Efficacy and safety of topical application of epidermal growth factor (EGF) for Korean acne patient

( Won Jong Oh ),( Eun Jung Ko ),( Sun Young Choi ),( Kwang Ho Yoo ),( Beom Joon Kim ),( Chang Kwun Hong ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: Commonly prescribed medications for acne vulgaris are oral antibiotics and retinoids. However, those have clinical limitation due to its resistance and teratogenicity, respectively. In that EGF helps reducing sebum secretion and enhances skin moisturizing, topicalapplication of EGF is implied as a new treatment modality for acne vulgaris. Objectives: We aim to evaluate the clinical efficacy and safety of topical recombinant human (rh) EGF in treating facial acne vulgaris. Methods: Twenty three Korean with mild acne vulgaris has applied topical rhEGF cream (Trouble control EGF) on the face twice daily for four weeks. Acne lesion counts were scored by investigator’s global assessment, while efficacy and satisfaction were evaluated by subjects. Skin sebum output, hydration and redness level were also measured at each visit. Results: Skin sebum level, transepidermal water loss, skin redness statistically decreased and acne lesions were significantly reduced. No severe side effects were observed during the study. Conclusion: Topical rhEGF seems to be an effective and safe adjuvant treatment option for mild acne vulgaris.

Surgical Treatment of Unruptured Intracranial Middle Cerebral Artery Aneurysms: Angiographic and Clinical Outcomes in 143 Aneurysms

Seung Won Choi,안재성,Jung Cheol Park,권도훈,Byung Duk Kwun,김창진 대한뇌혈관외과학회 2012 Journal of Cerebrovascular and Endovascular Neuros Vol.14 No.4

Objective:The purpose of this study was to determine the outcomes of surgical clipping in patients with unruptured middle cerebral artery (MCA) aneurysms. Methods:A retrospective single-center database of 125 consecutive patients with 143 small MCA aneurysms (< 10 mm) who underwent surgical clipping was reviewed from January 2007 to December 2010. Clinical outcomes were assessed based on surgery-related complications and follow-up (mean: 17 months) using the modified Rankin scale (mRS). Angiographic outcomes were evaluated by conventional angiography (N = 96) or computed tomography angiography (N = 29) at postoperative weeks 1 and 6. Results:There were no cases of mortality. There were three surgery-related complications (intracranial hemorrhage, meningitis and wound infection, respectively). The hemorrhagic event caused transient neurological deficits. All patients showed good clinical outcomes during follow-up (mRS 0-1). There was angiographic evidence of complete occlusion in 137 aneurysms (95.8%), a small residual neck in three aneurysms (2.2%) and partial for three aneurysms. In the three cases with partial clipping, the decision was made preoperatively to leave the residual sac to maintain distal flow, and muscular wrapping was performed. Conclusion:Our study demonstrates that surgical clipping of unruptured small MCA aneurysms yields favorable clinical and angiographic outcomes. Aneurysmal clipping can be safely recommended for patients with small unruptured MCA aneurysms.

Sorafenib에 의해 유발된 다형 홍반과 유사한 양상을 보인 약물발진

오원종 ( Won Jong Oh ),고은정 ( Eun Jung Ko ),최선영 ( Sun Young Choi ),박귀영 ( Kui Young Park ),이갑석 ( Kapsok Li ),김범준 ( Beom Joon Kim ),서성준 ( Seong Jun Seo ),김명남 ( Myeung Nam Kim ),홍창권 ( Chang Kwun Hong ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.7

Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib. (Korean J Dermatol 2015;53(7):542∼545)

Effect of topical application of quercetin on atopic dermatitis (AD) in NC/Nga mice

( Eun Jung Ko ),( Woo Sun Jang ),( Mi Sook Jeong ),( Ji Yunkim ),( Min Won Lee ),( Kui Young Park ),( Seong Jun Seo ),( Chang Kwun Hong ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3

Successful Obliteration of Unclippable Large and Giant Middle Cerebral Artery Aneurysms Following Extracranial-Intracranial Bypass and Distal Clip Application

Yoon, Won-Ki,Jung, Young-Jin,Ahn, Jae-Sung,Kwun, Byung-Duk The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.3

Large to giant middle cerebral artery aneurysm is a challenging disease, especially when incorporating important perforating arteries. Surgical risk increases by perforator infarction and anatomical complexity. In this clinical setting, extensive consideration of surgical options is needed. The two cases described here were unruptured and had rather stable wall. Because of their large and giant size, hardness and incorporated arteries, it was not affordable to isolate them by means of clipping or trapping. The procedure as the alternative to conventional treatment modalities, extracranial-intracranial bypass followed by clipping of only the efferent artery successfully treated the aneurysms.

