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Tao Chunrong,Yuan Guangxiong,Xu Pengfei,Wang Hao,Zhou Peiyang,Yi Tingyu,Li Kai,Cui Tao,Gao Jun,Li Rui,Sun Jun,Zhang Chao,Wang Li,Liu Tianlong,Song Jianlong,Yin Yamei,Nguyen Thanh N.,Li Qing,Hu Wei 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3
Background and Purpose To examine the clinical and safety outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO) with different anesthetic modalities. Methods This was a retrospective analysis using data from the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) registry. Patients were divided into two groups defined by anesthetic modality performed during EVT: general anesthesia (GA) or non-general anesthesia (non-GA). The association between anesthetic management and clinical outcomes was evaluated in a propensity score matched (PSM) cohort and an inverse probability of treatment weighting (IPTW) cohort to adjust for imbalances between the two groups. Results Our analytic sample included 1,672 patients from 48 centers. The anesthetic modality was GA in 769 (46.0%) and non-GA in 903 (54.0%) patients. In our primary analysis with the PSM-based cohort, non-GA was comparable to GA concerning the primary outcome (adjusted common odds ratio [acOR], 1.01; 95% confidence interval [CI], 0.82 to 1.25; <i>P</i>=0.91). Mortality at 90 days was 38.4% in the GA group and 35.8% in the non-GA group (adjusted risk ratio, 0.95; 95% CI, 0.83 to 1.08; <i>P</i>=0.44). In our secondary analysis with the IPTW-based cohort, the anesthetic modality was significantly associated with the distribution of modified Rankin Scale at 90 days (acOR: 1.45 [95% CI: 1.20 to 1.75]). Conclusion In this nationally-representative observational study, acute ischemic stroke patients due to BAO undergoing EVT without GA had similar clinical and safety outcomes compared with patients treated with GA. These findings provide the basis for large-scale randomized controlled trials to test whether anesthetic management provides meaningful clinical effects for patients undergoing EVT.
Knockdown of Bcl-3 Inhibits Cell Growth and Induces DNA Damage in HTLV-1-infected Cells)
Gao, Cai,Wang, Xia,Chen, Lin,Wang, Jin-Heng,Gao, Zhi-Tao,Wang, Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Oncoprotein Bcl-3 is perceived as an unusual member of $I{\kappa}B$ family since it can both stimulate and suppress NF-${\kappa}B$ activation. Aberrant Bcl-3 results in increased cell proliferation and survival, suggesting a contribution to malignant potential and elevated levels of Bcl-3 have been observed in many HTLV-1-infected T cell lines and ATL cells. To investigate the specific roles of Bcl-3 in HTLV-1-infected cells, we knocked down Bcl-3 expression using shRNA and then examined the consequences with regard to DNA damage and cell proliferation, as well as NF-${\kappa}B$ activation. The HTLV-1 encoded protein Tax promotes Bcl-3 expression and nuclear translocation. In HTLV-1-infected cells, Bcl-3 knockdown obviously induced DNA damage. Cell growth and NF-${\kappa}B$ activation were reduced in HTLV-1-infected or Tax positive cells when Bcl-3 expression was decreased. Together, our results revealed positive roles of Bcl-3 in DNA stabilization, growth and NF-${\kappa}B$ activation in HTLV-1-infected cells.
Analysis of the Difference of Spray Angles based on Various Definitions and Calculation Criterions
( Yuan Gao ),( Li Guang Li ),( Ya Gao ),( Wei Di Huang ),( Jun Deng ),( Tao Li Gu ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-
Spray angle is one of the key spray macro parameters which reflect fuel atomization characteristics and fuel and air entrainment quality directly; it then could affect the combustion efficiency and emission formation in cylinder. As the spray characteristics are widely investigated, there are already some kinds of definition and calculation methods for spray angle. Although all these definitions reflect the spray angle trends correspondingly, the difference between these definitions and calculation results was seldom studied. This paper focuses on the comparison and analysis the spray angle results based on the different calculation criterions, and the trend of these key points versus time at various calculation criterions which determine spray angle.
A Closed-loop GSPWM Method for Attenuating Circulating Leakage Current in PV Station
Tao Xu,Feng Gao,Tianqu Hao,Kangjia Zhou 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper proposes a closed-loop Global Synchronous Pulse Width Modulation (CL-GSPWM) method for attenuating circulating leakage current in PV station with many inverters connected in parallel. The CLGSPWM can well minimize leakage current without central calculation and the pre-known parameters of each inverter, such as leakage capacitors, feeder impedance, etc.. Each inverter can control its PWM phase shift angle to minimize the leakage current with the measured leakage current. Meanwhile, it only needs to transmit little information among inverters, which means the proposed method can be integrated into inverter without additional hardware. Experimental prototype with four down-scale inverters are employed to verify the performance of the proposed CLGSPWM.
