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Sun, Xiao-Hui,Hou, Wen-Gen,Zhao, Hong-Xing,Zhao, Yi-Lei,Ma, Chao,Liu, Ying Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
The effects of polymorphisms in ERCC5, ERCC6, XPC, CCNH and MMS19L on osteosarcoma response to chemotherapy and the survival of the affected patients were assessed. Genotyping of ERCC5, ERCC6, XPC, CCNH and MMS19L was performed by PCR-RFLP assay. The median PFS was 12.8 months, and the median OS was 18.6 months. Individuals carrying homozygous genotypes of ERCC5 rs17655 and ERCC5 rs1047768 were more like to have good response to treatment, while those carrying homozygous genotypes of MMS19L rs29001322 showed poor response. Osteosarcoma patients carrying TT genotype of ERCC5 rs1047768 showed a significantly longer PFS (16.8 months) and OS (21.4 months) than CC genotype, with HRs(95% CI) of 0.31 (0.10-0.93) and 0.32 (0.06-0.97), respectively. Conversely, those with the TT genotype of MMS19L rs29001322 demonstrated shorter PFS and OS, the HRs (95% CI) being 2.23 (1.08-4.15) and 4.62 (1.45-16.08), respectively. Our findings showed polymorphisms in ERCC5 rs1047768 and MMS19L rs29001322 to be associated with clinical outcome of osteosarcoma patients undergoing chemotherapy.
Dynamic and static properties of sandwich-like graphene-reinforced composite plate
Min Sun,Wen-xing Lu,Minghui Yao,Jianen Chen 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.6
A graphene-reinforced composite plate (GRCP) with a sandwich-like structure is proposed. The nonlinear mechanical characteristics of the sandwich-like GRCP are investigated and compared to those of functionally graded and uniform GRCPs. The modified HalpinTsai model is employed to estimate the material parameters, and the Hamilton principle is used to derive the governing equation for the composite plates. The effects of the graphene nanoplatelet (GPL) distribution patterns, weight fraction, and the number of layers on the static and dynamic nonlinear responses of the plates are investigated. The results show that the various GPL distribution patterns have different enhancement effects on plates. Compared with the graded and uniform distribution patterns, the sandwich-like distribution pattern has significant advantages in terms of anti-vibration and anti-bending properties. Furthermore, it is found that the stresses of the sandwich-like GRCPs are discontinuous, there exist stress mutation phenomena between the surface layers and the pure matrix layer.
Research on Flame Retardant Formaldehyde-Free Plywood Glued by Aqueous Polymer Isocyanate Adhesive
( Ming-yu Wen ),( Jia-zhi Zhu ),( Meng Zhu ),( Yao-xing Sun ),( Hee-jun Park ),( Junyou Shi ) 한국목재공학회 2020 목재공학 Vol.48 No.5
Due to pronounced mechanical performance and being environmental friendly, aqueous polymer isocyanate adhesive (API) has been widely applied in the production of formaldehyde-free wood products. In this study, flame retardant formaldehyde-free plywood was prepared by incorporation of flame retardants into the API adhesive. Partially phosphorylated poly (vinyl alcohol) (PPVA) which was prepared by reacting poly (vinyl alcohol) with phosphoric acid was used to replace PVA in API formula. In addition, Mg-Al layered double hydroxides (LDH) was chosen as additive flame retardant, replacing traditional filler CaCO<sub>3</sub> in API adhesive formula. And then, the flame retardant API adhesive with main agent (PPVA replacing PVA70wt.%, SBR emulsion 30wt.%), curing agent 10wt.% (accounts for of the main agent), and 20wt.% LDHs (accounts of the main agent) was used to prepare flame retardant plywood. The effect of application of PPVA and Mg-Al LDH on bonding strength of plywood was investigated. The flammability characteristics of the plywood were determined by cone calorimeter test (CCT). The results revealed that compared with the plywood prepared with API adhesive, the use of PPVA and LDH enhanced the flame retardancy of plywood without negatively affecting bonding strength. The CCT tests indicated that the heat release and smoke production flame retardant API plywood were lower than those of the ordinary API glued plywood. Promising developments for flame retardant API adhesive were expected in future applications of flame retardant formaldehyde-free plywood.