만성 HBsAg보유자에서 중합효소 연쇄반응법에 의한 혈청 HBV DNA의 검출

정일권(Il Kwun Jung),주재학(Jae Hak Joo),차상우(Sang Woo Cha),봉형근(Hyung Keun Bong),김진오(Jin Oh Kim),박찬욱(Chan Wook Park),이준성(Joon Seong Lee),이문성(Moon Sung Lee),조성원(Sung Won Cho),심찬섭(Chan Sup Shim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6

N/A Background/Aims: The purpose of this study was to investigate the serum HBV DNA status and clinical significance of polymerase chain reaction(PCR) in patients with chronic hepatitis B and asymptomatic HBsAg carriers. Methods: The subjects of this study were 80 patients with chronic hepatitis B(53 HBeAg posiiive patients, 27 HBeAg negative patients), 19 asymptomatic HBsAg carriers(8 HBeAg positive patients, l l HBeAg negative patients). Serum HBV DNA was measured by Dot blot hybrydization with a ' P labeled HBV DNA in all patients studied, and the PCR was used to detect serum HBV DNA in Dot blot negative patients. The PCR was performed with 2 primers in the C gene region of HBV. Amplified sequences were detected with ethidium bromide staining(PCR-EB) and southern blot hybridization(PCR-SBH). Dot blot allowed the detection of 10 ' pg of cloned HBV DNA, while 10 pg and 10' pg were detected by PCR-EB and PCR-SBH, respectively. Results: In the 80 patients with chronic hepatitis, 76patients(95%) were positive for HBV DNA by Dot blot or PCR. All 53 HBeAg positive chronic hepatitis patients had HBV DNA detectable by Dot blot(77.4%) or PCR(18.97c by PCR-EB, 3.7% by PCR-SBH). Out of 27 HBeAg negative patients, 23(85.2%) were positive for HBV DNA by Dot blot (40.8/o) or PCR (29.61o by PCR-EB, 14,8% by PCR-SBH). In the 19 asymptomatic HBsAg carriers, 13(68.4%) were positive for HBV DNA by Dot blot or PCR. All 8 HBeAg positive asymptomatic carriers had sufficient HBV DNA detectable by Dot blot. Out of 1 l HBeAg negative carriers, 5(45.5 7c) were positive for HBV DNA by Dot blot (9.1%) or PCR(36.4%). The positive rate for HBV DNA in patients with chronic hepatitis was significantly higher than that in asymptomatic HBsAg carriers(P=0.002 by Fisher exact test) and there is a significant difference in serum HBV DNA between HBeAg positive and negative asymtomatic HBsAg carriers(P=0.02 by Fisher exact test). Conclusions: These results suggest that minute amount of HBV DNA detected by PCR may have pathogenic relevance in chronic hepatitis B, and PCR may be used as a prognostic factor in asymptomatic HBsAg carriers. (Korean J Gastroenterol 1995;27: 651 - 658)

Induction of the surface plasmon resonance from C-incorporated Au catalyst in Si_1−<i>x</i>C_<i>x</i> nanowires

Lee, Woo-Jung,Ma, Jin Won,Bae, Jung Min,Park, Sang Han,Jeong, Kwang-Sik,Cho, Mann-Ho,Lee, Chul,Han, Kyong-Joo,Jeong, Kwun-Bum The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.37

