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Ultrasound-Triggered Drug Release of Hydroxyapatite Coated Liposomes
조성근,위태인,하정,조선행,한건,한희동,신병철,Cho, Sung Keun,Wee, Tae In,Ha, Jeung,Cho, Sun Hang,Han, Kun,Han, Hee Dong,Shin, Byung Cheol Korean Chemical Society 2013 대한화학회지 Vol.57 No.4
리포솜은 표적 약물을 봉입하여 병소에 안전하게 전달할 수 있는 약물전달체로서 연구되고 있다. 그러나 일반적인 리포솜은 표적부위에서 약물방출이 제한적인 문제점이 있다. 따라서 본 연구에서는 리포솜의 안정성을 향상시키고 표적부위에서 외부 초음파로부터 약물의 방출을 극대화시키기 위하여 하이드록시아파타이트(hydroxyapatite, HA)가 코팅된 리포솜을 개발하였다. 대조군 리포솜은 인지질과 콜레스테롤을 이용하여 제조하였고, 대조군 리포솜의 표면에 칼슘 아세테이트, 포스포릭에시드, 그리고 25% 암모니아용액을 이용하여 HA를 코팅하였다. 모델 약물로는 독소루비신을 사용하였다. HA코팅 리포솜의 크기는 120 nm 이었고, 약물봉입효율은 95% 이상이었다. 30% 혈장용액 내에서 HA코팅 리포솜의 입자크기는 일정한 상태를 유지하였으며, 대조군 리포솜은 크기가 1.4배 증가하였다. 외부 초음파 자극에 의한 리포솜으로부터 약물 방출을 유도한 후, 방출된 약물의 세포 이입율은 HA 코팅된 리포솜이 3배 이상 대조군 리포솜에 비하여 증가하였다. 본 연구에서는 외부 초음파 자극에 의하여 리포솜으로부터 약물의 방출을 극대화시키기 위한 초음파 민감형 리포솜을 개발하였고, 본 제형은 표적부위에서 약물의 방출을 효과적으로 제어하기 위한 분야에 활용이 가능할 것이다. Liposomes, which can deliver payload at target site, have been studied as drug carrier. However, conventional liposomes have limitation for drug release at target site. Therefore, we developed hydroxyapatite (HA) coated ultrasound sensitive liposomes to increase drug release at target site and to enhance stability in blood stream. Control liposome was prepared using hydrogenated soy phosphatidylcholine (HSPC) and cholesterol, and then we assessed HA coating on the surface of control liposomes using calcium acetate, phosphoric acid, and 25% ammonium solution. Doxorubicin was used as a model drug. Size of HA coated liposomes was 120 nm and encapsulation efficiency of doxorubicin in liposomes was up to 95%. Size of HA coated liposomes are not changed in 30% serum solution, however, the control liposomes was 1.4 fold increased. After ultrasound triggered drug release from liposomes, intracellular efficiency of drug released from HA coated liposomes was 3 fold increased compared to control liposomes. In this study, we developed ultrasound sensitive liposomes to enhance drug release, which will be applied in controlled drug release at disease site.
Evaluation of the implantable cardiac monitoring system in a mini-pig model
Ha-Young Jang,Sang-Hyun An,Jun-Sik Kim,Heejaung Kim,Gabbine Wee,Sang-Hyun Kim,Min-Soo Seo,Kyung-Ku Kang,Dae-Yong Han,Jung-Joo Rhyu,Sang-Kyoon Kim,Joon-Suk Park,Dong-Kyu Kim,Seonggon Kim,Taekwan Lee,Ch 한국실험동물학회 2014 한국실험동물학회 학술발표대회 논문집 Vol.2014 No.8
Sang-Hwa Yi,Don-Ha Hwang,Wee Sang Park 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
For on-line partial discharge (PD) monitoring of rotating machines, a novel sensor is proposed, which can be installed on the power lead inside the terminal box of the machine. The sensor has been designed to have high capacitance, and minimal reflection of measured pulses. As a sensitivity of the sensor, transfer impedance Zt has been measured and compared to conventional coupler-type sensors. A simple method is presented for measuring Zt of coupler sensors, using a vector network analyzer and a practical lead-cable of rotating machine. Through this method, it became possible to measure the Zt of coupler sensors including the installation environment of them. The Zt of the proposed sensor is higher than that of same sized other conventional couplers at frequencies between 30 and 92 MHz. Another sensitivity test has been performed using a PD calibrator as a test pulse source. The proposed sensor has higher measured peak voltage than the conventional coupler type sensors when the same charges were input.
Yi, Sang-Hwa,Hwang, Don-Ha,Park, Wee Sang The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.6
For on-line partial discharge (PD) monitoring of rotating machines, a novel sensor is proposed, which can be installed on the power lead inside the terminal box of the machine. The sensor has been designed to have high capacitance, and minimal reflection of measured pulses. As a sensitivity of the sensor, transfer impedance $Z_t$ has been measured and compared to conventional coupler-type sensors. A simple method is presented for measuring $Z_t$ of coupler sensors, using a vector network analyzer and a practical lead-cable of rotating machine. Through this method, it became possible to measure the $Z_t$ of coupler sensors including the installation environment of them. The $Z_t$ of the proposed sensor is higher than that of same sized other conventional couplers at frequencies between 30 and 92 MHz. Another sensitivity test has been performed using a PD calibrator as a test pulse source. The proposed sensor has higher measured peak voltage than the conventional coupler type sensors when the same charges were input.
Ryeong Ha Kwon,Heon-Woong Kim,Suji Lee,So-Jeong Lee,Hyemin Na,Ju Hyung Kim,Chi-Do Wee,Seon Mi Yoo,Sang Hoon Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, shoots and leaves of Acanthopanax senticosus (AST) were analyzed to identify triterpenoid saponins using UPLC-DAD-QToF/MS. The forty-three of saponins were isolated and identified by six standard compounds and published data (library) and the seventeen of saponins were tentatively confirmed for the first time as new compounds. According to aglycone types, triterpenoid saponins in shoots and leaves were classified to oleanane (mesembryanthemoidigenic acid, echinocystic acid, hederagenin, oleanolic acid), noroleanane (akebonic acid), lupane (chiisanogenin) classes. These saponins possessed structures in which arabinose (Ara, m/z 132), rhamnose (Rham, m/z 146), glucose and galactose (Glu and Gal, respectively, m/z 162) were bonded to C-3 of each aglycone and Rham-2Glu (m/z 470) or Rham-(acetyl)Glu-Glu (m/z 512) were bonded to C-28. The MS fragment pattern and intensity of the compounds were the crucial factors that tentatively identified to sugar type and position. It was the fundamental data that the result of composition of AST saponins support in future activity research and functional product development.