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Ting-Ting Sun,Xin-Lei Liang,He-Yun Zhu,Xu-Ling Peng,Xing-Jie Guo,Long-Shan Zhao 고려인삼학회 2016 Journal of Ginseng Research Vol.40 No.3
Background: Among the various ginseng strains, Shizhu ginseng is endemic to China, mainly distributed in Kuandian Manchu Autonomous County (Liaoning Province, China); however, not much is known about the compounds (especially saponins) in Shizhu ginseng. Methods: A rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with MS/MS (UHPLCeMS/MS) method was developed to separate and identify saponins in Shizhu ginseng. Results: The separation was carried out on a Waters ACQUITY UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 ㎛) with acetonitrile and 0.1% formic acid aqueous solution as the mobile phase under a gradient elution at 40℃. The detection was performed on a Micromass Quattro Micro API mass spectrometer equipped with electrospray ionization source in both positive and negative modes. Under the optimized conditions, a total of 31 saponins were identified or tentatively characterized by comparing retention time and MS data with related literatures and reference substances. Conclusion: The developed UHPLCeMS/MS method was suitable for identifying and characterizing the chemical constituents in Shizhu ginseng, which provided a helpful chemical basis for further research on Shizhu ginseng.
Ting-Yan Shi,Sheng Yin,Jianqing Zhu,Ping Zhang,Jihong Liu,Libing Xiang,Yaping Zhu,Sufang Wu,Xiaojun Chen,Xipeng Wang,Yin-Cheng Teng,Tao Zhu,Aijun Yu,Yingli Zhang,Yanling Feng,He Huang,Wei Bao,Yanli Li 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3
Background: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 phase II study showed that selected patients with second relapse who never received SCR at recurrence may still benefit from surgery. Moreover, poly(ADP-ribose) polymerase inhibitors (PARPi) maintenance now has been a standard care for platinum sensitive relapsed OC. To our knowledge, no published or ongoing trial is trying to answer the question if patient can benefit from a potentially complete resection combined with PARPi maintenance in OC patients with secondary recurrence. Methods: SOC-3 is a multi-center, open, randomized, controlled, phase II trial of SCR followed by chemotherapy and niraparib maintenance vs chemotherapy and niraparib maintenance in patients with platinum-sensitive second relapsed OC who never received SCR at recurrence. To guarantee surgical quality, if the sites had no experience of participating in any OC-related surgical trials, the number of recurrent lesions evaluated by central-reviewed positron emission tomography–computed tomography image shouldn't be more than 3. Eligible patients are randomly assigned in a 1:1 ratio to receive either SCR followed by 6 cycles of platinum-based chemotherapy and niraparib maintenance or 6 cycles of platinum-based chemotherapy and niraparib maintenance alone. Patients who undergo at least 4 cycles of chemotherapy and must be, in the opinion of the investigator, without disease progression, will be assigned niraparib maintenance. Major inclusion criteria are secondary relapsed OC with a platinum-free interval of no less than 6 months and a possibly complete resection. Major exclusion criteria are borderline tumors and non-epithelial ovarian malignancies, received debulking surgery at recurrence and impossible to complete resection. The sample size is 96 patients. Primary endpoint is 12-month non-progression rate. Trial Registration: ClinicalTrials.gov Identifier: NCT03983226
Improved fission neutron energy discrimination with <sup>4</sup>He detectors through pulse filtering
