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Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
Lingfeng He,Hong Zhu,Shiying Zhou,Ting Wu,Huan Wu,Huan Yang,Huiwen Mao,Chandra SekharKathera,Avilala Janardhan,Ashlin M. Edick,Anna Zhang,Zhigang Hu,Feiyan Pan,Zhigang Guo 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. 5-Fluorouracil (5-FU) is widely used in the treatment of cancers, but its antineoplastic activity is limited in drug-resistant cancer cells. To investigate the detailed mechanism of 5-FU resistance, we developed a model of 5-FU-resistant cells from HCT-8 cells, a wellestablished colorectal cancer cell line. We found that the drug-resistant cells demonstrated high expression of TCF4 and β-catenin, indicating an upregulated Wnt pathway. A microarray analysis revealed that the suppression of the checkpoint kinase 1 (CHK1) pathway explained the resistance to 5-FU, especially in p53 wild-type cancer cells such as HCT-8. Our data also demonstrated that the CHK1 pathway is suppressed by the Wnt pathway in 5-FU-resistant cells. In summary, we have discovered a novel mechanism for 5-FU resistance mediated by histone deacetylation, which also revealed the crosstalk between the Wnt pathway and CHK1 pathway.
Effect of the Liquid Density Difference on Interface Shape of Double-Liquid Lens
Meimei Kong,Lingfeng Zhu,Dan Chen,Zhongcheng Liang,Rui Zhao,Enming Xu 한국광학회 2016 Current Optics and Photonics Vol.20 No.3
The effect of the liquid density difference on interface shape of a double-liquid lens is analyzed indetail. The expressions of interface shape of two liquids with liquid density difference are analyzed andfitted with “even asphere”. The imaging analysis of the aspheric interface shape of a double-liquid lensis presented. The results show that the density difference of two liquids can cause the interface to bean aspheric surface, which can improve the image quality of a double-liquid lens. The result providesa new selection for the related further research and a wider application field for liquid lenses.
Partial oxidation of polyvinyl alcohol using a commercially available DSA anode
Guo-Ting Liang,Weiyong Zhu,Xiaoqi Chai,Lingfeng Zhu,Xiwang Zhang 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.31 No.-
The removal of polyvinyl alcohol (PVA) by electrochemical oxidation was investigated systematicallyunder various conditions using a commercial Dimensionally Stable Anodes anode. It was observed thathigher electrode potential led to more PVA degradation and gases evolution. Acidic conditions werebeneficial for PVA degradation. The higher degradation of PVA was achieved with KBr compared withother salts. The PVA degradation was slightly improved by ultraviolet irradiation while hydrogenperoxide lowered the degradation evidently. FTIR analysis indicated that PVA was partially oxidizedrather than completely mineralized. The iso-propanol quenching test indicated hydroxyl radicals weremainly responsible for PVA degradation.
Guoting Li,Weiyong Zhu,Lingfeng Zhu,Xiaoqi Chai 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
Sugarcane bagasse was pyrolyzed under oxygen-limited conditions from 100 to 600 oC and used for the adsorptive removal of oxidation intermediate p-benzoquinone, tetracycline, and polyvinyl alcohol. The three organic pollutants have different polarities and solubilities. The carbon content increased from 57.7% of the raw bagasse to 75.3% of the biochar pyrolyzed at 600 oC, while the O content decreased from 13.2% to 6.1%. Accordingly, the biochar surface became more hydrophobic with increasing pyrolytic temperature. Interestingly, the adsorption affinity of biochars towards the three pollutants improved with an increase in the pyrolytic temperature. The adsorption of tetracycline molecules was almost unaffected by its being negatively charged with increasing solution pH. A mechanism of π- π electron-donor-acceptor interaction might contribute to the adsorption of tetracycline and p-benzoquinone, while Hbond interaction between polyvinyl alcohol and the biochar might be dominant during adsorption. The Elovich model fitted the kinetic model well, indicating that the diffusional rate-determining step was more pronounced. An isotherm study indicated that the contribution of partitioning was also dominant in the adsorption processes. Wide application of the prepared biochars is expected for the efficient adsorptive removal of organic pollutants.