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      • KCI등재후보

        莫言戏劇文本的創作特点硏究

        王艶(Wang Yan) 중국인문학회 2018 中國人文科學 Vol.0 No.68

        This paper combed the Mo Yan's plays from 1978 to 2017. It simply analyzed his film scripts and TV scripts. The films and TV series promoted the popularization of Mo Yan's works. And in turn, because the writers participated in the creation of the films and TV series, so it improved the artistic taste of the film and TV series. They showed that Literature and the films and television series form a positive interaction. This paper analyzed the drama scripts which were independently created by Mo Yan: “Farewell My Concubine” “The Boiler Man's Wife” “Our Jing Ke” and “Beautiful Clothes”. By Mo Yan's personal understanding and the writing method of realism and romanticism, the drama scripts shaped the typical characters. It revealed the inner world of the characters. The works combined history, folk and real society organically. He reinterpreted the history in a literary way.

      • SCIESCOPUSKCI등재

        Differential Expression of PPARγ, FASN, and ACADM Genes in Various Adipose Tissues and Longissimus dorsi Muscle from Yanbian Yellow Cattle and Yan Yellow Cattle

        Ji,,Shuang,Yang,,Runjun,Lu,,Chunyan,Qiu,,Zhengyan,Yan,,Changguo,Zhao,,Zhihui Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.1

        The objective of this study was to investigate the correlation between cattle breeds and deposit of adipose tissues in different positions and the gene expressions of peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$), fatty acid synthase (FASN), and Acyl-CoA dehydrogenase (ACADM), which are associated with lipid metabolism and are valuable for understanding the physiology in fat depot and meat quality. Yanbian yellow cattle and Yan yellow cattle reared under the same conditions display different fat proportions in the carcass. To understand this difference, the expression of $PPAR{\gamma}$, FASN, and ACADM in different adipose tissues and longissimus dorsi muscle (LD) in these two breeds were analyzed using the Real-time quantitative polymerase chain reaction method (qRT-PCR). The result showed that $PPAR{\gamma}$ gene expression was significantly higher in adipose tissue than in LD in both breeds. $PPAR{\gamma}$ expression was also higher in abdominal fat, in perirenal fat than in the subcutaneous fat (p<0.05) in Yanbian yellow cattle, and was significantly higher in subcutaneous fat in Yan yellow cattle than that in Yanbian yellow cattle. On the other hand, FASN mRNA expression levels in subcutaneous fat and abdominal fat in Yan yellow cattle were significantly higher than that in Yanbian yellow cattle. Interestingly, ACADM gene shows greater fold changes in LD than in adipose tissues in Yan yellow cattle. Furthermore, the expressions of these three genes in lung, colon, kidney, liver and heart of Yanbian yellow cattle and Yan yellow cattle were also investigated. The results showed that the highest expression levels of $PPAR{\gamma}$ and FASN genes were detected in the lung in both breeds. The expression of ACADM gene in kidney and liver were higher than that in other organs in Yanbian yellow cattle, the comparison was not statistically significant in Yan yellow cattle.

      • KCI등재SCOPUS

        Differential Expression of PPARγ, FASN, and ACADM Genes in Various Adipose Tissues and Longissimus dorsi Muscle from Yanbian Yellow Cattle and Yan Yellow Cattle

        Shuang,Ji,Runjun,Yang,Chunyan,Lu,Zhengyan,Qiu,Changguo,Yan,Zhihui,Zhao 아세아·태평양축산학회 2014 Animal Bioscience Vol.27 No.1

        The objective of this study was to investigate the correlation between cattle breeds and deposit of adipose tissues in different positions and the gene expressions of peroxisome proliferator-activated receptor gamma (PPAR), fatty acid synthase (FASN), and Acyl-CoA dehydrogenase (ACADM), which are associated with lipid metabolism and are valuable for understanding the physiology in fat depot and meat quality. Yanbian yellow cattle and Yan yellow cattle reared under the same conditions display different fat proportions in the carcass. To understand this difference, the expression of PPAR, FASN, and ACADM in different adipose tissues and longissimus dorsi muscle (LD) in these two breeds were analyzed using the Real-time quantitative polymerase chain reaction method (qRT-PCR). The result showed that PPAR gene expression was significantly higher in adipose tissue than in LD in both breeds. PPAR expression was also higher in abdominal fat, in perirenal fat than in the subcutaneous fat (p<0.05) in Yanbian yellow cattle, and was significantly higher in subcutaneous fat in Yan yellow cattle than that in Yanbian yellow cattle. On the other hand, FASN mRNA expression levels in subcutaneous fat and abdominal fat in Yan yellow cattle were significantly higher than that in Yanbian yellow cattle. Interestingly, ACADM gene shows greater fold changes in LD than in adipose tissues in Yan yellow cattle. Furthermore, the expressions of these three genes in lung, colon, kidney, liver and heart of Yanbian yellow cattle and Yan yellow cattle were also investigated. The results showed that the highest expression levels of PPAR and FASN genes were detected in the lung in both breeds. The expression of ACADM gene in kidney and liver were higher than that in other organs in Yanbian yellow cattle, the comparison was not statistically significant in Yan yellow cattle.

