야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome

( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.

일반논문(一般論文) : 『황제내경(黃帝內經)』에 나타난 부인과(婦人科)에 관(關)한 문헌고찰(文獻考察)

김혜원 ( Hye Won Kim ),조정훈 ( Jung Hoon Cho ),장준복 ( Jun Bock Jang ),이경섭 ( Kyung Sub Lee ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2005 대한한의학원전학회지 Vol.18 No.1

현훈증 감별에 있어 뇌간청각유발전위의 진단적 의의

조경원,정원영,나정균,임건한 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Sudden onset vertigo is a common complaint in patients who are referred for neurological evaluation. But the entire physical examination and other diagnostic tests may be normal in these patients. Therefore we need more accurate diagnostic tools in the differential diagnosis between the peripheral and the contral vertigo. To evaluate diagnostic effectiveness, we performed Brainstem Auditory Evoked Potentials(BAEP) in the patients with 19 brainstem infarction, 23 peripheral vertigo, 20 vertebrobasilar transient ischemic attack(VB TIA) and analyzed the absolute latency of wave Ⅰ, Ⅲ, Ⅴ and interpeak latency of wave Ⅰ-Ⅲ, Ⅲ-Ⅴ,Ⅰ-Ⅴ compared to normal control data. The results were summerized as follows : 1. There was no significant differences in absolute and interpeak latencies of each BAEP waves between the group of normal control and the group of peripheral vertigo. 2. Among 19 VB TIA patients, prolonged absolute and interpeak latencies of BAEP waves were detected in eleven patients(57.9%) and in nine patients(47.3%), respectively. The abnormal findings were bilaterally in five patients(26.3%) 3. Among 20 brainstem infarction patients, ten patients(50%) showed abnormal BAEP findings, including prolonged interpeak latencies(in three, 15%) and absence of waveform(in seven, 35%). Therefore it is concluded that BAEP could be helpful in differential diagnosis of pathints with peripheral vertigo, V-B TlA, brainstem infarction and other disease of similiar symtomatology.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