Zhu, Ting,Liang, Yinong,Rolison, Lucas,Barker, Cathleen,Lewis, Jason,Gokhale, Sasmit,Chandra, Rico,Kiff, Scott,Chung, Heejun,Ray, Heather,Baciak, James E.,Enqvist, Andreas,Jordan, Kelly A. Elsevier 2017 Nuclear Instruments & Methods in Physics Research. Vol.848 No.-
<P><B>Abstract</B></P> <P>This paper presents experimental and computational techniques implemented for <SUP>4</SUP>He gas scintillation detectors for induced fission neutron detection. Fission neutrons are produced when natural uranium samples are actively interrogated by 2.45MeV deuterium-deuterium fusion reaction neutrons. Fission neutrons of energies greater than 2.45MeV can be distinguished by their different scintillation pulse height spectra since <SUP>4</SUP>He detectors retain incident fast neutron energy information. To enable the preferential detection of fast neutrons up to 10MeV and suppress low-energy event counts, the detector photomultiplier gain is lowered and trigger threshold is increased. Pile-up and other unreliable events due to the interrogating neutron flux and background radiation are filtered out prior to the evaluation of pulse height spectra. With these problem-specific calibrations and data processing, the <SUP>4</SUP>He detector's accuracy at discriminating fission neutrons up to 10MeV is improved and verified with <SUP>252</SUP>Cf spontaneous fission neutrons. Given the <SUP>4</SUP>He detector's ability to differentiate fast neutron sources, this proof-of-concept active-interrogation measurement demonstrates the potential of special nuclear materials detection using a <SUP>4</SUP>He fast neutron detection system.</P>
GENERALIZED WEYL’S THEOREM FOR FUNCTIONS OF OPERATORS AND COMPACT PERTURBATIONS
Ting Ting Zhou,Chun Guang Li,Sen Zhu 대한수학회 2012 대한수학회보 Vol.49 No.5
Let $\mathcal{H}$ be a complex separable infinite dimensional Hilbert space. In this paper, a necessary and sufficient condition is given for an operator T on $\mathcal{H}$ to satisfy that $f(T)$ obeys generalized Weyl's theorem for each function $f$ analytic on some neighborhood of ${\sigma}(T)$. Also we investigate the stability of generalized Weyl's theorem under (small) compact perturbations.
GENERALIZED WEYL'S THEOREM FOR FUNCTIONS OF OPERATORS AND COMPACT PERTURBATIONS
Zhou, Ting Ting,Li, Chun Guang,Zhu, Sen Korean Mathematical Society 2012 대한수학회보 Vol.49 No.5
Let $\mathcal{H}$ be a complex separable infinite dimensional Hilbert space. In this paper, a necessary and sufficient condition is given for an operator T on $\mathcal{H}$ to satisfy that $f(T)$ obeys generalized Weyl's theorem for each function $f$ analytic on some neighborhood of ${\sigma}(T)$. Also we investigate the stability of generalized Weyl's theorem under (small) compact perturbations.
Partial oxidation of polyvinyl alcohol using a commercially available DSA anode
Guo-Ting Liang,Weiyong Zhu,Xiaoqi Chai,Lingfeng Zhu,Xiwang Zhang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.31 No.-
The removal of polyvinyl alcohol (PVA) by electrochemical oxidation was investigated systematicallyunder various conditions using a commercial Dimensionally Stable Anodes anode. It was observed thathigher electrode potential led to more PVA degradation and gases evolution. Acidic conditions werebeneficial for PVA degradation. The higher degradation of PVA was achieved with KBr compared withother salts. The PVA degradation was slightly improved by ultraviolet irradiation while hydrogenperoxide lowered the degradation evidently. FTIR analysis indicated that PVA was partially oxidizedrather than completely mineralized. The iso-propanol quenching test indicated hydroxyl radicals weremainly responsible for PVA degradation.
