai,Li Meng,Guan Ying,Peng Qi-Yuan,Lu She-Ming,Liu Zhi-Hua,Wang Ming-Feng,Miao Ming-Ming,Chen Zhang-Yu,Li Xue-Mei,Bai Jie,Yao Jian-Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.11
Background: Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, the TAS2R38 status in Chinese smokers is still unclear. Objective: This study aims to investigate the possible relationship between genetic variations in TAS2R38 (A49P, V262A and I296V) and smoking behaviors in the Han Chinese population. Methods: The haplotype analyses were performed and smoking behavior questionnaire was completed by 1271 individuals. Genetic association analyses for smoking behavior were analyzed using chi-square test. Further, for investigating the molecular mechanism of TAS2R38 variants effect on smoking behavior, we conducted TAS2R38-PAV and TAS2R38-AVI expression plasmids and tested the cellular calcium assay by cigarette smoke compounds stimulus in HEK293. Results: Significant associations of genetic variants within TAS2R38 were identified with smoking behavior. We found a higher PAV/PAV frequency than AVI/AVI in moderate and high nicotine dependence (FTND ≥ 4; X2 = 4.611, 1 df, p = 0.032) and strong cigarette smoke flavor intensity preference (X2 = 4.5383, 1 df, p = 0.033) in participants. Furthermore, in the in vitro cellular calcium assay, total particle matter (TPM), N-formylnornicotine and cotinine, existing in cigarette smoke, activated TAS2R38-PAV but not TAS2R38-AVI-transfected cells. Conclusion: Our data highlights that genetic variations in TAS2R38 are related to smoking behavior, especially nicotine dependence and cigarette smoke flavor intensity preference. Our findings may encourage further consideration of the taste process to identify individuals susceptible to nicotine dependence, particularly Han Chinese smokers.
Spatial target path following and coordinated control of multiple UUVs
Qi, Xue,Xiang, Peng,Cai, Zhi-jun The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.-
The coordination control of multiple Underactuated Underwater Vehicles (UUVs) moving in three dimensional space is investigated in this paper. The coordinated path following control task is decomposed into two sub tasks, that is, path following control and coordination control. In the spatial curve path following control task, path following error dynamics is build in the Serret-Frenet coordinate frame. The virtual reference object can be chosen freely on the desired spatial path. Considering the speed of the UUV, the line-of-sight navigation is introduced to help the path following errors quickly converge to zero. In the coordination control sub task, the communication topology of multiple UUVs is described by the graph theory. The speed of each UUV is adjusted to achieve the coordination. The path following system and the coordination control system are viewed as the feedback connection system. Input-to-state stable of the coordinated path following system can be proved by small gain theorem. The simulation experiments can further demonstrate the good performance of the control method.
Spatial target path following and coordinated control of multiple UUVs
Qi, Xue,Xiang, Peng,Cai, Zhi-jun The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1
The coordination control of multiple Underactuated Underwater Vehicles (UUVs) moving in three dimensional space is investigated in this paper. The coordinated path following control task is decomposed into two sub tasks, that is, path following control and coordination control. In the spatial curve path following control task, path following error dynamics is build in the Serret-Frenet coordinate frame. The virtual reference object can be chosen freely on the desired spatial path. Considering the speed of the UUV, the line-of-sight navigation is introduced to help the path following errors quickly converge to zero. In the coordination control sub task, the communication topology of multiple UUVs is described by the graph theory. The speed of each UUV is adjusted to achieve the coordination. The path following system and the coordination control system are viewed as the feedback connection system. Input-to-state stable of the coordinated path following system can be proved by small gain theorem. The simulation experiments can further demonstrate the good performance of the control method.
스크린 프린팅 기술로 제작된 종이기반 Ag/CNT nanocomposite 스트레인 센서의 인쇄적성
제설(Xue Qi),임수만(Sooman Lim) 융복합지식학회 2021 융복합지식학회논문지 Vol.9 No.1
인쇄전자 기반으로 제작된 종이 기반 스트레인 센서는 다양한 응용 분야가 있으며, 특히 저항 기반 센서는 환경 친화적이며 웨어러블 장치에 사용할 수 있어 천천히 변화하는 변형, 무거운 하중을 받는 구조 또는 극한 이벤트로 인한 예기치 않은 영향을 감지하는데 적합하다. 본 연구에서는 Ag/CNT 스크린 프린팅 공정을 사용하여 GF 20 이상의 종이 기반 스트레인 센서를 제작하였고 인쇄적성에 따른 센서 제작 및 센싱 효과를 체계적으로 분석하였다. 그 결과, gap이 0.38에서 0.5 mm로 증가할 경우 선폭이 546 um에서 최대 396 um로 감소함 확인하였고 스퀴지가 스크린 메쉬에 5 mm에서 9 mm로 가까워질수록 패턴 폭은 581에서 721 um로 증가됨을 볼 수 있었다. 또한, 100°C에서 저항값이 352 Ω에서 220°C일 때 100 Ω까지 감소하였는데 이러한 온도 변화는 Ag/CNT의 결합구조에 영향을 미치고 이는 감도 차이를 생성함을 확인할 수 있었다. 이를 통해 스크린 프린팅 공정으로 종이기반 스트레인 센서 기술 개발을 위한 의미 있는 기본 데이터로 사용될 수 있다고 사료된다. Paper-based strain sensors produced based on printed electronics have a variety of applications for slowly changing deformation, heavy-loaded structures, or extreme events. Especially resistance-based sensors which can be used in wearable devices, are affected by printability. In this study, a strain sensor based on GF 20 or higher was fabricated using the Ag/CNT screen printing process, and the sensor fabrication and sensing effects were systematically analyzed according to its printability. As a result, when the gap between mesh and sbustrate is increased from 0.38 to 0.5 mm, line width decreases from 546 um to a maximum of 396 um. As the confirmed squeegee approaches the screen mesh from 5 mm to 9 mm, the pattern width increases from 581 to 721 um. In addition, it can be seen that the resistance value decreases from 352 Ω to 100 Ω when drying temperature increased from 100°C to 220°C, which is attributed to the bonding structure of Ag/CNTs and creates a sensitivity difference. Through this, it is considered a number of meaningful basic data for the development of paper-based strain sensor technology as a screen printing process.