숯첨가 사료투여가 넙치의 면역반응에 미치는 영향

권문경,이윤호,박상언,김봉석,박수일 한국어병학회 2002 한국어병학회지 Vol.15 No.1

숯첨가 사료 투여가 넙치에 미치는 영향을 알기 위하여, 넙치에 숯 1%, 3%, 5% 첨가사료를 8주간 투여하면서 성장, 혈액성분, 비특이적면역능을 분석하였으며 어병세균인 Edwardsiella tarda 균의 공격 시험에 대한 방어능을 조사하였다. 숯 첨가 사료 투여는 넙치의 성장과 라이소자임 활성에서는 유의적인 차이를 나타내지 못했지만, 5% 숯첨가구에서 혈액 중의 total protein과 cholesterol의 농도가 대조구에 비하여 낮게 나타났다. 그리고, 숯 3% 첨가구에서 두신 식세포의 활성 및 병원성 세균인 E. tarda에 대한 방어능도 가장 높게 나타났다. The charcoal effects on the immune responses of flounder, Paralichthys olivaceus were studied. Fish were fed an experimental diet supplemented with 1%, 3% or 5% of charcoal to a commercial diet. Several factors such as weight gain, hematological parameters, nonspecific immune responses and resistance against Edwardsiella tarda were evaluated 4 and 8 weeks after the administraion. The changes of body weight and lysozyme activities were not signigicant among tested groups. But cholesterol and total protein concentration in the blood were significantly lower in the 5% supplemented group than in the control. The production of superoxide by macrophage from the head kidney, examined by NBT reduction, was significantly higher in the 3% charcoal supplemented groups than in the control. The survival rate after an artificial challenge with 1×10^exp(7) cells of E. tarda per fish was significantly the highest in the 3% charcoal supplemented group.

Jageum-Jung, the herbal pharmaceuticals, inhibits the hepatic fibrogenesis as mediated with TGF-β1/smad signaling

송유림,Jang Mi Hee,Jang Boyun,Bae Su Jin,Bak Seon Been,Lee Sung Min,Yun Un-Jung,Lee Ju Hee,Park Sang Mi,Jung Dae Hwa,Sa Bok Suk,Song Jong Kuk,이은혜,김광연,Park Kwang-Il,김영우,김상찬 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2

Background Herbal prescriptions have various effects and their efficacy is potentiated by the use of combinations of medicinal herbs. Objective Jageum-Jung (JGJ) is a traditional oriental medical prescription composed of five herbs. It has been used for detoxifi cation, and as an anti-inflammatory and antitumor agent. However, the effect of JGJ on hepatic fibrogenesis is unclear. Results We investigated the role of JGJ in TGF-β1/smad signaling, which is implicated in fibrogenesis, and its hepatoprotective effect in CCl 4 -treated mice with liver fi brosis. Treatment of LX-2 cells with TGF-β induced expression of mediators (α-SMA, PAI-1, and MMP-2) of fibrogenesis and activation of proinflammatory cytokines (TNF-α, IL-1β, and IL-6). However, these were downregulated by pretreatment with JGJ. In mice, oral administration of JGJ prevented liver injury induced by CCl 4 , as indicated by decreases in the ALT and AST levels. Conclusions JGJ inhibits hepatic fibrogenesis and TGF-β1/Smad signaling.

중요 여행 정보를 찾기 위한 지능 검색 시스템

윤은일(Un-Il Yun),신현일(Hyeon-Il Shin),류근호(Keun-Ho Ryu) 한국컴퓨터정보학회 2009 韓國컴퓨터情報學會論文誌 Vol.14 No.11

최근 주 5일 근무의 시행범위가 확대되면서 여가활동에 대한 관심이 증대되고 있다. 또한 인터넷과 모바일 인프라가 널리 보급되어 특정 정보를 필요로 하는 사용자들은 검색 엔진을 이용하여 원하는 정보를 얻을 수 있게 되었다. 그러나 공유되는 정보의 양이 급속하게 증가함에 따라, 검색되는 정보는 많지만 사용자가 원하는 정확한 정보만을 제공받기는 쉽지 않다. 단적인 예로, 여행 정보의 경우사용자들은 자신이 필요한 정보를 검색하지만, 그 결과로는 수많은 여행 상품의 광고들을 보게 된다. 이 논문에서는 정보 수집 에이전트를 이용하여 여행 정보 검색 시스템(TIRS)을 설계하고 구현한다. 정보 수집 에이전트는 포털 사이트의 여행 관련 카테고리 페이지와 주요 언론사들의 여행 기사 페이지를 주기적으로 방문하여 여행과 관련된 정보를 수집하고, 수집된 정보를 데이터베이스에 저장한다. 이를 이용하여 사용자들은 여행에 관련된 정보를 얻기 위해 여러 광고들에 둘러싸일 필요 없이 TIRS의 질의서버를 통하여 필요한 정보를 간편하게 검색할 수 있다. The increasing interest in leisure activities of a five-day work per week has been recently prevailed. Additionally, as internet and mobile infrastructures have been becoming widespread, the user can get specific information using a search engine. However, it is difficult for the user to get accurate information they really want as shared information has been rapidly increased and the information has been searched. For example, users can retrieve required travel information, but they also must see a huge number of travel advertisements. In this paper, we design and implement a retrieval system using travel information collecting agent. The information gathering agent regularly visits travel-related category pages of the portal sites and major media travel-article pages to collect information related to travel, and the agent stores the gathered information to a database. Then, users can search the travel information conveniently without the need to view advertisements.