Microstructure and Performance Study of Al/Cu Laser Welding with Ag Interlayer
Tao Chen,Fei Liu,Lihui Pang,Hao Hu,Ping Gao 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.1
In the past research, there was a gap in the field of Al/Cu dissimilar metal welding with Ag intermediate layer, and attention to the joint resistivity is insufficient. This paper has used laser welding to study this problem. The mechanical and electrical properties of the joints were tested, and the microstructure and fracture surface of the weld were observed, along with the analysis of their phase composition and formation mechanism. The results show that the Ag–Al–Cu ternary system forms on the weld, and Ag inhibits the formation of IMC in the Al/Cu system, with the main IMCs being Al2Cu and Ag3Al. Part of the Ag-rich and Al-rich phases are dispersed in small particle shape, providing a strengthening effect in various areas. After adjusting the welding parameters, excellent joints can be obtained, with a tensile strength of 98.05 MPa, which is 78.5% of the base metal, and a resistivity of 2.47 μΩ cm. The fracture occurs in the softened zone of the Al-side base metal, indicating a ductile fracture. These findings have demonstrated that good mechanical and electrical properties can be obtained by adding Ag as an intermediate layer of the joint.
Tao Liu,Jingjing Dong,Chaonan Ye,Xianyan Wu,Wei Fan,Linlin Lu,Jingyu Kang,Xingzhong Gao,Baozhong Sun,Honglei Yi 한국섬유공학회 2022 Fibers and polymers Vol.23 No.12
In this work, the bending modal properties of three-dimensional (3D) braided composites were investigated withthe experimental and numerical methods. Three braided angles were selected to study the braided angle effect on the modalbehavior of 3D braided composites. According to the experimental parameters, a homogeneous model containing the interior,surface and corner representative unit cells of the braided composites were proposed to compute the elastic constants of eachcomposite. Besides, the fiber breakage defects were introduced to the homogeneous model to improve the accuracy ofpredicting the modal behavior of the braided composite. The results indicate that the increase of the braided angle and thefiber breakage defects could apparently reduce the natural frequency of the braided composite. The modal propertiessimulated by the homogeneous models containing some fiber breakage defects could fit well with the correspondingexperimental results. The proposed method to create the homogenous model can be used to predict the modal behavior of the3D braided composites.
Numerical Simulation of Thermal Fluctuation of Hot and Cold Fluids Mixing in a Tee Junction
Gao, Kai,Lu, Tao The International Promotion Agency of Culture Tech 2015 International Journal of Advanced Culture Technolo Vol.3 No.2
In this work, mixing processes of hot and cold fluids of three different jet types are predicted by large-eddy simulation (LES) on FLUENT platform. Temperature at different positions of internal wall and mixing conditions of T-junctions at different times are obtained, then the simulated normalized mean and root-mean square (RMS) temperature, temperature contour and velocity vector of every case are compared. The results indicate that, the mixing regions in the tee junction is related to the jet type, and temperature fluctuations on the pipe wall in the type of the deflecting jet is the least.
Gao, Pan,Tao, Ning,Ma, Qin,Fan, Wen-Xi,Ni, Chen,Wang, Hui,Qin, Zhi-Hai Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Aim: The purpose of this study was to investigate anti-tumor effects and safety of DH332, a new ${\beta}$-carboline alkaloids derivatives in vitro and in vivo. Materials and Methods: The effects of DH332 on human (RAMOS RA.1) and mouse (J558) B lymphoma cell lines were detected using a CCK-8 kit (Cell Counting Kit-8), and apoptosis was detected by flow cytometry with PI/annexinV staining. Western blotting was used to detected caspase-3 and caspase-8. Neurotoxic and anti-tumor effects were evaluated in animal experiments. Results: DH332 exerts a lower neurotoxicity compared with harmine. It also possesses strong antitumor effects against two B cell lymphoma cell lines with low $IC_{50s}$. Moreover, DH332 could inhibit the proliferation and induce the apoptosis of RAMOS RA.1 and J558 cell lines in a dose-dependent manner. Our results suggest that DH332 triggers apoptosis by mainly activating the caspase signaling pathway. In vivo studies of tumor-bearing BALB/c mice showed that DH332 significantly inhibited growth of J558 xenograft tumors. Conclusions: DH332 exerts effective antitumor activity in vitro and in vivo, and has the potential to be a promising drug candidate for lymphoma therapy.