      • KCI등재

        LPL gene Pvu II polymorphism and hypertriglycer-idemia: a meta-analysis involving 1,640 subjects

        ( Yan-yan Li ), ( Yan-hong Zhou ), ( Ge Gong ), ( Hong-yu Geng ), ( Xin-xing Yang ), ( Xiang-ming Wang ), ( Chuan-wei Zhou ), ( Jian Xu ), ( Yun Qian ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.6

        Background/Aims: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. Methods: A meta-analysis of 1,640 subjects from six individual studies was conducted to better elucidate the potential relationship between the LPL gene Pvu II polymorphism and HT within the Chinese population. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were evaluated by using fixed effect models. Results: Our analysis indicated a significant association between LPL gene Pvu II polymorphism and HT within the Chinese population under allelic (OR, 1.550; 95% CI, 1.320 to 1.830; p = 1.158 × 10<sup>-7</sup>), recessive (OR, 0.540; 95% CI, 0.390 to 0.750; p = 0.0002), dominant (OR, 1.889; 95% CI, 1.501 to 2.377; p = 5.960 × 10<sup>-8</sup>), homozygous (OR, 2.167; 95% CI, 1.531 to 3.067; p = 1.242 × 10<sup>-5</sup>), heterozygous (OR, 1.810; 95% CI, 1.419 to 2.309; p = 1.842 × 10<sup>-6</sup>), and additive genetic models (OR, 1.553; 95% CI, 1.320 to 1.828; p = 1.158 × 10<sup>-7</sup>). Conclusions: Because LPL gene Pvu II restriction fragment length polymorphism polymorphism was associated with an elevated risk of HT, the P+ allele carriers of the LPL gene might be predisposed to HT.

      • KCI등재

        The Influence of Nozzles on Bottomhole Flow Field of Dual-diameter PDC Bit

        Yan,Yan,Zhichuan,Guan,Cai,Yang,Han,Yan 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.1

        In order to improve cleaning efficiency of dual-diameter PDC bit, the total flow area, inclination angle and azimuth angle of bit's pilot and reaming nozzles were analyzed. By numerical simulation, the velocity, pressure and particle distribution of bottomhole are obtained. The results show that low pressure area of pilot downhole decreases while low pressure of reamer downhole increases with the increase of total flow area. The mud velocity of central bottomhole has the negative relationship with inclination angle and positive relationship with azimuth angle. Best cleaning efficiency can be achieved when total flow area is 12 ㎠, inclination angles of pilot and reamer are respectively 15° and 25°, and azimuth angles of pilot and reamer are respectively 60° and 30°.

      • Phase II Study on Javanica Oil Emulsion Injection (Yadanzi<sup>®</sup>) Combined with Chemotherapy in Treating Patients with Advanced Lung Adenocarcinoma

        Lu,,Yan-Yan,Huang,,Xin-En,Cao,,Jie,Xu,,Xia,Wu,,Xue-Yan,Liu,,Jin,Xiang,,Jin,Xu,,Lin Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

        Purpose: To investigate the efficacy and safety of Javanica oil emulsion injection (Yadanzi$^{(R)}$) combined with pemetrexed and platinum (PP) for treating patients with advanced lung cancer. Patients and Methods: From June 2011 to June 2013, we recruited 58 patients with advanced lung cancer, and divided them into two groups. Twenty eight patients received Yadanzi$^{(R)}$ (from ZheJiang Jiuxu Pharmaceutical Co., Ltd.) together with PP chemotherapy (combined group), while the others were given only PP chemotherapy (control group). After two cycles of treatment, efficacy and safety of treatment were evaluated. Results: The overall respnse rate [(CR+PR+SD)/(CR+PR+SD+PD)] of the combined group was higher than that of control group (89.7% vs. 86.2%, p>0.05). Regarding rate of life improvement, it was 82.8% in combined group, and 51.7% in the control group (p<0.05). In terms of side effects, leukopenia in combined group was less frequent than that in control group (p<0.05). More patients in the control group were found to suffer liver toxicity. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced lung adenocarcinoma. It can improve the quality of life and reduce the possibility of leukopenia. Further clinical trials with a large sample size should be conducted to confirm whether addition of Yadanzi$^{(R)}$ to chemotherapy could increase the response rate, reduce toxicity, enhance tolerability and improve quality of life for patients with advanced lung cancer.