<P>Si<SUB>1−<I>x</I></SUB>C<SUB><I>x</I></SUB> nanowires (NWs) were synthesized by varying the ratio of SiH<SUB>4</SUB> and CH<SUB>3</SUB>SiH<SUB>3</SUB> gases using a vapor–liquid–solid (VLS) procedure using Au as a catalyst. The growth rate of the Si<SUB>1−<I>x</I></SUB>C<SUB><I>x</I></SUB> NWs and the change in the wire shape from straight to helical near the Au tip were found to be closely related to the ratio of the CH<SUB>3</SUB>SiH<SUB>3</SUB> content. The large concentration of C in the Si<SUB>1−<I>x</I></SUB>C<SUB><I>x</I></SUB> NWs was proportional to the CH<SUB>3</SUB>SiH<SUB>3</SUB> content, overcoming the extremely low solubility of C in Si, resulting in an interstitial incorporation of C atoms in the wire. This incorporation can be attributed to the cleavage of Si–C bonds in the CH<SUB>3</SUB>SiH<SUB>3</SUB> compound through the Au catalyst (an Au–Si liquid-state cluster of about 70–100 nm) during wire growth by the VLS method. Simultaneously supplying CH<SUB>3</SUB>SiH<SUB>3</SUB> and SiH<SUB>4</SUB> gases enhanced the diffusion of Au atoms from the tip to the sidewall of the wire, while also deforming the shape of the Au tip. When the CH<SUB>3</SUB>SiH<SUB>3</SUB> gas was increased to 1.5 sccm, the number of Au nanoparticles (2–3 nm in size) at the lateral surface induced a surface plasmon resonance (SPR) and improved the optical conductivity (<I>σ</I>) of the Si<SUB>1−<I>x</I></SUB>C<SUB><I>x</I></SUB> NWs. For 2 sccm of CH<SUB>3</SUB>SiH<SUB>3</SUB>, a remarkable increase in the number of C atoms incorporated in the Au nanoparticles along the sidewall red shifted the SPR peak, suggesting that the SPR can be modulated by the Au–C interactions in the nanoparticles.</P> <P>Graphic Abstract</P><P>Si<SUB>1−<I>x</I></SUB>C<SUB><I>x</I></SUB> nanowires (NWs) were synthesized by varying the ratio of SiH<SUB>4</SUB> and CH<SUB>3</SUB>SiH<SUB>3</SUB> gases using a vapor–liquid–solid (VLS) procedure using Au as a catalyst. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm33527a'> </P>

고 위험 임신에서 태아 제대 적혈구 조혈 인자

김석원(Seock Won Kim),김사진(Sa Jin Kim),이귀세라(Gui Se Ra Lee),권인(In Kwun),이재동(Jae Dong Lee),이형근(Hyung Gun Lee),박정희(Jung Hui Park),진기홍(Gi Hong Jin),신종철(Jong Chul Shin),김수평(Su Pyung Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6

목적 : 고위험 임신 산모에서 제대 동맥혈 검사값과 적혈구 조혈 인자의 연관성을 알아보기 위하여. 방법 : 1998년 12월부터 1999년 12월 까지 가톨릭 대학교 성가병원에 내원하여 제왕 절개술을 시행한 88명에서 제대 동맥혈검사 값과 방사 면역 측정으로 얻은 적혈구 조혈 인자를 검사한 정상 대조군 39예(쌍태아 12예), 45예의 고 위험 임신, 미 분류 4예를 대상으로 하였고, 통계학적 분석은 단측 t-검정과 회귀분석을 시행하였으며 p 값이 0.05 미만일 때 통계학적으로 유의한 것으로 하였다. 결과 : 제대 동맥의 산도와 적혈구 조혈인자는 통계학적으로 의의 있는 역 상호 관계를 보여 주었으며, 임신성 당뇨와 자궁내 태아 발육 부전 군에서 정상 군 보다 의의 있는 적혈구 조혈인자의 증가를 보여 주었으나 태아 긴박증이나, 전자간증에서는 증가된 양상을 보였으나 통계학 적인 의의는 없었다. 결론 : 증가된 제대 동맥의 epo 농도는 태아의 저 산소증과 연관성이 있으며, 자궁내 태아 발육 부전과 임신성 당뇨에서 epo의 의의 있는 증가는 만성 저산소증에 대한 임상적 지표의 가능성을 보여 주었다. Objective: To investigate the relationship between umbilical plasma erythropoietin(epo) concentrations and umbilical cord pH in high risk pregnancies. Methods: We measured epo concentrations and gas in 103 cases of cord blood obtained from 88 cesarean section (15 of twin) composed of 39 cases of normal control (12 of normal twins), 45 cases of high risk pregnancies and 4 cases of unclassified group using an RIA kit from december,1998 to December, 1999. Statistical analysis was performed using the student's t test and regression analysis. P values less than 0.05 were considered statistically significant Results: Umbilcal plasma epo concentrations revealed significant inverse correlation (P<0.05) with umbilical acidosis and cord blood epo levels, and it were significantly higher in GDM and IUGR than normal pregnancies (control: 1.60 1.15, n=39 versus GDM: 7.78 7.18, n=11 versus IUGR: 64.77 90.57 n=10, p<0.05), but 11 cases of fetal distress and 13 cases of preeclampsia did not differ significantly from umbilical plasma epo of normal control. Conclusions: Elevated epo concentrations in cord blood indicate fetal hypoxia and It is significantly increased in IUGR and GDM, these findings show that cord blood epo may serve as a clinically useful marker for chronic fetal hypoxia.