흉선종의 병리학적 검색 및 bcl-2 단백과 MIC-2 단백표현에 대한 면역조직화학적 연구

양경무,조미연,홍순원,김태승,박찬일,양우익 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.5

중·고등학교 가정과 「의복마련계획」 영역의 의복 색채 선택 학습을 위한 지도 방안

조성희,강경원,송선희,정규욱 전주대학교 교육문제연구소 2000 敎育論叢 Vol.15 No.-

치질을 투과한 조사광에 의한 복합레진 중합시 치질의 두께, 광세기 및 조사 시간이 복합레진의 표면 경도에 미치는 영향

조수경,김동준,황윤찬,오원만,황인남 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.2

본 연구에서는 치질을 투과한 광에너지량을 측정하고 치질을 투과한 광에너지에 의한 광중합 복합레진의 중합 정도를 표면 경도를 측정하여 분석하였다. 광조사기로는 할로겐 광원을 사용하는 Optilux 501 (Demetron, USA)을 사용하였으며, 중합용 light guide는 840 mW/cm²의 광세기를 갖는 직경 12 mm의 light guide와 1100 nW/cm²의 광세기를 갖는 직경 7 mm의 Turbo light guide를 사용하였다. 광원을 투과시킬 치질은 건전한 상악 중절치의 순면에서부터 법랑질과 상아질을 포함하도록 0.7x0.7cm 의 크기로 두께 1.0 mm와 2.0 mm의 치아 절편을 준비하였다. 직경 5 mm, 두께 2 mm의 주형에 Al 색상의 광중합 복합레진(Charisma, Kulzer, Germany)을 충전하고 각 군에 주어진 조건에 따라 광중합하였다. 시편은 크게 치질의 두께에 따라 (대조군, 1 mm, 2 mm) 3개의 군으로 나누었으며, 각 군은 다시 light guide의 종류와 광조사 시간에 따라 4개의 군으로 나누었다. 제작된 시편은 미세경도측정기를 이용해 광조사면의 비커스 경도를 측정한 결과, 2 mm 치질군과 대조군의 Turbo-light guide으로 40초 동안 중합한 시편이 가장 높은 표면 경도값을 보였으며, 2 mm 치질군에서 light guide의 종류에 상관없이 20초 동안 중합한 시편들이 가장 낮은 표면 경도값을 보였다 (p < 0.05). 이상의 결과는 1 mm 이하와 같은 얇은 치질을 투과하여 복합레진을 중합하는 경우 광세기와 광조사 시간을 증가시키면 중합 정도도 증가하나, 특정 두께 이상의 치질을 투과 시 광세기나 광조사 시간을 증가시키더라도 중합 정도의 증가는 기대하기 어렵다는 것을 시사한다. In this study we measured the amount of light energy that was projected through the tooth material and analyzed the degree of polymerization by measuring the surface hardness of composites. For polymerization, Optilux 501 (Demetron, USA) with two types of light guide was used: a 12 mm diameter light guide with 840 nW/cm² light intensity and a 7 mm diameter turbo light guide with 1100 nW/cm². Specimens were divided into three groups according to thickness of penetrating tooth (1 mm, 2 mm, 0 mm). Each group was further divided into four subgroups according to type of light guide and curing time (20 seconds, 40 seconds). Vickers' hardness was measured by using a microhardness tester. In 0 mm and 1 mm penetrating tooth group, which were polymerized by a turbo light guide for 40 seconds, showed the highest hardness values. The specimens from 2 mm penetrating tooth group, which were polymerized for 20 seconds, demonstrated the lowest hardness regardless of the types of light guides (p < 0.05). The results of this study suggest that, when projecting tooth material over a specified thickness, the increase of polymerization will be limited even if light intensity or curing time is increased.

대한제국 말 여학생용 교과서에 나타난 여성교육론의 특성과 한계 : 『녀자독본』『초등여학독본』『녀자소학수신서』를 중심으로

조경원 이화여자대학교 교육과학연구소 1999 교육과학연구 Vol.30 No.-

을사조약이후, 한일합방까지 학교교육에서 사용되었던 여자용 교과서 『녀자독본』『초등여학독본』및『녀자소학수신서』의 내용을 분석하여, 대한제국말 여성교육론의 특성이 국가중심의 현모양처론임을 논하였다.전통적인 유교적 여성관을 수용하면서도 근대적 여성교육의 중요성이 강조된다.특히 국권회복을 위하여 실력 양성하는 방법의 하나로 자녀 교육을 담당하는 어머니 능력의 중요성이 강조되었다.그리하여 여자용 교과서는 대체로 전통적 여성상을 제시하면서도 불완전한 상태로 능동적인 평등한 여성상을 동시에 제시하고 있다.이 시기에 여성교육론은 국가 중심의 현모양처론으로 특징지워진다.국가의 근본은 가정이고 가정의 근본은 여자이며 어머니로서 여자는 국민을 낳아 기르고 교육하는 바이므로 여성교육이 시급하다는 것이다.국가적 위기에 처하여 애국심이 강한 자녀를 키울 수 있는 어머니 양성이라는 여성교육론은 그 한계에도 불구하고 여성교육에 대한 사회적 인식을 확대시켰다. This paper aims to analyze girls' textbooks which had been used in schools during the period from 1905 to 1910. these are included such as Readings for Women, Elementary Readings for Women, Ethics for Female Students. The urgent demand of the period was the development of national power and children's education for future against Japanese invasion. So women's problems and education were not taken into consideration from the feminist point of view. Women's education were focused on producing wise mothers and good wives in the modern sense in order to raise their children well. While education for women had been emphasized for empowering the nation in the end of the Daehan Empire, educational practices, especially textbooks remained within marked boundaries of Confucian virtuous women. A new idea of God-given human right and freedom appeared frequently.