Ting-Ting Li,Fei Sun,Xing Liu,Hua-Ling Wu,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6
High-modulus PET filaments and thermal bonding are used to reinforce the puncture resistance stability of the insole composite. This study aims to discuss the influences of the amount of low-melting-point polyester fibers (LMPET) and needle densities (ND) on tensile, bursting, and quasi-static puncture resistance properties. Besides, significance of LMPET amount and ND on puncture resistance against flat-head (A), spherical-head (B), and pointed-head (C) probes are in particular investigated to simulate the diversified application environments for insoles. Research result shows that, LMPET amount significantly affects the static puncture resistance against three probes; ND only significantly influences the puncture resistance against Probe A and C. Thermal bonding significantly improves the puncture strength against Probe B with various LMPET amounts of insoles, but evidently increases the puncture resistance against Probe A and C when being punched at various ND. The amount of LMPET fibers has a positive influence on the puncture strength of insoles, and 70 wt% of LMPET provide the average static puncture resistance up to 342.6 N. The high-modulus resultant insoles have advantages of flexibility, ease of process, and bendability with a higher and more stabilized puncture resistances.
Ran An,Shuai Wen,Dong-Li Li,Qiu-Hua Li,Xing-Fei Lai,Wen-Ji Zhang,Ruo-Hong Chen,Jun-Xi Cao,Zhi-Gang Li,Qiu-Sheng Huang,Ling-Li Sun,Shi-Li Sun 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9
Tea and citrus maxima are natural, medicinal homologous plants, typically used for making beverages, which have anticancer, antiobesity, and antioxidation properties. Green tea, yellow tea, and black tea were combined with citrus maxima to obtain green tea and Citrus maxima (GTCM), yellow tea and Citrus maxima (YTCM), and black tea and Citrus maxima (BTCM). The biochemical components of these mixtures were analyzed, and their possible effects and mechanisms on relieving liver lipid deposition were explored. The tea polyphenols, free amino acids, phenolamine ratio, and caffeine were comparable in YTCM and GTCM, being significantly higher than those in BTCM. In addition, the content of esterified catechins, nonesterified catechins, and total catechins in YTCM was significantly higher than those in GTCM and BTCM. All three mixtures of Citrus maxima tea significantly reduced lipid deposition in HepG2 cells, with GTCM and YTCM being slightly more effective than BTCM. Regarding the possible mechanism, Western blot analysis revealed that the three Citrus maxima tea mixtures could activate the AMPK/ACC signaling pathway, upregulate the expression of p-AMPK, p-ACC, and CPT-1 proteins, and downregulate the expression of SREBP1c and fatty acid synthase proteins to inhibit fat synthesis, thereby relieving lipid deposition in liver cells. In conclusion, as a novel and healthy beverage, Citrus maxima tea has the potential to alleviate liver lipid deposition, and further could be responsible for obesity treatment.
Yu Hai Wang,Zhe Dai,Chao Yue Zhang,Guo Wen Sun,Zhong Wei Lu,Xiu Ping Gao,Geng Zhi Sun,Wei Lan,Zhen Xing Zhang,Xiao Jun Pan,Jin Yuan Zhou 한국물리학회 2020 Current Applied Physics Vol.20 No.9
It was demonstrated that the electrochemical performance enhancements in KOH-activated carbon materials should be mainly due to the created polar oxygen-containing functional groups (OFGs, such as such as C–O, C–– O, –OH, and O–C–– O), while the role of each OFGs on the electrochemical enhancements is still unclear. In this work, KOH activation treatments were systematically conducted on carbon nanotubes (CNTs) to explore the role of each OFG on the performance enhancements of Li–S batteries (LSBs). Results showed that the capacity of activated-CNT-sulfur (a-CNT-S) cathodes is 33% higher than that of the pristine CNT-S cathodes, and their rate capability and cycling stability are also enhanced. And the electrochemical analysis combining with Fourier transform infrared spectroscopy indicated that the formed C–O bonds are the real factor for the enhanced electrochemical performances of a-CNT-S cathodes. Furthermore, the optimal activation conditions on CNTbased cathodes for LSBs were optimized to be 10 min at 700 ℃.
Isolation, Culture and Identification of Porcine Skeletal Muscle Satellite Cells
Li, Bo-jiang,Li, Ping-hua,Huang, Rui-hua,Sun, Wen-xing,Wang, Han,Li, Qi-fa,Chen, Jie,Wu, Wang-jun,Liu, Hong-lin Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.8
The objective of this study was to establish the optimum protocol for the isolation and culture of porcine muscle satellite cells. Mononuclear muscle satellite cells are a kind of adult stem cell, which is located between the basal lamina and sarcolemma of muscle fibers and is the primary source of myogenic precursor cells in postnatal muscle. Muscle satellite cells are a useful model to investigate the mechanisms of muscle growth and development. Although the isolation and culture protocols of muscle satellite cells in some species (e.g. mouse) have been established successfully, the culture system for porcine muscle satellite cells is very limited. In this study, we optimized the isolation procedure of porcine muscle satellite cells and elaborated the isolation and culture process in detail. Furthermore, we characterized the porcine muscle satellite cells using the immunofluorecence. Our study provides a reference for the isolation of porcine muscle satellite cells and will be useful for studying the molecular mechanisms in these cells.