돈(豚)에서 분리(分離)한 Shigella균유래(菌由來) R plasmid의 유전적(遺傳的) 특성(特性)에 관한 연구(硏究)

최원필,권해병,정석찬,Choi, Won-pil,Kwun, Hae-byeng,Jung, Suk-chan 대한수의학회 1989 大韓獸醫學會誌 Vol.29 No.1

This paper dealt with the distribution of Shigella spp. on 5 piggeries in Taegu and Kyungpook during the period from August to October 1987. Isolated Shigella were examined for serogrouping, antimicrobial drug resistance and detection of R plasmid. Genetic properties of R plasmid in Shigella have examined to fertility inhibition (Fi) and gel electrophoresis was performed for the isolation of plasmid DNA. The results obtained were summarised as followings; 1. Of total 2,978 samples from 5 piggeries, 82 strains (2.8%) of Shigella spp. were isolated from 82 samples. The isolated strains were identified as S dysenteriae (60 strains), S flexneri (20 strains) and S sonnei (2 strains). 2. Of the 82 strains examined 67 (95.1%) were resistant to one or more antibiotics, such as ampicillin (Am), chloramphenicol (Cm), kanamycin (Km), nalidixic acid (Na), rifampicin (Rf), streptomycin (Sm), sulfademethoxine (Su), and tetracycline (Tc) and higher resistant to Su (90.2%), Sm (63.4%) and Tc (63.4%). 3. Of the 78 resistant Shigella strains 26 (33.3%) harbored conjugative R plasmids and the transfer frequency of Sm (50.0%), Cm(33.3%) resistance was much higher than that of the other drug resistance. 4. The most common resistant patterns were SmSuTc, Su and AmSmSuTc. 5. Out of the 26 Shigella R plasm ids examined for Fi, 14(53.8%) were $Fi^+$ and the remainder were $Fi^-$. 6. The plasmid DNA profiles in Shigella spp. (9 strains) isolated from pigs were confirmed as being 2 to 9 fragments by the gel electrophoresis. Their molecular size ranged 2.17 to 87.62 kilobase (Kb). All strains of Shigella spp. consisted in 15.4 Kb plasmids.

ITS기반 상호작용 방식의 자격증 시험 학습시스템

권준아(Jun A Kwun),김원중(Won Jung Kim),최원호(Won Ho Choi),이정금(Jung Keum Lee),서동기(Dong Ki Seo),심현(Hyun Sim) 한국전자통신학회 2017 한국전자통신학회 논문지 Vol.12 No.1

본 연구는 ITS(: Intelligent Tutoring System)기반의 전문가모델과 학습모델에 기반하여 자격증 취득 모의 프로그램을 설계하고, 버기모델(Buggy Model)을 통하여 학습자의 수준에 적합한 문제를 제공하는 시스템이다. 사용자의 요구 조사를 통하여 편의성, 효과성, 확장성, 신뢰성이 요구되었으며, 이를 반영하기 위하여 다양한 문제개발과 문제유형분석, 난이도 조절, 학생성적 및 수준관리 등을 반영한 문제개발이 이루어졌다. 자격증 취득 시험을 준비하는 사용자들은 개발 시스템을 사용하여 본인의 수준에 맞는 문제의 풀이와 다양한 형태의 문제들을 실전과 같은 환경에서 학습하여 자격증 취득 준비기간을 대폭 단축할 수 있을 것으로 기대된다. This study is a system that provides a suitable level of the problem, designing the learner certification simulation program based on the ITS(: Intelligent Tutoring System) based on the model and the learning expert model, the model through a buggy (Buggy Model). In the demand survey that reflects the needs of users, convenience, effectiveness, scalability, and reliability were required. In order to reflect this, various problems were developed, problem type analysis, difficulty control, student grades and level management. Users who are preparing for the certification test are expected to use the development system to solve the problems according to their own level and to solve various types of problems in a practical environment to greatly shorten the preparation period for certification.