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- 저자 : ( Yuan Gao ) (검색결과 237 건)
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Yuan-Yuan Gao,Wen Tian,Hui-Nan Zhang,Yang Sun,Jing-Ru Meng,Wei Cao,Xiao-Qiang Li 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4
Canonical transient receptor potential channels(TRPCs) are nonselective, high calcium permeability cationicchannels. The TRPCs family includes TRPC1, TRPC2,TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7. These channelsare widely expressed in the cardiovascular and nervoussystems and exist in many other human tissues and celltypes, playing several crucial roles in the human physiologicaland pathological processes. Hence, the emergenceof TRPCs modulators can help investigate these channels’applications in health and disease. It is worth noting that theTRPCs subfamilies have structural and functional similarities,which presents a signifi cant diffi culty in screening anddiscovering of TRPCs modulators. In the past few years,only a limited number of selective modulators of TRPCswere detected; thus, additional research on more potent andmore selective TRPCs modulators is needed. The presentreview focuses on the striking desired therapeutic eff ectsof TRPCs modulators, which provides intel on the structuralmodifi cation of TRPCs modulators and further pharmacologicalresearch. Importantly, TRPCs modulators cansignifi cantly facilitate future studies of TRPCs and TRPCsrelated diseases.
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Gao Yuan,Zhang Liang,Zhou Jiawei,Wei Bojia,Yan Zhongchao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5
For the first time, the fault tree mapping dynamic Bayesian network (DBN) method is applied to the reliability research study of centrifugal compressor units, and its usability and reliability are evaluated dynamically. First, the fault data using the K-means method eliminates abnormal data and builds a fault tree model. The structure is mapped to the DBN structure to complete the structure learning, and the logic gate is mapped to the conditional probability to achieve the parameter learning. Then the model is solved bidirectionally. The change rule of system node reliability with time is solved forward, and the posterior probability of the system node is solved reversely to complete fault diagnosis. Finally, Monte Carlo simulation analysis and the Markov process verify the dynamic reliability and steady-state availability. The results show that the Monte Carlo simulation method is almost consistent with the reliability prediction curve of the DBN model. Indicating that the accuracy of the DBN model is reliable and the computational efficiency is improved by about 81434 times. The steady-state availability calculated using the DBN model is approximately 0.99963, which is close to reality compared to the Markov process. This method can better describe centrifugal compressor units’ dynamic reliability and maintainability and provide decision support for regular maintenance of essential parts and enterprise procurement.
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Gao, Yuan,Deng, Zhixiang,Choi, Dongmin,Choi, Chang Elsevier 2018 Journal of parallel and distributed computing Vol.114 No.-
<P><B>Abstract</B></P> <P>In this paper, we propose a cooperative spectrum sensing scheme including a combined pre-detection and sleeping policy. In the scheme, the designed pre-detection sub-phase is applied at the beginning of the detection of the presence of a primary user, where all sensing nodes are involved to improve the detection performance. The sleeping policy is applied for each sensing node respectively at the end of the pre-detection sub-phase and the beginning of the transmission of the local detection results, in order to decrease sensing energy consumption. We formulate the problem of minimizing the maximum average energy consumption per sensing node in Rayleigh fading channels, considering the constraints of the required global detection and false alarm probabilities and the tolerable interference caused to the primary user. Numerical results show that the scheme achieves significant energy saving as compared to a scheme that includes only a sleeping policy and does not consider pre-detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We propose a combined pre-detection and sleeping scheme for spectrum sensing. </LI> <LI> The sensing performance is not affected by a high sleeping rate of secondary relays. </LI> <LI> An analytical framework is based on more practical channel conditions. </LI> <LI> A search algorithm is studied to obtain low complexity for solving the optimal problem. </LI> <LI> The proposed scheme achieves significant energy saving for spectrum sensing. </LI> </UL> </P>
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Yuan Gao,Hong-jing Yu,Bin Wen 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.5
BIFICO is a main microecological drug that the main ingredient is Bifidobacterium longum ATCC BAA- 2753. It’s necessary to detect the number of Bifidobacterium longum ATCC BAA-2753 for quality control during the production of BIFICO. Plate count assay (PCA) is the most commonly used method for counting microbial cells. However, not all microorganisms can be counted by PCA. (e.g. uncultured microorganisms under specific growth conditions). In this study, a method of fluorescent techniques in combination with flow cytometry (FCM) was established for the counting of Bifidobacterium longum BAA-2753. Using SYTO9 and PI stain, flow cytometric analysis could easily differentiate live bacteria and dead bacteria. The number of live bacteria determined by FCM was about fourfold higher than that counted by PCA. Therefore, the FCM method could be a practical tool for the quality control of Bifidobacterium longum BAA-2753 in the industrial production of BIFICO.