      • Clinical Observations on Associations Between the UGT1A1 Genotype and Severe Toxicity of Irinotecan

        Lu,,Yan-Yan,Huang,,Xin-En,Wu,,Xue-Yan,Cao,,Jie,Liu,,Jin,Wang,,Lin,Xiang,,Jin Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

        Background: Severe toxicity is commonly observed in cancer patients receiving irinotecan (CPT-11) UDPglucuronosyltransferase1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38 but the relationship between UGT1A1 and severe toxicity remains unclear. Our study aimed to assess this point to guide clinical use of CPT-11. Materials and Methods: 89 cancer patients with advanced disease received CPT-11-based chemotherapy for at least two cycles. Toxicity, including GI and hematologic toxicity was recorded in detail and UGT1A1 variants were genotyped. Regression analysis was used to analyse relationships between these variables and tumor response. Results: The prevalence of grade III-IV diarrhea was 10.1%, this being more common in patients with the TA 6/7 genotype (5 of 22 patients, 22.7%) (p<0.05). The prevalence of grade III-IV neutropenia was 13.4%and also highest in patients with the TA 6/7 genotype (4 of 22 patients; 18.2%) but without significance (p>0.05). The retreatment total bilirubin levels were significantly higher in TA6/7 patients (mean, $12.75{\mu}mol/L$) with compared to TA6/6 (mean, $9.92{\mu}mol/L$) with p<0.05. Conclusions: Our study support the conclusion that patients with a $UGT1A1^*28$ allele (s) will suffer an increased risk of severe irinotecan-induced diarrhea, whether with mid-or low-dosage. However, the $UGT1A1^*28$ allele (s) did not increase severe neutropenia. Higher serum total bilirubin is an indication that patients UGT1A1 genotype is not wild-type, with significance for clinic usage of CPT-11.

      • Potential Predictors of Sensitivity to Pemetrexed as First-line Chemotherapy for Patients with Advanced Non-Squamous NSCLCs

        Lu,,Yan-Yan,Huang,,Xin-En,Xu,,Lin,Liu,,De-Gan,Cao,,Jie,Wu,,Xue-Yan,Liu,,Jin,Xiang,,Jin Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Background: Pemetrexed (PEM) is effective in first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC). However there are currently no definitive determinants to certify which patients could benefit from PEM. To improve the efficacy of PEM combined with platinum as first-line therapy for advanced non-squamous NSCLC, we conducted this retrospective study to detect potential determinants of this regimen. Methods: We recruited 109 patients with advanced non-squamous NSCLC who received PEM with a platinum as first-line therapy from June 2006 to February 2013 in Jiangsu Cancer Hospital. Multiple variables (age, sex, smoking, degree of cell differentiation, hemoglobin, platinum drugs combined, positions of metastasis) were selected. Logistic regression analysis was used to analyse relationships between these variables and tumor response. Result: In univariate analysis, we found that age and platinum significantly influenced the results of PEM therapy (P<0.05). In multivariable analysis, no factors were independently significant. Conclusion: Our analysis did not suggest that the age, sex, metastasis of liver or other organs, hemoglobin, smoking history and pathological differentiation are associated with the response of PEM. We should conduct further analyses with larger sample size to reconfirm this issue.

      • KCI등재

        ≪장자(莊子)≫에 나타난 `소설(小說)`의 의미에 대한 고찰

        왕비연 ( Wang Fei-yan ) 중국어문연구회 2017 中國語文論叢 Vol.0 No.80

        In the history of Chinese Literature, `Xiaoshuo(小說)` originated in Zhuangzi. The sentence is “use `Xiao-shuo` to earn a great reputation(飾小說以幹縣令)”. Many scholars have considered `Xiao-shuo` to mean trivial tales or short stories, which have nothing to do with the great Tao(道). This paper studied the whole text of Zhuangzi, in order to research the significance of `Xiaoshuo`. I conclude `Xiaoshuo` does not mean trivial tales or short stories, but some other theories of Ancient Chinese Classics which do not concern the great Tao. Zhuangzi asserts that the greatest theories should follow the great Tao. This is what Taoism usually refers to, but some theories do not follow or derive from the great Tao, just minor or trivial lectures. He called such theories `Xiaoshuo`. In Zhuangzi, Chuang-tzu also called something similar as `Xiao-shuo`, including `Xiao-yan(小言)`, `Su-yan(俗言)` and `Ye-yu(野語)`. Each type is distinctive, seems the `suk-yan(俗言)` is the most similar to interesting tales. After 20th `Xiao-shuo` became like `novel` in West literature. In old China it has many significance like tale, fiction, story, and novel, But in Zhuangzi, it doesn`t mean that.

      • KCI등재SCOPUS

        Motion behavior research of liquid micro-particles filtration at various locations in a rotational flow field

        Yan,Yan,Yuanzai,Lin,Jie,Cheng,Zhonghua,Ni 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.62 No.2

        This study presents a particle-wall filtration model for predicting the particle motion behavior in a typical rotational flow field-filtration in blower system of cooker hood. Based on computational fluid dynamics model, air flow and particles has been simulated by Lagrangian-particle/ Eulerian-gas approaches and get verified by experiment data from a manufacturer. Airflow volume, particle diameter and local structure, which are related to the particle filtration has been studied. Results indicates that: (1) there exists an optimal airflow volume of 1243 m3/h related to the most appropriate filtration rate; (2) Diameter of particle is the significant property related to the filtration rate. Big size particles can represent the filtration performance of blower; (3) More than 86% grease particles are caught by impeller blades firstly, and then splashed onto the corresponding location of worm box internal wall. These results would help to study the micro-particle motion behavior and evaluate the filtration rate and structure design of blower.

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