De-Zhang Zhu,Yan-Ting Wang,Yan-Li Zhuo,Kong-Juan Zhu,Xiang-Zhen Wang,Ai-Jie Liu 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
The purpose of this study was to investigatethe protective eff ects of fucoidan on Lipopolysaccharide(LPS)-induced acute lung injury (ALI) in mice. The micewere divided into the control, LPS, and LPS + fucoidan(20, 40, or 80 mg/kg) groups. LPS was given by intrachealinstillation and fucoidan was given 1 h before LPS treatment. Myeloperoxidase (MPO) activity, malondialdehyde(MDA), superoxide dismutase (SOD), reactive oxygen species(ROS), glutathione (GSH) contents, and infl ammatorycytokine production were detected. The results showed thatLPS-induced TNF-α, IL-1β, and IL-6 production, lung wet/dry (W/D) ratio, ROS, MDA content, and MPO activity weresuppressed by fucoidan. The levels of SOD and GSH wereincreased by fucoidan. Meanwhile, LPS-induced nuclearfactor kappa-B (NF-κB) activation was dose-dependentlyattenuated by fucoidan. Furthermore, fucoidan increasedthe expression of nuclear factor erythroid-2 related factor2 (Nrf2), Glycogen synthase kinase3β (GSK-3β), and hemeoxygenase (HO-1). In vitro, the results demonstrated thatfucoidan or GSK-3β inhibitor signifi cantly inhibited LPSinducedTNF-α production in A549 cells. And the inhibitionof fucoidan on TNF-α production was blocked by Nrf2siRNA. This study showed fucoidan protected mice againstLPS-induced ALI through inhibiting inflammatory andoxidative responses via regulating GSK-3β-Nrf2 signalingpathway.
Rong Jiang,Jianqing Zhu,김재원,Jihong Liu,Kazuyoshi Kato,김희승,Yuqin Zhang,Ping Zhang,Tao Zhu,Daisuke Aoki,Aijun Yu,Xiaojun Chen,Xipeng Wang,Ding Zhu,Wei Zhang,Huixun Jia,Ting-Yan Shi,Wen Gao,Sheng Yin,Yan 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5
Background: Two randomized phase III trials (EORTC55971 and CHORUS) showed similarprogression-free and overall survival in primary or interval debulking surgery in ovariancancer, however both studies had limitations with lower rate of complete resection and lack ofsurgical qualifications for participating centers. There is no consensus on whether neoadjuvantchemotherapy followed by interval debulking surgery (NACT-IDS) could be a preferred approachin the management of advanced epithelial ovarian cancer (EOC) in the clinical practice. Methods: The Asian SUNNY study is an open-label, multicenter, randomized controlled,phase III trial to compare the effect of primary debulking surgery (PDS) to NACT-IDS instages IIIC and IV EOC, fallopian tube cancer (FTC) or primary peritoneal carcinoma (PPC). The hypothesis is that PDS enhances the survivorship when compared with NACT-IDS inadvanced ovarian cancer. The primary objective is to clarify the role of PDS and NACT-IDS inthe treatment of advanced ovarian cancer. Surgical quality assures include at least 50% of nogross residual (NGR) in PDS group in all centers and participating centers should be nationalcancer centers or designed ovarian cancer section or those with the experience participatingsurgical trials of ovarian cancer. Any participating center should be monitored evaluatingthe proportions of NGR by a training set. The aim of the surgery in both arms is maximalcytoreduction. Tumor burden of the disease is evaluated by diagnostic laparoscopy orpositron emission tomography/computed tomography scan. Patients assigned to PDS groupwill undergo upfront maximal cytoreductive surgery within 3 weeks after biopsy, followed by6 cycles of standard adjuvant chemotherapy. Patients assigned to NACT group will undergo 3cycles of NACT-IDS, and subsequently 3 cycles of adjuvant chemotherapy. The maximal timeinterval between IDS and the initiation of adjuvant chemotherapy is 8 weeks. Major inclusioncriteria are pathologic confirmed stage IIIC and IV EOC, FTC or PPC; ECOG performancestatus of 0 to 2; ASA score of 1 to 2. Major exclusion criteria are non-epithelial tumors as wellas borderline tumors; low-grade carcinoma; mucinous ovarian cancer. The sample size is 456subjects. Primary endpoint is overall survival. Trial Registration: ClinicalTrials.gov Identifier: NCT02859038