Evaluating the phototactic behavior responses of the diamondback moth, Plutella xylostella, to some different wavelength LED lights in laboratory and field

Yun Chol-Nam,Maeng Il-Song,Yang Son-Hui,Hwang Un-Jo,Kim Kil-Nam,Kim Kyong-Chol,Ho Kum-Chol,Ri Chung-Song,Yang Hyon-Son,Jang Song-Hun 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.3

Light traps equipped with light emitting diodes (LEDs) have been applied to manage some phototactic insect pests. The diamondback moth, Plutella xylostella, is a cosmopolitan insect pest to be seriously harmful to many cruciferous plants. The present research focused on evaluating the phototactic behavior responses of the moths to several wavelengths and photon flux densities of LED lights under laboratory and field conditions. The results from the laboratory showed that the highest phototactic behavior responses of P. xylostella moths were recorded for UV (380 nm) LED light under 1.5 µmol m − 2 s − 1 and 2.5 µmol m − 2 s − 1 . The moths were more attracted to light traps equipped with 4 LEDs and 6 LEDs of 380 nm, respectively, between 20:00 and 22:00 than the other groups and night times in the field. The finding from the field was consistent with the results from the laboratory. We found that the 380 nm LED light results in the strongest attraction rate of the moths by 92.4 % and the moths caught in light trap with the UV LEDs was 1.62 times more than that with a black light. These data clearly demonstrate that P. xylostella moths have a high sensitivity to 380 nm, therefore, a 380 nm LED light trap could be useful for monitoring and controlling the moths.

장티푸스에서의 N. B. T. 및 Stimulated N. B. T. 검사

고윤웅 ( Yun Woong Ko ),채응석 ( Eung Suk Chai ),한지숙 ( Jee Sook Hahn ),문언 ( Un Moon ),김경석 ( Kyung Suk Kim ),선우일남 ( Il Nam Sunwoo ) 대한내과학회 1975 대한내과학회지 Vol.18 No.8

Production of Large Scale Sequence Information and Development of Sequence-based DNA Markers to Uncover Ginseng Genome

Hong-Il Choi(최홍일),Nam Hoon Kim,Jun-Ha Kim,Jee-Young Park,Yun-Sun Lee,Shailendra Karki,Sang-Un Park,In-Ok Ahn,Tae-Jin Yang 고려인삼학회 2009 고려인삼학회 학술대회 Vol.2009 No.5

UMAP분석을 통한 만성질환 질병들의 연관 관계 규명

조일영(Il-Yeong Cho),김동운(Dong-Un Kim),엄지수(Ji-Su Eom),윤유용(Yu-Yong Yun),한용재(Yong-Jae Han),정연만(Yeon-Man Jeong),조동욱(Dong-Uk Cho) 한국통신학회 2023 한국통신학회 학술대회논문집 Vol.2023 No.6

주제어 가중치 기법에 의한 효율적인 블로그 검색 시스템

신현일(Hyeon-Il Shin),윤은일(Un-Il Yun),류근호(Keun-Ho Ryu) 한국컴퓨터정보학회 2010 韓國컴퓨터情報學會論文誌 Vol.15 No.4

Web 2.0으로 불리는 새로운 세대의 웹에서, 블로그를 통하여 누구나 손쉽게 정보나 의견을 세상에 알릴 수 있게 되었고 이러한 블로그를 효과적으로 검색하기 위해서 블로그의 특성을 고려한 검색 알고리즘들이 새롭게 제안이 되고 있다. 그러나 실제 블로그 검색 시스템에 적용된 키워드 기반 검색이나 블로그간의 링크 분석을 통한 랭킹만으로는 사용자가 기대하는 성능을 발휘하지 못한다. 본 논문에서는 검색 결과를 향상시키기 위해 블로그 글과 검색어와의 연관성을 고려한 주제어 가중치 기반의 블로그검색 시스템을 제안한다. 제안된 시스템은 블로그 글 마다 주제어(Topic)를 추출하여 색인어보다 더 높은 가중치를 부여한다. 기존 시스템과의 비교에서 제안된 방법이 실제 검색 결과에서 재현율이 향상됨을 알 수 있었다. In the new generation of Web, commonly called "Web 2.0", blogging has facilitated the publishing information or his/her opinion on the web. Various blog retrieval algorithms have been proposed to search for blogs more effectively. However, actually keyword-based searching or link-analysis blog ranking system cannot satisfy the user's requirement. In this paper, we suggest a topic-based weighting blog retrieval system in which the links between blog writings and searching words are considered to improve the search results. Our system extracts topics from each blog and weights them much higher than other guide words. In the comparison with other systems, we see that the proposed topic-base system has better recall rate of search results.