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Yuan, Gao-Feng,Yuan, Jing-Qun,Li, Duo The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.2
The incorporation and metabolism of orally administered punicic acid (PA), one isomer of conjugated linolenic acid (CLNA), in rat tissues and plasma were studied over a 24-hour period. The punic acid was derived from Trichosanthes kirilowii Maxim seed oil, a unique PA-containing material, and identified and analyzed by high-performance liquid chromatography and gas chromatography-mass spectrometry. The results show that PA was incorporated and metabolized to 9c,11t-conjugated linoleic acid (CLA) in rat plasma, liver, kidney, heart, brain, and adipose tissue. The level of PA and CLA in liver and plasma was higher than in brain, heart, kidney, and adipose tissue, and the lowest accumulation occurred in the brain. The observation that PA can be converted into 9c,11t-CLA has gained increased importance since it has been demonstrated that 9c,11t-CLA exerts many biological activities. Therefore natural resources containing CLNA, especially edible T. kirilowii seed, could be a potential dietary source of CLA, following PA metabolism. PA is expected to be used as a functional food and nutraceutical.
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Yuan Gao,Yubin Ji,Fuling Wang,Wenlan Li,Xiaomeng Zhang,Zhihui Niu,Zhuo Wang 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.13
Blueberry residue is usually discarded as waste,but has a high anthocyanins content. The extraction methodof anthocyanins from blueberry residue with ultrasonicassisted dual-aqueous phase system was optimized. Interms of the principle of central group and design (CCD)experimental design, three-factor and five-level responsesurface analysis was adopted to optimize the extractionconditions with the extraction rate of anthocyanins. Theoptimum extraction rate of anthocyanin was12.372 ± 0.078 mg/g. Anthocyanin extract could protectthe pBR322 DNA oxidative damage induced by Fentonreagent, increase the superoxide dismutase(SOD) and glutathioneperoxidase (GSH-Px) enzyme activities, anddecrease the H2O2-induced cell apoptosis of human normalliver cell (LO2 cell). The study indicates that the extractionrate of anthocyanin was increased by optimized ultrasonicassisted dual-aqueous phase system. The anthocyaninextract could protect DNA and LO2 cell from oxidativedamage.
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Spectrum Hole Utilization in Cognitive Two-way Relaying Networks
( Yuan Gao ),( Changping Zhu ),( Yibin Tang ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.3
This paper investigates the spectrum hole utilization of cooperative schemes for the two-way relaying model in order to improve the utilization efficiency of limited spectrum holes in cognitive radio networks with imperfect spectrum sensing. We propose two specific bidirectional secondary data transmission (BSDT) schemes with two-step and three-step two-way relaying models, i.e., two-BSDT and three-BSDT schemes, where the spectrum sensing and the secondary data transmission are jointly designed. In the proposed cooperative schemes, the best two-way relay channel between two secondary users is selected from a group of secondary users serving as cognitive relays and assists the bi-directional communication between the two secondary users without a direct link. The closed-form asymptotic expressions for outage probabilities of the two schemes are derived with a primary user protection constraint over Rayleigh fading channels. Based on the derived outage probabilities, the spectrum hole utilization is calculated to evaluate the percentage of spectrum holes used by the two secondary users for their successful information exchange without channel outage. Numerical results show that the spectrum hole utilization depends on the spectrum sensing overhead and the channel gain from a primary user to secondary users. Additionally, we compare the spectrum hole utilization of the two schemes as the varying of secondary signal to noise ratio, the number of cognitive relays, and symmetric and asymmetric channels.
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Gao, Wen Yuan,Lei Fan,Paek, Kee Yoeup 한국식물학회 1999 Journal of Plant Biology Vol.42 No.2
Amyloplast structure and intercellular transport in old and new scales of Fritillaria ussuriensis were observed by means of electron microscope. Most amyloplasts in old scales contained one starch grain, which was constructed by the layered deposition of starch around the hilum. Membrane systems and stroma of amyloplasts were pushed aside to form a shell surrounding the starch grain. In contrast, amyloplast shells in new scales contained a relatively light stroma and few internal membranes that were not organized into grana and stroma thylakoids. Active intercellular transport was observed in both new and old scales. Encytosis and exocytosis were common in the cell membrane and produced many vesicles containing numerous particles and filaments. These results lay the foundation for the further study on the mechanisms of growth and development in.
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Gao-Feng Yuan,Jing-Qun Yuan,Duo Li 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2
The incorporation and metabolism of orally administered punicic acid (PA), one isomer of conjugated linolenic acid (CLNA), in rat tissues and plasma were studied over a 24-hour period. The punic acid was derived from Trichosanthes kirilowii Maxim seed oil, a unique PA-containing material, and identified and analyzed by high-performance liquid chromatography and gas chromatography-mass spectrometry. The results show that PA was incorporated and metabolized to 9c,11t-conjugated linoleic acid (CLA) in rat plasma, liver, kidney, heart, brain, and adipose tissue. The level of PA and CLA in liver and plasma was higher than in brain, heart, kidney, and adipose tissue, and the lowest accumulation occurred in the brain. The observation that PA can be converted into 9c,11t-CLA has gained increased importance since it has been demonstrated that 9c,11t-CLA exerts many biological activities. Therefore natural resources containing CLNA, especially edible T. kirilowii seed, could be a potential dietary source of CLA, following PA metabolism. PA is expected to be used as a functional food and nutraceutical.
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