Lysophosphatidic acid‐induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer

Choi, Kyung Un,Yun, Jeong Sup,Lee, Il Hwan,Heo, Soon Chul,Shin, Sang Hun,Jeon, Eun Su,Choi, Yoon Ji,Suh, Dong‐,Soo,Yoon, Man‐,Soo,Kim, Jae Ho Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.2

<P><B>Abstract</B></P><P>Lysophosphatidic acid (LPA) is a bioactive lipid crucial for the initiation and progression of ovarian cancer. Identification of LPA‐induced biomarkers is necessary for predicting prognosis of ovarian cancer patients. Here we report periostin, an extracellular matrix protein, as an LPA‐induced protein in stromal cells and as a prognostic marker in patients with epithelial ovarian cancer (EOC). In human EOC tissues, periostin was mainly expressed in cancer‐associated stromal fibroblasts, but not in cancer cells. The expression levels of periostin highly correlated with poor survival and tumor recurrence of ovarian cancer patients. Treatment of human adipose tissue‐derived stromal cells with LPA or conditioned media from human ovarian adenocarcinoma cell lines, such as SK‐OV‐3 and OVCAR‐3, induced expression of periostin. The periostin expression induced by cancer‐conditioned media was abrogated by silencing of the LPA receptor 1 expression using small hairpin RNA lentivirus. Recombinant periostin stimulated adhesion and invasion of SK‐OV‐3 human ovarian adenocarcinoma cells and induced expression of matrix metalloprotease‐2 in the cancer cells. These results suggest that LPA is associated with the expression of periostin in cancer‐associated fibroblasts of EOC.</P>

블로그 검색 성능 향상을 위한 주제-랭크 기법

신현일(Hyeon-Il Shin),윤은일(Un-Il Yun),류근호(Keun-Ho Ryu) 한국컴퓨터정보학회 2011 韓國컴퓨터情報學會論文誌 Vol.16 No.1

1인 미디어인 블로그에 대한 관심이 증가함에 따라, 블로그 검색과 관련된 다양한 랭킹 알고리즘들이 제안되었다. 이러한 알고리즘들은 블로그가 웹 페이지와 다르게 갖는 구조적 특징에 맞게 변형되었으며, 각 블로그간의 연결이나, 댓글, 트랙백들을 통해 이루어진 상호소통 속에서 나타난 결과들을 바탕으로 블로그의 평판이나 인기도를 수치화하여 검색 시스템에 반영한다. 하지만 실제 블로그 검색에서는 블로그 자체의 랭크뿐만 아니라 검색어와 블로그 글과의 적합성과시간등의요소를복합적으로사용하게된다. 그런데기존에알려진요소만으로는검색결과의품질이낮을수 있다. 본 논문에서는 블로그의 주제와 관련도가 가장 높은 블로그를 찾아 낼 수 있는 주제-랭크 기법을 제안한다. 이 기법은 블로그와 블로그 글의 색인어뿐만 아니라, 블로그 글을 대표하는 주제와의 관계까지 랭킹을 매기는 방법이다. 제안된 기법을 통해 블로그 검색에서 검색어와 블로그의 연관성에 따라 랭킹을 효과적으로 부여할 수 있다. 본 논문 제안하는 주제-랭크 기법을 적용한 블로그 검색 시스템의 정확률과 적용률을 국내의 다른 블로그 검색 시스템들과 비교해 본 결과, 주제-랭크 기법을 사용한 블로그 검색 시스템의 성능이 타 시스템에 비해 더 우수함을 알 수 있었다. As people have heightened attention to blogs that are individual media, a variety rank algorithms was proposed for the blog search. These algorithms was modified for structural features of blogs that differ from typical web sites, and measured blogs' reputations or popularities based on the interaction results like links, comments or trackbacks and reflected in the search system. But actual blog search systems use not only blog-ranks but also search words, a time factor and so on. Nevertheless, those might not produce desirable results. In this paper, we suggest a topic-rank technique, which can find blogs that have significant degrees of association with topics. This technique is a method which ranks the relations between blogs and indexed words of blog posts as well as the topics representing blog posts. The blog rankings of correlations with search words are can be effectively computed in the blog retrieval by the proposed technique. After comparing precisions and coverage ratios of our blog retrieval system which applis our proposed topic-rank technique, we know that the performance of the blog retrieval system using topic-rank technique is more effective than others.